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HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of Isotretinoin from Wuhan, Hubei, China. It is made obtainable from us a

Top Quality Isotretinoin to Treat Cystic Acne 4759-48-2

Cas:4759-48-2

Min.Order:1 Kilogram

FOB Price: $4.8 / 5.0

Type:Trading Company

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Isotretinoin

Cas:4759-48-2

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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HANGZHOU CLAKE BIOTECH CO.,LTD

1. GMP AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Appearance:yellow crystalline powder Storage:in cool Package:as request Application:active pharmaceutical ingredient Transportation:as request Port:any po

Isotretinoin

Cas:4759-48-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Strict quality control: good raw materials, good quality, Zenuo Biology has always regarded quality as the life of the enterprise. Zenuo Biology has an independent quality control department and long-term cooperation with the third-party detection

Isotretinoin Manufactuered in China best quality

Cas:4759-48-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Isotretinoin Manufacturer/High quality/Best price/In stock

Cas:4759-48-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

98% up by HPLC USP 13-cis-Vitamin A acid Isotretinoin 4759-48-2

Cas:4759-48-2

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Dingyan Chem Co., Ltd

Analysis tests Standard Results Appearance Yellow crystalline powder Conform Identification

High quality isotretinoin with best price cas:4759-48-2

Cas:4759-48-2

Min.Order:1 Kilogram

FOB Price: $250.0 / 350.0

Type:Manufacturers

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Kono Chem Co.,Ltd

Description: It is used on the skin (topically) in the treatment of mild to moderate acne. Product name: Vitamin A acid Tretinoin INCI Name: Vitamin A acid CAS. NO.: 4759-48-2 Chemical name: 3, 7-

CAS:4759-48-2 Isotretinoin low price

Cas:4759-48-2

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

High purity 99% Isotretinoin in stock factory

Cas:4759-48-2

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Isotretinoin Cas 4759-48-2 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Storage:?20°C Package:1kg/foil bag, 25kg/drum or as you requi

Manufacture supply Isotretinoin Cas 4759-48-2 with high quality low price

Cas:4759-48-2

Min.Order:1 Gram

FOB Price: $35.0

Type:Trading Company

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shangha

Isotretinoin 4759-48-2 API

Cas:4759-48-2

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

Isotretinoin[CAS:4759-48-2] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thin

Manufacture Isotretinoin USP with ISO

Cas:4759-48-2

Min.Order:1 Kilogram

Negotiable

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Isotretinoin

Cas:4759-48-2

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 13-cis-Vitamin A acid 4759-48-2 ISO Producer

Cas:4759-48-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Isotretinoin

Cas:4759-48-2

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Isotretinoin

Cas:4759-48-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Isotretinoin

Cas:4759-48-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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GIHI CHEMICALS CO.,LIMITED

GIHI CHEMICALS exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, GIHI CHEMICALS is your best choice. pls contact with us freely for getting detailed prod

Isotretinoin

Cas:4759-48-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hubei DiBo chemical co., LTD

Name:isotretinoin The alias:13-cis-retinoic acid; 13-cis-vitamin a acid; CAS NO: 4759-48-2 Molecular formula:C20H27O2 Molecular weight:299.4277 Product Quality 12 years of chemical raw materials Mature operation of the industry System stabili

isotretinoin/CAS:4759-48-2/Manufacturer

Cas:4759-48-2

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

High Purity Isotretinoin4759-48-2 in stock

Cas:4759-48-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Isotretinoin

Cas:4759-48-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturing

Isotretinoin Powder 4759-48-2 with Best Price

Cas:4759-48-2

Min.Order:1 Kilogram

FOB Price: $25.0 / 55.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 4759-48-2 with fast shipping

Cas:4759-48-2

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Isotretinoin

Cas:4759-48-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Prodcut name Isotretinoin MOQ 1KG CAS No. 4759-48-2 Appearance Yellow crystalline powder Molecular Formula C20H28O2 Molecular Weight 300.44g/mol Assay 99% Appea

Isotretinoin CAS:4759-48-2

Cas:4759-48-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Leader Biochemical Group

About Product Details CAS: 4759-48-2 MF: C20H28O

China Biggest factory Manufacturer Supply High Quality Isotretinoin CAS 4759-48-2

Cas:4759-48-2

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Lab/Research institutions

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:yellowish crystalline powder Storage:Room temperature Package:25kg/drum Application:Chemicals Transportation:Express/Sea/Air Port:Any port in china

