2,4,5,6-Tetraaminopyrimidine sulfate supplier

Name
Pyrimidinetetramine sulfate
EINECS 226-393-0
CAS No. 5392-28-9
Density 1.648g/cm3
Solubility slightly soluble in water
Melting Point >300 °C(lit.)
Formula C₄H₁₀N₆O₄S
Boiling Point 563.9 °C at 760 mmHg
Molecular Weight 238.227
Flash Point 329.4 °C
Transport Information
Appearance Light yellow crystal powder
Safety 22-24/25-37/39-26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms NSC 248648;Tetraaminopyrimidine sulfate;2,4,5,6-Tetraaminopyrimidine sulfate salt;2,4,5,6-Tetraminopyrimidine sulfate;
PSA 212.84000
LogP 1.55820

Synthetic route

: 63192-57-4
bis(3-hydroxyphenyl)ethane-1,2-dione

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol sulfate

Conditions

Conditions	Yield
In 3-methyl-phenol at 50 - 220℃; for 2 - 2.25h;	100%

: 75-15-0
carbon disulfide

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 462066-71-3
2,6-diamino-9H-purine-8-thiol

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol for 24h; Heating;	97%

: 70935-14-7
3-hydroxyphenylglyoxal

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: TG100110

Conditions

Conditions	Yield
Stage #1: 3-hydroxyphenylglyoxal With hydrogenchloride; acetone oxime at 50℃; for 1h; pH=2 - 3; Stage #2: 2,4,5,6-tetraaminopyrimidine sulfate for 9h; Heating; Further stages.;	96.5%

: 70935-14-7
3-hydroxyphenylglyoxal

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 127-06-0
acetone oxime

: TG100110

Conditions

Conditions	Yield
Stage #1: 3-hydroxyphenylglyoxal; acetone oxime With hydrogenchloride In methanol; water at 50℃; for 1h; pH=~ 2 - ~ 3; Stage #2: 2,4,5,6-tetraaminopyrimidine sulfate In water at 20℃; for 9h; Heating / reflux; Stage #3: With water; sodium hydrogencarbonate at 20℃; pH=~ 6 - ~ 7;	96.5%

...Expand

: 63192-57-4
bis(3-hydroxyphenyl)ethane-1,2-dione

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 677297-51-7
TG100-115

Conditions

Conditions	Yield
With sodium hydrogencarbonate In diethyl ether; water	93.3%

: 79948-21-3
1-butylsulfanylpropan-2-one

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 4215-07-0
2,4-diamino-7-methylpteridine

Conditions

Conditions	Yield
With piperidine In water at 20℃; for 268h;	93%

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 383424-15-5
thioacetic acid S-[5-(4-formylphenoxy)pentyl] ester

: S-5-{4-[(2,4,6-triamino-N5-pyrimidinylidene)methyl]phenoxy}pentyl thioacetate

Conditions

Conditions	Yield
With potassium carbonate In isopropyl alcohol Heating;	90%

: 27318-90-7
1,10-phenanthroline-5,6-dione

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 928057-09-4
2,4,5,6-tetraaminopyrimidine[3,2-a:2',3'-c]phenazine

Conditions

Conditions	Yield
With acetic acid at 130℃; for 3h; Inert atmosphere;	87%
Stage #1: 2,4,5,6-tetraaminopyrimidine sulfate With sodium hydroxide In water at 50℃; for 0.666667h; Stage #2: 1,10-phenanthroline-5,6-dione In ethanol; water for 3h; Reflux;	75%

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 88297-80-7
1-chloro-1-benzamidoacetone

: 4215-07-0
2,4-diamino-7-methylpteridine

Conditions

Conditions	Yield
With piperidine In water at 20℃; for 168h;	86%

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: (1Z,4Z,9Z,15Z)-5,10,15,20-Tetrakis-(3,5-di-tert-butyl-phenyl)-porphyrin-2,3-dione

: 8,11,14,17-tetrakis(3,5-di-tert-butylphenyl)-2,4-diaminopteridino[2,3,b]porphyrin

Conditions

Conditions	Yield
In pyridine for 24h; Heating;	85%

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 84-11-7
9,10-phenanthrenequinone

: phenanthro[9,10-g]pteridine-11,13-diamine

Conditions

Conditions	Yield
Stage #1: 2,4,5,6-tetraaminopyrimidine sulfate With sodium hydroxide In water at 50℃; for 0.666667h; Stage #2: 9,10-phenanthrenequinone In ethanol; water for 3h; Reflux;	79%

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 82-86-0
acenaphthene quinone

: 38284-03-6
acenaphtho[1,2-g]pteridine-9,11-diamine

Conditions

Conditions	Yield
Stage #1: 2,4,5,6-tetraaminopyrimidine sulfate With sodium hydroxide In water at 50℃; for 0.666667h; Stage #2: acenaphthene quinone In ethanol; water for 3h; Reflux;	78%

