1,2,8-Indolizinetriol,octahydro-, (1S,2R,8R,8aR)- supplier

Name
SWAINSONINE
EINECS
CAS No. 72741-87-8
Article Data55
CAS DataBase
Density 1.382 g/cm³
Solubility
Melting Point 148-149oC
Formula C₈H₁₅NO₃
Boiling Point 353.302 °C at 760 mmHg
Molecular Weight 173.212
Flash Point 209.735 °C
Transport Information
Appearance White Crystalline Solid
Safety 36
Risk Codes 20/21/22
Molecular Structure
Hazard Symbols Xn
Synonyms 1,2,8-Indolizinetriol,octahydro-, [1S-(1a,2a,8b,8ab)]-;(-)-Swainsonine;D-Swainsonine;Swainsonine;Tridolgosir;(1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol;(1S,2R,8R,8aR)-Octahydro-1,2,8-indolizinetriol;1,2,8-Indolizinetriol, octahydro-, (1S,2R,8R,8aR)-;
PSA 63.93000
LogP -1.51500

Synthetic route

: 72741-89-0
Acetic acid (1S,2R,8R,8aR)-1,2-diacetoxyoctahydroindolizin-8-yl ester

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With potassium carbonate In methanol at 20℃; Hydrolysis;	100%
With Amberlite IRA-402 In methanol for 18h;	97%
With Amberlite IRA-401(OH) In methanol at 20℃; for 2h;	96%

: 85624-09-5
(3aR,9R,9aR,9bS)-octahydro-2,2-dimethyl-[1,3]dioxolo[4,5-a]indolizin-9-ol

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran for 12h; Ambient temperature;	96%
With hydrogenchloride; water In tetrahydrofuran at 20℃; for 4h;	96%
With hydrogenchloride	95%

: 129421-04-1
(1S,2R,8R,8aR)-1,2-(cyclohexylidenedioxy)-8-hydroxyindolizidine

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With hydrogenchloride at 65 - 70℃; for 0.5h;	95%

: 130412-86-1
(1S,2R,8R,8aR)-octahydro-8-hydroxy-1,2-bis(phenylmethoxy)indolizine

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With hydrogen; palladium dichloride In methanol at 20℃; under 760 Torr; for 2h;	93%

: C14H27NO4Si

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
Stage #1: C14H27NO4Si With hydrogenchloride In methanol at 20℃; for 3h; Stage #2: With lithium aluminium tetrahydride In tetrahydrofuran for 8h; Reflux;	90%

: 253778-10-8
[1S,2R,8R,8aR]-8-Triisopropylsilyloxy-1,2-(isopropylidenedioxy)indolizidine

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With hydrogenchloride; water In tetrahydrofuran at 20℃; for 14h; Hydrolysis;	88%

: 1002754-00-8
3-((2R,3S,4S,5S,6S)-3-azido-6-(benzyloxy)-tetrahydro-4,5-dihydroxy-2H-pyran-2-yl)propyl methanesulfonate

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With hydrogen; palladium dihydroxide In ethanol at 20℃; under 5171.62 Torr; for 72h;	86%
With hydrogen; palladium dihydroxide In ethanol at 20℃; under 5171.48 Torr;

: 162470-36-2
(-)-8-benzyloxy-swainsonine

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
Stage #1: (-)-8-benzyloxy-swainsonine With hydrogen; palladium dichloride In methanol at 20℃; under 760.051 Torr; for 1h; Stage #2: In water	85%
Multi-step reaction with 3 steps 1: 60 mg / p-toluenesulfonic acid / CH2Cl2 / 3 h / 20 °C 2: 100 percent / H2; palladium(II) chloride / methanol / 0.5 h / 20 °C 3: 94.3 percent / hydrochloric acid / H2O; tetrahydrofuran / 20 h / 20 °C View Scheme

: (2S,3R)-3-(tert-butyldimethylsilyloxy)-2-styrylpiperidine

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 20℃; for 5h;	85%

: 94349-19-6
(1S,2R,8R,8aS)-8-(tert-Butyl-dimethyl-silanyloxy)-octahydro-indolizine-1,2-diol

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With Dowex 50W-X8 In methanol for 24h;	84%

: 1148122-99-9
(3aR,9R,9aS,9bS)-9-(tert-butyldimethylsilyloxy)-2,2-dimethyl-octahydro-[1,3]dioxolo[4,5-a]indolizine

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With hydrogenchloride; water In tetrahydrofuran at 20℃; for 12h;	83%

: 90706-28-8
swainsonine tribenzylate

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With cyclohexene; palladium dihydroxide	72%
With cyclohexene; palladium dihydroxide In ethanol for 44h; Heating;	72%

: 117270-04-9
(1S)-(1α,2α,8β,8aβ)-1-acetoxy-2,8-bis<(2,2-dimethylpropanoyl)oxy>octahydroindolizine

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With methylamine In methanol for 46h;	63%

: 1579996-95-4
(1S,2R,8R,8aR)-1,2,8-tris(benzyloxy)-1,2,3,5,8,8a-hexahydroindolizine

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
Stage #1: (1S,2R,8R,8aR)-1,2,8-tris(benzyloxy)-1,2,3,5,8,8a-hexahydroindolizine With hydrogenchloride; 10 wt% Pd(OH)2 on carbon; hydrogen In methanol; water at 20℃; under 760.051 Torr; for 48h; Inert atmosphere; Stage #2: In methanol; water	62%

: 132430-77-4
(R)-4-((3aS,4R,6aR)-5-Benzyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-4-yl)-4-benzyloxy-butan-1-ol

: 124-63-0
methanesulfonyl chloride

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal 1.) CH2Cl2, RT, 16h, 2.) EtOH, MeOH, 1 atm, RT, 6h; Yield given. Multistep reaction;

: 113626-62-3
(2R,3S,4R)-N-benzyl-2-<(1R)-1-benzyloxy-4-hydroxybutanyl>-3,4-bis(benzyloxy)pyrrolidine

: 124-63-0
methanesulfonyl chloride

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal 1.) CH2Cl2, RT, 16h, 2.) EtOH, MeOH, 1 atm, RT, 6h; Yield given. Multistep reaction;

: 107080-62-6, 127420-72-8, 98362-03-9
(1S,2R,8R,8aR)-8-hydroxy-1,2-(isopropylidenedioxy)octahydroindolizin-5-one

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With dimethylsulfide; borane; trifluoroacetic acid Yield given. Multistep reaction;
Multi-step reaction with 2 steps 1: 94 percent / borane-methyl sulfide complex / tetrahydrofuran / 0 deg C, 30 min, room temperature, 2 h 2: 96 percent / conc. HCl / tetrahydrofuran / 12 h / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: 60 percent / NaBH4 / ethanol; tetrahydrofuran / Heating 2: 75 percent / 6N HCl / tetrahydrofuran / Ambient temperature View Scheme

: 92735-17-6
(3aS,4S,5aR,9aR,9bS)-4-Methoxy-2,2-dimethyl-octahydro-[1,3]dioxolo[4',5':4,5]pyrano[3,2-b]pyridine

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With boron trichloride; sodium cyanoborohydride 1.) -78 deg C, 1.5 h, CHCl3; RT, 16 h, CHCl3, 2.) MeOH/H2O(1:1), pH=(6-7) (with 0.1 mol/l hydrochloric acid), RT, 24 h; Yield given. Multistep reaction;

: 107794-67-2
Benzoic acid (3aR,9R,9aR,9bS)-2,2-dimethyl-octahydro-[1,3]dioxolo[4,5-a]indolizin-9-yl ester

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With sodium methylate; trifluoroacetic acid 1.) MeOH, r.t., 2.) H2O, r.t.; Yield given. Multistep reaction;

: (3aR,9R,9aR,9bS)-5-Benzyl-9-benzyloxy-2,2-dimethyl-octahydro-[1,3]dioxolo[4,5-a]indolizin-5-ium; chloride

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
Yield given. Multistep reaction;

: 113626-63-4
(1S,2R,8R,8aR)-4-Benzyl-1,2,8-tris-benzyloxy-octahydro-indolizinium; chloride

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; palladium on activated charcoal In ethanol Yield given;

: 72741-88-9
swainsonine diacetate

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran at 25℃; for 24h;	10 mg

: 154815-12-0
(3aR,9R,9aR,9bS)-octahydro-2,2-dimethyl-9-(phenylmethoxy)-1,3-dioxolo[4,5-a]indolizine

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
Stage #1: (3aR,9R,9aR,9bS)-octahydro-2,2-dimethyl-9-(phenylmethoxy)-1,3-dioxolo[4,5-a]indolizine With hydrogen; palladium dichloride Stage #2: With hydrogenchloride
Multi-step reaction with 2 steps 1: 100 percent / H2; palladium(II) chloride / methanol / 0.5 h / 20 °C 2: 94.3 percent / hydrochloric acid / H2O; tetrahydrofuran / 20 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: HCOOH / Pd/C / methanol / 2 h 2: 39 mg / 6N HCl / tetrahydrofuran / 2 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: 86 percent / H2 / PdCl2 / methanol / 0.5 h 2: 66 percent / 2 N aq. HCl / tetrahydrofuran / 14 h / Ambient temperature View Scheme

: 262282-77-9
(8R,8aR)-Octahydro-indolizine-1,2,8-triol

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 143 mg / DMAP / CH2Cl2; pyridine / 48 h 2: 97 percent / amberlite IRA-402 / methanol / 18 h View Scheme

: 914616-18-5
(1R,8R,8aS)-8-(triisopropylsilyloxy)-octahydroindolizin-1-ol

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: Martin sulfurane / diethyl ether / 0.5 h / 0 °C 2: AD-mix-α; methylsulfonamide / 2-methyl-propan-2-ol; H2O / 216 h / 4 °C 3: TBAF / tetrahydrofuran / 27 h / 20 °C 4: 143 mg / DMAP / CH2Cl2; pyridine / 48 h 5: 97 percent / amberlite IRA-402 / methanol / 18 h View Scheme

: 262282-76-8
(8R,8aS)-8-Triisopropylsilanyloxy-octahydro-indolizine-1,2-diol

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: TBAF / tetrahydrofuran / 27 h / 20 °C 2: 143 mg / DMAP / CH2Cl2; pyridine / 48 h 3: 97 percent / amberlite IRA-402 / methanol / 18 h View Scheme

: 914616-14-1
(1R,8R,8aS)-1-hydroxy-8-(triisopropylsilyloxy)-tetrahydroindolizin-3(1H,2H,5H)-one

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: LiAlH4 / tetrahydrofuran / 1.3 h / Heating 1.2: 92 percent / aq.NaOH; water / 20 °C 2.1: Martin sulfurane / diethyl ether / 0.5 h / 0 °C 3.1: AD-mix-α; methylsulfonamide / 2-methyl-propan-2-ol; H2O / 216 h / 4 °C 4.1: TBAF / tetrahydrofuran / 27 h / 20 °C 5.1: 143 mg / DMAP / CH2Cl2; pyridine / 48 h 6.1: 97 percent / amberlite IRA-402 / methanol / 18 h View Scheme

Yield

Multi-step reaction with 6 steps
1.1: LiAlH4 / tetrahydrofuran / 1.3 h / Heating
1.2: 92 percent / aq.NaOH; water / 20 °C
2.1: Martin sulfurane / diethyl ether / 0.5 h / 0 °C
3.1: AD-mix-α; methylsulfonamide / 2-methyl-propan-2-ol; H2O / 216 h / 4 °C
4.1: TBAF / tetrahydrofuran / 27 h / 20 °C
5.1: 143 mg / DMAP / CH2Cl2; pyridine / 48 h
6.1: 97 percent / amberlite IRA-402 / methanol / 18 h
View Scheme

: 5-(1-hydroxyallyl)-4-((S)-1-(2,4,6-triisopropylphenyl)ethoxy)pyrrolidin-2-one

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
Multi-step reaction with 11 steps 1.1: i-Pr2NEt / CH2Cl2 / 1 h 1.2: 81 percent / AcOH / tetrahydrofuran; H2O 2.1: 95 percent / n-Bu4N; H2SO4 / CH2Cl2; aq. NaOH / 20 °C 3.1: 84 percent / Grubbs II catalyst / CH2Cl2 / 3 h / Heating 4.1: 87 percent / H2 / Pd/C / ethyl acetate / 2.5 h / 20 °C 5.1: 97 percent / TFA / CH2Cl2 / 20 °C 6.1: LiAlH4 / tetrahydrofuran / 1.3 h / Heating 6.2: 92 percent / aq.NaOH; water / 20 °C 7.1: Martin sulfurane / diethyl ether / 0.5 h / 0 °C 8.1: AD-mix-α; methylsulfonamide / 2-methyl-propan-2-ol; H2O / 216 h / 4 °C 9.1: TBAF / tetrahydrofuran / 27 h / 20 °C 10.1: 143 mg / DMAP / CH2Cl2; pyridine / 48 h 11.1: 97 percent / amberlite IRA-402 / methanol / 18 h View Scheme

Yield

Multi-step reaction with 11 steps
1.1: i-Pr2NEt / CH2Cl2 / 1 h
1.2: 81 percent / AcOH / tetrahydrofuran; H2O
2.1: 95 percent / n-Bu4N; H2SO4 / CH2Cl2; aq. NaOH / 20 °C
3.1: 84 percent / Grubbs II catalyst / CH2Cl2 / 3 h / Heating
4.1: 87 percent / H2 / Pd/C / ethyl acetate / 2.5 h / 20 °C
5.1: 97 percent / TFA / CH2Cl2 / 20 °C
6.1: LiAlH4 / tetrahydrofuran / 1.3 h / Heating
6.2: 92 percent / aq.NaOH; water / 20 °C
7.1: Martin sulfurane / diethyl ether / 0.5 h / 0 °C
8.1: AD-mix-α; methylsulfonamide / 2-methyl-propan-2-ol; H2O / 216 h / 4 °C
9.1: TBAF / tetrahydrofuran / 27 h / 20 °C
10.1: 143 mg / DMAP / CH2Cl2; pyridine / 48 h
11.1: 97 percent / amberlite IRA-402 / methanol / 18 h
View Scheme

: 4-((S)-1-(2,4,6-triisopropylphenyl)ethoxy)-5-((R)-1-(triisopropylsilyloxy)-allyl)-pyrrolidin-2-one

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
Multi-step reaction with 10 steps 1.1: 95 percent / n-Bu4N; H2SO4 / CH2Cl2; aq. NaOH / 20 °C 2.1: 84 percent / Grubbs II catalyst / CH2Cl2 / 3 h / Heating 3.1: 87 percent / H2 / Pd/C / ethyl acetate / 2.5 h / 20 °C 4.1: 97 percent / TFA / CH2Cl2 / 20 °C 5.1: LiAlH4 / tetrahydrofuran / 1.3 h / Heating 5.2: 92 percent / aq.NaOH; water / 20 °C 6.1: Martin sulfurane / diethyl ether / 0.5 h / 0 °C 7.1: AD-mix-α; methylsulfonamide / 2-methyl-propan-2-ol; H2O / 216 h / 4 °C 8.1: TBAF / tetrahydrofuran / 27 h / 20 °C 9.1: 143 mg / DMAP / CH2Cl2; pyridine / 48 h 10.1: 97 percent / amberlite IRA-402 / methanol / 18 h View Scheme

Yield

Multi-step reaction with 10 steps
1.1: 95 percent / n-Bu4N; H2SO4 / CH2Cl2; aq. NaOH / 20 °C
2.1: 84 percent / Grubbs II catalyst / CH2Cl2 / 3 h / Heating
3.1: 87 percent / H2 / Pd/C / ethyl acetate / 2.5 h / 20 °C
4.1: 97 percent / TFA / CH2Cl2 / 20 °C
5.1: LiAlH4 / tetrahydrofuran / 1.3 h / Heating
5.2: 92 percent / aq.NaOH; water / 20 °C
6.1: Martin sulfurane / diethyl ether / 0.5 h / 0 °C
7.1: AD-mix-α; methylsulfonamide / 2-methyl-propan-2-ol; H2O / 216 h / 4 °C
8.1: TBAF / tetrahydrofuran / 27 h / 20 °C
9.1: 143 mg / DMAP / CH2Cl2; pyridine / 48 h
10.1: 97 percent / amberlite IRA-402 / methanol / 18 h
View Scheme

: 914616-13-0
(1R,8R,8aS)-1-((S)-1-(2,4,6-triisopropylphenyl)ethoxy)-8-(triisopropylsilyloxy)-8,8a-dihydroindolizin-3(1H,2H,5H)-one

: 72741-87-8
swainsonine

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1.1: 87 percent / H2 / Pd/C / ethyl acetate / 2.5 h / 20 °C 2.1: 97 percent / TFA / CH2Cl2 / 20 °C 3.1: LiAlH4 / tetrahydrofuran / 1.3 h / Heating 3.2: 92 percent / aq.NaOH; water / 20 °C 4.1: Martin sulfurane / diethyl ether / 0.5 h / 0 °C 5.1: AD-mix-α; methylsulfonamide / 2-methyl-propan-2-ol; H2O / 216 h / 4 °C 6.1: TBAF / tetrahydrofuran / 27 h / 20 °C 7.1: 143 mg / DMAP / CH2Cl2; pyridine / 48 h 8.1: 97 percent / amberlite IRA-402 / methanol / 18 h View Scheme

Yield

Multi-step reaction with 8 steps
1.1: 87 percent / H2 / Pd/C / ethyl acetate / 2.5 h / 20 °C
2.1: 97 percent / TFA / CH2Cl2 / 20 °C
3.1: LiAlH4 / tetrahydrofuran / 1.3 h / Heating
3.2: 92 percent / aq.NaOH; water / 20 °C
4.1: Martin sulfurane / diethyl ether / 0.5 h / 0 °C
5.1: AD-mix-α; methylsulfonamide / 2-methyl-propan-2-ol; H2O / 216 h / 4 °C
6.1: TBAF / tetrahydrofuran / 27 h / 20 °C
7.1: 143 mg / DMAP / CH2Cl2; pyridine / 48 h
8.1: 97 percent / amberlite IRA-402 / methanol / 18 h
View Scheme

: 72741-87-8
swainsonine

: swainsonine N-oxide

Conditions

Conditions	Yield
With dihydrogen peroxide In ethanol at 20 - 60℃; for 20h; Sealed tube;	98%

: 106-31-0
butanoic acid anhydride

: 72741-87-8
swainsonine

: 1,2,8-tri-O-butyrylswainsonine

Conditions

Conditions	Yield
In pyridine at 25℃; for 48h;	92%

: 72741-87-8
swainsonine

: 50-78-2
aspirin

: C17H21NO6

Conditions

Conditions	Yield
Stage #1: aspirin With thionyl chloride; N,N-dimethyl-formamide at 25℃; for 1h; Cooling with ice; Stage #2: swainsonine at 25℃; for 10h; Time;	88.2%

: 72741-87-8
swainsonine

1195: 1195

: 85624-09-5
(3aR,9R,9aR,9bS)-octahydro-2,2-dimethyl-[1,3]dioxolo[4,5-a]indolizin-9-ol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In acetone at 5℃; for 48h;	85%

: 108-24-7
acetic anhydride

: 72741-87-8
swainsonine

: 72741-89-0
Acetic acid (1S,2R,8R,8aR)-1,2-diacetoxyoctahydroindolizin-8-yl ester

Conditions

Conditions	Yield
In pyridine at 25℃; for 48h;	84%

: 72741-87-8
swainsonine

: 77-76-9
2,2-dimethoxy-propane

: 85624-09-5
(3aR,9R,9aR,9bS)-octahydro-2,2-dimethyl-[1,3]dioxolo[4,5-a]indolizin-9-ol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid for 1.25h; Heating;	70%

: 57392-44-6
2,2,2-trichloroethyl butyrate

: 72741-87-8
swainsonine

A: 2-O-butyrylswainsonine

B: 1,2-di-O-butyrylswainsonine

Conditions

Conditions	Yield
With porcine pancreatic lipase In tetrahydrofuran at 37℃; for 16h;	A 6% B 31%

...Expand

: 57392-44-6
2,2,2-trichloroethyl butyrate

: 72741-87-8
swainsonine

: 2-O-butyrylswainsonine

Conditions

Conditions	Yield
With subtilisin In pyridine at 45℃; for 72h;	25%

: 72741-87-8
swainsonine

: 72741-89-0
Acetic acid (1S,2R,8R,8aR)-1,2-diacetoxyoctahydroindolizin-8-yl ester

1,2,8-Indolizinetriol,octahydro-, (1S,2R,8R,8aR)- Specification

The 1,2,8-Indolizinetriol,octahydro-, (1S,2R,8R,8aR)-, with the CAS registry number 72741-87-8, has the systematic name of (1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol. It is a kind of white crystalline solid, and belongs to the following product categories: Alkaloids; Glycosidase Inhibitors; Inhibitors. And the molecular formula of the chemical is C₈H₁₅NO₃.

The characteristics of 1,2,8-Indolizinetriol,octahydro-, (1S,2R,8R,8aR)- are as followings: (1)ACD/LogP: 0.08; (2)# of Rule of 5 Violations: 0; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 1; (6)ACD/KOC (pH 7.4): 6.568; (7)#H bond acceptors: 4; (8)#H bond donors: 3; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 63.93 Å²; (11)Index of Refraction: 1.609; (12)Molar Refractivity: 43.396 cm³; (13)Molar Volume: 125.351 cm³; (14)Polarizability: 17.204×10^-24cm³; (15)Surface Tension: 68.456 dyne/cm; (16)Density: 1.382 g/cm³; (17)Flash Point: 209.735 °C; (18)Enthalpy of Vaporization: 69.263 kJ/mol; (19)Boiling Point: 353.302 °C at 760 mmHg; (20)Vapour Pressure: 0 mmHg at 25°C.

Uses of 1,2,8-Indolizinetriol,octahydro-, (1S,2R,8R,8aR)-: It is a plant alkaloid derived from Swainsona canescens (a leguminous plant). And it is a reversible, active-site directed inhibitor of a-mannosidase at concentrations of 5-10mM. At acid pH, swainsonine resembles an intermediate in the hydroly.

You should be cautious while dealing with this chemical. It is harmful by inhalation, in contact with skin and if swallowed. Therefore, you had better wear suitable protective clothing.

Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: C1C[C@H]([C@@H]2[C@@H]([C@@H](CN2C1)O)O)O
(2)InChI: InChI=1/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1
(3)InChIKey: FXUAIOOAOAVCGD-WCTZXXKLBP

Product Name

SWAINSONINE

Synthetic route

1,2,8-Indolizinetriol,octahydro-, (1S,2R,8R,8aR)- Specification

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