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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White crystalline powder Storage:ln stock Package:25kg/Barrel Application:Anti-inflammatory corticosteroids Transportation:Express/Sea/Air Port:Any port in china

Desonide

Cas:638-94-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan PharmChem Co.,Ltd

Appearance:White to off-white crystalline powder Storage:Store in a cool, dry and well-ventilated area Package:10g/foil bag; 1kg/tin Application:Pharmaceutical intermediates Transportation:Prompt delivery Port:Shanghai port

99% Desonide C24H32O6

Cas:638-94-8

Min.Order:10 Gram

FOB Price: $6.0

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Desonide

Cas:638-94-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Desonide Cas 638-94-8 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Storage:Refrigerator Package:1kg/bag or as you required Application:Hormone

Wholesale high quality Desonide Cas 638-94-8 with factory low price

Cas:638-94-8

Min.Order:1 Kilogram

FOB Price: $2500.0

Type:Trading Company

inquiry

Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

Lab grade 99% Desonide powder supplier CAS:638-94-8

Cas:638-94-8

Min.Order:50 Gram

FOB Price: $1.28 / 1.78

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% Desonide 638-94-8 Producer

Cas:638-94-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Desonide

Cas:638-94-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--638-94-8 -- Desonide factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business relationship

TIANFUCHEM--638-94-8 -- Desonide factory price

Cas:638-94-8

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

DesonideCAS:638-94-8

Cas:638-94-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 638-94-8 with best quality

Cas:638-94-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Desonide 638-94-8

Cas:638-94-8

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

PREDNACINOLONE

Cas:638-94-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Desonide/ LIDE PHARMA- Factory supply / Best price

Cas:638-94-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Name: Desonide CAS: 638-94-8 Molecular formula: C24H32O6 Molecular weight: 416.51 Appearance:White Powder Storage:Store in cool and dry place, away from sun lig

Desonide ??CAS: 638-94-8

Cas:638-94-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Desonide 638-94-8

Cas:638-94-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Desonide 99%

Cas:638-94-8

Min.Order:1 Kilogram

FOB Price: $42.0 / 50.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality Desonide manufacturer 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and expo

High quality Desonide manufacturer

Cas:638-94-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Desonide CAS 638-94-8 Desonide Powder

Cas:638-94-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Desonide

Cas:638-94-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Desonide

Cas:638-94-8

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

Desonide

Cas:638-94-8

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

Q1: Are you a manufacturer?Answer: Yes, we are factory founded on 2002. Q2: How to contact with us?Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours. Q3:Which kind of payment terms do yo

Desonide

Cas:638-94-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Desonide

Cas:638-94-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

Good Quality Breviscapinun

Cas:638-94-8

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Desonide 638-94-8

Cas:638-94-8

Min.Order:5 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Desonide

Cas:638-94-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Desonide (1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one CAS NO: 638-94-8 BP/EP/USP Assay:99% Desonide API supplier Application:638-

Desonide 638-94-8

Cas:638-94-8

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Desonide micro

Cas:638-94-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

TIANFU CHEM 638-94-8 Desonide Appearance:white powder Storage:room temperature Package:according to customers' requirements Application:Pharma intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...

638-94-8 Desonide

Cas:638-94-8

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Synthetic route

desonide
13951-70-7

desonide

acetone

acetone

Conditions
ConditionsYield
With boron trifluoride In tetrahydrofuran; acetonitrile at -5 - 10℃; Inert atmosphere;85%
With methanesulfonic acid at -10℃; for 0.133333h; Temperature;
C26H32O7

C26H32O7

desonide
638-94-8

desonide

Conditions
ConditionsYield
With sodium hydroxide In methanol at 30℃; for 0.666667h; Temperature; Inert atmosphere; Large scale;81%
desonide
13951-70-7

desonide

desonide
638-94-8

desonide

Conditions
ConditionsYield
With perchloric acid; acetone
11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide 21-acetate
25092-25-5

11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide 21-acetate

desonide
638-94-8

desonide

Conditions
ConditionsYield
With sodium hydroxide In methanol; dichloromethane at -5 - 5℃; for 2h; Inert atmosphere;8.60 g
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
37413-91-5

