1,2-Dimethylhydrazine dihydrochloride supplier

Name
1,2-DIMETHYLHYDRAZINE DIHYDROCHLORIDE
EINECS 206-183-5
CAS No. 306-37-6
Article Data2
CAS DataBase
Density 0.759 g/cm3
Solubility almost transparency
Melting Point 167-169 °C
Formula C₂H₈N₂.2ClH
Boiling Point 81.5 °C at 760 mmHg
Molecular Weight 133.021
Flash Point 1.1°C
Transport Information
Appearance SOLID
Safety 53-45-61
Risk Codes 45-23/24/25-51/53
Molecular Structure
Hazard Symbols T,N
Synonyms 1,2-Dimethylhydrazinedihydrochloride;Dimethylhydrazinedihydrochloride;Dimethylhydrazinium dichloride;N,N'-Dimethylhydrazinedihydrochloride;sym-Dimethylhydrazine dihydrochloride;
PSA 24.06000
LogP 1.72600

Synthetic route

: 7647-01-0
hydrogenchloride

: C44H82N6Sc2

A: C42H76Cl2N4Sc2

B: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran; diethyl ether at -78 - 20℃; for 1h; Inert atmosphere; Schlenk technique;	A 48% B 89%

...Expand

: 28752-82-1
2-(allyloxy)benzaldehyde

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 108120-71-4
(3aS,9bR)-1,2-Dimethyl-1,2,3,3a,4,9b-hexahydro-chromeno[4,3-c]pyrazole

Conditions

Conditions	Yield
In ethanol for 3h; Heating;	100%

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 135351-20-1
(3E)-1,1,1-trifluoro-4-methoxy-pent-3-en-2-one

: 1,2,5-trimethyl-3-trifluoromethyl-2H-pyrazol-1-ium; chloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 5h; Heating;	100%

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 135351-18-7
(E)-1,1,1-trichloro-4-methoxypent-3-en-2-one

: 3-methyl-5-trichloromethyl-1,2-dimethyl-1H-pyrazolium chloride

Conditions

Conditions	Yield
In toluene at 80℃; for 0.2h; microwave irradiation;	98%
With hydrogenchloride In ethanol for 4h; Heating;	90%

: 59938-06-6
(E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 1,2-dimethyl-3-trifluoromethyl-2H-pyrazol-1-ium; chloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 5h; Heating;	97%

: 1161-13-3
N-Cbz-L-Phe

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 1043922-50-4
(S)-benzyl (1-(1,2-dimethylhydrazinyl)-1-oxo-3-phenylpropan-2-yl)carbamate

Conditions

Conditions	Yield
Stage #1: N-Cbz-L-Phe With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -25℃; Stage #2: N,N'-Dimethylhydrazine dihydrochloride With sodium hydroxide In tetrahydrofuran; water at -25 - 20℃; for 2h;	97%
Stage #1: N-Cbz-L-Phe With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.833333h; Stage #2: N,N'-Dimethylhydrazine dihydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 28h;	83%

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: C2H8N2*2HNO3

Conditions

Conditions	Yield
With silver nitrate In water at 20℃; for 2h; Darkness;	97%

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: C2H8N2*2ClHO4

Conditions

Conditions	Yield
With silver perchlorate In water at 20℃; for 0.5h; Darkness;	96%

: 59938-07-7
(3E)-1,1,1-trichloro-4-ethoxybut-3-en-2-one

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 5-trichloromethyl-1,2-dimethyl-1H-pyrazolium chloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 4h; Heating;	95%
In toluene at 80℃; for 0.166667h; microwave irradiation;	80%

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 438537-10-1
(E)-1,1,1-Trichloro-4-methoxy-hept-3-en-2-one

: 3-propyl-5-trichloromethyl-1,2-dimethyl-1H-pyrazolium chloride

Conditions

Conditions	Yield
In toluene at 80℃; for 0.2h; microwave irradiation;	95%
With hydrogenchloride In ethanol for 4h; Heating;	76%

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: (E)-1,1,1-Trifluoro-4-(4-fluoro-phenyl)-4-methoxy-but-3-en-2-one

: 5-(4-fluoro-phenyl)-1,2-dimethyl-3-trifluoromethyl-2H-pyrazol-1-ium; chloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 5h; Heating;	95%

: 52086-98-3
1-Adamantylmalonaldehyd

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 4-(Adamantan-1-yl)-1,2-dimethylpyrazolium-perchlorat

Conditions

Conditions	Yield
With perchloric acid In methanol for 16h; Ambient temperature;	94%

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: (E)-1,1,1-Trichloro-4-methoxy-3-methyl-but-3-en-2-one

: 1,2,4-trimethyl-3-trichloromethyl-2H-pyrazol-1-ium; chloride

Conditions

Conditions	Yield
In toluene at 80℃; for 0.2h; microwave irradiation;	94%
With hydrogenchloride In ethanol for 4h; Heating;	90%

: [(CO)5CrC(OC2H5)(CC(C5H4)Fe(C5H5))]

