98900-30-2

Basic information

• Product Name: 2-Pyrrolidinemethanol, 3-hydroxy-, hydrochloride, (2R,3S)-
• Synonyms: 2-Pyrrolidinemethanol, 3-hydroxy-, hydrochloride, (2R,3S)-;(2R,3R)-3-hydroxypyrrolidine-2-carboxamide hydrochloride(WX192160S1)
• CAS NO: 98900-30-2
• Molecular Formula: C5H11 N O2 . Cl H
• Molecular Weight: 0
• Mol File: 98900-30-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 110-112 °C
• Appearance: /
• CAS DataBase Reference: 2-Pyrrolidinemethanol, 3-hydroxy-, hydrochloride, (2R,3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinemethanol, 3-hydroxy-, hydrochloride, (2R,3S)-(98900-30-2)
• EPA Substance Registry System: 2-Pyrrolidinemethanol, 3-hydroxy-, hydrochloride, (2R,3S)-(98900-30-2)

Safety Data

• Hazardous Substances Data: 98900-30-2(Hazardous Substances Data)

Upstream product

• 126029-46-7 (2R,3S)-3-Hydroxy-2-hydroxymethyl-pyrrolidine-1-carboxylic acid methyl ester 
• 156129-72-5 (2R,3S)-tert-butyl 3-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 121686-87-1 (2R,3S)-N-benzyl-3-hydroxy-2-hydroxymethylpyrrolidine 
• 220317-69-1 (4aR,7aS)-2,2-Dimethyl-tetrahydro-[1,3]dioxino[5,4-b]pyrrole-5-carboxylic acid tert-butyl ester 
• 220458-80-0 (2R,3S)-1-benzyl-2-benzyloxymethyl-3-hydroxypyrrolidine 
• 294188-28-6 3,5-di-O-benzyl-1,2,4-trideoxy-1,4-imino-D-erythro-pentitol 
• 91510-99-5 (2S,3R)-(3-hydroxy-5-oxotetrahydrofuran-2-yl)methyl 4-methylbenzenesulfonate 
• 82130-86-7 2,5-di-O-tosyl-D-ribono-1,4-lactone 
• 78185-09-8 2-deoxy-D-ribonolactone-4-hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one 
• 158976-98-8 3,5-di-O-benzyl-2-deoxy-L-threo-pentono-1,4-lactone 
• 5336-08-3 D-Ribono-1,4-lactone 
• 294188-24-2 3,5-di-O-acetyl-2-deoxy-L-threo-pentono-1,4-lactone 
• 294188-25-3 (3S,4S)-3,5-bis(benzyloxy)pentane-1,4-diol 
• 1054683-61-2 methanesulfonic acid (1S,2S)-2-benzyloxy-1-benzyloxymethyl-4-methanesulfonyloxybutyl ester 

Relevant articles and documents

AZA-BENZOFURANYL COMPOUNDS AND METHODS OF USE

The invention relates to azabenzofuranyl compounds of Formula (I) with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzofuranyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

GUANIDINO-SUBSTITUTED QUINAZOLINONE COMPOUNDS AS MC4-R AGONISTS

A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.

Synthesis of (2R,3S)-3-hydroxy-2-hydroxymethylpyrrolidine from (4S,5S)-3-benzyl-4-formyl-5-vinyl-2-oxazolidinone

(4S,5S)-3-BenzyI-4-formyl-5-vinyl-2-oxazolidinone (2), readily prepared via the reductive elimination of the mannose-derived iodo phenyl sulfone (6b), is used in the synthesis of the alkaloid (2R,3S)-3-hydroxy-2-hydroxymethylpyrrolidine (1).