92002-48-7Relevant articles and documents
Electrochemistry of Cytochrome c at a Lipid Langmuir Blodgett Monolayer Electrode
Nakashima, Naotoshi,Abe, Kazuhiro,Hirohashi, Toshiaki,Hamada, Keiko,Kunitake, Masashi,Manabe, Osamu
, p. 1021 - 1024 (1993)
Cytochrome c was found to undergo electron transfer reactions at a gold electrode modified with a Langmuir-Blodgett monolayer of 20-mercaptoeicosane-1-ol/dioleoyl-L-α-phosphatidylcholine (molar ratio, 1/20).The stability of the monolayer and the adsorption behavior of cytochrome c to the monolayer was also examined.
Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors
Gorecki, Lukas,Andrys, Rudolf,Schmidt, Monika,Kucera, Tomas,Psotka, Miroslav,Svobodova, Barbora,Hrabcova, Veronika,Hepnarova, Vendula,Bzonek, Petr,Jun, Daniel,Kuca, Kamil,Korabecny, Jan,Musilek, Kamil
, p. 65 - 71 (2019/12/25)
Acetylcholinesterase cysteine-targeted insecticides against malaria vector Anopheles gambia and other mosquitos have already been introduced. We have applied the olefin metathesis for the preparation of cysteine-targeted insecticides in high yields. The prepared compounds with either a succinimide or maleimide moiety were evaluated on Anopheles gambiae and human acetylcholinesterase with relatively high irreversible inhibition of both enzymes but poor selectivity. The concept of cysteine binding was not proved by several methods, and poor stability was observed of the chosen most potent/selective compounds in a water/buffer environment. Thus, our findings do not support the proposed concept of cysteine-targeted selective insecticides for the prepared series of succinimide or maleimide compounds.
Preparation of ω-functionalized eicosane-phosphate building blocks
Jablonkai, Istvan,Oroszlan, Peter
, p. 103 - 112 (2007/10/03)
New 1,20-substituted eicosanes carrying phosphate headgroups and readily derivatizable thiol, maleimido, and activated carboxylic ester moieties were prepared. The C20-backbone of these molecules was assembled by a halopolycarbon homologation from 1,8-dichlorooctane and 1,6-dibromohexane. 20-Mercapto- and 20-maleimido-icosylphosphates were synthesized via ω-bromo di-t-butyl protected icosylphosphate while 20-phosphonooxy- icosanoic acid N-hydroxysuccinimidoyl ester was prepared via ω-bromo dibenzyl protected icosylphosphate in multistep syntheses. These molecules can serve as model compounds for studying binding and structural organization on different surfaces with potential applications in the fields of biosensors.
