We are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of Isotretinoin from Wuhan, Hubei, China. It is made obtainable from us a
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inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
1. GMP AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Appearance:yellow crystalline powder Storage:in cool Package:as request Application:active pharmaceutical ingredient Transportation:as request Port:any po
Strict quality control: good raw materials, good quality, Zenuo Biology has always regarded quality as the life of the enterprise. Zenuo Biology has an independent quality control department and long-term cooperation with the third-party detection
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
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inquiryAnalysis tests Standard Results Appearance Yellow crystalline powder Conform Identification
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inquiryDescription: It is used on the skin (topically) in the treatment of mild to moderate acne. Product name: Vitamin A acid Tretinoin INCI Name: Vitamin A acid CAS. NO.: 4759-48-2 Chemical name: 3, 7-
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryUnique advantages for Isotretinoin Cas 4759-48-2 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Storage:?20°C Package:1kg/foil bag, 25kg/drum or as you requi
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inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shangha
Isotretinoin[CAS:4759-48-2] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thin
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
GIHI CHEMICALS exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, GIHI CHEMICALS is your best choice. pls contact with us freely for getting detailed prod
Name:isotretinoin The alias:13-cis-retinoic acid; 13-cis-vitamin a acid; CAS NO: 4759-48-2 Molecular formula:C20H27O2 Molecular weight:299.4277 Product Quality 12 years of chemical raw materials Mature operation of the industry System stabili
Cas:4759-48-2
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:4759-48-2
Min.Order:1 Gram
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturing
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Prodcut name Isotretinoin MOQ 1KG CAS No. 4759-48-2 Appearance Yellow crystalline powder Molecular Formula C20H28O2 Molecular Weight 300.44g/mol Assay 99% Appea
About Product Details CAS: 4759-48-2 MF: C20H28O
Cas:4759-48-2
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inquiryAppearance:yellowish crystalline powder Storage:Room temperature Package:25kg/drum Application:Chemicals Transportation:Express/Sea/Air Port:Any port in china
Cas:4759-48-2
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Yellow powder Storage:Store in sealed containers at cool & d
Cas:4759-48-2
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inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr
Cas:4759-48-2
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inquiryShanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many ye
Cas:4759-48-2
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Type:Lab/Research institutions
inquiryacide-2-carboxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2E,4E,6E,8E-tetraenoique
13-cis-retinoic acid
Conditions | Yield |
---|---|
With 2,6-dimethylpyridine for 2h; Heating; | 90% |
With lutidine Heating; | 63% |
With 2,6-dimethylpyridine for 1.5h; Decarboxylation; | 56% |
With 2,6-dimethylpyridine for 0.3h; Heating; |
(Z)-3-methyl-4-oxobut-2-enoic acid
5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
13-cis-retinoic acid
Conditions | Yield |
---|---|
