Product Name

  • Name

    bermoprofen

  • EINECS
  • CAS No. 78499-27-1
  • Article Data3
  • CAS DataBase
  • Density 1.1874 (rough estimate)
  • Solubility
  • Melting Point 128-129°
  • Formula C18H16 O4
  • Boiling Point 397.92°C (rough estimate)
  • Molecular Weight 296.323
  • Flash Point
  • Transport Information
  • Appearance
  • Safety Poison by ingestion, intraperitoneal, and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Risk Codes
  • Molecular Structure Molecular Structure of 78499-27-1 (bermoprofen)
  • Hazard Symbols
  • Synonyms AD1590; AJ 1590; Bermoprofen; Dibenon
  • PSA 63.60000
  • LogP 3.71420

10,11-DIHYDRO-α-8-DIMETHYL-11-OXO-DIBENZ(b,f)OXEPIN-2-ACETIC ACID Chemical Properties

IUPAC Name: 2-(3-Methyl-6-oxo-5H-benzo[b][1]benzoxepin-8-yl)propanoic acid
The molecular formula of Bermoprofen (CAS NO.78499-27-1) is C18H16O4.

                               
The molecular weight of Bermoprofen (CAS NO.78499-27-1) is 296.3172.
Synonyms of Bermoprofen (CAS NO.78499-27-1): 10,11-Dihydro-alpha,8-dimethyl-11-oxo-dibenz(b,f)oxepin-2-acetic acid ; 2-(8-Methyl-11-oxo-10,11-dihydro-dibenzo[b,f]oxepin-2-yl)-propionic acid ; Bermoprofen
Enthalpy of Vaporization: 84.13 kJ/mol
Index of Refraction: 1.611 
Density: 1.275 g/ml 
Flash Point: 195.3 °C   
Boiling Point: 525.1 °C

10,11-DIHYDRO-α-8-DIMETHYL-11-OXO-DIBENZ(b,f)OXEPIN-2-ACETIC ACID Uses

 Bermoprofen (CAS NO.78499-27-1) is used as non-steroidal anti-inflammatory analgesic.

10,11-DIHYDRO-α-8-DIMETHYL-11-OXO-DIBENZ(b,f)OXEPIN-2-ACETIC ACID Production

The reaction of 2-iodo-5-methylbenzoic acid (I) with 4-hydroxyacetophenone (II) by means of K2CO3 in nitrobenzene at 150°C gives 2-(4-acetylphenoxy)-5-methylbenzoic acid (III), which by reduction with LiAlH4 in refluxing THF is converted into 2-[4-(1-hydroxyethyl)phenoxy]-5-methylbenzyl alcohol (IV). The reaction of (IV) with SOCl2 in refluxing CHCl3 affords 2-[4-(1-chloroethyl)phenoxy]-5-methylbenzyl chloride (V), which is treated with NaCN in refluxing dioxane ethanol-water yielding the dinitrile (VI). The hydrolysis of (VI) with KOH in refluxing ethanol-water gives 2-[4-[2-(carboxymethyl)-4-methylphenoxy]phenyl]propionic acid (VII), which is finally cyclized by treatment with polyphosphoric acid (PPA) at 120 °C.

10,11-DIHYDRO-α-8-DIMETHYL-11-OXO-DIBENZ(b,f)OXEPIN-2-ACETIC ACID Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 191mg/kg (191mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: NORMOCYTIC ANEMIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 2701, 1988.
mouse LD50 oral 212mg/kg (212mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: NORMOCYTIC ANEMIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 2701, 1988.
mouse LD50 subcutaneous 387mg/kg (387mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: NORMOCYTIC ANEMIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 2701, 1988.
rat LD50 intraperitoneal 391mg/kg (391mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: NORMOCYTIC ANEMIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 2701, 1988.
rat LD50 oral 147mg/kg (147mg/kg) BEHAVIORAL: ANALGESIA Journal of Medicinal Chemistry. Vol. 25, Pg. 1065, 1982.
rat LD50 subcutaneous 483mg/kg (483mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: NORMOCYTIC ANEMIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 2701, 1988.
rat LDLo intravenous 160mg/kg (160mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 108, Pg. 788, 1988.
 

10,11-DIHYDRO-α-8-DIMETHYL-11-OXO-DIBENZ(b,f)OXEPIN-2-ACETIC ACID Safety Profile

Poison by ingestion, intraperitoneal, and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

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