95907-03-2

Basic information

• Product Name: 2-Hydroxynicotinonitrile
• Synonyms: 2-Hydroxynicotinonitrile 98%;2-Hydroxypyridine-3-carbonitrile
• CAS NO: 95907-03-2
• Molecular Formula: C6H4N2O
• Molecular Weight: 120.11
• Mol File: 95907-03-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 352.3 °C at 760 mmHg
• Flash Point: 166.9 °C
• Appearance: /
• Density: 1.27 g/cm³
• Vapor Pressure: 3.87E-05mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Hydroxynicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxynicotinonitrile(95907-03-2)
• EPA Substance Registry System: 2-Hydroxynicotinonitrile(95907-03-2)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:
• Safety Statements: S26:; S36:
• Hazardous Substances Data: 95907-03-2(Hazardous Substances Data)

Usage

General Description

2-Hydroxynicotinonitrile is a chemical compound with the molecular formula C6H4N2O. It is a derivative of nicotinic acid and belongs to the class of nitriles. 2-Hydroxynicotinonitrile is used in the synthesis of pharmaceuticals and agrochemicals. It is also a key intermediate in the production of various organic compounds. 2-Hydroxynicotinonitrile is a highly versatile compound that plays a crucial role in the development of different chemical products and has various applications in the fields of medicine, agriculture, and industry.

InChI:InChI=1/C6H4N2O/c7-4-5-2-1-3-8-6(5)9/h1-3H,(H,8,9)

Upstream product

• 110-89-4 piperidine 
• 5444-80-4 1,3,3-triethoxypropene 
• 107-91-5 cyanoacetic acid amide 
• 14906-64-0 3-cyanopyridine N-oxide 
• 122-31-6 malondialdehyde bis(diethyl acetal) 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 1986-81-8 nicotinamide N-oxide 
• 102-52-3 malonaldehydebis(dimethylacetal) 
• 3939-13-7 3-cyano-2-fluoropyridine 
• 542-78-9 Malondialdehyde 

Downstream Products

• 405224-23-9 5-bromo-2-chloropyridine-3-carbonitrile 

Relevant articles and documents

Pyrazolopyridine hydroxamic acid compound as well as preparation method and application thereof

The invention relates to the technical field of chemical synthesis, in particular to a pyrazolopyridine hydroxamic acid compound as well as a preparation method and application thereof. The pyrazolopyridine hydroxamic acid compound comprises a compound as shown in a formula (1), an isomer thereof, and a hydrate thereof or a pharmaceutically acceptable salt thereof, wherein n is an integer, and R is any one of a substituted or unsubstituted aromatic ring group and a substituted alkyl group. The compound can well inhibit cancer cell proliferation, and then has an excellent treatment effect on tumors.

A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives

A highly efficient and green method has been developed for the rapid preparation of highly functionalized isoxazolopyridin-3-amine derivatives in excellent yields. This process has a broad substrate scope, is operationally simple, and generally requires no chromatographic purification. In addition, the process is scalable and significantly greener than current alternatives with a PMI of 18 and water as the reaction solvent.

Discovery of dual death-associated protein related apoptosis inducing protein kinase 1 and 2 inhibitors by a scaffold hopping approach

DRAK2 emerged as a promising drug target for the treatment of autoimmune diseases and to prevent graft rejection after organ transplantation. Screening of a compound library in a DRAK2 binding assay led to the identification of an isothiazolo[5,4-b]pyridine derivative as a novel ligand for DRAK2, displaying a Kdvalue of 1.6 μM. Subsequent medicinal chemistry work led to the discovery of a thieno[2,3-b]pyridine derivative with strong DRAK2 binding affinity (Kd= 9 nM). Moreover, this compound also behaves as a functional inhibitor of DRAK2 enzymatic activity, displaying an IC50value of 0.82 μM, although lacking selectivity, when tested against DRAK1. This paper describes for the first time functionally active dual DRAK1 and DRAK2 inhibitors that can be used as starting point for the synthesis of chemical tool compounds to study DRAK1 and DRAK2 biology, or they can be considered as hit compounds for hit-to-lead optimization campaigns in drug discovery programs.