916596-04-8Relevant articles and documents
THIADIAZOLE MODULATORS OF S1P AND METHODS OF MAKING AND USING
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Paragraph 0276, (2017/01/26)
The invention is directed to compounds of the formula: wherein each of the variables are defined herein, as well as methods of making and using the compounds as agonists of S1P1 and/or S1P5 for instance treating an autoimmune disease.
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066
De Fusco, Claudia,Brear, Paul,Iegre, Jessica,Georgiou, Kathy Hadje,Sore, Hannah F.,Hyv?nen, Marko,Spring, David R.
supporting information, p. 3471 - 3482 (2017/05/29)
Recently we reported the discovery of a potent and selective CK2α inhibitor CAM4066. This compound inhibits CK2 activity by exploiting a pocket located outside the ATP binding site (αD pocket). Here we describe in detail the journey that led to the discov
NOVEL OXADIAZOLE COMPOUNDS
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Page/Page column 62, (2011/06/26)
Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation o