Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantiti
Cas:302-79-4
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryProduct Name: Tretinoin/Vitamin A acid/Retompoc Acid CAS:302-79-4 Standard: USP40 Tretinoin/Vitamin A acid/Retompoc Acid HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufactu
Cas:302-79-4
Min.Order:500 Gram
Negotiable
Type:Other
inquiryAbout us We are a Professionally Managed Biotech Company exclusively into the manufacturing, Marketing and Exporting of Plant Extracts and Health Care Products.There are 15 experts in our research team. We insist in innovation and pr
Our company SINOWAY advantages : 1) ISO 9001:2015 & SGS audited supplier 2) Established in 1987, exported 37 years in pharmaceutical /cosmetic raw materials and health care products. 3) We are members of SINOSURE ,we can do better payment te
Cas:302-79-4
Min.Order:1 Kilogram
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Type:Trading Company
inquiry1. GMP AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Appearance:yellow crystalline powder Storage:in cool Package:as request Application:active pharmaceutical ingredient Transportation:Air / SEA BOTH OK Port
Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP
Tretinoin Basic information Dermatology drugs Clinical application Physicochemical property Pharmacological action PharmacodynamicsPharmacokinetics Vitamin A acid medicine The indications Usage dosage Adver
Cas:302-79-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:302-79-4
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiryStrict quality control: good raw materials, good quality, Zenuo Biology has always regarded quality as the life of the enterprise. Zenuo Biology has an independent quality control department and long-term cooperation with the third-party detect
Cas:302-79-4
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryProduct name: Tretinoin CAS No.:302-79-4 Molecule Formula:C20H27O2 Molecule Weight: 299.4277 Purity: 99.9% Package: 1kg/bag Description:Yellow or light orange crystalline powder Manufacture Standards:USP/CP Testing
Items Standard Result Appearance Yellow crystalline powder Yellow crystalline powder Assay 98
Cas:302-79-4
Min.Order:1 Kilogram
FOB Price: $1300.0 / 1600.0
Type:Trading Company
inquiryHebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ
Cas:302-79-4
Min.Order:100 Gram
FOB Price: $2.0
Type:Manufacturers
inquiryUnique advantages for Tretinoin Cas302-79-4 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Yellow or light orange crystalline powder Storage:Store in 2-8℃ Package:1kg/
Cas:302-79-4
Min.Order:1 Kilogram
FOB Price: $600.0 / 800.0
Type:Trading Company
inquiryXi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi
Cas:302-79-4
Min.Order:1 Kilogram
FOB Price: $558.0 / 598.0
Type:Manufacturers
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:302-79-4
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquirySales: 1.24hours to reply your E-mail 2.Market information trend share with customers Suggestion for purchase decision Reputation: 1.Implementing contract terms strictly 2.Timely solve any discrepancy or goods claims Take our responsibility for loss
Name Tretinoin Synonyms 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; all-trans-Retinoic acid; Vitamin A acid Molecular Str
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:302-79-4
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
Cas:302-79-4
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Manufacturers
inquiryName:Tretinoin CAS NO:302-79-4 Grade:Medical scientific research and export Molecular formula:C20H27O2 Molecular weight:299.4277 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data sto
Cas:302-79-4
Min.Order:25 Kilogram
FOB Price: $2.0 / 3.0
Type:Other
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:302-79-4
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturing
Cas:302-79-4
Min.Order:1 Kilogram
FOB Price: $15.0 / 50.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:302-79-4
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: High quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:302-79-4
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Product Name: Retinoic acid Synonyms: TRETINOIN;TRETINOIN VITAMIN A ACID;TRANS-RETINOIC ACID; TRANS VITAMIN A ACID;VITAMIN A ACID;VITAMIN A ACID, ALL-TRANS; RETINOIC ACID;RETIN
About Product Details
Cas:302-79-4
Min.Order:1 Kilogram
FOB Price: $3.0 / 10.0
Type:Lab/Research institutions
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:302-79-4
Min.Order:10 Gram
Negotiable
Type:Other
inquiryAppearance:Yellow powder Storage:Room temperature Package:25kg/drum Application:stimulate skin growth and keep epidermic normal. Transportation:Express/Air/sea Port:Any port in china
Cas:302-79-4
Min.Order:5 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
With sodium hydroxide In methanol at 50℃; for 0.5h; | 98% |
With potassium hydroxide In ethanol | 83% |
With potassium hydroxide In ethanol at 50℃; | 83% |
With potassium hydroxide In ethanol for 0.166667h; Heating; | 71% |
Conditions | Yield |
---|---|
With tris(triphenylphosphine)ruthenium(II) chloride; oxygen; bis-(3-methyl-1-imidazolyl)ethylene tetrafluoroborate In hexane at 50℃; under 760.051 Torr; for 3h; Reagent/catalyst; Darkness; | 90.2% |
Multi-step reaction with 2 steps 1: MnO2 / CH2Cl2 / 2 h / Ambient temperature 2: 80 percent / AgO, NaCN / methanol / 18 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: 90 percent / MnO2 / CH2Cl2 / Ambient temperature 2: AgO / CNNa / methanol View Scheme |
(6R,7R)-3-[(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoyloxymethyl]-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
A
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With β-lactamase from Staphylococcus aureus 95; deuterated phosphate buffer In dimethylsulfoxide-d6 at 25℃; pH=7.2; | A n/a B 86% |
trans-β-formyl crotonic acid
all-trans-retinoic-acid
Conditions | Yield |
---|---|
Stage #1: trans-β-formyl crotonic acid; [3-methyl-5-(2,6,6-trimethylcyclohexene-1-yl)-2E,4E-pentadiene]-triphenyl phosphonic chloride With potassium hydroxide In isopropyl alcohol at -5 - 0℃; for 2h; Wittig Olefination; Inert atmosphere; Stage #2: With hydrogenchloride; palladium diacetate In isopropyl alcohol at 50℃; pH=7 - 8; pH-value; Reagent/catalyst; Temperature; | 85.3% |
trans-β-formyl crotonic acid
[(2E,4E)-3-methyl-5-(2,6,6-trimethylcyclohex-1-en-1-yl)penta-2,4-dienyl]triphenylphosphonium chloride
all-trans-retinoic-acid
Conditions | Yield |
---|---|
Stage #1: trans-β-formyl crotonic acid; [(2E,4E)-3-methyl-5-(2,6,6-trimethylcyclohex-1-en-1-yl)penta-2,4-dienyl]triphenylphosphonium chloride With potassium hydroxide In isopropyl alcohol at -5 - 0℃; for 2h; Wittig Olefination; Inert atmosphere; Stage #2: With hydrogenchloride; palladium diacetate In isopropyl alcohol at 50℃; pH=7-8; Reagent/catalyst; Temperature; pH-value; Inert atmosphere; | 85.3% |
Conditions | Yield |
---|---|
With silver(II) oxide; sodium cyanide In methanol for 18h; Ambient temperature; | 80% |
With sodium cyanide; silver(l) oxide | 80% |
With silver(II) oxide; sodium cyanide In methanol Yield given; |
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol for 0.5h; Heating; Yield given; | A n/a B 77% |
With potassium hydroxide In ethanol for 0.5h; Heating; Yields of byproduct given; | A n/a B 77% |
(2E,4E)-5-iodo-3-methylpenta-2,4-dienoic acid
all-trans-retinoic-acid
Conditions | Yield |
---|---|
[PdCl2(NCMe)2] In N,N-dimethyl-formamide at 25℃; for 3h; Stille cross-coupling reaction; | 73% |