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: pentacarbonyl[1,2-dimethyl-5-ferrocenyl-1,2-pyrazolin-3-ylidene]chromium

Conditions

Conditions	Yield
With NaOH In tetrahydrofuran; water byproducts: C2H5OH; using Schlenk techniques; addn. dropwise soln. of NaOH in water at 0°C to soln. of 1,2-dimethylhydrazine dihydrochloride in H2O; stirringfor 15 min; addn. of to (CO)5Cr(OEt)CC(C5H4)Fe(C5H5) in THF for 1 min; removal of solvent in vac., chromy. on silica gel at -20°C using petrol ether/CH2Cl2 as the eluent; elem. anal.;	94%

: 935-50-2
4,4-dimethoxycyclohexa-2,5-dienone

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 8,8-dimethoxy-6,7-dimethyl-6,7-diazabicyclo[3.2.1]octan-3-one

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In isopropyl alcohol for 3h; Reflux; regioselective reaction;	94%

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 1,1,1-trifluoro-4-methoxy-4-(4-methylphenyl)-3-buten-2-one

: 1,2-dimethyl-5-p-tolyl-3-trifluoromethyl-2H-pyrazol-1-ium; chloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 5h; Heating;	92%

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: (E)-1,1,1-Trifluoro-4-methoxy-dec-3-en-2-one

: 5-hexyl-1,2-dimethyl-3-trifluoromethyl-2H-pyrazol-1-ium; chloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 5h; Heating;	92%

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 1,1,1-trifluoro-4-methoxy-4-phenyl-3-buten-2-one

: 1,2-dimethyl-5-phenyl-3-trifluoromethyl-2H-pyrazol-1-ium; chloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 5h; Heating;	91%

: pentacarbonyl[3-(dimethylamino)-3-phenyl-1,2-propadienylidene]chromium

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

A: pentacarbonyl(1,2-dimethyl-5-phenyl-2,3-dihydropyrazol-3-ylidene)chromium

B: pentacarbonyl(1,3-bis(dimethylamino)-3-phenylprop-2-en-1-ylidene)chromium

Conditions

Conditions	Yield
With NaOH In tetrahydrofuran; water (under inert atm., Schlenk); soln. of ligand reacted with NaOH in H2O atroom temp., added to soln. of Cr-complex in THF, warmed to 50°C; solvent removed in vacuo, silica gel column chromy. with pentane/CH2Cl2 2:1-1:2 at -20°C, collected, solvent removed in vacuo;	A 91% B 4%

...Expand

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 233272-56-5
(E)-1,1,1-Trichloro-4-methoxy-hex-3-en-2-one

: 3-ethyl-5-trichloromethyl-1,2-dimethyl-1H-pyrazolium chloride

Conditions

Conditions	Yield
In toluene at 80℃; for 0.2h; microwave irradiation;	90%
With hydrogenchloride In ethanol for 4h; Heating;	81%

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: (E)-1,1,1-Trifluoro-4-methoxy-hept-3-en-2-one

: 1,2-dimethyl-5-propyl-3-trifluoromethyl-2H-pyrazol-1-ium; chloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 5h; Heating;	90%

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: (E)-4-(4-Chloro-phenyl)-1,1,1-trifluoro-4-methoxy-but-3-en-2-one

: 5-(4-chloro-phenyl)-1,2-dimethyl-3-trifluoromethyl-2H-pyrazol-1-ium; chloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 5h; Heating;	90%

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: (E)-1,1,1-Trifluoro-4-methoxy-4-(4-nitro-phenyl)-but-3-en-2-one

: 1,2-dimethyl-5-(4-nitro-phenyl)-3-trifluoromethyl-2H-pyrazol-1-ium; chloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 5h; Heating;	90%

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: (E)-10,10,10-Trichloro-7-methoxy-9-oxo-dec-7-enoic acid ethyl ester

: 5-(5-ethoxycarbonyl-pentyl)-1,2-dimethyl-3-trichloromethyl-2H-pyrazol-1-ium; chloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 12h; Heating;	89%

: 3,4-bis(5-chloro-2-methylthiophen-3-yl)furan-2,5-dione

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 3,4-bis(5-chloro-2-methylthiophen-3-yl)-1-methyl-1H-pyrrole-2,5-dione

Conditions

Conditions	Yield
With PEG400 at 160℃; for 12h;	86%

: 340722-24-9
((C6H5(CH3(CH2)5)2(CH3)2C10HN2)2)RhI(CH3OH)

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 351496-49-6
((C6H5(CH3(CH2)5)2(CH3)2C10HN2)2)RhI(CH3NH)2

Conditions

Conditions	Yield
With NaOH In dichloromethane; water slight excess of hydrazine in water added to a soln. of Rh(III) porphyrin in CH2Cl2; 10% NaOH added; mixt. shaken; org. layer sepd., dried over MgSO4 and evapd.;	85%

