Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantiti
Cas:37413-91-5
Min.Order:100 Gram
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Type:Lab/Research institutions
inquiryWe are concentrating on APIs and pharmaceutical intermediates. It is made obtainable from us at the most reasonable rate. Our Service: 1. Rich experience: Our company is a professional production leading factory in China in pharmaceutical are
Cas:37413-91-5
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inquiryProduct Name: 3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate Synonyms: Pregna-1,4,9(11),16-tetraen-21-ol-3,20-dione 21-acetate;21-Acetoxypregna-1,4,9(11),16-tetrene-3,20-dione;3,20-Dioxopregna-1,4,9(11),16-tetrene-21-ol acetate;21-(Acetylox
Cas:37413-91-5
Min.Order:100 Gram
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Type:Lab/Research institutions
inquiry21-(Acetyloxy)-pregna-1,4,9(11),16-tetraene-3,20-dione Cas 37413-91-5 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed
Cas:37413-91-5
Min.Order:10 Kilogram
FOB Price: $10.0
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:37413-91-5
Min.Order:1
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Type:Other
inquiryItems Standard Result Assay 98%min -----------------------------------------------------------------------------------------------
Cas:37413-91-5
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:37413-91-5
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:37413-91-5
Min.Order:1 Kilogram
FOB Price: $1000.0
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:37413-91-5
Min.Order:1 Gram
FOB Price: $6.0 / 9.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:37413-91-5
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:37413-91-5
Min.Order:1 Gram
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Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
Cas:37413-91-5
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:37413-91-5
Min.Order:1 Kilogram
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inquiryProduct Name: 3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate Synonyms: Pregna-1,4,9(11),16-tetraen-21-ol-3,20-dione 21-acetate;21-Acetoxypregna-1,4,9(11),16-tetrene-3,20-dione;3,20-Dioxopregna-1,4,9(11),16-tetrene-21-ol acetate;21-(Acetylo
Beluga chemical professional supply 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione CAS 37413-91-5 Why choose Beluga chemical 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical sup
Cas:37413-91-5
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:37413-91-5
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:37413-91-5
Min.Order:4 Kilogram
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Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:37413-91-5
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:For medicine , pesticid
Cas:37413-91-5
Min.Order:1 Kilogram
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Type:Trading Company
inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:37413-91-5
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiryProduct name: Tetraene Acetate CAS No.:37413-91-5 Molecule Formula:C23H26O4 Molecule Weight:366.45 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITEMS
Cas:37413-91-5
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
Cas:37413-91-5
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:37413-91-5
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:37413-91-5
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:37413-91-5
Min.Order:1 Gram
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Type:Lab/Research institutions
inquirystock,low price,high quality,high purity,good sevice Appearance:37413-91-5 Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g,1kg,5kg...more Application:R&D Transportation:by land,by a
Cas:37413-91-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquirypregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Conditions | Yield |
---|---|
Stage #1: pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate With pyridine; N-chloro-succinimide at -15℃; for 1h; Inert atmosphere; Stage #2: With sulfur dioxide at -10℃; for 0.5h; Inert atmosphere; | 98.8% |
prednisolone 21-acetate
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Conditions | Yield |
---|---|
Stage #1: prednisolone 21-acetate With pyridine; N-chloro-succinimide at -15 - 20℃; for 0.416667h; Inert atmosphere; Stage #2: With sulfur dioxide for 1h; Inert atmosphere; | 83.5% |
prednisolone 21-acetate
A
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
B
pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate
Conditions | Yield |
---|---|
With pyridine; thionyl chloride In N,N-dimethyl-formamide at 20℃; Reagent/catalyst; Temperature; | A 50% B n/a C n/a D n/a |
21-acetoxy-pregna-4,9(11),16-triene-3,20-dinone
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Conditions | Yield |