Stage #1: (Z)-3-methyl-4-oxobut-2-enoic acid; 5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide With sodium hydroxide In isopropyl alcohol at 20 - 30℃; for 3h; Wittig Olefination; Inert atmosphere; Stage #2: With hydrogenchloride; palladium diacetate In isopropyl alcohol at 60℃; pH=7 - 8; | 86.3% |
Stage #1: (Z)-3-methyl-4-oxobut-2-enoic acid; 5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide With sodium hydroxide In isopropyl alcohol at 20 - 30℃; for 3h; Wittig Olefination; Inert atmosphere; Stage #2: With hydrogenchloride; palladium diacetate In isopropyl alcohol at 60℃; pH=7-8; Inert atmosphere; | 86.3% |
4-methyl-6-[(1E,3E)-2-methyl-4-(2,6,6-trimethylcyclohex-1-en-1-yl)buta-1,3-dien-1-yl]-5,6-dihydro-2H-pyran-2-one
13-cis-retinoic acid
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at 0℃; for 1h; | 80% |
With pyrographite for 0.5h; Reflux; | 55 g |
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol for 0.5h; Heating; Yield given; | A n/a B 77% |
With potassium hydroxide In ethanol for 0.5h; Heating; Yields of byproduct given; | A n/a B 77% |
13-cis-ethyl retinoate
13-cis-retinoic acid
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol at 50℃; | 70% |
With sodium hydroxide |
(2Z,4E)-5-iodo-3-methylpenta-2,4-dienoic acid
13-cis-retinoic acid
Conditions | Yield |
---|---|
[PdCl2(NCMe)2] In N,N-dimethyl-formamide at 25℃; for 3h; Stille cross-coupling reaction; | 70% |
11-cis,13-cis-12-carboxyretinoic acid
13-cis-retinoic acid
Conditions | Yield |
---|---|
With copper (I) acetate In various solvent(s) at 110℃; for 2.5h; | 68.2% |
With 2,4-lutidine; copper diacetate |
β-ionone
methylmagnesium bromide
dimethyl 2-[(2E)-3-(dimethylamino)-1-methyl-2-propenylidene]malonate
A
13-cis-retinoic acid
B
all-trans-retinoic-acid
Conditions | Yield |
---|---|
Multistep reaction.; | A 12% B 61% |
acide-2-carboxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2E,4E,6E,8E-tetraenoique
A
13-cis-retinoic acid
B
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 20℃; for 20h; | A n/a B 60% |
With barium dihydroxide In benzene for 0.5h; |
11-cis,13-cis-12-carboxyretinoic acid
A
13-cis-retinoic acid
B
2-((1E,3E,5E)-3,7-dimethylocta-1,3,5,7-tetraen-1-yl)-1,3,3-trimethylcyclohex-1-ene
Conditions | Yield |
---|---|
With copper (I) acetate In pyridine at 100℃; for 2h; Product distribution; other solvents, other temperatures, other times; | A 49.8% B 33.9% |
With copper (I) acetate In pyridine at 100℃; for 3h; | A 45.6% B 30.8% |
4-Methyl-6-<(1E,3E)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3-butadien-1-yl>-2H-pyran-2-on
13-cis-retinoic acid
Conditions | Yield |
---|---|
With potassium hydroxide; sodium tetrahydroborate In methanol for 6h; Heating; | 42% |
(2E,4E,6E,8E)-3,7-dimethyl-9-{6,6-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)-1-cyclohexenyl}-2,4,6,8-nonatetraenoicacid ethyl ester
methyl iodide
A
13-cis-retinoic acid
C
all-trans-retinoic-acid
Conditions | Yield |
---|---|
Stage #1: (2E,4E,6E,8E)-3,7-dimethyl-9-{6,6-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)-1-cyclohexenyl}-2,4,6,8-nonatetraenoicacid ethyl ester; methyl iodide With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; tris-(o-tolyl)phosphine In water; N,N-dimethyl-formamide at 60℃; for 0.0833333h; Inert atmosphere; Schlenk technique; Stage #2: With potassium hydroxide In methanol; water; N,N-dimethyl-formamide at 100℃; for 0.0333333h; Inert atmosphere; Schlenk technique; Stage #3: With formic acid In methanol; water; N,N-dimethyl-formamide Inert atmosphere; Schlenk technique; | A 10% B 0.5% C 32% |
ethyl 3-methylbut-2-enoate
(2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienal
13-cis-retinoic acid
Conditions | Yield |
---|---|
With sodium amide |
methyl 5-benzenesulphonyl-3.7-dimethyl-9-(2'.6'.6'.trimethyl-cyclohexen-1'-yl)-2.6.8-nonatrienoate
A
13-cis-retinoic acid
B
all-trans-retinoic-acid
Conditions | Yield |
---|---|
