96036-02-1

Basic information

• Product Name: Protected meropenem
• Synonyms: P-NITROBENZYL(4R,5S,6S)-3-[(3S,5S)-(5-DIMETHYLAMINOCARBONYL-1-P-NITROBENZYLOXYCARBONYL)-PYRROLIDIN-3-YLSULFANYL]-6-((R)-1-HYDROXY-ETHYL)-4-METHYL-7-OXO-1-AZA-BICYCLO[3.2.0]HEPT-2ENE-4-CARBOXYLATE;PROTECTED MEROPENEM;(4R,5S,6S)-4-NITROBENZYL-3-[[(3S,5S)-5-[(DIMETHYLAMINO)CARBONYL]-1-[[(4-NITROBENZYL)OXY] CARBONYL]-3-PYRROLIDINYL]THIO]-6-[(1R)-1-HYDROXYETHYL]-4-METHYL-7-OXO-1-AZABICYCLO[3,2,0] HEPT-2-ENE-2-CARBOXYLATE;4-nitrobenzyl (5s,6s)-3-[((3s,5s)-5-[(dimethylamino)carbonyl]-1-{[(4-nitrobenzyl)oxy]carbonyl}pyrrolidinyl)sulfanyl]-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate;3-[[5-[(DIMETHYLAMINO)CARBONY PYRROLIDINYL] THIO]-6-(1-HYDROXYETHYL)-4-METHYL-7-OXO-1-AZABICYCLO[3.2.0]HEPT-2-ENE-2-CARBOXYLIC ACID, (4-NITROPHENYL)METHYL ESTER;3-[[5-[(Dimethylamino)Carbonypyrrolidinyl]Thio]-6-(1-Hydroxyethyl)-4-Methyl-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid, (4-Nitrophenyl)Methyl Ester;3-[[5-[(Dimethylamino)Carbonyl-Pyrrolidinyl]Thio]-6-(1-Hydroxyethyl)-4-Methyl-7-Oxo-
• CAS NO: 96036-02-1
• Molecular Formula: C₃₂H₃₅N₅O₁₁S
• Molecular Weight: 697.7122
• EINECS: 1312995-182-4
• Mol File: 96036-02-1.mol
• Article Data: 18

Chemical Properties

• Melting Point: 150-153°C (dec.)
• Boiling Point: 900.3 °C at 760 mmHg
• Flash Point: 498.3 °C
• Appearance: /
• Density: 1.49 g/cm³
• Vapor Pressure: 6.99E-35mmHg at 25°C
• Refractive Index: 1.672
• Storage Temp.: 2-8°C
• PKA: 14.36±0.20(Predicted)
• CAS DataBase Reference: Protected meropenem(CAS DataBase Reference)
• NIST Chemistry Reference: Protected meropenem(96036-02-1)
• EPA Substance Registry System: Protected meropenem(96036-02-1)

Safety Data

• Hazardous Substances Data: 96036-02-1(Hazardous Substances Data)

Usage

Description

Protected meropenem, with the chemical abstracts service number 96036-02-1, is a derivative of meropenem (M225668). It is an ultra-broad spectrum injectable antibiotic that is utilized for treating a diverse range of infections, such as meningitis and pneumonia. Protected meropenem is characterized by its white powder form, which is indicative of its chemical properties.

Uses

Used in Pharmaceutical Industry:
Protected meropenem is used as an antibiotic agent for the treatment of various infections. Its application is primarily due to its ultra-broad spectrum nature, which allows it to combat a wide array of bacterial infections effectively. This makes it a valuable asset in the medical field for managing conditions like meningitis and pneumonia, where a broad-spectrum approach is often necessary to address the causative pathogens.
The specific use of Protected meropenem in treating meningitis and pneumonia highlights its importance in addressing severe and potentially life-threatening conditions. Its role in the pharmaceutical industry is therefore critical, providing a potent tool for healthcare professionals to combat serious infections.

