949-38-2

Basic information

• Product Name: 1-(benzyloxy)-3-chlorobenzene
• Synonyms: 1-(Benzyloxy)-3-chlorobenzene; benzene, 1-chloro-3-(phenylmethoxy)-
• CAS NO: 949-38-2
• Molecular Formula: C₁₃H₁₁ClO
• Molecular Weight: 218.6788
• Mol File: 949-38-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 321.1°C at 760 mmHg
• Flash Point: 149°C
• Density: 1.175g/cm³
• Vapor Pressure: 0.000573mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 1-(benzyloxy)-3-chlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(benzyloxy)-3-chlorobenzene(949-38-2)
• EPA Substance Registry System: 1-(benzyloxy)-3-chlorobenzene(949-38-2)

Safety Data

• Hazardous Substances Data: 949-38-2(Hazardous Substances Data)

Usage

Appearance

White solid

Molecular weight

216.68 g/mol

Uses

a. Intermediate in the synthesis of pharmaceuticals
b. Intermediate in the synthesis of agrochemicals
c. Intermediate in the synthesis of other organic compounds
d. Production of dyes and pigments

Toxicity

Moderate toxicity

Safety precautions

Handle with care and follow proper safety and handling practices

Upstream product

• 95-57-8 2-monochlorophenol 
• 3204-68-0 benzyldimethylphenylammonium chloride 
• 100-44-7 benzyl chloride 
• 1193-00-6 sodium 4-chlorophenolate 
• 100-39-0 benzyl bromide 
• 40400-13-3 2-Iodobenzyl bromide 

Downstream Products

• 26926-56-7 4-(3-benzyloxy-phenyl)-morpholine 
• 20967-96-8 2-(3-benzyloxyphenyl)acetonitrile 
• 32045-70-8 4-(5-benzyloxy-1,3,4,8b-tetrahydro-2H-biphenylen-4a-yl)-morpholine 
• 1484-26-0 3-(benzyloxy)aniline 
• 32045-69-5 2-(3-Benzyloxyphenyl)-cyclohexanon 
• 4525-75-1 2-chlorophenyl acetate 
• 1239569-26-6 2-(2-(benzyloxy)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane 
• 95-57-8 2-monochlorophenol 
• 6954-45-6 (2-chlorophenyl)(phenyl)methanol 
• 100-39-0 benzyl bromide 

Relevant articles and documents

Visible light mediated synthesis of 6H-benzo[c]chromenes: transition-metal-free intramolecular direct C-H arylation

A synthetic approach towards the 6H-benzo[c]chromene ring under visible light and transition-metal-free conditions has been developed. Benzochromenes are synthesized from the corresponding (2-halobenzyl) phenyl ethers or (2-halophenyl) benzyl ethers using

Exploring the Reactivity of α-Lithiated Aryl Benzyl Ethers: Inhibition of the [1,2]-Wittig Rearrangement and the Mechanistic Proposal Revisited

By carefully controlling the reaction temperature, treatment of aryl benzyl ethers with tBuLi selectively leads to α-lithiation, generating stable organolithiums that can be directly trapped with a variety of selected electrophiles, before they can undergo the expected [1,2]-Wittig rearrangement. This rearrangement has been deeply studied, both experimentally and computationally, with aryl α-lithiated benzyl ethers bearing different substituents at the aryl ring. The obtained results support the competence of a concerted anionic intramolecular addition/elimination sequence and a radical dissociation/recombination sequence for explaining the tendency of migration for aryl groups. The more favored rearrangements are found for substrates with electron-poor aryl groups that favor the anionic pathway.

NiCl2·6H2O/NaBH4 in methanol: A mild and efficient strategy for chemoselective deallylation/debenzylation of aryl ethers

Deprotection of allyl/benzyl aryl ethers was achieved chemoselectively. The mild and inexpensive reagent combination of NiCl2·6H 2O/NaBH4 in methanol afforded the products in high yields, within a reaction time of 5-10 min.