Factory Supply Isotretinoin Yellow Raw Steroid Powder

Cas:4759-48-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Yellow powder Storage:Store in sealed containers at cool & d

Severe Acne Treatment 4759-48-2 Isotretinoin Vitamin A Raw Materials Powder

Cas:4759-48-2

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr

High quality Isotretinoin 99.0%

Cas:4759-48-2

Min.Order:1 Kilogram

FOB Price: $11.0

Type:Lab/Research institutions

inquiry

ShangHai Soyoung Biotechnology Inc

Shanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many ye

Vitamin A palmitate 79-81-2 Vitamin A Palmitatein liquid

Cas:4759-48-2

Min.Order:20 Kilogram

FOB Price: $85.0

Type:Lab/Research institutions

inquiry

Synthetic route

acide-2-carboxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2E,4E,6E,8E-tetraenoique
20013-34-7

acide-2-carboxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2E,4E,6E,8E-tetraenoique

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
With 2,6-dimethylpyridine for 2h; Heating;90%
With lutidine Heating;63%
With 2,6-dimethylpyridine for 1.5h; Decarboxylation;56%
With 2,6-dimethylpyridine for 0.3h; Heating;
(Z)-3-methyl-4-oxobut-2-enoic acid
70143-04-3

(Z)-3-methyl-4-oxobut-2-enoic acid

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide
62285-98-7

5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
Stage #1: (Z)-3-methyl-4-oxobut-2-enoic acid; 5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide With sodium hydroxide In isopropyl alcohol at 20 - 30℃; for 3h; Wittig Olefination; Inert atmosphere;
Stage #2: With hydrogenchloride; palladium diacetate In isopropyl alcohol at 60℃; pH=7 - 8;
86.3%
Stage #1: (Z)-3-methyl-4-oxobut-2-enoic acid; 5-(2,6,6-trimethylcyclohexenyl)-3-methyl-2,4-pentadienyltriphenylphosphonium bromide With sodium hydroxide In isopropyl alcohol at 20 - 30℃; for 3h; Wittig Olefination; Inert atmosphere;
Stage #2: With hydrogenchloride; palladium diacetate In isopropyl alcohol at 60℃; pH=7-8; Inert atmosphere;
86.3%
4-methyl-6-[(1E,3E)-2-methyl-4-(2,6,6-trimethylcyclohex-1-en-1-yl)buta-1,3-dien-1-yl]-5,6-dihydro-2H-pyran-2-one
43059-50-3

4-methyl-6-[(1E,3E)-2-methyl-4-(2,6,6-trimethylcyclohex-1-en-1-yl)buta-1,3-dien-1-yl]-5,6-dihydro-2H-pyran-2-one

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 0℃; for 1h;80%
With pyrographite for 0.5h; Reflux;55 g
Conditions
ConditionsYield
With potassium hydroxide In ethanol for 0.5h; Heating; Yield given;A n/a
B 77%
With potassium hydroxide In ethanol for 0.5h; Heating; Yields of byproduct given;A n/a
B 77%
13-cis-ethyl retinoate
59699-82-0

13-cis-ethyl retinoate

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 50℃;70%
With sodium hydroxide
(2Z,4E)-5-iodo-3-methylpenta-2,4-dienoic acid
220212-07-7

(2Z,4E)-5-iodo-3-methylpenta-2,4-dienoic acid

tributyl[(1E,3E)-2-methyl-4-(2,6,6-trimethylcyclohex-1-enyl)buta-1,3-dienyl]stannane

tributyl[(1E,3E)-2-methyl-4-(2,6,6-trimethylcyclohex-1-enyl)buta-1,3-dienyl]stannane

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
[PdCl2(NCMe)2] In N,N-dimethyl-formamide at 25℃; for 3h; Stille cross-coupling reaction;70%
11-cis,13-cis-12-carboxyretinoic acid
81176-73-0

11-cis,13-cis-12-carboxyretinoic acid

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
With copper (I) acetate In various solvent(s) at 110℃; for 2.5h;68.2%
With 2,4-lutidine; copper diacetate
β-ionone
105593-28-0

β-ionone

methylmagnesium bromide
75-16-1

methylmagnesium bromide

dimethyl 2-[(2E)-3-(dimethylamino)-1-methyl-2-propenylidene]malonate
419550-09-7

dimethyl 2-[(2E)-3-(dimethylamino)-1-methyl-2-propenylidene]malonate

A

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

B

all-trans-retinoic-acid
302-79-4

all-trans-retinoic-acid

Conditions
ConditionsYield
Multistep reaction.;A 12%
B 61%
acide-2-carboxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2E,4E,6E,8E-tetraenoique
20013-34-7

acide-2-carboxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2E,4E,6E,8E-tetraenoique