2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

desonide
638-94-8

desonide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: formic acid; potassium permanganate / acetone; water / 0.5 h / -7 - -3 °C / Industrial scale
2: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; perchloric acid / water; tetrahydrofuran / 1 h / -8 - -4 °C / Industrial scale
3: chromium(III) chloride hexahydrate; zinc; mercaptoacetic acid / N,N-dimethyl-formamide; dimethyl sulfoxide / 1 h / -10 °C / Inert atmosphere; Industrial scale
4: perchloric acid / 1.5 h / 26 - 35 °C / Inert atmosphere
5: sodium hydroxide / methanol; dichloromethane / 2 h / -5 - 5 °C / Inert atmosphere
View Scheme
16α,17α,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione-21-acetate
77017-20-0

16α,17α,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione-21-acetate

desonide
638-94-8

desonide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; perchloric acid / water; tetrahydrofuran / 1 h / -8 - -4 °C / Industrial scale
2: chromium(III) chloride hexahydrate; zinc; mercaptoacetic acid / N,N-dimethyl-formamide; dimethyl sulfoxide / 1 h / -10 °C / Inert atmosphere; Industrial scale
3: perchloric acid / 1.5 h / 26 - 35 °C / Inert atmosphere
4: sodium hydroxide / methanol; dichloromethane / 2 h / -5 - 5 °C / Inert atmosphere
View Scheme
9α-bromo-11β,16α,17α,21-tetrahydroxypregnane-1,4-diene-3,20-dione-21-acetate
91160-89-3

9α-bromo-11β,16α,17α,21-tetrahydroxypregnane-1,4-diene-3,20-dione-21-acetate

desonide
638-94-8

desonide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: chromium(III) chloride hexahydrate; zinc; mercaptoacetic acid / N,N-dimethyl-formamide; dimethyl sulfoxide / 1 h / -10 °C / Inert atmosphere; Industrial scale
2: perchloric acid / 1.5 h / 26 - 35 °C / Inert atmosphere
3: sodium hydroxide / methanol; dichloromethane / 2 h / -5 - 5 °C / Inert atmosphere
View Scheme
11β,16α,17α,21-tetrahydroxypregnane-1,4-diene-3,20-dione-21-acetate
86401-80-1

11β,16α,17α,21-tetrahydroxypregnane-1,4-diene-3,20-dione-21-acetate

desonide
638-94-8

desonide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: perchloric acid / 1.5 h / 26 - 35 °C / Inert atmosphere
2: sodium hydroxide / methanol; dichloromethane / 2 h / -5 - 5 °C / Inert atmosphere
View Scheme
2-Methylpropionic anhydride
97-72-3

2-Methylpropionic anhydride

desonide
638-94-8

desonide

desonide 21-isobutyrate
78806-61-8

desonide 21-isobutyrate

Conditions
ConditionsYield
With potassium carbonate In acetone for 1.5h; ethanol;99.7%
With potassium carbonate In acetone Reflux;
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

desonide
638-94-8

desonide

11β-hydroxy-16α,17α-isopropylidenedioxy-21-mesyloxy-1,4-pregnadiene-3,20-dione
5541-39-9

11β-hydroxy-16α,17α-isopropylidenedioxy-21-mesyloxy-1,4-pregnadiene-3,20-dione

Conditions
ConditionsYield
With pyridine at 0℃;99%
butyraldehyde

butyraldehyde

desonide
638-94-8

desonide

budesonide
51372-29-3

budesonide

Conditions
ConditionsYield
With phosphoric acid at 0 - 5℃; for 21.5h; Product distribution / selectivity;98.6%
desonide
638-94-8

desonide

A

11β-hydroxy-16α,17α-<(1-methylethylidene)bis(oxy)>-3-oxoandrosta-1,4-diene

11β-hydroxy-16α,17α-<(1-methylethylidene)bis(oxy)>-3-oxoandrosta-1,4-diene

B

11β-hydroxy-16α,17α-<(1-methylethylidene)bis(oxy)>-3-oxoandrosta-1,4-diene-17β-carboxylic acid

11β-hydroxy-16α,17α-<(1-methylethylidene)bis(oxy)>-3-oxoandrosta-1,4-diene-17β-carboxylic acid

Conditions
ConditionsYield
With potassium hydroxide; dihydrogen peroxide In methanol for 2h; ambient temperature;A 7.5%
B 88%
acetic anhydride
108-24-7

acetic anhydride

desonide
638-94-8

desonide

desonide diacetate

desonide diacetate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; Inert atmosphere;82%
desonide
638-94-8

desonide

11β,21-dihydroxy-16α,17α-(1-methylethylidenedioxy)-1,5-cyclopregn-3-ene-2,20-dione

