Product Name: 1,6-Dibromomannitol
CAS Registry Number: 488-41-5
Synonyms: 1,6-Dibrom-1,6-didesoxy-D-mannit ; 1,6-Dibrom-1,6-didesoxy-D-mannit [German] ; 1,6-Dibromo-1,6-D-didesoxymannitol ; 1,6-Dibromo-1,6-dideoxy-D-mannitol ; 1,6-Dibromo-1,6-dideoxymannitol ; 1,6-Dibromo-D-mannitol ; 1,6-Dibromomannitol ; 1,6-Dideoy-1,6-dibromo-D-mannitol ; 3-01-00-02373 (Beilstein Handbook Reference) ; AI3-52331 ; BRN 1721919 ; CCRIS 2750 ; DBM ; Dibromannit ; Dibromannitol ; Dibromomannitol ; EINECS 207-676-8 ; Mielobromol ; Mitobronitol ; Mitobronitolum ; Mitobronitolum [INN-Latin] ; Myebrol ; Myelobromol ; NCI-C04762 ; NSC-94100 ; R 54 ; UNII-5UP30YED7N
Systematic Name: 1,6-Dibromo-1,6-dideoxy-D-mannitol ; D-Mannitol, 1,6-dibromo-1,6-dideoxy- ; Mannitol, 1,6-dibromo-1,6-dideoxy-, D- ; Mitobronitol
IUPAC Name: (2R,3S,4S,5R)-1,6-dibromohexane-2,3,4,5-tetrol
Molecular Weight: 307.96508 [g/mol]
Molecular Formula: C6H12Br2O4
XLogP3: -0.3
H-Bond Donor: 4
H-Bond Acceptor: 4
EINECS: 207-676-8
Surface Tension: 77.4 dyne/cm
Density: 2.117 g/cm3
Flash Point: 263 °C
Enthalpy of Vaporization: 90.04 kJ/mol
Boiling Point: 511.2 °C at 760 mmHg
Vapour Pressure: 1.37E-12 mmHg at 25°C
Product Categories: Carbohydrates;Carbohydrates A to;Carbohydrates D-FBiochemicals and Reagents;Monosaccharide
Following is the molecular structure of 1,6-Dibromomannitol (CAS NO.488-41-5) is:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 900mg/kg (900mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972. |
mouse | LD50 | intravenous | 2200mg/kg (2200mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 680, 1977. | |
mouse | LD50 | oral | 1380mg/kg (1380mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972. |
mouse | LD50 | subcutaneous | 2200mg/kg (2200mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972. |
rabbit | LD50 | oral | 1080mg/kg (1080mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972. | |
rat | LD50 | intraperitoneal | 900mg/kg (900mg/kg) | BLOOD: NORMOCYTIC ANEMIA BLOOD: THROMBOCYTOPENIA | European Journal of Cancer. Vol. 4, Pg. 617, 1968. |
rat | LD50 | intravenous | 1370mg/kg (1370mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 680, 1977. | |
rat | LD50 | oral | 1500mg/kg (1500mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: OTHER CHANGES BLOOD: NORMOCYTIC ANEMIA | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972. |
rat | LD50 | subcutaneous | 1240mg/kg (1240mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: OTHER CHANGES BLOOD: NORMOCYTIC ANEMIA | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972. |
NCI Carcinogenesis Bioassay Completed; Results Positive: mouse, rat ( RRCRBU Recent Results in Cancer Research. 52 (1975),1. ).
Safty information about 1,6-Dibromomannitol (CAS NO.488-41-5) is:
Moderately toxic by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Questionable carcinogen with experimental carcinogenic and neoplastigenic data. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of Br−.
Hazard Codes:
T
Risk Statements:
R45:May cause cancer.
R22:Harmful if swallowed.
Safety Statements:
S53:Avoid exposure - obtain special instructions before use.
S22:Do not breathe dust.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: OP2800000
General Description about 1,6-Dibromomannitol (CAS NO.488-41-5) ,it is a white powder. It insoluble in water. And it is a halogenated alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.Also it is probably combustible.
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