951666-45-8

Basic information

• Product Name: N-butyl-5-fluoro-2-nitroaniline
• Synonyms: N-butyl-5-fluoro-2-nitroaniline
• CAS NO: 951666-45-8
• Molecular Weight: 212.224
• Mol File: 951666-45-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-butyl-5-fluoro-2-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-butyl-5-fluoro-2-nitroaniline(951666-45-8)
• EPA Substance Registry System: N-butyl-5-fluoro-2-nitroaniline(951666-45-8)

Safety Data

• Hazardous Substances Data: 951666-45-8(Hazardous Substances Data)

Upstream product

• 109-65-9 1-bromo-butane 
• 2369-11-1 5-fluoro-2-nitroaniline 
• 700-36-7 2-bromo-4-fluoronitrobenzene 
• 109-73-9 N-butylamine 
• 446-35-5 2,4-Difluoronitrobenzene 
• 2106-50-5 2-chloro-4-fluoro-1-nitrobenzene 

Relevant articles and documents

Flavin mimetics: Synthesis and photophysical properties

We report the synthesis of new isoalloxazines using a microwave-assisted approach to make N-substituted-2-nitroanilines followed by one-pot reduction and condensation via Hemmerich's method. The influence of substituents on positions 7, 8, and 10 of flavin core on the optical properties is investigated. The aliphatic functionalities on N10 give rise to quantum yields of 0.7, while aromatic side-chains quench fluorescence. Relaxed geometries (DFT) of chiral and achiral derivatives have been used for TD-DFT calculations, which yielded good agreement with the experimental UV and CD data.

Nonpolar solvent a key for highly regioselective SNAr reaction in the case of 2,4-difluoronitrobenzene

A practical and highly regioselective aromatic nucleophilic substitution reaction for the substrate 2,4-difluoronitrobenzene is demonstrated with various O/S/N-nucleophiles. Solvent screens substantiate the role of a nonpolar solvent in ortho-selective nucleophilic substitution through a six-membered polar transition state.

Design and syntheses of a series of novel serotonin3 antagonists

From a structural comparison study between serotonin and serotonin3 (5- HT3) antagonists using a two-dimensional grid template composed of regular hexagons, we deduced structural modification patterns from agonists to antagonists, an