With potassium hydroxide In methanol for 2.5h; Heating; Yield given. Yields of byproduct given; |
8-<2-(methylthio)-1,3-dithian-2-yl>-3,7-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)octa-1E,3E,5E,7E-tetraene
A
13-cis-retinoic acid
B
all-trans-retinoic-acid
Conditions | Yield |
---|---|
Yield given. Multistep reaction. Yields of byproduct given; |
(2Z,4E,6E,8E)-methyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate
13-cis-retinoic acid
Conditions | Yield |
---|---|
With potassium hydroxide In methanol at 50℃; for 2h; |
(E)-2-(but-1-en-3-ynyl)-1,3,3-trimethylcyclohex-1-ene
(2Z,4E)-5-iodo-3-methylpenta-2,4-dienoic acid
methyl iodide
13-cis-retinoic acid
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
13-cis-vitamin A aldehyde
A
13-cis-retinoic acid
B
4-hydroxy-13-cis-retinal
Conditions | Yield |
---|---|
With rabbit liver microsomal P450 1A1 isozyme; NADPH; NADPH-cytochrome P450 reductase In phosphate buffer at 30℃; for 0.25h; pH=7.4; Enzyme kinetics; Further Variations:; Reaction partners; Oxidation; Enzymatic reaction; |
Conditions | Yield |
---|---|
With cytosolic aldehyde dehydrogenase from human liver In phosphate buffer; dimethyl sulfoxide at 25℃; for 1h; pH=7.5; Enzyme kinetics; | |
Multi-step reaction with 2 steps 1: 60 percent / NaCN, AgO, MnO2 / 14 h / 40 °C 2: 70 percent / 6 M NaOH / ethanol / 50 °C View Scheme | |
Multi-step reaction with 2 steps 1: AgO, MnO2, NaCN 2: NaOH View Scheme |
acide-2-carboxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2E,4E,6E,8E-tetraenoique
A
13-cis-retinoic acid
B
all-trans-retinoic-acid
C
2-((1E,3E,5E)-3,7-dimethylocta-1,3,5,7-tetraen-1-yl)-1,3,3-trimethylcyclohex-1-ene
Conditions | Yield |
---|---|
With triethylamine In benzene for 0.3h; Heating; |
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol; water at 40℃; for 0.75h; | A 1.05 g B 5 g |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 85 percent / potassium hydroxide / methanol / 64 h / 20 °C 2: 49.8 percent / copper acetate / pyridine; various solvent(s) / 2 h / 100 °C / other solvents, other temperatures, other times View Scheme | |
Multi-step reaction with 2 steps 1: 85 percent / potassium hydroxide / methanol / 64 h / 20 °C 2: 68.2 percent / copper acetate / various solvent(s) / 2.5 h / 110 °C View Scheme |
(2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienal
13-cis-retinoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 85 percent / potassium hydroxide / methanol / 64 h / 20 °C 2: 49.8 percent / copper acetate / pyridine; various solvent(s) / 2 h / 100 °C / other solvents, other temperatures, other times View Scheme | |
Multi-step reaction with 2 steps 1: 85 percent / potassium hydroxide / methanol / 64 h / 20 °C 2: 68.2 percent / copper acetate / various solvent(s) / 2.5 h / 110 °C View Scheme | |
Multi-step reaction with 3 steps 1: MeOK 2: KOH / methanol; H2O 3: 2,6-dimethylpiridine / 0.3 h / Heating View Scheme |
diethyl bromoisopropylidenemalonate
13-cis-retinoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 74 percent / tetrahydrofuran; hexane / 1.5 h / -78 - 20 °C 2.1: 58 percent / KOH / propan-2-ol / 27 h / 20 °C 3.1: 63 percent / lutidine / Heating View Scheme |
5-(2,6,6-trimethyl-cyclohex-1-enyl)-3-methyl-1-phenyl-sulphonyl-penta-2,4-diene
13-cis-retinoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 74 percent / tetrahydrofuran; hexane / 1.5 h / -78 - 20 °C 2.1: 58 percent / KOH / propan-2-ol / 27 h / 20 °C 3.1: 63 percent / lutidine / Heating View Scheme | |
Multi-step reaction with 2 steps 1: potassium t-butoxide / tetrahydrofuran; various solvent(s) / 1 h / -65 °C 2: potassium hydroxide / methanol / 2.5 h / Heating View Scheme |
2-[(4E,6E)-3-Benzenesulfonyl-1,5-dimethyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-4,6-dienylidene]-malonic acid diethyl ester