11β,21-dihydroxy-16α,17α-(1-methylethylidenedioxy)-1,5-cyclopregn-3-ene-2,20-dione

Conditions
ConditionsYield
With oxygen In acetonitrile for 2.5h; UV-irradiation;67%
methylsulfanyl-acetic acid
2444-37-3

methylsulfanyl-acetic acid

desonide
638-94-8

desonide

11β-Hydroxy-16α,17α-isopropylidenedioxy-21-(methylthio)acetoxy-1,4-pregnadiene-3,20-dione
121507-18-4

11β-Hydroxy-16α,17α-isopropylidenedioxy-21-(methylthio)acetoxy-1,4-pregnadiene-3,20-dione

Conditions
ConditionsYield
With tributyl-amine; 2-chloro-1-methyl-pyridinium iodide In dichloromethane for 4h; Heating;64%
desonide
638-94-8

desonide

A

17β-hydroperoxy-11β-hydroxy-16α,17α-(1-methylethylidenedioxy)androsta-1,4-diene-3-one

17β-hydroperoxy-11β-hydroxy-16α,17α-(1-methylethylidenedioxy)androsta-1,4-diene-3-one

B

11β,21-dihydroxy-16α,17α-(1-methylethylidenedioxy)-1,5-cyclopregn-3-ene-2,20-dione

11β,21-dihydroxy-16α,17α-(1-methylethylidenedioxy)-1,5-cyclopregn-3-ene-2,20-dione

Conditions
ConditionsYield
With oxygen In acetonitrile for 2.5h; UV-irradiation;A 52%
B 26%
desonide
638-94-8

desonide

11β-hydroxy-16α,17α-<(1-methylethylidene)bis(oxy)>-3-oxoandrosta-1,4-diene

11β-hydroxy-16α,17α-<(1-methylethylidene)bis(oxy)>-3-oxoandrosta-1,4-diene

Conditions
ConditionsYield
In acetonitrile for 2h; UV-irradiation;50%
4-pentenal
2100-17-6

4-pentenal

desonide
638-94-8

desonide

C26H34O6

C26H34O6

Conditions
ConditionsYield
With perchloric acid at 20℃;33%
desonide
638-94-8

desonide

tert butyl 4-formylpiperidine-1-carboxylate
137076-22-3

tert butyl 4-formylpiperidine-1-carboxylate

(1S,2S,4R,6R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-(piperidin-4-yl)-5,7-dioxapentacyclo[10.8.0.02'9.04'8.013'18]icosa-14,17-dien-16-one

(1S,2S,4R,6R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-(piperidin-4-yl)-5,7-dioxapentacyclo[10.8.0.02'9.04'8.013'18]icosa-14,17-dien-16-one

Conditions
ConditionsYield
With perchloric acid In water at 0 - 20℃;13%
desonide
638-94-8

desonide

11β,16α-dihydroxyandrosta-1,4-diene-3,17-dione

11β,16α-dihydroxyandrosta-1,4-diene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 52 percent / oxygen / acetonitrile / 2.5 h / UV-irradiation
2: 15 mg / triphenylphosphine / CH2Cl2 / 2 h
View Scheme
desonide
638-94-8

desonide

11β-hydroxy-16α,17α-isopropylidenedioxy-21-mercapto-1,4-pregnadiene-3,20-dione
119137-96-1

11β-hydroxy-16α,17α-isopropylidenedioxy-21-mercapto-1,4-pregnadiene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 99 percent / pyridine / 0 °C
2: 1) acetone, 30 min, 2) acetone, 6 h, reflux
3: 85 percent / hydrazine hydrate / tetrahydrofuran / 0.25 h / -10 - -5 °C
View Scheme
desonide
638-94-8

desonide

11-β-hydroxy-16α,17α-isopropylidenedioxy-21-methylthio-1,4-pregnadiene-3,20-dione
119138-00-0

11-β-hydroxy-16α,17α-isopropylidenedioxy-21-methylthio-1,4-pregnadiene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 99 percent / pyridine / 0 °C
2: 1) acetone, 30 min, 2) acetone, 6 h, reflux
3: 85 percent / hydrazine hydrate / tetrahydrofuran / 0.25 h / -10 - -5 °C
4: 78 percent / Et3N / dimethylformamide
View Scheme
desonide
638-94-8

desonide

11-β-hydroxy-16α,17α-isopropylidenedioxy-21-ethylthio-1,4-pregnadiene-3,20-dione
119138-01-1

