939791-42-1

Basic information

• Product Name: N-(3-(aminomethyl)pyridin-2-yl)-N-methylmethanesulfonamide
• Synonyms: N-(3-(aminomethyl)pyridin-2-yl)-N-methylmethanesulfonamide;Methanesulfonamide, N-[3-(aminomethyl)-2-pyridinyl]-N-methyl-
• CAS NO: 939791-42-1
• Molecular Formula: C₈H₁₃N₃O₂S
• Molecular Weight: 215.27272
• Mol File: 939791-42-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 386.047°C at 760 mmHg
• Flash Point: 187.275°C
• Appearance: /
• Density: 1.331
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: N-(3-(aminomethyl)pyridin-2-yl)-N-methylmethanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-(aminomethyl)pyridin-2-yl)-N-methylmethanesulfonamide(939791-42-1)
• EPA Substance Registry System: N-(3-(aminomethyl)pyridin-2-yl)-N-methylmethanesulfonamide(939791-42-1)

Safety Data

• Hazardous Substances Data: 939791-42-1(Hazardous Substances Data)

Usage

General Description

N-(3-(aminomethyl)pyridin-2-yl)-N-methylmethanesulfonamide, also known as TAK-603, is a chemically synthesized compound with potential anti-inflammatory and immunosuppressive properties. It belongs to the class of methanesulfonamides and acts as an inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH), which is involved in the biosynthesis of pyrimidine. By blocking this enzyme, TAK-603 inhibits the proliferation of activated T and B lymphocytes, leading to decreased production of proinflammatory cytokines and suppression of the immune response. N-(3-(aminomethyl)pyridin-2-yl)-N-methylmethanesulfonamide has shown potential as a therapeutic agent for the treatment of autoimmune diseases and inflammatory conditions.

InChI:InChI=1/C8H13N3O2S/c1-11(14(2,12)13)8-7(6-9)4-3-5-10-8/h3-5H,6,9H2,1-2H3

Upstream product

• 1061357-93-4 tert-butyl (2-(N-methylmethylsulfonamido)pyridin-3-yl)methylcarbamate 
• 73161-37-2 N-(3-cyanopyridin-2-yl)-N-methylmethanesulfonamide 
• 3939-13-7 3-cyano-2-fluoropyridine 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 

Downstream Products

• 1420885-74-0 N-(3-{[5-cyano-2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-ylamino]methyl}pyridin-2-yl)-N-methylmethanesulfonamide 

Relevant articles and documents

Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs

Focal adhesion kinase (FAK), a cytoplasmic protein tyrosine kinase, exerts kinase-dependent enzymatic functions and kinase-independent scaffolding functions, both of which are crucial in cancer development, early embryonic development, and reproduction. H

Compound for degrading FAK (Focal Adhesion Kinase) protein in targeting manner and application thereof

The invention provides a compound. The compound is a compound shown as a formula I or a stereoisomer, a geometric isomer, a tautomer, nitrogen oxide, hydrate, a solvate, a metabolic product, pharmaceutically acceptable salt or a prodrug thereof: X-Y-Z (formula I), wherein X represents a ligand of FAK protein, Z represents ligand of E3 ligase and Y represents a chain for connecting the X and the Z.

PYRROLOPYRIMIDINES AS FAK AND ALK INHIBITERS FOR TREATMENT OF CANCERS AND OTHER DISEASES

Disclosed are compounds which inhibit the activity of focal adhesion kinase (FAK) and anaplastic lymphoma kinase (ALK), compositions containing the compounds, and methods of treating diseases during which FAK and ALK are expressed. The diseases are, for example, cancers.