13-cis-retinoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 58 percent / KOH / propan-2-ol / 27 h / 20 °C 2: 63 percent / lutidine / Heating View Scheme |
dimethyl isopropylidenemalonate
13-cis-retinoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 95 percent / methanol / 18 h / 95 °C 2: 65 percent / iPr2NH / 1,2-dimethoxy-ethane; hexane / 2 h / Heating 3: 69 percent / tetrahydrofuran / 0.5 h / -10 °C 4: 1.05 g / KOH / ethanol; H2O / 0.75 h / 40 °C View Scheme | |
Multi-step reaction with 3 steps 1: MeOK 2: KOH / methanol; H2O 3: 2,6-dimethylpiridine / 0.3 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: MeOK 2: KOH / methanol; H2O 3: Ba(OH)2 / benzene / 0.5 h View Scheme |
dimethyl 2-[(2E)-3-(dimethylamino)-1-methyl-2-propenylidene]malonate
13-cis-retinoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 65 percent / iPr2NH / 1,2-dimethoxy-ethane; hexane / 2 h / Heating 2: 69 percent / tetrahydrofuran / 0.5 h / -10 °C 3: 1.05 g / KOH / ethanol; H2O / 0.75 h / 40 °C View Scheme |
dimethyl 2-[(3E,6E)-1-methyl-5-oxo-7-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3,6-heptatrienyl]malonate
13-cis-retinoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 69 percent / tetrahydrofuran / 0.5 h / -10 °C 2: 1.05 g / KOH / ethanol; H2O / 0.75 h / 40 °C View Scheme |
13-cis-retinoic acid
diazomethyl-trimethyl-silane
(2Z,4E,6E,8E)-methyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate
Conditions | Yield |
---|---|
In methanol; hexane; benzene | 83% |
In methanol; hexane; benzene | 83% |
In methanol; hexane; benzene at 20℃; for 0.75h; |
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; for 24h; optical yield given as %de; | 81% |
13-cis-retinoic acid
retinoyl chloride
all-(E)-retinoic and 13-(Z)-retinoic anhydride
Conditions | Yield |
---|---|
With triethylamine In benzene for 0.5h; Ambient temperature; | 76.7% |
13-cis-retinoic acid
(2R,3R,4S,5R,6S)-2-(acetoxymethyl)-6-(4-(hydroxymethyl)phenoxy)-tetrahydro-2H-pyran-3,4,5-triyl triacetate
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; | 74% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 10h; | 73.2% |
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In dichloromethane for 5h; | 70% |
acetic acid 4,5-diacetoxy-6-acetoxymethyl-2-(5-hydroxymethyl-2-methoxy-phenoxy)-tetrahydro-pyran-3-yl ester
13-cis-retinoic acid
3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid 4-methoxy-3-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-benzyl ester
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 10h; | 67.1% |
Conditions | Yield |
---|---|
With 1,1'-carbonyldiimidazole In benzene 1.) 20-25 deg C, 3 h, 50 deg C, 15 min, 2.) 10-20 deg C, 2 h; | 66% |
Conditions | Yield |
---|---|
With dmap; potassium hydroxide In dichloromethane for 9h; Heating; | 65% |
Conditions | Yield |
---|---|
With dmap; potassium hydroxide In dichloromethane for 6h; Heating; | 61.4% |
4-Aminobutanol
13-cis-retinoic acid
13-cis-N-(4-Hydroxybutyl)retinamide
Conditions | Yield |
---|---|
With 1,1'-carbonyldiimidazole In benzene 1.) 20-25 deg C, 3 h, 50 deg C, 15 min, 2.) 10-20 deg C, 2 h; | 60% |
Conditions | Yield |
---|---|
With dmap; potassium hydroxide In dichloromethane for 9h; Heating; | 55.6% |
[2-(hydroxymethyl)phenyl]-2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside
13-cis-retinoic acid
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 10h; | 55.4% |
Conditions | Yield |
---|---|
With caesium carbonate In N-methyl-acetamide; water | 54% |
13-cis-retinoic acid
2,3,6,2',3',4',6'-hepta-O-acetyl-α-D-maltosyl bromide
Conditions | Yield |
---|---|
With dmap; potassium hydroxide In dichloromethane for 9h; Heating; | 53.1% |
13-cis-retinoic acid
Conditions | Yield |
---|---|
35% |
13-cis-retinoic acid
L-homocysteic acid
Conditions | Yield |
---|---|
25% |
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