92260-82-7

Basic information

• Product Name: 4,5-Dihydro-6-oxiMe-iMidazo[4,5,1-jk][1]benzazepine-2,6,7(1H)-trione
• Synonyms: 4,5-Dihydro-6-oxiMe-iMidazo[4,5,1-jk][1]benzazepine-2,6,7(1H)-trione;7-(Hydroxyimino)-8,9-dihydro-2,9a-diazabenzo[cd]azulene-1,6(2H,7H)-dione;Imidazo[4,5,1-jk][1]benzazepine-2,6,7(1H)-trione, 4,5-dihydro- 6-oxime;10-(HYDROXYIMINO)-1,3-DIAZATRICYCLO[6.4.1.0(4,13)]TRIDECA-4,6,8(13)-TRIENE-2,9-DIONE
• CAS NO: 92260-82-7
• Molecular Formula: C₁₁H₉N₃O₃
• Molecular Weight: 231.21
• Product Categories: Agro-Products, Chiral Reagents, Heterocycles
• Mol File: 92260-82-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.69±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: DMF (Very Slightly, Heated), DMSO (Slightly)
• PKA: 9.00±0.20(Predicted)
• CAS DataBase Reference: 4,5-Dihydro-6-oxiMe-iMidazo[4,5,1-jk][1]benzazepine-2,6,7(1H)-trione(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Dihydro-6-oxiMe-iMidazo[4,5,1-jk][1]benzazepine-2,6,7(1H)-trione(92260-82-7)
• EPA Substance Registry System: 4,5-Dihydro-6-oxiMe-iMidazo[4,5,1-jk][1]benzazepine-2,6,7(1H)-trione(92260-82-7)

Safety Data

• Hazardous Substances Data: 92260-82-7(Hazardous Substances Data)

Usage

Description

4,5-Dihydro-6-oxiMe-iMidazo[4,5,1-jk][1]benzazepine-2,6,7(1H)-trione is a complex organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals. Its unique molecular structure allows it to play a significant role in the development of medications with specific therapeutic properties.

Uses

Used in Pharmaceutical Industry:
4,5-Dihydro-6-oxiMe-iMidazo[4,5,1-jk][1]benzazepine-2,6,7(1H)-trione is used as a key intermediate in the synthesis of Zilpaterol (Z430000), a β-Adrenergic agonist. This application is crucial for the development of medications that target specific adrenergic receptors, which can have various therapeutic effects, such as bronchodilation in the treatment of asthma or relaxation of smooth muscles in the gastrointestinal tract.

Upstream product

• 92260-81-6 5,6-dihydroimidazo[4,5,1-jk][1]benzazepin-2,7-[1H,4H]-dione 
• 1021910-67-7 chloro 2,3-dihydro-2-oxo-1H-benzimidazol-1-butanoate 
• 3273-68-5 4-(1,2-dihydro-2-oxobenzo[d]imidazole-3-yl)butanoic acid 
• 52099-72-6 1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one 
• 95-54-5 1,2-diamino-benzene 
• 116199-87-2 ethyl 2,3-dihydro-3-(1-methyl-ethenyl)-2-oxo-1H-benzimidazol-1-butanoate 
• 52099-78-2 4-(3-isopropenyl-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-butyric acid 

Downstream Products

• 119520-06-8 trans-(+/-)-4,5,6,7-tetrahydro-7-hydroxy-6-[(1-methylethyl)amino]-imidazo[4,5,1-jk][1]benzazepin-2(1H)-one hydrochloride 
• 1019769-22-2 (6S,7S)-7-hydroxy-6-{[(S)-3-(2-hydroxyphenyl)-1-methylpropyl]amino}-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one 
• 1019768-88-7 (6R,7R)-7-hydroxy-6-{[(R)-3-(2-hydroxyphenyl)-1-methylpropyl]amino}-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one 

Relevant articles and documents

PROCESS FOR MAKING A CRYSTALLINE ZILPATEROL SALT

This invention generally relates to processes for making a crystalline zilpaterol salt, particularly zilpaterol hydrochloride. This invention also relates to methods of treatment using a crystalline zilpaterol salt prepared in accordance with this invention to increase the rate of weight gain, improve feed efficiency, and/or increase carcass leanness in livestock, poultry, and fish.

BENZAZEPIN-2(1H)-ONE DERIVATIVES

Compounds of formula (I) and pharmaceutically acceptable salts thereof are agonists at the beta-2 adrenoceptor. They are useful as feed additives for livestock animals.

HETEROCYCLIC COMPOUNDS USEFUL AS ANABOLIC AGENTS FOR LIVESTOCK ANIMALS

Compounds of formula (I) and pharmaceutically acceptable salts thereof are agonists at the beta-2 adrenoceptor. They are useful as feed additives for livestock animals.