2-(2,7-Dichloro-9H-fluoren-4-yl)oxirane supplier

Name
2-(2,7-DICHLORO-9H-FLUORENYL-4-YL)OXIRANE
EINECS 922-480-9
CAS No. 53221-14-0
Article Data4
CAS DataBase
Density 1.449±0.06 g/cm3(Predicted)
Solubility
Melting Point
Formula C₁₅H₁₀Cl₂O
Boiling Point 442.0±45.0 °C(Predicted)
Molecular Weight 277.15
Flash Point
Transport Information
Appearance white crystal powder
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2-(2,7-Dichloro-9H-fluoren-4-yl)-Oxirane
PSA 12.53000
LogP 4.63590

Synthetic route

: 2-chloro-1-(2, 7-dichloro-9H-fluoren-4-yl) ethanol

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

Conditions

Conditions	Yield
With sodium methylate at 50 - 60℃;
With sodium hydroxide In methanol Reflux;
With sodium ethanolate In ethanol Large scale;	235 kg

: 7012-16-0
2,7-dichloro-9H-fluorene

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aluminum (III) chloride / dichloromethane / -5 - 0 °C 2: sodium tetrahydroborate / ethanol / 1 h / -5 - 5 °C 3: sodium methylate / 50 - 60 °C View Scheme
Multi-step reaction with 3 steps 1: aluminum (III) chloride / dichloromethane / 0 - 5 °C 2: sodium tetrahydroborate / methanol / 0 - 20 °C 3: sodium hydroxide / methanol / Reflux View Scheme
Multi-step reaction with 3 steps 1: aluminum (III) chloride / dichloromethane / 8 h / 0 - 5 °C / Large scale 2: sodium tetrahydroborate / ethanol / 3 h / -5 - 5 °C / Large scale 3: sodium ethanolate / ethanol / Large scale View Scheme

: 2-chloro-1-(2,7-dichloro-9H-fluoren-4-yl)-ethan-1-one

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / ethanol / 1 h / -5 - 5 °C 2: sodium methylate / 50 - 60 °C View Scheme
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / methanol / 0 - 20 °C 2: sodium hydroxide / methanol / Reflux View Scheme
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / ethanol / 3 h / -5 - 5 °C / Large scale 2: sodium ethanolate / ethanol / Large scale View Scheme

: 86-73-7
9H-fluorene

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: chlorine / acetic acid / 15 h / 35 - 45 °C 2: aluminum (III) chloride / dichloromethane / -5 - 0 °C 3: sodium tetrahydroborate / ethanol / 1 h / -5 - 5 °C 4: sodium methylate / 50 - 60 °C View Scheme
Multi-step reaction with 4 steps 1: chlorine; acetic acid / 40 - 42 °C 2: aluminum (III) chloride / dichloromethane / 0 - 5 °C 3: sodium tetrahydroborate / methanol / 0 - 20 °C 4: sodium hydroxide / methanol / Reflux View Scheme
Multi-step reaction with 4 steps 1: hydrogenchloride; chlorine; acetic acid / 10 h / 90 °C / Inert atmosphere; Large scale 2: aluminum (III) chloride / dichloromethane / 8 h / 0 - 5 °C / Large scale 3: sodium tetrahydroborate / ethanol / 3 h / -5 - 5 °C / Large scale 4: sodium ethanolate / ethanol / Large scale View Scheme

: 75-77-4
chloro-trimethyl-silane

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: (2-chloro-2-(2,7-dichloro-9H-fluoren-4-yl)ethoxy)trimethylsilane

Conditions

Conditions	Yield
With zinc(II) oxide In dichloromethane at 20℃; for 2h;	73%

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 7101-31-7
dimethyl diselenide

: 1-(2,7-dichloro-9H-fluoren-4-yl)-2-(methylselanyl)ethan-1-ol

Conditions

Conditions	Yield
In methanol at 5 - 10℃; Inert atmosphere;	73%

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 111-92-2
dibutylamine

: 69759-61-1
2-dibutylamino-1-(2,7-dichloro-9H-fluoren-4-yl)ethanol

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 53221-25-3
2,7-dichloro-4-[2-(dibutyl amino)-1-hydroxyethyl]-9H-fluoren-9-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ethanol / 15 h / 78 °C 2: sodium hydroxide; oxygen / ethanol / 6 h / 23 - 70 °C View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

A: 2-dibutylamino-1-{2,7-dichloro-9-[1-(4-chlorophenyl)meth-(E)-ylidene]-9H-fluoren-4-yl}ethanol

