938461-09-7

Basic information

• Product Name: 2-bromo-N-methoxy-N,4-dimethylbenzamide
• Synonyms: 2-bromo-N-methoxy-N,4-dimethylbenzamide
• CAS NO: 938461-09-7
• Molecular Weight: 258.115
• Mol File: 938461-09-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-bromo-N-methoxy-N,4-dimethylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-N-methoxy-N,4-dimethylbenzamide(938461-09-7)
• EPA Substance Registry System: 2-bromo-N-methoxy-N,4-dimethylbenzamide(938461-09-7)

Safety Data

• Hazardous Substances Data: 938461-09-7(Hazardous Substances Data)

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 7697-27-0 2-bromo-4-methylbenzoic acid 
• 122334-36-5 N-methoxy-N,4-dimethylbenzamide 
• 874-60-2 4-methyl-benzoyl chloride 
• 99-94-5 p-Toluic acid 

Downstream Products

• 824-54-4 2-bromo-4-methylbenzaldehyde 
• 69617-43-2 (2-bromophenyl-4-methyl)phenylmethanone 
• 40138-17-8 (2-formyl-5-methylphenyl)boronic acid 

Relevant articles and documents

Synthesis of Substituted Naphthalenes by 1,4-Palladium Migration Involved Annulation with Internal Alkynes

The palladium catalyzed annulation of 1-bromo-2-vinylbenzene derivatives with internal alkynes was realized for the efficient synthesis of substituted naphthalenes. A controllable aryl to vinylic 1,4-palladium migration process is the key for success.

Palladium-Catalyzed, ortho-Selective C-H Halogenation of Benzyl Nitriles, Aryl Weinreb Amides, and Anilides

A palladium-catalyzed, ortho-selective C-H halogenation methodology is reported herein. The highlight of the work is the highly selective C(sp2)-H functionalization of benzyl nitriles in the presence of activated C(sp3)-H bond, which results in good yields of the halogenated products with excellent regioselectivity. Along with benzyl nitriles, aryl Weinreb amides and anilides have been evaluated for the transformation using aprotic conditions. Mechanistic studies yield interesting aspects with respect to the pathway of the reaction and the directing group abilities.