acide-2-carboxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2E,4E,6E,8E-tetraenoique
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With pyridine In dichloromethane | 67% |
5-(2,6,6-trimethyl-cyclohex-1-enyl)-3-methyl-1-phenyl-sulphonyl-penta-2,4-diene
(E)-4-bromo-3-methyl-2-butenoic acid
all-trans-retinoic-acid
Conditions | Yield |
---|---|
Stage #1: 5-(2,6,6-trimethyl-cyclohex-1-enyl)-3-methyl-1-phenyl-sulphonyl-penta-2,4-diene With potassium tert-butylate In tetrahydrofuran at -20℃; for 0.5h; Stage #2: (E)-4-bromo-3-methyl-2-butenoic acid In tetrahydrofuran at -20 - 60℃; for 4h; Julia olefination; | 65% |
β-ionone
methylmagnesium bromide
dimethyl 2-[(2E)-3-(dimethylamino)-1-methyl-2-propenylidene]malonate
A
13-cis-retinoic acid
B
all-trans-retinoic-acid
Conditions | Yield |
---|---|
Multistep reaction.; | A 12% B 61% |
acide-2-carboxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2E,4E,6E,8E-tetraenoique
A
13-cis-retinoic acid
B
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 20℃; for 20h; | A n/a B 60% |
With barium dihydroxide In benzene for 0.5h; |
Conditions | Yield |
---|---|
With phosphoric acid In 1,4-dioxane; ethanol; hexane | 55.9% |
all-trans-retinoic-acid
Conditions | Yield |
---|---|
Stage #1: [(2Z,4E)-3-methyl-5-(2,6,6-trimethylcyclohex-1-en-1-yl)penta-2,4-dienyl]triphenylphosphonium chloride With sodium methylate In methanol at -7.5℃; for 1h; Wittig Reaction; Stage #2: With methanol; sodium hydroxide; ethanol; water at 20℃; Heating / reflux; Stage #3: With water; acetic acid In dichloromethane | 46% |
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol; water for 2h; Heating; | A 38% B n/a |
retinoyl fluoride
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With water In isopropyl alcohol for 23h; | 38% |
(2E,4E,6E,8E)-3,7-dimethyl-9-{6,6-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)-1-cyclohexenyl}-2,4,6,8-nonatetraenoicacid ethyl ester
methyl iodide
A
13-cis-retinoic acid
C
all-trans-retinoic-acid
Conditions | Yield |
---|---|
Stage #1: (2E,4E,6E,8E)-3,7-dimethyl-9-{6,6-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)-1-cyclohexenyl}-2,4,6,8-nonatetraenoicacid ethyl ester; methyl iodide With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; tris-(o-tolyl)phosphine In water; N,N-dimethyl-formamide at 60℃; for 0.0833333h; Inert atmosphere; Schlenk technique; Stage #2: With potassium hydroxide In methanol; water; N,N-dimethyl-formamide at 100℃; for 0.0333333h; Inert atmosphere; Schlenk technique; Stage #3: With formic acid In methanol; water; N,N-dimethyl-formamide Inert atmosphere; Schlenk technique; | A 10% B 0.5% C 32% |
trans-β-formyl crotonic acid
(1E)-1-(2,6,6-trimethylcyclohex-1-enyl)-3-methyl-1,4-pentadien-3-ol
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With triphenylphosphine |
ethyl 3-methylbut-2-enoate
(2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienal
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With potassium amide |
(+/-)-7-hydroxy-3.7-dimethyl-1t-(2.2.6-trimethyl-cyclohexen-(6)-yl)-nonatrien-(1.3t.5t)-oic acid-(9)-ethyl ester
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With iodine; Petroleum ether Behandeln des erhaltenen all-trans-Retinsaeure-aethylesters mit wss.-aethanol. Kalilauge unter Stickstoff bei Lichtausschluss; |
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With oxalic acid unter vermindertem Druck und Behandeln mit methanol. oder aethanol. Kalilauge; | |
With toluene-4-sulfonic acid; benzene Behandeln mit methanol. oder aethanol. Kalilauge; | |
With phenyl isocyanate at 110℃; Behandeln mit methanol. oder aethanol. Kalilauge; |
(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With iodine |