B: lumefantrine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ethanol / 15 h / 78 °C 2: sodium hydroxide / ethanol / 6 h / 23 - 70 °C View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: (RS,Z)-2-dibutylamino-2-[2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl]ethanol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: zinc(II) oxide / dichloromethane / 2 h / 20 °C 2: potassium carbonate / acetonitrile / 16 h / Inert atmosphere; Reflux 3: hydrogenchloride / tetrahydrofuran; water / 50 °C / Inert atmosphere 4: sodium hydroxide / ethanol / 1 h / Inert atmosphere; Reflux; Green chemistry View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: N-butyl-N-(1-(2,7-dichloro-9H-fluoren-4-yl)-2-(trimethylsilyloxy)ethyl)butylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: zinc(II) oxide / dichloromethane / 2 h / 20 °C 2: potassium carbonate / acetonitrile / 16 h / Inert atmosphere; Reflux View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 2-dibutylamino-2-[2,7-dichloro-9H-fluoren-4-yl]ethanol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: zinc(II) oxide / dichloromethane / 2 h / 20 °C 2: potassium carbonate / acetonitrile / 16 h / Inert atmosphere; Reflux 3: hydrogenchloride / tetrahydrofuran; water / 50 °C / Inert atmosphere View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 1-(9-benzylidene-2,7-dichloro-9Hfluoren-4-yl)-2-(methylselanyl)ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol / 5 - 10 °C / Inert atmosphere 2: sodium hydroxide / methanol / 50 - 70 °C / Inert atmosphere View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 1-(2,7-dichloro-9-[3,4-dimethoxybenzylidene]-9H-fluoren-4-yl)-2-(methylselanyl)ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol / 5 - 10 °C / Inert atmosphere 2: sodium hydroxide / methanol / 50 - 70 °C / Inert atmosphere View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 5-((2,7-dichloro-4-(1-hydroxy-2-(methylselanyl)ethyl)-9H-fluoren-9-ylidene)methyl)-2-methoxyphenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol / 5 - 10 °C / Inert atmosphere 2: sodium hydroxide / methanol / 50 - 70 °C / Inert atmosphere View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 1-(2,7-dichloro-9-[3,4-dimethylbenzylidene]-9H-fluoren-4-yl)-2-(methylselanyl)ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol / 5 - 10 °C / Inert atmosphere 2: sodium hydroxide / methanol / 50 - 70 °C / Inert atmosphere View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: (2,7-dichloro-9-[2,4,6-trichlorobenzylidene]-9H-fluoren-4-yl)-2-(methylselanyl)ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol / 5 - 10 °C / Inert atmosphere 2: sodium hydroxide / methanol / 50 - 70 °C / Inert atmosphere View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 2-((2,7-dichloro-4-(1-hydroxy-2-(methylselanyl)ethyl)-9H-fluoren-9-ylidene)methyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol / 5 - 10 °C / Inert atmosphere 2: sodium hydroxide / methanol / 50 - 70 °C / Inert atmosphere View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 1-(9-[4-bromobenzylidene]-2,7-dichloro-9H-fluoren-4-yl)-2-(methylselanyl)ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol / 5 - 10 °C / Inert atmosphere 2: sodium hydroxide / methanol / 50 - 70 °C / Inert atmosphere View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 1-(2,7-dichloro-9-[2,3-dichlorobenzylidene]-9H-fluoren-4-yl)-2-(methylselanyl)ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol / 5 - 10 °C / Inert atmosphere 2: sodium hydroxide / methanol / 50 - 70 °C / Inert atmosphere View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 1-(2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl)-2-(methylselanyl)ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol / 5 - 10 °C / Inert atmosphere 2: sodium hydroxide / methanol / 50 - 70 °C / Inert atmosphere View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 1-(9-([1,1'-biphenyl]-4-ylmethylene)-2,7-dichloro-9H-fluoren-4-yl)-2-(methylselanyl)ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol / 5 - 10 °C / Inert atmosphere 2: sodium hydroxide / methanol / 50 - 70 °C / Inert atmosphere View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 4-((2,7-dichloro-4-(1-hydroxy-2-(methylselanyl)ethyl)-9H-fluoren-9-ylidene)methyl)benzene-1,3-diol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol / 5 - 10 °C / Inert atmosphere 2: sodium hydroxide / methanol / 50 - 70 °C / Inert atmosphere View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 1-(2,7-dichloro-9-(4-[dimethylamino]benzylidene)-9Hfluoren-4-yl)-2-(methylselanyl)ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol / 5 - 10 °C / Inert atmosphere 2: sodium hydroxide / methanol / 50 - 70 °C / Inert atmosphere View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 1-(2,7-dichloro-9-[2,3,4-trimethoxybenzylidene]-9Hfluoren-4-yl)-2-(methylselanyl)ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol / 5 - 10 °C / Inert atmosphere 2: sodium hydroxide / methanol / 50 - 70 °C / Inert atmosphere View Scheme

2-(2,7-Dichloro-9H-fluoren-4-yl)oxirane Chemical Properties

Product Name: 2-(2,7-Dichloro-9H-fluoren-4-yl)oxirane
Molecular Structure of 2-(2,7-Dichloro-9H-fluoren-4-yl)oxirane (CAS NO.53221-14-0):

Molecular Formula: C₁₅H₁₀Cl₂O
Molecular Weight: 277.15
CAS NO: 53221-14-0

Product Name

2-(2,7-DICHLORO-9H-FLUORENYL-4-YL)OXIRANE

Synthetic route

2-(2,7-Dichloro-9H-fluoren-4-yl)oxirane Chemical Properties

Related Products

Hot Products