638-94-8 Usage
Description
Desonide, also known as triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9, is a corticosteroid anti-inflammatory. It is an off-white solid and is used topically for the treatment of various skin disorders. Desonide is also found as an impurity in budesonide (B689490), another anti-inflammatory.
Used in Pharmaceutical Industry:
Desonide is used as an anti-inflammatory agent for the treatment of various skin disorders. It is effective in reducing inflammation, redness, and itching associated with these conditions.
Used in Antifungal Applications:
Desonide is used as an antifungal agent, helping to treat fungal infections of the skin.
Used in Anti-Inflammatory Applications:
Desonide is used as an anti-inflammatory agent for reducing inflammation and other symptoms associated with various skin conditions.
Brand names for Desonide include Desowen (Galderma) and Tridesilon (Perrigo).
Originator
Tridesilon,Dome,US,1972
Indications
Desonide (DesOwen, Tridesilon) is a synthetic corticosteroid.
Manufacturing Process
Preparation of 11β,21-Dihydroxy-16α,17α-Isopropylidenedioxy-1,4-
Pregnadiene-3,20-Dione: A solution of 11β,16α,17α,21-tetrahydroxy-1,4-
pregnadiene-3,20-dione (40 mg) in acetone (10 ml) containing hydrochloric
acid (three drops; d 1.19) is boiled 3n the steam bath for two minutes and then allowed to stand for eighteen hours at room temperature. The reaction
mixture is diluted with water (50 ml) and extracted with chloroform (3x25
ml), the combined extracts then being washed with water (30 ml) and dried
over anhydrous sodium sulfate. The residue obtained by removal of solvent
crystallized from ethyl acetate-petroleum ether as small plates (25 mg),
melting point 257°-260°C.
Therapeutic Function
Antiinflammatory
Check Digit Verification of cas no
The CAS Registry Mumber 638-94-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 8 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 638-94:
(5*6)+(4*3)+(3*8)+(2*9)+(1*4)=88
88 % 10 = 8
So 638-94-8 is a valid CAS Registry Number.
InChI:InChI=1/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,20+,22-,23-,24+/m0/s1
638-94-8Relevant articles and documents
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Bernstein et al.
, p. 4573 (1959)
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A synthesis method of budesonide (by machine translation)
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Paragraph 0030; 0032; 0038; 0046; 0054, (2018/07/30)
The invention discloses a budesonide synthetic method, under the protection of inert gas, under the catalysis of the 1st catalyst, sulfur dioxide will prednisone acetate eliminated reaction, then under the catalysis of the 2nd catalyst, through the oxidizing agent after the elimination of the products of the oxidation reaction, then under the catalysis of the 3rd catalyst, after oxidation through the acetone to products of the condensation process, the condensation product of the 4th under catalysis of the catalyst for selective reduction, finally 5th after reduction of the product of the hydrolysis catalyst under the catalysis of the reaction Desonide; the invention relates to a synthesis method of budesonide to prednisone acetate as raw materials through eliminating, oxidation, condensation, reduction, hydrolysis can be budesonide, synthesis process all the solvent in the process of all the recycled, and the reaction process in the absence of a heavy metal involved in the reaction, the technological process is mild, low energy consumption, is a green clean synthesis method. (by machine translation)
NOVEL PROCESS FOR PREPARATION OF GLUCOCORTICOID STEROIDS
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Page/Page column 19, (2016/08/23)
The present invention discloses a process for the preparation of 16, 17-acetals of pregnane derivatives having formula (I) wherein each substituent is independently selected from; R1 is H or CH3; R2 is C1-C6 linear or branched alkyl, alkynyl group or cycloalkyl group; aryl or heteroaryl group; or R1 and R2 combine to form saturated, unsaturated C3-C6 cyclic or heterocyclic ring; R3 and R4 are same or different and each independently represents H or halogen; R5 is -OH or –OCOR wherein R represents H or C1-C6 linear, branched or cyclic alkyl group that may be substituted.