methyl 5-benzenesulphonyl-3.7-dimethyl-9-(2'.6'.6'.trimethyl-cyclohexen-1'-yl)-2.6.8-nonatrienoate
A
13-cis-retinoic acid
B
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With potassium hydroxide In methanol for 2.5h; Heating; Yield given. Yields of byproduct given; |
8-<2-(methylthio)-1,3-dithian-2-yl>-3,7-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)octa-1E,3E,5E,7E-tetraene
A
13-cis-retinoic acid
B
all-trans-retinoic-acid
Conditions | Yield |
---|---|
Yield given. Multistep reaction. Yields of byproduct given; |
(2E,4E,8E/2Z,4E,8E)-7-hydroxy-7-methyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,8-trienoic acid
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With iodine; toluene-4-sulfonic acid 1.) methylene dichloride, reflux; 2.) diethyl ether/benzene, rt, 7 h; Yield given; | |
Multi-step reaction with 2 steps 1: 95 percent / p-toluenesulfonic acid / CH2Cl2 / Heating 2: I2 View Scheme |
(E)-2-(but-1-en-3-ynyl)-1,3,3-trimethylcyclohex-1-ene
(2E,4E)-5-iodo-3-methylpenta-2,4-dienoic acid
methyl iodide
all-trans-retinoic-acid
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
all-trans-Retinal
A
all-trans-retinoic-acid
B
4-hydroxy-all-trans-retinal
Conditions | Yield |
---|---|
With rabbit liver microsomal P450 1A1 isozyme; NADPH; NADPH-cytochrome P450 reductase In phosphate buffer at 30℃; for 0.25h; pH=7.4; Enzyme kinetics; Further Variations:; Reaction partners; Oxidation; Enzymatic reaction; |
Conditions | Yield |
---|---|
With triphenylphosphine |
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With triphenylphosphine |
all-trans-retinoic-acid
diazomethyl-trimethyl-silane
all-trans-methyl retinoate
Conditions | Yield |
---|---|
In methanol; hexane; benzene at 20℃; for 0.75h; | 100% |
With methanol In benzene at 20℃; Methylation; |
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; for 24h; optical yield given as %de; | 99% |
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; | 99% |
all-trans-retinoic-acid
1,1'-carbonyldiimidazole
N-(all-trans-Retinoyl)-imidazole
Conditions | Yield |
---|---|
In acetonitrile for 1h; Heating; | 98.6% |
In N,N-dimethyl-formamide Ambient temperature; | 80% |
In benzene at 20℃; for 1h; | 60% |
all-trans-retinoic-acid
3-(tert-butyldisulfanyl)propane-1,2-diol
(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid 2-tert-butyldisulfanyl-1-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoyloxymethyl]-ethyl ester
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran for 12h; Ambient temperature; | 98% |
Chloromethyl pivalate
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 70℃; for 3h; Alkylation; | 98% |
Conditions | Yield |
---|---|
With diethyl cyanophosphonate; triethylamine In tetrahydrofuran | 98% |
all-trans-retinoic-acid
(+)-octan-2-ol
(+)-2-octanoyl retinoate
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In diethyl ether 1.) 0 deg C, 30 min, 2.) 25 deg C, 1 h; | 96% |
Conditions | Yield |
---|---|
With thionyl chloride; triethylamine In N,N-dimethyl-formamide | 96% |
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In diethyl ether 1.) 0 deg C, 30 min, 2.) 25 deg C, 1 h; | 95% |
(i) N,N'-carbonyl-di-imidazole, (ii) /BRN= 1718733/, NaOEt; Multistep reaction; |
1,1'-Carbonyl-di-(1,2,4-triazole)
all-trans-retinoic-acid
Conditions | Yield |
---|---|
In acetonitrile for 1h; Heating; | 95% |
In N,N-dimethyl-formamide 1.) RT; 15 min, 2.) 40 deg C, 4 h; | 87% |
all-trans-retinoic-acid
(+)-α-phenethyl alcohol
(+)-α-phenethylretinoate
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In diethyl ether 1.) 0 deg C, 30 min, 2.) 25 deg C, 1 h; | 95% |
all-trans-retinoic-acid
(-)-α-phenethyl alcohol
(-)-α-phenethylretinoate
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In diethyl ether 1.) 0 deg C, 30 min, 2.) 25 deg C, 1 h; | 95% |