A

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

B

all-trans-retinoic-acid
302-79-4

all-trans-retinoic-acid

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 20h;A n/a
B 60%
With barium dihydroxide In benzene for 0.5h;
11-cis,13-cis-12-carboxyretinoic acid
81176-73-0

11-cis,13-cis-12-carboxyretinoic acid

A

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

B

2-((1E,3E,5E)-3,7-dimethylocta-1,3,5,7-tetraen-1-yl)-1,3,3-trimethylcyclohex-1-ene
70244-78-9, 94440-28-5

2-((1E,3E,5E)-3,7-dimethylocta-1,3,5,7-tetraen-1-yl)-1,3,3-trimethylcyclohex-1-ene

Conditions
ConditionsYield
With copper (I) acetate In pyridine at 100℃; for 2h; Product distribution; other solvents, other temperatures, other times;A 49.8%
B 33.9%
With copper (I) acetate In pyridine at 100℃; for 3h;A 45.6%
B 30.8%
4-Methyl-6-<(1E,3E)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3-butadien-1-yl>-2H-pyran-2-on
87424-83-7

4-Methyl-6-<(1E,3E)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3-butadien-1-yl>-2H-pyran-2-on

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
With potassium hydroxide; sodium tetrahydroborate In methanol for 6h; Heating;42%
(2E,4E,6E,8E)-3,7-dimethyl-9-{6,6-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)-1-cyclohexenyl}-2,4,6,8-nonatetraenoicacid ethyl ester
1620084-74-3

(2E,4E,6E,8E)-3,7-dimethyl-9-{6,6-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)-1-cyclohexenyl}-2,4,6,8-nonatetraenoicacid ethyl ester

methyl iodide
74-88-4

methyl iodide

A

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

C

all-trans-retinoic-acid
302-79-4

all-trans-retinoic-acid

Conditions
ConditionsYield
Stage #1: (2E,4E,6E,8E)-3,7-dimethyl-9-{6,6-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)-1-cyclohexenyl}-2,4,6,8-nonatetraenoicacid ethyl ester; methyl iodide With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; tris-(o-tolyl)phosphine In water; N,N-dimethyl-formamide at 60℃; for 0.0833333h; Inert atmosphere; Schlenk technique;
Stage #2: With potassium hydroxide In methanol; water; N,N-dimethyl-formamide at 100℃; for 0.0333333h; Inert atmosphere; Schlenk technique;
Stage #3: With formic acid In methanol; water; N,N-dimethyl-formamide Inert atmosphere; Schlenk technique;
A 10%
B 0.5%
C 32%
ethyl 3-methylbut-2-enoate
638-10-8

ethyl 3-methylbut-2-enoate

(2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienal
3917-41-7

(2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienal

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
With sodium amide
methyl 5-benzenesulphonyl-3.7-dimethyl-9-(2'.6'.6'.trimethyl-cyclohexen-1'-yl)-2.6.8-nonatrienoate
41551-56-8, 78088-24-1, 78088-25-2, 78088-26-3

methyl 5-benzenesulphonyl-3.7-dimethyl-9-(2'.6'.6'.trimethyl-cyclohexen-1'-yl)-2.6.8-nonatrienoate

A

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

B

all-trans-retinoic-acid
302-79-4

all-trans-retinoic-acid

Conditions
ConditionsYield
With potassium hydroxide In methanol for 2.5h; Heating; Yield given. Yields of byproduct given;
8-<2-(methylthio)-1,3-dithian-2-yl>-3,7-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)octa-1E,3E,5E,7E-tetraene
146558-55-6

8-<2-(methylthio)-1,3-dithian-2-yl>-3,7-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)octa-1E,3E,5E,7E-tetraene

A

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

B

all-trans-retinoic-acid
302-79-4

all-trans-retinoic-acid

Conditions
ConditionsYield
Yield given. Multistep reaction. Yields of byproduct given;
(2Z,4E,6E,8E)-methyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate
16760-45-5

(2Z,4E,6E,8E)-methyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
With potassium hydroxide In methanol at 50℃; for 2h;
(E)-2-(but-1-en-3-ynyl)-1,3,3-trimethylcyclohex-1-ene
73395-75-2

