TRIFLUOROACETIC ACID HYDRAZIDE

The IUPAC name of 2,2,2-Trifluoroacetohydrazide is 2,2,2-trifluoroacetohydrazide. With the CAS registry number 1538-08-5, it is also named as Trifluoroacetic acid hydrazide. In addition, its molecular formula is C₂H₃F₃N₂O and molecular weight is 128.05.

The other characteristics of this product can be summarized as: (1)ACD/LogP: -0.12; (2)# of Rule of 5 Violations: 0; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 20.63; (6)ACD/KOC (pH 7.4): 20.47; (7)#H bond acceptors: 3; (8)#H bond donors: 3; (9)#Freely Rotating Bonds: 1; (10)Polar Surface Area: 23.55 Å²; (11)Index of Refraction: 1.351; (12)Molar Refractivity: 18.93 cm³; (13)Molar Volume: 87.5 cm³; (14)Polarizability: 7.5×10^-24cm³; (15)Surface Tension: 25.8 dyne/cm; (16)Density: 1.462 g/cm³; (17)Flash Point: 70.1 °C; (18)Melting Point: 111 °C; (19)Enthalpy of Vaporization: 42.85 kJ/mol; (20)Boiling Point: 192.3 °C at 760 mmHg; (21)Vapour Pressure: 0.493 mmHg at 25 °C.

Preparation of 2,2,2-Trifluoroacetohydrazide: this chemical can be prepared by trifluoroacetic acid ethyl ester.



This reaction needs hydrazine hydrate and ethanol for 2 hours. The yield is 92 %.

Uses of 2,2,2-Trifluoroacetohydrazide: it can react with carbonyl dichloride to get 5-trifluoromethyl-1,3,4-oxadiazolin-2-one.



This reaction needs H₂O at temperature of 10 - 20 °C for 30 min. The yield is 66 %.

When you are using this chemical, please be cautious about it as the following: it is irritating to eyes, respiratory system and skin. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing, gloves and eye/face protection.

People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: C(=O)(C(F)(F)F)NN
(2)InChI: InChI=1S/C2H3F3N2O/c3-2(4,5)1(8)7-6/h6H2,(H,7,8)
(3)InChIKey: OFUCCBIWEUKISP-UHFFFAOYSA-N