Product Name

  • Name

    2,4-Dichloro-5-sulfamoylbenzoic acid

  • EINECS 220-358-3
  • CAS No. 2736-23-4
  • Density 1.744 g/cm3
  • Solubility insoluble in water
  • Melting Point 230-232 °C (dec.)(lit.)
  • Formula C7H5Cl2NO4S
  • Boiling Point 503.8 °C at 760 mmHg
  • Molecular Weight 270.093
  • Flash Point 258.5 °C
  • Transport Information
  • Appearance white to off-white crystalline powder
  • Safety 26-37/39
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 2736-23-4 (2,4-Dichloro-5-sulfamoylbenzoic acid)
  • Hazard Symbols IrritantXi
  • Synonyms Benzoicacid, 2,4-dichloro-5-sulfamoyl- (7CI,8CI);2,4-Dichloro-5-sulfamoylbenzoicacid;3-Sulfamoyl-4,6-dichlorobenzoic acid;5-Aminosulfonyl-2,4-dichlorobenzoicacid;5-Carboxy-2,4-dichlorobenzenesulfonamide;
  • PSA 105.84000
  • LogP 3.12010

2,4-Dichloro-5-sulfamoylbenzoic acid Chemical Properties

Product Name: 2,4-Dichloro-5-sulfamoylbenzoic acid (CAS NO.2736-23-4)

Molecular Formula: C7H5Cl2NO4S
Molecular Weight: 270.089900 g/mol
Appearance:Crystallization in ethanol solution
Melting Point: 230-232 °C (dec.)(lit.)
Insolubility: Water
Density: 1.744 g/cm3 
Flash Point: 258.5 °C 
Boiling Point: 503.8 °C at 760 mmHg 
Index of Refraction: 1.63 
Molar Refractivity: 55.12 cm3 
Molar Volume: 154.8 cm3 
Surface Tension: 69.9 dyne/cm
Enthalpy of Vaporization: 81.41 kJ/mol
Vapour Pressure: 5.7E-11 mmHg at 25°C
XLogP3-AA: 1.3
H-Bond Donor: 2
H-Bond Acceptor: 5
Structure Descriptors of 2,4-Dichloro-5-sulfamoylbenzoic acid (CAS NO.2736-23-4):
  IUPAC Name: 2,4-dichloro-5-sulfamoylbenzoic acid
  Canonical SMILES: C1=C(C(=CC(=C1S(=O)(=O)N)Cl)Cl)C(=O)O
  InChI: InChI=1S/C7H5Cl2NO4S/c8-4-2-5(9)6(15(10,13)14)1-3(4)7(11)12/h1-2H,(H,11,
12)(H2,10,13,14) 
  InChIKey: ZSHHRBYVHTVRFK-UHFFFAOYSA-N
Categories: BenzoicAcidDerivative; Organic acids; Organic Building Blocks; Sulfonamides/Sulfinamides; Sulfur Compounds

2,4-Dichloro-5-sulfamoylbenzoic acid Uses

 2,4-Dichloro-5-sulfamoylbenzoic acid (CAS NO.2736-23-4) is used as pharmaceutical intermediate for the synthesis of Furosemide microphones, furosemide and other drugs.

2,4-Dichloro-5-sulfamoylbenzoic acid Toxicity Data With Reference

1.    

eye-rbt 100 mg SEV

     FCTOD7    Food and Chemical Toxicology. 20 (1982),573.
2.    

eye-rbt 100 mg/4S RNS MLD

     FCTOD7    Food and Chemical Toxicology. 20 (1982),573.
3.    

ipr-mus LD50:15 g/kg

     PCJOAU    Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. 19 (1985),697.

2,4-Dichloro-5-sulfamoylbenzoic acid Safety Profile

Safety Information of 2,4-Dichloro-5-sulfamoylbenzoic acid (CAS NO.2736-23-4):
Hazard Codes:Xi 
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin  
Safety Statements:26-37/39
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
37/39:Wear suitable gloves and eye/face protection  
WGK Germany:3
RTECS:DG8100000
Slightly toxic by intraperitoneal route. A severe eye irritant. When heated to decomposition it emits toxic fumes of NOx, SOx, and Cl−.

2,4-Dichloro-5-sulfamoylbenzoic acid Specification

 2,4-Dichloro-5-sulfamoylbenzoic acid , its CAS NO. is 2736-23-4, the synonyms are 3-Sulfamoyl-4,6-dichlorobenzoic acid ; 5-Aminosulfonyl-2,4-dichlorobenzoic acid ; 5-Carboxy-2,4-dichlorobenzenesulfonamide ; Lasamide  ; Benzoic acid, 2,4-dichloro-5-sulfamoyl- ; Benzoic acid, 5-(aminosulfonyl)-2,4-dichloro- .

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