(E)-2-(but-1-en-3-ynyl)-1,3,3-trimethylcyclohex-1-ene

(2Z,4E)-5-iodo-3-methylpenta-2,4-dienoic acid
220212-07-7

(2Z,4E)-5-iodo-3-methylpenta-2,4-dienoic acid

methyl iodide
74-88-4

methyl iodide

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
Yield given. Multistep reaction;
13-cis-vitamin A aldehyde
472-86-6

13-cis-vitamin A aldehyde

A

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

B

4-hydroxy-13-cis-retinal
71423-68-2

4-hydroxy-13-cis-retinal

Conditions
ConditionsYield
With rabbit liver microsomal P450 1A1 isozyme; NADPH; NADPH-cytochrome P450 reductase In phosphate buffer at 30℃; for 0.25h; pH=7.4; Enzyme kinetics; Further Variations:; Reaction partners; Oxidation; Enzymatic reaction;
13-cis-vitamin A aldehyde
472-86-6

13-cis-vitamin A aldehyde

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
With cytosolic aldehyde dehydrogenase from human liver In phosphate buffer; dimethyl sulfoxide at 25℃; for 1h; pH=7.5; Enzyme kinetics;
Multi-step reaction with 2 steps
1: 60 percent / NaCN, AgO, MnO2 / 14 h / 40 °C
2: 70 percent / 6 M NaOH / ethanol / 50 °C
View Scheme
Multi-step reaction with 2 steps
1: AgO, MnO2, NaCN
2: NaOH
View Scheme
acide-2-carboxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2E,4E,6E,8E-tetraenoique
20013-34-7

acide-2-carboxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2E,4E,6E,8E-tetraenoique

A

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

B

all-trans-retinoic-acid
302-79-4

all-trans-retinoic-acid

C

2-((1E,3E,5E)-3,7-dimethylocta-1,3,5,7-tetraen-1-yl)-1,3,3-trimethylcyclohex-1-ene
70244-78-9, 94440-28-5

2-((1E,3E,5E)-3,7-dimethylocta-1,3,5,7-tetraen-1-yl)-1,3,3-trimethylcyclohex-1-ene

Conditions
ConditionsYield
With triethylamine In benzene for 0.3h; Heating;
methyl 14-(methoxycarbonyl)-retro-retionate

methyl 14-(methoxycarbonyl)-retro-retionate

A

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

B

all-trans-retinoic-acid
302-79-4

all-trans-retinoic-acid

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 40℃; for 0.75h;A 1.05 g
B 5 g
diethyl 3-methylpent-2-enedioate
924-59-4

diethyl 3-methylpent-2-enedioate

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / potassium hydroxide / methanol / 64 h / 20 °C
2: 49.8 percent / copper acetate / pyridine; various solvent(s) / 2 h / 100 °C / other solvents, other temperatures, other times
View Scheme
Multi-step reaction with 2 steps
1: 85 percent / potassium hydroxide / methanol / 64 h / 20 °C
2: 68.2 percent / copper acetate / various solvent(s) / 2.5 h / 110 °C
View Scheme
(2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienal
3917-41-7

(2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienal

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / potassium hydroxide / methanol / 64 h / 20 °C
2: 49.8 percent / copper acetate / pyridine; various solvent(s) / 2 h / 100 °C / other solvents, other temperatures, other times
View Scheme
Multi-step reaction with 2 steps
1: 85 percent / potassium hydroxide / methanol / 64 h / 20 °C
2: 68.2 percent / copper acetate / various solvent(s) / 2.5 h / 110 °C
View Scheme
Multi-step reaction with 3 steps
1: MeOK
2: KOH / methanol; H2O
3: 2,6-dimethylpiridine / 0.3 h / Heating
View Scheme
diethyl bromoisopropylidenemalonate
13830-91-6

diethyl bromoisopropylidenemalonate

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 74 percent / tetrahydrofuran; hexane / 1.5 h / -78 - 20 °C
2.1: 58 percent / KOH / propan-2-ol / 27 h / 20 °C
3.1: 63 percent / lutidine / Heating
View Scheme
5-(2,6,6-trimethyl-cyclohex-1-enyl)-3-methyl-1-phenyl-sulphonyl-penta-2,4-diene
38987-91-6