---|---|
With selenium(IV) oxide; tert-butyl alcohol | |
With pyridine; selenium(IV) oxide In tert-butyl alcohol for 24h; Reflux; Inert atmosphere; | 25.27 g |
2,4,6-trimethyl-pyridine
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
prednisolon
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: thionyl chloride / tetrahydrofuran / 0.67 h / 0 °C / Inert atmosphere 1.2: 1.25 h / 5 - 20 °C 2.1: dmap / dichloromethane / 0.5 h / 20 °C / Inert atmosphere 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 3 h / 60 °C / Inert atmosphere View Scheme |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dmap / dichloromethane / 0.5 h / 20 °C / Inert atmosphere 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 3 h / 60 °C / Inert atmosphere View Scheme |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 60℃; for 3h; Inert atmosphere; | 1.92 g |
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 50℃; for 5h; Inert atmosphere; | 27.6 g |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Conditions | Yield |
---|---|
With potassium acetate; acetic acid In N,N-dimethyl-formamide at 105℃; for 5h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Large scale; | 965 g |
androsta-1,4,9(11)-triene-3,17-dione
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium hydroxide / tetrahydrofuran; acetone / 2 h / 0 - 40 °C / Inert atmosphere; Large scale 1.2: 15 h / -5 - 5 °C / Large scale 2.1: dmap; triethylamine / dichloromethane / 7 h / Inert atmosphere; Reflux; Large scale 3.1: N-Bromosuccinimide / acetone; tert-butyl alcohol / 2 h / 10 - 20 °C / Large scale 3.2: 1 h / 30 - 35 °C / Inert atmosphere; Large scale 4.1: potassium acetate; acetic acid / N,N-dimethyl-formamide / 5 h / 105 °C / Inert atmosphere; Large scale View Scheme |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: dmap; triethylamine / dichloromethane / 7 h / Inert atmosphere; Reflux; Large scale 2.1: N-Bromosuccinimide / acetone; tert-butyl alcohol / 2 h / 10 - 20 °C / Large scale 2.2: 1 h / 30 - 35 °C / Inert atmosphere; Large scale 3.1: potassium acetate; acetic acid / N,N-dimethyl-formamide / 5 h / 105 °C / Inert atmosphere; Large scale View Scheme |
androst-4,9(11)-dien-3,17-dione
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: acetone / 0.5 h / 20 °C 2.1: calcium oxide; calcium chloride; iodine / methanol; dichloromethane; water / 1.5 h / 20 °C / Inert atmosphere 3.1: potassium acetate / N,N-dimethyl-formamide / 2 h / 65 °C / Inert atmosphere 3.2: 0.5 h / Inert atmosphere 4.1: toluene-4-sulfonic acid; trifluoroacetic anhydride / dichloromethane / 2.5 h / 20 °C 4.2: 0.25 h 5.1: potassium acetate / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere 5.2: 0.5 h / Inert atmosphere 6.1: pyridine; selenium(IV) oxide / tert-butyl alcohol / 24 h / Reflux; Inert atmosphere View Scheme |
9-alpha-hydroxyandrost-4-ene-3,17-dione
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: diethyl ether / 0.5 h / 20 °C 2.1: calcium oxide; calcium chloride; iodine / methanol; dichloromethane; water / 1.5 h / 20 °C / Inert atmosphere 3.1: potassium acetate / N,N-dimethyl-formamide / 2 h / 65 °C / Inert atmosphere 3.2: 0.5 h / Inert atmosphere 4.1: toluene-4-sulfonic acid; trifluoroacetic anhydride / dichloromethane / 2.5 h / 20 °C 4.2: 0.25 h 5.1: potassium acetate / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere 5.2: 0.5 h / Inert atmosphere 6.1: pyridine; selenium(IV) oxide / tert-butyl alcohol / 24 h / Reflux; Inert atmosphere View Scheme |
17α-Hydroxy-21-iodopregna-4,9(11)-diene-3,20-dione
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium acetate / N,N-dimethyl-formamide / 2 h / 65 °C / Inert atmosphere 1.2: 0.5 h / Inert atmosphere 2.1: toluene-4-sulfonic acid; trifluoroacetic anhydride / dichloromethane / 2.5 h / 20 °C 2.2: 0.25 h 3.1: potassium acetate / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere 3.2: 0.5 h / Inert atmosphere 4.1: pyridine; selenium(IV) oxide / tert-butyl alcohol / 24 h / Reflux; Inert atmosphere View Scheme |
pregna-4,9(11)-diene-3,20-dione-17-hydroxy-21-methyl
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: calcium oxide; calcium chloride; iodine / methanol; dichloromethane; water / 1.5 h / 20 °C / Inert atmosphere 2.1: potassium acetate / N,N-dimethyl-formamide / 2 h / 65 °C / Inert atmosphere 2.2: 0.5 h / Inert atmosphere 3.1: toluene-4-sulfonic acid; trifluoroacetic anhydride / dichloromethane / 2.5 h / 20 °C 3.2: 0.25 h 4.1: potassium acetate / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere 4.2: 0.5 h / Inert atmosphere 5.1: pyridine; selenium(IV) oxide / tert-butyl alcohol / 24 h / Reflux; Inert atmosphere View Scheme |
anecortave
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: toluene-4-sulfonic acid; trifluoroacetic anhydride / dichloromethane / 2.5 h / 20 °C 1.2: 0.25 h 2.1: potassium acetate / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere 2.2: 0.5 h / Inert atmosphere 3.1: pyridine; selenium(IV) oxide / tert-butyl alcohol / 24 h / Reflux; Inert atmosphere View Scheme |
