96044-43-8Relevant articles and documents
Synthesis, biological evaluation and SAR of naftopidil-based arylpiperazine derivatives
Chen, Hong,Wang, Cai-Lu,Sun, Tao,Zhou, Zhan,Niu, Jiang-Xiu,Tian, Xiu-Mei,Yuan, Mu
, p. 1534 - 1539 (2018)
For the development of potential anti-prostate cancer agents, 24 kinds of novel naftopidil-based arylpiperazine derivatives have been synthesized and characterized by spectroscopic methods. Their antitumor activities were evaluated against several classic
Synthesis, structure-activity relationship and biological evaluation of novel arylpiperzines as α1A/1D-AR subselective antagonists for BPH
Xu, Fang,Chen, Hong,Xu, Jingyi,Liang, Xue,He, Xuelan,Shao, Binhao,Sun, Xianqiang,Li, Bing,Deng, Xiaoliang,Yuan, Mu
, p. 7735 - 7742 (2015)
A series of novel arylpiperazine derivatives as α1A/1D-adrenergic receptors (AR) subtype selective antagonists were designed, synthesized and evaluated for their antagonistic activities towards α1-ARs (α1A, α1B,
Synthesis and biological evaluation of arylpiperazine derivatives as potential anti-prostate cancer agents
Chen, Hong,Yu, Yu-Zhong,Tian, Xiu-Mei,Wang, Cai-Lu,Qian, Yu-Na,Deng, Zai-An,Zhang, Jing-Xiao,Lv, Dao-Jun,Zhang, Hai-Bo,Shen, Jian-Liang,Yuan, Mu,Zhao, Shan-Chao
, p. 133 - 143 (2019)
A novel scaffold of arylpiperazine derivatives was discovered as potent androgen receptor (AR) antagonist through rational drug designation based on our pre-work, leading to the discovery of a series of new antiproliferative compounds. Compounds 10, 16, 2
FENTANYL HAPTENS FOR THE PREPARATION OF A FENTANYL VACCINE
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Paragraph 0199, (2021/07/24)
Described is the preparation of novel fentanyl haptens of Formula (1) through (6) and their use in the preparation of effective fentanyl vaccines.
Compounds and Their Use in Treating Cancer
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Paragraph 0964; 0965, (2019/07/10)
The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts and prodrugs thereof, where R1, R4, R5, R6, R7, Linker, X, Y, A, G, D and E have any of the meanings defined herein. This specification also relates to the use of such compounds and pharmaceutically acceptable salts and prodrugs thereof in methods of treatment of the human or animal body, for example in prevention or treatment of cancer. This specification also relates to processes and intermediate compounds involved in the preparation of such compounds and to pharmaceutical compositions containing them.