5-(2,6,6-trimethyl-cyclohex-1-enyl)-3-methyl-1-phenyl-sulphonyl-penta-2,4-diene

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 74 percent / tetrahydrofuran; hexane / 1.5 h / -78 - 20 °C
2.1: 58 percent / KOH / propan-2-ol / 27 h / 20 °C
3.1: 63 percent / lutidine / Heating
View Scheme
Multi-step reaction with 2 steps
1: potassium t-butoxide / tetrahydrofuran; various solvent(s) / 1 h / -65 °C
2: potassium hydroxide / methanol / 2.5 h / Heating
View Scheme
2-[(4E,6E)-3-Benzenesulfonyl-1,5-dimethyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-4,6-dienylidene]-malonic acid diethyl ester
777916-02-6

2-[(4E,6E)-3-Benzenesulfonyl-1,5-dimethyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-4,6-dienylidene]-malonic acid diethyl ester

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 58 percent / KOH / propan-2-ol / 27 h / 20 °C
2: 63 percent / lutidine / Heating
View Scheme
dimethyl isopropylidenemalonate
22035-53-6

dimethyl isopropylidenemalonate

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 95 percent / methanol / 18 h / 95 °C
2: 65 percent / iPr2NH / 1,2-dimethoxy-ethane; hexane / 2 h / Heating
3: 69 percent / tetrahydrofuran / 0.5 h / -10 °C
4: 1.05 g / KOH / ethanol; H2O / 0.75 h / 40 °C
View Scheme
Multi-step reaction with 3 steps
1: MeOK
2: KOH / methanol; H2O
3: 2,6-dimethylpiridine / 0.3 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: MeOK
2: KOH / methanol; H2O
3: Ba(OH)2 / benzene / 0.5 h
View Scheme
dimethyl 2-[(2E)-3-(dimethylamino)-1-methyl-2-propenylidene]malonate
419550-09-7

dimethyl 2-[(2E)-3-(dimethylamino)-1-methyl-2-propenylidene]malonate

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 65 percent / iPr2NH / 1,2-dimethoxy-ethane; hexane / 2 h / Heating
2: 69 percent / tetrahydrofuran / 0.5 h / -10 °C
3: 1.05 g / KOH / ethanol; H2O / 0.75 h / 40 °C
View Scheme
dimethyl 2-[(3E,6E)-1-methyl-5-oxo-7-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3,6-heptatrienyl]malonate
419550-36-0

dimethyl 2-[(3E,6E)-1-methyl-5-oxo-7-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3,6-heptatrienyl]malonate

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 69 percent / tetrahydrofuran / 0.5 h / -10 °C
2: 1.05 g / KOH / ethanol; H2O / 0.75 h / 40 °C
View Scheme
13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

(2Z,4E,6E,8E)-methyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate
16760-45-5

(2Z,4E,6E,8E)-methyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate

Conditions
ConditionsYield
In methanol; hexane; benzene83%
In methanol; hexane; benzene83%
In methanol; hexane; benzene at 20℃; for 0.75h;
1-Hexadecanol
36653-82-4

1-Hexadecanol

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

C36H60O2
847550-90-7

C36H60O2

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; for 24h; optical yield given as %de;81%
13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

retinoyl chloride
53839-60-4

retinoyl chloride

all-(E)-retinoic and 13-(Z)-retinoic anhydride
138752-02-0

all-(E)-retinoic and 13-(Z)-retinoic anhydride

Conditions
ConditionsYield
With triethylamine In benzene for 0.5h; Ambient temperature;76.7%
13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

(2R,3R,4S,5R,6S)-2-(acetoxymethyl)-6-(4-(hydroxymethyl)phenoxy)-tetrahydro-2H-pyran-3,4,5-triyl triacetate
64291-41-4

(2R,3R,4S,5R,6S)-2-(acetoxymethyl)-6-(4-(hydroxymethyl)phenoxy)-tetrahydro-2H-pyran-3,4,5-triyl triacetate

3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid 4-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-benzyl ester

3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid 4-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-benzyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;74%
13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

1,2:3,4-di-O-isopropylidene-α-D-galactopyranose
4064-06-6

1,2:3,4-di-O-isopropylidene-α-D-galactopyranose

6-O-13-cis-retinoyl-1,2:3,4-di-O-isopropylidene-α-D-galactopyranose

6-O-13-cis-retinoyl-1,2:3,4-di-O-isopropylidene-α-D-galactopyranose

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 10h;73.2%
4-aminopyridine
504-24-5