pregna-4,9(11)-diene-17α,21-diol-3,20-dione 17,21-diacetate
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium acetate / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere 1.2: 0.5 h / Inert atmosphere 2.1: pyridine; selenium(IV) oxide / tert-butyl alcohol / 24 h / Reflux; Inert atmosphere View Scheme |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
N,N-dimethyl-formamide
Conditions | Yield |
---|---|
Stage #1: 2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate; N,N-dimethyl-formamide With perchloric acid In water at 20 - 27℃; Inert atmosphere; Stage #2: With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione In water; N,N-dimethyl-formamide at 20 - 35℃; Inert atmosphere; | 99% |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
16α,17α,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione-21-acetate
Conditions | Yield |
---|---|
Stage #1: 2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate With formic acid In acetone at -5 - 0℃; for 0.0833333h; Stage #2: With potassium permanganate In water; acetone at -5 - 0℃; for 0.166667h; | 96% |
With potassium permanganate | |
With potassium permanganate; formic acid In water; acetone at -7 - -3℃; for 0.5h; Industrial scale; | 15 kg |
With potassium permanganate; oxalic acid In water; butanone at -5℃; Reagent/catalyst; Solvent; Temperature; | 50.5 g |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Conditions | Yield |
---|---|
Stage #1: 2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate With perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione In water; acetone at -10 - -5℃; for 2h; Stage #2: With potassium carbonate In water; acetone at -5 - 35℃; for 12h; | 96% |
Stage #1: 2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate With perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione In acetone at -10 - -5℃; Stage #2: With potassium carbonate In acetone at 33 - 37℃; | 83.36% |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Conditions | Yield |
---|---|
With potassium permanganate; formic acid In water; acetone at -5 - 0℃; for 0.5h; Solvent; Temperature; Inert atmosphere; | 86% |
(phenylthio)nitromethane
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Acetic acid 2-[(8S,10S,13S,14S,16R,17S)-10,13-dimethyl-16-(nitro-phenylsulfanyl-methyl)-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl ester
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran; tert-butyl alcohol Yield given; |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
methyl-d3-magnesium iodide
Conditions | Yield |
---|---|
With methylmagnesium chloride; copper(II) propionate In tetrahydrofuran at -9 - -7℃; for 0.666667h; |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
<14C>methyl iodide
Conditions | Yield |
---|---|
With methylmagnesium chloride; copper(II) propionate In tetrahydrofuran at -9 - -7℃; for 0.666667h; |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
17α,21-dihydroxy-16β-methyl-1,4,9(11)-pregnatriene-3,20-dione 21-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: DBU / 2-methyl-propan-2-ol; tetrahydrofuran 2: 70 percent / HOAc 3: m-chloroperbenzoic acid 5: 90 percent / Wilkinson catalyst View Scheme | |
Multi-step reaction with 5 steps 1: DBU / 2-methyl-propan-2-ol; tetrahydrofuran 2: 70 percent / HOAc 3: 57 percent / m-chloroperbenzoic acid 5: 90 percent / Wilkinson catalyst View Scheme |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Acetic acid 2-((8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-16-methylene-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: DBU / 2-methyl-propan-2-ol; tetrahydrofuran 2: 70 percent / HOAc 3: m-chloroperbenzoic acid View Scheme | |
Multi-step reaction with 4 steps 1: DBU / 2-methyl-propan-2-ol; tetrahydrofuran 2: 70 percent / HOAc 3: 57 percent / m-chloroperbenzoic acid View Scheme |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Acetic acid 2-[(8S,10S,13S,14S,16R,17S)-16-(bis-phenylsulfanyl-methyl)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: DBU / 2-methyl-propan-2-ol; tetrahydrofuran 2: 70 percent / HOAc View Scheme |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Acetic acid 2-[(8S,10S,13S,14S,16R,17S)-16-(benzenesulfinyl-phenylsulfanyl-methyl)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: DBU / 2-methyl-propan-2-ol; tetrahydrofuran 2: 70 percent / HOAc 3: m-chloroperbenzoic acid View Scheme |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Acetic acid 2-[(8S,10S,13S,14S,16R,17S)-16-(bis-benzenesulfinyl-methyl)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: DBU / 2-methyl-propan-2-ol; tetrahydrofuran 2: 70 percent / HOAc 3: 57 percent / m-chloroperbenzoic acid View Scheme |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