11-β-hydroxy-16α,17α-isopropylidenedioxy-21-ethylthio-1,4-pregnadiene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 99 percent / pyridine / 0 °C
2: 1) acetone, 30 min, 2) acetone, 6 h, reflux
3: 85 percent / hydrazine hydrate / tetrahydrofuran / 0.25 h / -10 - -5 °C
4: 39 percent / Et3N / dimethylformamide
View Scheme
desonide
638-94-8

desonide

21-acetylthio-11β-hydroxy-16α,17α-isopropylidenedioxy-1,4-pregnadiene-3,20-dione
119137-93-8

21-acetylthio-11β-hydroxy-16α,17α-isopropylidenedioxy-1,4-pregnadiene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 99 percent / pyridine / 0 °C
2: 1) acetone, 30 min, 2) acetone, 6 h, reflux
View Scheme
desonide
638-94-8

desonide

11-β-hydroxy-16α,17α-isopropylidenedioxy-21-methoxycarbonylthio-1,4-pregnadiene-3,20-dione
119138-02-2

11-β-hydroxy-16α,17α-isopropylidenedioxy-21-methoxycarbonylthio-1,4-pregnadiene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 99 percent / pyridine / 0 °C
2: 1) acetone, 30 min, 2) acetone, 6 h, reflux
3: 85 percent / hydrazine hydrate / tetrahydrofuran / 0.25 h / -10 - -5 °C
4: 1) EtN(iPr)2 / 1) CH2Cl2, 0 deg C, 10 min, 2) CH2Cl2, 0 deg C, 30 min
View Scheme
desonide
638-94-8

desonide

11-β-hydroxy-16α,17α-isopropylidenedioxy-21-ethoxycarbonylthio-1,4-pregnadiene-3,20-dione
119138-03-3

11-β-hydroxy-16α,17α-isopropylidenedioxy-21-ethoxycarbonylthio-1,4-pregnadiene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 99 percent / pyridine / 0 °C
2: 1) acetone, 30 min, 2) acetone, 6 h, reflux
3: 85 percent / hydrazine hydrate / tetrahydrofuran / 0.25 h / -10 - -5 °C
4: 1) EtN(iPr)2 / 1) CH2Cl2, 0 deg C, 10 min, 2) CH2Cl2, 0 deg C, 30 min
View Scheme
N-methyl-piperidine-4-carboxaldehyde
50675-21-3

N-methyl-piperidine-4-carboxaldehyde

desonide
638-94-8

desonide

A

16-α-hydroxyprednisolone-16,17-αβ-acetal of N-methyl-4-formylpiperidine

16-α-hydroxyprednisolone-16,17-αβ-acetal of N-methyl-4-formylpiperidine

B

C28H39NO6

C28H39NO6

Conditions
ConditionsYield
With perchloric acid In water; 1-Nitropropane at 20℃; for 48h;
desonide
638-94-8

desonide

cyclohexanecarbaldehyde
2043-61-0

cyclohexanecarbaldehyde

desisobutyryl ciclesonide
161115-59-9

desisobutyryl ciclesonide

Conditions
ConditionsYield
With perchloric acid In water; 1-Nitropropane at 0 - 20℃;59 %Chromat.
desonide
638-94-8

desonide

C27H36O8S

C27H36O8S

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: perchloric acid / 20 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
View Scheme
desonide
638-94-8

desonide

C36H42N2O5S

C36H42N2O5S

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: perchloric acid / 20 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
3: potassium carbonate / acetone / Reflux
View Scheme
desonide
638-94-8

desonide

A

C34H38N2O5S

C34H38N2O5S

B

C34H38N2O5S

C34H38N2O5S

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: perchloric acid / 20 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
3: potassium carbonate / acetone / Reflux
4: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 70 °C
View Scheme
glutaric anhydride,
108-55-4

glutaric anhydride,

desonide
638-94-8

desonide

triamcinolone acetonoide-21-glutarate

triamcinolone acetonoide-21-glutarate

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl acetamide; N,N-dimethyl-formamide for 24h;
Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: methanesulfonic acid / 1 h / 65 - 80 °C
1.2: 12 h / -5 - 15 °C
2.1: sodium hydroxide / methanol; dichloromethane / -10 - 0 °C / Inert atmosphere
View Scheme

Raw Materials

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