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 54972-21-3
1-tosyl-4,5-dimethylimidazolin-2-one

: 1425-63-4
6,7-dimethyl-2,4-pteridine-2,4-diamine

Conditions

Conditions	Yield
With triethylamine In water; N,N-dimethyl-formamide at 20℃; for 264h;	77%

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 65765-30-2
1-bromo-1-acetamidoacetone

: 4215-07-0
2,4-diamino-7-methylpteridine

Conditions

Conditions	Yield
With piperidine; sodium carbonate In hydrogenchloride at 20℃; for 144h;	76%

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 619-66-9
4-Carboxybenzaldehyde

: TTPS

Conditions

Conditions	Yield
Stage #1: 2,4,5,6-tetraaminopyrimidine sulfate With barium(II) chloride at 60℃; for 0.166667h; Stage #2: 4-Carboxybenzaldehyde In benzene for 6h;	74%

: 85296-31-7
2-butylthiopropanal

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 4215-07-0
2,4-diamino-7-methylpteridine

Conditions

Conditions	Yield
With triethylamine In water; N,N-dimethyl-formamide at 20℃; for 720h;	72%

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 134-81-6
benzil

: 18181-93-6
2,4-diamino-6,7-diphenylpteridine

Conditions

Conditions	Yield
Stage #1: 2,4,5,6-tetraaminopyrimidine sulfate With sodium hydroxide In water at 50℃; for 0.666667h; Stage #2: benzil In ethanol; water for 3h; Reflux;	68%

: 872-85-5
pyridine-4-carbaldehyde

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 74783-48-5
2,4,6-triamino-5-(4-pyridylmethyleneamino)pyrimidine

Conditions

Conditions	Yield
In sodium hydroxide at 90℃; for 0.5h;	64%

: 863684-19-9
2,5-bis(5''-formyl-5',2''-bithienyl-2'-yl)-3,4-ethylenedioxythiophene

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: C32H26N12O2S5

Conditions

Conditions	Yield
In isopropyl alcohol	61%

: 873436-93-2
benzo[1,3]dioxol-5-yl-acetyl fluoride

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 873436-95-4
8-(benzo[d][1,3]dioxol-5-ylmethyl)-9H-purine-2,6-diamine

Conditions

Conditions	Yield
Stage #1: benzo[1,3]dioxol-5-yl-acetyl fluoride; 2,4,5,6-tetraaminopyrimidine sulfate With sodium hydroxide In water; N,N-dimethyl-formamide at 20 - 70℃; for 1.83333h; Stage #2: With sodium methylate In methanol at 90℃; for 18h;	56%

: 7333-07-5
2,2'-thenil

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 6,7-di(thiophen-2-yl)pteridine-2,4-diamine

Conditions

Conditions	Yield
Stage #1: 2,4,5,6-tetraaminopyrimidine sulfate With sodium hydroxide In water at 50℃; for 0.666667h; Stage #2: 2,2'-thenil In ethanol; water for 3h; Reflux;	55%

: 96-26-4
dihydroxyacetone

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 945-24-4
2,4-diamino-6-(hydroxymethyl)pteridine

Conditions

Conditions	Yield
Stage #1: 2,4,5,6-tetraaminopyrimidine sulfate With barium(II) chloride In water at 100℃; for 0.166667h; Stage #2: dihydroxyacetone With sodium acetate; DL-cysteine hydrochloride In water at 20℃; for 24h;	54%

: 24645-80-5
(4-hydroxylphenyl)glyoxal

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 4-(2,4-diaminopteridin-6-yl)phenol

Conditions

Conditions	Yield
Stage #1: (4-hydroxylphenyl)glyoxal With hydroxylamine hydrochloride In methanol at 50℃; for 0.25h; Stage #2: 2,4,5,6-tetraaminopyrimidine sulfate In methanol for 3h; Heating; Further stages.;	50%

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 492-94-4
furil

: 6,7-di(furan-2-yl)pteridine-2,4-diamine

Conditions

Conditions	Yield
Stage #1: 2,4,5,6-tetraaminopyrimidine sulfate With sodium hydroxide In water at 50℃; for 0.666667h; Stage #2: furil In ethanol; water for 3h; Reflux;	42%

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 248588-29-6
S-(6-(4-formylphenoxy)hexyl)ethanethioate

: Thioacetic acid S-[6-(4-{[(E)-2,4,6-triamino-pyrimidin-5-ylimino]-methyl}-phenoxy)-hexyl] ester

Conditions

Conditions	Yield
With potassium carbonate In isopropyl alcohol Heating;	27%

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 65-85-0
benzoic acid

: 26216-55-7
2,6-diamino-8-phenylpurine

Conditions

Conditions	Yield
With PPA; Polyphosphoric acid (PPA) at 170℃; for 1h;	10%

: 96-26-4
dihydroxyacetone

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 73978-41-3
2,4-diamino-6-(hydroxymethyl)pteridine hydrochloride

