912641-74-8

Basic information

• Product Name: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(6-trifluoroacetamido)hexyluridine
• Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(6-trifluoroacetamido)hexyluridine
• CAS NO: 912641-74-8
• Molecular Weight: 741.761
• Mol File: 912641-74-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(6-trifluoroacetamido)hexyluridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(6-trifluoroacetamido)hexyluridine(912641-74-8)
• EPA Substance Registry System: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(6-trifluoroacetamido)hexyluridine(912641-74-8)

Safety Data

• Hazardous Substances Data: 912641-74-8(Hazardous Substances Data)

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 165381-00-0 5'-O-(dimethoxytrityl)-2'-O-(hexylamino)uridine 
• 51224-09-0 6-(2,2,2-trifluoroacetamido)hexyl 4-methylbenzenesulfonate 
• 51224-10-3 1-iodo-6-(trifluoroacetamido)hexane 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 42822-78-6 2,3’-O-dibutylstannyleneuridine 
• 40248-34-8 6-trifluoroacetamido-1-hexanol 
• 4048-33-3 6-amino-1-hexanol 

Relevant articles and documents

Zwitterionic oligonucleotides: A study on binding properties of 2′-O-aminohexyl modifications

2′-O-Aminohexyl side chains provide excellent conditions for zwitterionic interstrand and intrastrand interactions of oligonucleotides. 2′-O-Aminoalkylated phosphoramidites of adenosine and undine were synthesized and incorporated in increasing number int

TRANSTHYRETIN (TTR) IRNA COMPOSITION AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED OCULAR DISEASES

The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR- associated ocular diseases.