2-amino-5-bromobenzonitrile
2-Chlorobenzeneboronic acid
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
Conditions | Yield |
---|---|
With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate In 2-methyltetrahydrofuran; water at 80℃; for 36h; | 58% |
o-chlorobenzoyl chloride
4-bromo-aniline
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
Conditions | Yield |
---|---|
Stage #1: o-chlorobenzoyl chloride; 4-bromo-aniline at 0 - 120℃; for 1h; Stage #2: With zinc(II) chloride at 120 - 195℃; for 3h; Stage #3: With hydrogenchloride; sulfuric acid; water more than 3 stages; | 37% |
(i) ZnCl2, (ii) aq. HCl, (iii) H2SO4; Multistep reaction; |
3-hydroxy-7-bromo-5-(2'-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepin-2-one
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
Conditions | Yield |
---|---|
With hydrogenchloride for 0.5h; boiling water bath; |
phenazepam
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
Conditions | Yield |
---|---|
With hydrogenchloride for 0.5h; boiling water bath; |
N-phthaloylglycine chloride
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
5-bromo-2'-chloro-2-(phthalimidoacetamido)benzophenone
Conditions | Yield |
---|---|
In chloroform for 5h; Heating; | 97% |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
2-amino-5-bromo-4'-chlorobenzhydrol
Conditions | Yield |
---|---|
With sodium tetrahydroborate In water at 25 - 30℃; for 2h; | 96% |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
Conditions | Yield |
---|---|
Condensation; | 90% |
sodium cyanide
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
4-amino-3-(2-chlorobenzoyl)benzonitrile
Conditions | Yield |
---|---|
With copper(l) iodide; potassium iodide; N,N`-dimethylethylenediamine In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 16h; Inert atmosphere; | 76% |
4-phenyl-semicarbazide
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol for 5h; | A 35% B 21% |
2-Bromoacetyl bromide
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
5-bromo-2-(2-bromo-acetylamino)-2'-chloro-benzophenone
Conditions | Yield |
---|---|
With pyridine |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
epichlorohydrin
2-(3-chloro-2-hydroxy-propylamino)-5-bromo-2'-chloro-benzophenone
Conditions | Yield |
---|---|
In acetic acid at 70℃; for 20h; | 26.5 g |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
Conditions | Yield |
---|---|
With hydrogenchloride; sodium nitrite In acetic acid at 1℃; for 0.5h; |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aq. NaNO2, conc. HCl / acetic acid / 0.5 h / 1 °C 2: SnCl2*2H2O, conc. HCl / acetic acid / 0.5 h View Scheme |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: aq. NaNO2, conc. HCl / acetic acid / 0.5 h / 1 °C 2: SnCl2*2H2O, conc. HCl / acetic acid / 0.5 h 3: KOH / toluene / 6 h / Heating View Scheme |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 96 percent / NaBH4 / H2O / 2 h / 25 - 30 °C 2: CHCl3 / 0.25 h / -20 - -18 °C View Scheme |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
9b-(2'-chlorophenyl)-2,3,5,6,7,9b-hexahydro-8-bromo-5-methylbenzo(6,7)-4,1-oxazepine-(3,5)-oxolan
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 26.5 g / acetic acid / 20 h / 70 °C 2: 19.0 g / formic acid; H2O / 2.5 h 3: 0.5 g / NH3 / methanol / 4 h / 120 - 130 °C View Scheme |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
2-(3-chloro-2-hydroxy-1-methyl-propylamino)-5-bromo-2'-chloro-benzophenone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 26.5 g / acetic acid / 20 h / 70 °C 2: 19.0 g / formic acid; H2O / 2.5 h View Scheme |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
8-bromo-1-methyl-3-hydroxy-6-(2'-chlorophenyl)-1,2,3,4-tetrahydro-1,5-benzodiazocine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 26.5 g / acetic acid / 20 h / 70 °C 2: 19.0 g / formic acid; H2O / 2.5 h 3: 10.4 g / NH3 / methanol / 4 h / 120 - 130 °C View Scheme |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