4-aminopyridine

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

(13cis)-15-(pyridin-4-ylamino)retinal

(13cis)-15-(pyridin-4-ylamino)retinal

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane for 5h;70%
acetic acid 4,5-diacetoxy-6-acetoxymethyl-2-(5-hydroxymethyl-2-methoxy-phenoxy)-tetrahydro-pyran-3-yl ester
929016-73-9

acetic acid 4,5-diacetoxy-6-acetoxymethyl-2-(5-hydroxymethyl-2-methoxy-phenoxy)-tetrahydro-pyran-3-yl ester

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid 4-methoxy-3-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-benzyl ester
929016-74-0

3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid 4-methoxy-3-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-benzyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 10h;67.1%
13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

ethanolamine
141-43-5

ethanolamine

13-cis-N-(2-Hydroxyethyl)retinamide
75686-05-4

13-cis-N-(2-Hydroxyethyl)retinamide

Conditions
ConditionsYield
With 1,1'-carbonyldiimidazole In benzene 1.) 20-25 deg C, 3 h, 50 deg C, 15 min, 2.) 10-20 deg C, 2 h;66%
13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

1-bromo-2,3,4-tri-O-acetyl-α-D-xylopyranose
3068-31-3

1-bromo-2,3,4-tri-O-acetyl-α-D-xylopyranose

1-O-13-cis-retinoyl-2,3,4-tri-O-acetyl-β-D-xylopyranose

1-O-13-cis-retinoyl-2,3,4-tri-O-acetyl-β-D-xylopyranose

Conditions
ConditionsYield
With dmap; potassium hydroxide In dichloromethane for 9h; Heating;65%
13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide
572-09-8

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide

1-O-13-cis-retinoyl-2,3,4,6-tetra-O-acetyl-β-D-glucopyranose

1-O-13-cis-retinoyl-2,3,4,6-tetra-O-acetyl-β-D-glucopyranose

Conditions
ConditionsYield
With dmap; potassium hydroxide In dichloromethane for 6h; Heating;61.4%
4-Aminobutanol
13325-10-5

4-Aminobutanol

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

13-cis-N-(4-Hydroxybutyl)retinamide
84680-31-9

13-cis-N-(4-Hydroxybutyl)retinamide

Conditions
ConditionsYield
With 1,1'-carbonyldiimidazole In benzene 1.) 20-25 deg C, 3 h, 50 deg C, 15 min, 2.) 10-20 deg C, 2 h;60%
13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

2,3,6,2',3',4',6'-hepta-O-acetyl-lactosyl bromide
4753-07-5

2,3,6,2',3',4',6'-hepta-O-acetyl-lactosyl bromide

1-O-13-cis-retinoyl-2,3,6,2',3',4',6'-hepta-O-acetyl-β-lactose

1-O-13-cis-retinoyl-2,3,6,2',3',4',6'-hepta-O-acetyl-β-lactose

Conditions
ConditionsYield
With dmap; potassium hydroxide In dichloromethane for 9h; Heating;55.6%
[2-(hydroxymethyl)phenyl]-2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside
929016-65-9

[2-(hydroxymethyl)phenyl]-2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid 2-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-benzyl ester

3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid 2-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-benzyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 10h;55.4%
13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

2-chloro-1-(4-methoxyphenyl)ethanone
2196-99-8

2-chloro-1-(4-methoxyphenyl)ethanone

2-(13-cis-retinoyloxy)-4'-methoxyacetophenone

2-(13-cis-retinoyloxy)-4'-methoxyacetophenone

Conditions
ConditionsYield
With caesium carbonate In N-methyl-acetamide; water54%
13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

1-O-13-cis-retinoyl-2,3,6,2',3',4',6'-hepta-O-acetyl-β-maltose

1-O-13-cis-retinoyl-2,3,6,2',3',4',6'-hepta-O-acetyl-β-maltose

Conditions
ConditionsYield
With dmap; potassium hydroxide In dichloromethane for 9h; Heating;53.1%
L-cysteic acid monohydrate

L-cysteic acid monohydrate

13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

N-(13-cis-retinoyl)-L-cysteic acid (Sodium Salt)

N-(13-cis-retinoyl)-L-cysteic acid (Sodium Salt)

Conditions
ConditionsYield
35%
13-cis-retinoic acid
4759-48-2

13-cis-retinoic acid

L-homocysteic acid
14857-77-3

L-homocysteic acid

N-(13-cis-retinoyl)-L-homocysteic Acid (Sodium Salt)

N-(13-cis-retinoyl)-L-homocysteic Acid (Sodium Salt)

Conditions
ConditionsYield
25%

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