92260-81-6

Basic information

• Product Name: 5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione
• Synonyms: 5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione ;8,9-dihydro-2H,7H-2,9a-diaza-benzo[cd]azulene-1,6-dione;5,6-Dihydro-iMidazo[4,5,l...;5,6-Dihydro-iMidazo[4,5,l-j-k][1]benzazepine-2,7-[1H,4H]-dione;IMidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione, 5,6-dihydro;InterMediates of Zilpaterol;8,9-Dihydro-2,9a-diazabenzo[cd]azulene-1,6(2H,7H)-dione
• CAS NO: 92260-81-6
• Molecular Formula: C₁₁H₁₀N₂O₂
• Molecular Weight: 202.2093
• Product Categories: azulene;Aromatics;Heterocycles
• Mol File: 92260-81-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.42±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 13.26±0.20(Predicted)
• CAS DataBase Reference: 5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione(92260-81-6)
• EPA Substance Registry System: 5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione(92260-81-6)

Safety Data

• Hazardous Substances Data: 92260-81-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 92260-81-6 differently. You can refer to the following data:
1. 5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione is a compound useful in organic synthesis.
2. 5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione (cas# 92260-81-6) is a compound useful in organic synthesis.

Chemical Properties

Pale Yellow Solid

Application

5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione is a compound useful in organic synthesis.

Upstream product

• 3273-68-5 4-(1,2-dihydro-2-oxobenzo[d]imidazole-3-yl)butanoic acid 
• 1021910-67-7 chloro 2,3-dihydro-2-oxo-1H-benzimidazol-1-butanoate 
• 52099-72-6 1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one 
• 95-54-5 1,2-diamino-benzene 
• 116199-87-2 ethyl 2,3-dihydro-3-(1-methyl-ethenyl)-2-oxo-1H-benzimidazol-1-butanoate 
• 52099-78-2 4-(3-isopropenyl-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-butyric acid 

Downstream Products

• 92260-82-7 4,5,6,7-tetrahydro-6-hydroxyimino-imidazo[4,5,1-jk]-[1]-benzazepine-2,7(1H,6H)-dione 
• 119520-06-8 trans-(+/-)-4,5,6,7-tetrahydro-7-hydroxy-6-[(1-methylethyl)amino]-imidazo[4,5,1-jk][1]benzazepin-2(1H)-one hydrochloride 
• 1019768-88-7 (6R,7R)-7-hydroxy-6-{[(R)-3-(2-hydroxyphenyl)-1-methylpropyl]amino}-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one 

Relevant articles and documents

Method for preparing 2, 3-dihydro-2-oxo-1H-benzimidazole-1-butyric acid

The invention relates to a method for preparing 2, 3-dihydro-2-oxo-1H-benzimidazole-1-butyric acid, which comprises the following steps of: dehydrating 1, 3-dihydro-1-(1-methylvinyl)-2H-benzimidazole-2-one in an organic solvent at 100-120 DEG C under the action of an acid-binding agent, adding ethyl 4-bromobutyrate for reaction after dehydration, cooling the reaction liquid to 70-90 DEG C after the reaction is finished, adding water preheated to 40-60 DEG C, stirring and splitting phases at proper time; and adding alkali into an organic phase, carrying out saponification reaction under the environment of 45-80 DEG C and 150-200 mbar, slowly adding hydrochloric acid at the temperature of 40-60 DEG C after the saponification reaction is finished, then reacting for 2-4 hours at the temperature of 90-110 DEG C, cooling, filtering, washing a filter cake with water, and drying the filter cake to constant weight at 50-70 DEG C and 100-180 mbar. Potassium carbonate is used to replace sodium hydride, so that the problems of high potential safety hazard, serious three-waste pollution and the like in the traditional process are fundamentally eliminated, the production process is simpler and more convenient by frying in one pot, and the production cost is reduced; and meanwhile, the method is simple, convenient and safe to operate, reasonable in process condition, high in reaction yield and relatively high in implementation value.

PROCESS FOR MAKING A CRYSTALLINE ZILPATEROL SALT

This invention generally relates to processes for making a crystalline zilpaterol salt, particularly zilpaterol hydrochloride. This invention also relates to methods of treatment using a crystalline zilpaterol salt prepared in accordance with this invention to increase the rate of weight gain, improve feed efficiency, and/or increase carcass leanness in livestock, poultry, and fish.

BENZAZEPIN-2(1H)-ONE DERIVATIVES

Compounds of formula (I) and pharmaceutically acceptable salts thereof are agonists at the beta-2 adrenoceptor. They are useful as feed additives for livestock animals.