InChI:InChI=1/C32H35N5O11S/c1-17-26-25(18(2)38)30(40)35(26)27(31(41)47-15-19-5-9-21(10-6-19)36(43)44)28(17)49-23-13-24(29(39)33(3)4)34(14-23)32(42)48-16-20-7-11-22(12-8-20)37(45)46/h5-12,17-18,23-26,38H,13-16H2,1-4H3/t17-,18-,23?,24+,25-,26-/m1/s1

Upstream product

• 105344-45-4 p-nitrobenzyl (4R,5S,6S)-3-<(3S,5S)-5-dimethylaminocarbonyl-1-(p-nitrobenzyloxycarbonyl)pyrrolidin-3-ylthio>-4-methyl-7-oxo-6-<(1R)-1-trimethylsilyloxoethyl>-1-azabicyclo<3.2.0>hept-2-en-2-carboxylate 
• 93711-81-0 (4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 
• 96034-64-9 (2S,4S)-1-p-nitrobenzyloxycarbonyl-2-dimethylaminocarbonyl-4-thiolpyrrolidine 
• 93711-85-4 (2R)-2-[(2S,3S)-3-{(1R)-1-(t-butyldimethylsilyloxy)ethyl}-4-oxoazetidin-2-yl]propionic acid 
• 96035-98-2 (3S,4S)-4-<(1R)-1-benzyloxycarbonylethyl>-3-<(1R)-1-tert-butyldimethylsilyloxyethyl>-2-azetidinone 
• 105318-32-9 (3S,4S)-1-(p-nitrobenzyloxycarbonylmethyl)-4-<(1R)-1-phenylthiocarbonylethyl>-3-<(1R)-1-trimethylsilyloxyethyl>-2-azetidinone 
• 161692-28-0 (4R,5R,6S,8R)-p-nitrobenzyl-3-(diphenylphosphoryloxy)-4-methyl-6-(1-(trimethylsilyloxy)ethyl)-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate 
• 105318-23-8 (3S,4S)-3-[(1R)-1-hydroxyethyl]-4-[(1R)-1-phenylthiocarbonylethyl]-1-carboxymethylazetidin-2-one 
• 105318-05-6 (3S,4S)-1-(tert-butoxycarbonylmethyl)-3-<(1R)-1-tert-butyldimethylsilyloxyethyl>-4-<(1R)-1-carboxyethyl>-2-azetidinone 
• 105318-06-7 (3S,4S)-1-(tert-butoxycarbonylmethyl)-3-<(1R)-1-tert-butyldimethylsilyloxyethyl>-4-<(1R)-1-phenylthiocarbonylethyl>-2-azetidinone 
• 105318-04-5 (3S,4S)-4-<(1R)-1-benzyloxycarbonylethyl>-1-(tert-butoxycarbonylmethyl)-3-<(1R)-1-tert-butyldimethylsilyloxy>-2-azetidinone 
• 105318-30-7 (3S,4S)-3-<(1R)-1-hydroxyethyl>-1-(p-nitrobenzyloxycarbonylmethyl)-4-<(1R)-1-phenylthiocarbonylethyl>-2-azetidinone 
• 124-40-3 dimethyl amine 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 96036-03-2 meropenem 

Relevant articles and documents

METHOD FOR PREPARING MEROPENEM USING ZINC POWDER

The present invention relates to an improved method for synthesizing meropenem trihydrate [(1R,5S,6S)-2-[((2′S,4′S)-2′-dimethylaminocarbozyl)pyrrolidin-4′-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid, trihydrate], which is a novel carbapenem antibiotic.

AN IMPROVED PROCESS FOR THE PREPARATION OF MEROPENEM

The present invention provides an improved process for the preparation of methyl carbapenem derivative of formula (I) or its pharmaceutically acceptable salts or hydrates thereof in a pure form.

Preparation of Carbapenem Intermediate and Their Use

The present invention relates to preparing carbapenem intermediates that are useful to produce Ertapenem, Meropenem and Doripenem.