Conditions

Conditions	Yield
With ammonium hydroxide; l-cysteine hydrochloride; oxygen; ammonium chloride; barium(II) chloride 1.) H2O, 90 deg C, 15 min, 2.) H2O, RT, 45 h; Yield given. Multistep reaction;

: 867-54-9
1,1-dibromopropan-2-one

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

A: 4215-07-0
2,4-diamino-7-methylpteridine

B: 708-74-7
2,4-diamino-6-methylpteridine

Conditions

Conditions	Yield
With sodium hydrogensulfite In water at 80℃; for 5.5h; Product distribution; further cyclizating agents;

...Expand

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 79614-35-0
1-(benzenesulfonyl)-4-methylimidazolin-2-one

A: 4215-07-0
2,4-diamino-7-methylpteridine

B: 708-74-7
2,4-diamino-6-methylpteridine

Conditions

Conditions	Yield
With piperidine In water for 550h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 5392-28-9
2,4,5,6-tetraaminopyrimidine sulfate

: 79614-36-1
1-(4'-chlorobenzenesulfonyl)-4-methylimidazolin-2-one

A: 13040-58-9
7-methylpterin

B: 708-75-8
2-amino-6-methylpteridin-4(1H)-one

Conditions

Conditions	Yield
With piperidine; potassium hydroxide 1.) water, 20 deg C, 7 d, 2.) heating; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

2,4,5,6-Tetraaminopyrimidine sulfate Chemical Properties

Molecular Formula: C₄H₁₀N₆O₄S
Formula Weight: 238.23
Melting point: >300 °C(lit.)
Flash Point: 329.4 °C
Boiling Point: 563.9 °C at 760 mmHg
Vapour Pressure: 9.68E-13 mmHg at 25 °C
Water Solubility: slightly soluble
Appearence: Light yellow crystal powder
Structure of 2,4,5,6-Tetraaminopyrimidine sulfate (CAS NO.5392-28-9):

IUPAC Name: Pyrimidine-2,4,5,6-tetramine ; Sulfuric acid
Canonical SMILES: C1(=C(N=C(N=C1N)N)N)N.OS(=O)(=O)O
InChI: InChI=1S/C4H8N6.H2O4S/c5-1-2(6)9-4(8)10-3(1)7;1-5(2,3)4/h5H2,(H6,6,7,8,9,10);(H2,1,2,3,4)
InChIKey: MQEFDQWUCTUJCP-UHFFFAOYSA-N
Product Category of 2,4,5,6-Tetraaminopyrimidine sulfate (CAS NO.5392-28-9): Amines;(intermediate of methotrexate);Pyrimidines;Heterocyclic Building Blocks

2,4,5,6-Tetraaminopyrimidine sulfate Uses

2,4,5,6-Tetraaminopyrimidine sulfate (CAS NO.5392-28-9) is used as the intermediate of antineoplastic agent.

2,4,5,6-Tetraaminopyrimidine sulfate Production

2,4,5,6-Tetraaminopyrimidine sulfate (CAS NO.5392-28-9) can be obtained by nitrosification and reduction of 2,4,6-Triaminopyrimidine .

2,4,5,6-Tetraaminopyrimidine sulfate Safety Profile

Safety: WARNING: Irritates lungs, eyes, skin
Hazard Codes: Xi (Irritant)
Risk Statements: 36/37/38 (Irritating to eyes, respiratory system and skin)
Safety Statements: 22-24/25-37/39-26-36 (Do not breathe dust; Avoid contact with skin and eyes; Wear suitable protective clothing and eye/face protection; In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable protective clothing)
WGK Germany: 3
RTECS: UV9738000

2,4,5,6-Tetraaminopyrimidine sulfate Standards and Recommendations

ASSAY: 98.0% min
RESIDUE ON IGNITION: 0.3% max
MOISTURE: 0.5% max

2,4,5,6-Tetraaminopyrimidine sulfate Specification

2,4,5,6-Tetraaminopyrimidine sulfate , its cas register number is 5392-28-9. It also can be called Pyrimidine, tetraamino-, sulfate (1:1) ; 2,4,5,6-Pyrimidinetetramine, sulfate (1:1) ; and Pyrimidinetetramine, sulfate (1:1) . 2,4,5,6-Tetraaminopyrimidine sulfate (CAS NO.5392-28-9) should be stored in cool, dry conditions in well sealed containers. It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.

Product Name

Pyrimidinetetramine sulfate

Synthetic route

2,4,5,6-Tetraaminopyrimidine sulfate Chemical Properties

2,4,5,6-Tetraaminopyrimidine sulfate Uses

2,4,5,6-Tetraaminopyrimidine sulfate Production

2,4,5,6-Tetraaminopyrimidine sulfate Safety Profile

2,4,5,6-Tetraaminopyrimidine sulfate Standards and Recommendations

2,4,5,6-Tetraaminopyrimidine sulfate Specification

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