8-bromo-5-(2-chlorophenyl)-1-methyl-4H-s-triazolo<4,3-a>-1,4-benzodiazepine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 97 percent / CHCl3 / 5 h / Heating 2: 90 percent / 18 percent aq. N2H4 / methanol / 1.) 60 deg C, 3 h, 2.) R.T. 30 min. 3: 60 percent / P2S5 / pyridine / 0.75 h / Heating 4: 81 percent / butan-1-ol / 7 h / Heating View Scheme |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
8-bromo-5-(2-chlorophenyl)-1-(methylthiomethyl)-4H-s-triazolo<4,3-a>-1,4-benzodiazepine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 97 percent / CHCl3 / 5 h / Heating 2: 90 percent / 18 percent aq. N2H4 / methanol / 1.) 60 deg C, 3 h, 2.) R.T. 30 min. 3: 60 percent / P2S5 / pyridine / 0.75 h / Heating 4: 89 percent / butan-1-ol / 7 h / Heating View Scheme |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
7-bromo-5-(2-chlorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-thione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 97 percent / CHCl3 / 5 h / Heating 2: 90 percent / 18 percent aq. N2H4 / methanol / 1.) 60 deg C, 3 h, 2.) R.T. 30 min. 3: 60 percent / P2S5 / pyridine / 0.75 h / Heating View Scheme |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
phenazepam
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 97 percent / CHCl3 / 5 h / Heating 2: 90 percent / 18 percent aq. N2H4 / methanol / 1.) 60 deg C, 3 h, 2.) R.T. 30 min. View Scheme |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
10-bromo-11b-(2-chloro-phenyl)-3-methyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Py 2: (i) CH2Cl2, (ii) AcOH, EtOH View Scheme |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
10-bromo-11b-(2-chloro-phenyl)-7-methyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Py 2: (i) CH2Cl2, (ii) AcOH, EtOH 3: (i) NaOMe, MeOH, (ii) /BRN= 969135/, DMF View Scheme |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
10-bromo-11b-(2-chloro-phenyl)-2,7-dimethyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Py 2: (i) CH2Cl2, (ii) AcOH, EtOH 3: (i) NaOMe, MeOH, (ii) /BRN= 969135/, DMF View Scheme |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
10-bromo-11b-(2-chloro-phenyl)-7-ethyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Py 2: (i) CH2Cl2, (ii) AcOH, EtOH 3: (i) NaOMe, MeOH, (ii) (ethylation) View Scheme |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
10-bromo-11b-(2-chloro-phenyl)-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Py 2: (i) CH2Cl2, (ii) AcOH, EtOH View Scheme |
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
10-bromo-11b-(2-chloro-phenyl)-2-methyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Py 2: (i) CH2Cl2, (ii) AcOH, EtOH View Scheme |
2-Bromoacetyl bromide
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
phenazepam
Conditions | Yield |
---|---|
Stage #1: 2-Bromoacetyl bromide; (2-amino-5-bromophenyl)(2-chlorophenyl)methanone With sodium hydrogencarbonate Stage #2: With ammonia In methanol | |
Stage #1: 2-Bromoacetyl bromide; (2-amino-5-bromophenyl)(2-chlorophenyl)methanone With sodium hydrogencarbonate Stage #2: With ammonia In methanol |
Molecular Structure of Methanone,(2-amino-5-bromophenyl)(2-chlorophenyl)- (CAS NO.60773-49-1):
Molecular Formula: C13H9BrClNO
Molecular Weight: 310.5737
IUPAC Name: (2-Amino-5-bromophenyl)-(2-chlorophenyl)methanone
Synonyms of Methanone,(2-amino-5-bromophenyl)(2-chlorophenyl)- (CAS NO.60773-49-1): 5-Bromo-2'-chloro-2-aminobenzophenone ; BCABP
CAS NO: 60773-49-1
Classification Code: Aromatic Benzophenones & Derivatives (substituted)
Index of Refraction: 1.657
Molar Refractivity: 72.86 cm3
Molar Volume: 197.9 cm3
Surface Tension: 54.9 dyne/cm
Density: 1.568 g/cm3
Flash Point: 229.7 °C
Enthalpy of Vaporization: 71.61 kJ/mol
Boiling Point: 456.2 °C at 760 mmHg
Vapour Pressure of Methanone,(2-amino-5-bromophenyl)(2-chlorophenyl)- (CAS NO.60773-49-1): 1.65E-08 mmHg at 25°C
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