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 98-88-4
benzoyl chloride

: 1226-43-3
N'-benzoyl-N,N'-dimethylbenzohydrazide

Conditions

Conditions	Yield
Stage #1: N,N'-Dimethylhydrazine dihydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 0.333333h; Stage #2: benzoyl chloride In dichloromethane at 0 - 20℃;	85%

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 1,1,1-trichloro-4-methoxy-4-phenyl-3-buten-2-one

: 3-phenyl-5-trichloromethyl-1,2-dimethyl-1H-pyrazolium chloride

Conditions

Conditions	Yield
In toluene at 80℃; for 0.2h; microwave irradiation;	84%
With hydrogenchloride In ethanol for 12h; Heating;	70%

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 98-88-4
benzoyl chloride

: 80791-41-9
Benzoesaeure-1,2-dimethylhydrazid

Conditions

Conditions	Yield
Stage #1: N,N'-Dimethylhydrazine dihydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.25h; Stage #2: benzoyl chloride In dichloromethane at 0℃; for 0.75h;	82%
With sodium hydroxide In 1,4-dioxane; water for 1h; Ambient temperature;	39%

: 909095-75-6
2-(4-chloro-2-methylsulfanylpyrimidin-5-yl)-1-(2,6-dichlorophenyl)ethanone

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 909095-76-7
1-(2,6-dichloro-phenyl)-2-[4-(N,N'-dimethyl-hydrazino)-2-methylsulfanyl-pyrimidin-5-yl]-ethanone

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran Heating;	82%

1,2-Dimethylhydrazine dihydrochloride Chemical Properties

Chemical Name: 1,2-Dimethylhydrazine dihydrochloride
IUPAC NAME: 1,2-Dimethylhydrazine dihydrochloride
CAS No.: 306-37-6
EINECS: 206-183-5
RTECS: MV2800000
Molecular Formula: C₂H₁₀Cl₂N₂
Molecular Weight: 133.02 g/mol
Melting Point: 167-169 °C (dec.)(lit.)
Boiling Point: 81.5 °C at 760 mmHg
Following is the structure of 1,2-Dimethylhydrazine dihydrochloride (306-37-6):

The chemical synonymous of 1,2-Dimethylhydrazine dihydrochloride (306-37-6) are 1,2-Dimethyl-hydrazindihydrochloride ; 1,2-Dimethylhydraziniumdichloride ; 1,2-Dimethylhydrazine 2hcl ; 1,2-Dimethylhydrazine dihydrochloride ; n,n'-Dimethylhydrazine di hcl (sym) ; n,n'-Dimethylhydrazine dihydrochloride ; sym-Dimethylhydrazine dihydrochloride ; n,n'-Dimethylhydrazine (sym.) dihydrochloride

1,2-Dimethylhydrazine dihydrochloride Toxicity Data With Reference

1.	otr-rat-ipr 100 mg/kg	CALEDQ Cancer Letters (Shannon, Ireland). 26 (1982),191.
2.	dnd-rat-orl 1700 µg/kg/2D-C	CRNGDP Carcinogenesis. 4 (1983),529.
3.	dns-rat-orl 1700 µg/kg/4D-C	CRNGDP Carcinogenesis. 4 (1983),529.
4.	dni-rat-orl 1700 µg/kg/2D-C	CRNGDP Carcinogenesis. 4 (1983),529.
5.	dni-mus:oth 500 µmol/L	JJIND8 JNCI, Journal of the National Cancer Institute. 68 (1982),1015.
6.	orl-rat LD50:100 mg/kg	23HZAR Carcinoma of the Colon and Antecedent Epithelium W.J. Burdette,Springfield, IL.: C.C. Thomas,1970,267.
7.	scu-rat LD50:122 mg/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD-A062-138 .
8.	scu-mus LD50:25,400 µg/kg	CRNGDP Carcinogenesis. 3 (1982),603.
9.	scu-ham LD50:50 mg/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD-A062-138 .

1,2-Dimethylhydrazine dihydrochloride Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

1,2-Dimethylhydrazine dihydrochloride Safety Profile

Suspected carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion and subcutaneous routes. Experimental reproductive effects. Mutation data reported. A rocket fuel. When heated to decomposition it emits very toxic fumes of HCl and NO_x.
Hazard Codes:
T: Toxic
N: Dangerous for the environment
Risk Statements about 1,2-Dimethylhydrazine dihydrochloride (306-37-6):
R45 May cause cancer.
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements about 1,2-Dimethylhydrazine dihydrochloride (306-37-6):
S53 Avoid exposure - obtain special instructions before use.
S24/25 Avoid contact with skin and eyes.
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Name

1,2-DIMETHYLHYDRAZINE DIHYDROCHLORIDE

Synthetic route

1,2-Dimethylhydrazine dihydrochloride Chemical Properties

1,2-Dimethylhydrazine dihydrochloride Toxicity Data With Reference

1,2-Dimethylhydrazine dihydrochloride Consensus Reports

1,2-Dimethylhydrazine dihydrochloride Safety Profile

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