16α,21-diacetoxy-17-hydroxy-pregna-1,4,9(11)-triene-3,20-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: KMnO4 View Scheme |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
9β,11β-epoxy-21-hydroxypregna-1,4,16-triene-3,20-dione 21-acetate
Isopropenyl acetate
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
3,21-diacetyloxy-pregna-1,3,5,9(11),16-pentaene-20-one
Conditions | Yield |
---|---|
toluene-4-sulfonic acid In water at 80℃; for 4h; |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
6α-fluoro-1,4,9,16-tetraenepregna-3,20-dione-21-acetate
Conditions | Yield |
---|---|
With Selectfluor In acetonitrile at -10 - 25℃; for 5h; |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
methylmagnesium chloride
methyl iodide
2-oxo-2-((8S,10S,13S,14S,16R,17S)-10,13,16,17-tetramethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethyl acetate
Conditions | Yield |
---|---|
Stage #1: 2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate; methylmagnesium chloride; copper(II) propionate In tetrahydrofuran Cooling with acetone-dry ice; Stage #2: methyl iodide In tetrahydrofuran |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
methylmagnesium chloride
1-(Trimethylsilyl)imidazole
(Z)-2-((8S,10S,13S,14S,16R)-10,13,16-trimethyl-3-oxo-7,8,12,13,15,16-hexahydro-3H-cyclopenta[a]phenanthren-17(6H,10H,14H)-ylidene)-2-(trimethylsilyloxy)ethyl acetate
Conditions | Yield |
---|---|
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; copper(II) propionate In tetrahydrofuran; dichloromethane at -50 - -30℃; Inert atmosphere; |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
17α,21-dihydroxy-16α-methyl-1,4,9(11)-pregnatriene-3,20-dione 21-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; copper(II) propionate / dichloromethane; tetrahydrofuran / -50 - -30 °C / Inert atmosphere 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: dichloromethane; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere 1.2: 3 h / 20 °C / Inert atmosphere 1.3: -50 °C / Inert atmosphere 2.1: acetic acid; peracetic acid / toluene / 0.5 h / -10 °C / Inert atmosphere View Scheme |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
(8S,10S,13S,14S,16R,17S)-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,10,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; copper(II) propionate / dichloromethane; tetrahydrofuran / -50 - -30 °C / Inert atmosphere 2: hydrogenchloride; water / ethyl acetate 3: triethylsilane / Wilkinson's catalyst / dichloromethane / 40 °C 4: potassium carbonate; water / dichloromethane; methanol / 2 h / 5 °C / Inert atmosphere; Cooling with ice View Scheme |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
16α-methyl-21-hydroxypregna-1,4,9(11)-triene-3,20-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; copper(II) propionate / dichloromethane; tetrahydrofuran / -50 - -30 °C / Inert atmosphere 2: hydrogenchloride; water / ethyl acetate 3: potassium carbonate; water / dichloromethane; methanol / 2 h / 5 °C / Inert atmosphere; Cooling with ice View Scheme |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
2-oxo-2-((8S,10S,13S,14S,16R,17S)-10,13,16-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)ethyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; copper(II) propionate / dichloromethane; tetrahydrofuran / -50 - -30 °C / Inert atmosphere 2: hydrogenchloride; water / ethyl acetate View Scheme |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
2-oxo-2-((8S,10S,13S,14S,16R,17S)-10,13,16-trimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethyl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; copper(II) propionate / dichloromethane; tetrahydrofuran / -50 - -30 °C / Inert atmosphere 2: hydrogenchloride; water / ethyl acetate 3: triethylsilane / Wilkinson's catalyst / dichloromethane / 40 °C View Scheme |
chloro-trimethyl-silane
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
methylmagnesium chloride
Conditions | Yield |
---|---|
Stage #1: methylmagnesium chloride With copper dichloride In tetrahydrofuran at 3℃; for 0.0166667h; Inert atmosphere; Stage #2: 2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate In tetrahydrofuran at 3℃; for 0.0333333h; Grignard Reaction; Inert atmosphere; Stage #3: chloro-trimethyl-silane; methylmagnesium chloride In tetrahydrofuran at 2℃; for 0.2h; Inert atmosphere; |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
17α,21-dihydroxy-9β,11β-epoxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: perchloric acid / water / 20 - 27 °C / Inert atmosphere 1.2: 20 - 35 °C / Inert atmosphere 2.1: potassium carbonate / water; acetone / 40 - 46 °C / Inert atmosphere 3.1: copper dichloride / tetrahydrofuran / 0.02 h / 3 °C / Inert atmosphere 3.2: 0.03 h / 3 °C / Inert atmosphere 3.3: 1.75 h / 2.5 °C / Inert atmosphere 4.1: peracetic acid; acetic acid / dichloromethane / 18 h / 4 - 20 °C / Inert atmosphere View Scheme |
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