all-trans-retinoic-acid
2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide
all-trans-retinoic acid-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylester
Conditions | Yield |
---|---|
With pyridine; silver(l) oxide for 1.5h; | 95% |
chloromethyl isobutyrate
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 70℃; for 3h; Alkylation; | 94% |
Conditions | Yield |
---|---|
With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} In dichloromethane at 20℃; for 0.166667h; Inert atmosphere; | 93% |
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With tert-butylimino-tri(pyrrolidino)phosphorane In dichloromethane at 30℃; for 0.166667h; Schlenk technique; | 93% |
all-trans-retinoic-acid
(2-bromoethyl)(hexyl)(2-hydroxyethyl)phosphate
2-((2-bromoethoxy)(hexyloxy)phosphoryl)ethoxyretinoate
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine; chlorotri(pyrrolidin-1-yl)phosphonium hexafluorophosphate In dichloromethane for 24h; Inert atmosphere; Reflux; | 92% |
With dmap; N-ethyl-N,N-diisopropylamine; chlorotri(pyrrolidin-1-yl)phosphonium hexafluorophosphate In dichloromethane for 24h; Reflux; Inert atmosphere; | 92% |
all-trans-retinoic-acid
propargyl bromide
(2E,4E,6E,8E)-prop-2-yn-1-yl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate
Conditions | Yield |
---|---|
With caesium carbonate In tetrahydrofuran at 20℃; for 1h; | 92% |
With caesium carbonate In tetrahydrofuran at 20℃; | 89% |
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 2h; Inert atmosphere; | 92% |
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 2h; Inert atmosphere; |
all-trans-retinoic-acid
4-hydroxy-benzaldehyde
4-formylphenyl(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoate
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 24h; | 91% |
With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 24h; | 91% |
Conditions | Yield |
---|---|
Stage #1: all-trans-retinoic-acid With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In dimethyl sulfoxide at 20℃; for 20h; Stage #2: ethylenediamine In dimethyl sulfoxide at 20℃; for 24h; | 91% |
Stage #1: all-trans-retinoic-acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Cooling with ice; Stage #2: ethylenediamine In dichloromethane at 20℃; | 63% |
all-trans-retinoic-acid
retinoyl fluoride
Conditions | Yield |
---|---|
With (2-chloro-1,2,2-trifluoro-ethyl)-diethyl-amine In tetrahydrofuran for 0.25h; Heating; | 90% |
With perfluoropropylene; diethylamine | |
With diethylamino-sulfur trifluoride In diethyl ether 1.) -70 deg C, 60 min, 2.) r.t., 2 h; | 9.1 g |
all-trans-retinoic-acid
methyl (2S)-2-amino-3-phenylpropanoate
N-(all-trans-retinoyl)-L-phenylalanine methyl ester
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 0.5h; Ambient temperature; | 90% |
Conditions | Yield |
---|---|
With sodium chloride; argon In ethyl acetate; N,N-dimethyl-formamide | 90% |
With sodium chloride In ethyl acetate; N,N-dimethyl-formamide | 90% |
1-hydroxy-pyrrolidine-2,5-dione
all-trans-retinoic-acid
N-(all-trans-Retinoyloxy)-succinimide
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 20℃; Inert atmosphere; Darkness; | 90% |
With dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 25℃; for 0.208333h; | 73% |
With dicyclohexyl-carbodiimide In dimethyl sulfoxide at 20℃; for 72h; | |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In dichloromethane at 20℃; for 3h; | |
With dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 20℃; |
all-trans-retinoic-acid
3-Hydroxypropionitrile
(2E,4E,6E,8E)-2-cyanoethyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoate
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 18h; | 90% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; Inert atmosphere; | 90% |
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