2-Dimethylaminoisopropyl chloride hydrochloride supplier

Name
2-Dimethylaminoisopropyl chloride hydrochloride
EINECS 224-971-7
CAS No. 4584-49-0
Article Data4
CAS DataBase
Density
Solubility 2000 g/L (20 °C) in water
Melting Point 187-190 °C(lit.)
Formula C₅H₁₃Cl₂N
Boiling Point 81.1 °C at 760 mmHg
Molecular Weight 158.071
Flash Point 2.9 °C
Transport Information UN 2811
Appearance Colourless to pale beige crystalline powder
Safety 26-36
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms 1-Propanamine,2-chloro-N,N-dimethyl-, hydrochloride (9CI);Propylamine,2-chloro-N,N-dimethyl-, hydrochloride (7CI,8CI);(2-Chloropropyl)dimethylaminehydrochloride;1-(Dimethylamino)-2-chloropropane hydrochloride;1-Dimethylamino-2-propylchloride hydrochloride;1-Dimethylaminopropan-2-yl chloride hydrochloride;1-Methyl-2-dimethylaminoethyl chloride hydrochloride;2-(Dimethylamino)isopropyl chloride hydrochloride;2-Chloro-N,N-dimethyl-1-propanamine hydrochloride;2-Chloro-N',N'-dimethylaminopropane hydrochloride;Dimethylaminoisopropyl chloride hydrochloride;N,N-Dimethyl-2-chloropropylaminehydrochloride;NSC 53532;NSC 5367;
PSA 3.24000
LogP 1.97730

Synthetic route

: 108-16-7
1-methyl-2-N,N-dimethylaminoethanol

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In chloroform at 0 - 20℃; for 1h; Reflux;	95%
With thionyl chloride In chloroform	95%
With thionyl chloride In chloroform Reflux; Cooling with ice;

: 1-dimethylamino-2-propanol hydrochloride

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 60℃; for 24h;

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 550372-56-0
6,7-methylenedioxyquinoline-4-carboxylic acid N-(2-iodo-4,5-dimethoxyphenyl)amide

: 6,7-methylenedioxyquinoline-4-carboxylic acid N-[2-(N,N-dimethylamino)isopropyl]-N-(2-iodo-4,5-dimethoxyphenyl)amide

Conditions

Conditions	Yield
With sodium hydride; sodium iodide In N,N-dimethyl-formamide at 65℃; for 3h;	89%

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 108-14-5
2-chloro-1-dimethylaminopropane

Conditions

Conditions	Yield
With sodium hydroxide In water	82%

: 7-methoxy-3-phenyl-4{2-[4-hydroxy-phenyl]-vinyl}chromen-2-one

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 4{2-[4-(2-dimethylamino-1-methyl-ethoxy)phenyl]-vinyl}-7-methoxy-3-phenylchromen-2-one

Conditions

Conditions	Yield
With potassium carbonate In acetone for 6h; Reflux;	80%

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 2-azido-3-(N,N-dimethylamino)propane

Conditions

Conditions	Yield
With sodium azide In water at 80℃;	80%

: 1469863-78-2
1-(3-(4-hydroxyphenyl)-7-methoxy-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl)ethanone

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 1469863-82-8
C25H31N3O3

Conditions

Conditions	Yield
With potassium carbonate In chloroform; acetone at 80℃;	75%

: 1469863-67-9
8-methoxy-4-(4-hydroxyphenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 1469863-71-5
4-(4-(1-(dimethylamino)propan-2-yloxy)phenyl)-5,6-dihydro-8-methoxybenzo[h]quinazolin-2-amine

Conditions

Conditions	Yield
With potassium carbonate In chloroform; acetone at 80℃;	75%
With potassium carbonate In chloroform; acetone at 80℃;	75%

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 160985-00-2
1-(5-cyano-2-mercaptobenzenesulphonyl)-2-imidazolidinone

: 4-(2-Dimethylamino-1-methyl-ethylsulfanyl)-3-(2-oxo-imidazolidine-1-sulfonyl)-benzonitrile

Conditions

Conditions	Yield
With sodium isopropylate In isopropyl alcohol for 16h; Heating;	65%

: 571-72-2
4'-Hydroxywogonin

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 5-(1-(dimethylamino)propan-2-yloxy)-3-hydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one

Conditions

Conditions	Yield
With potassium carbonate In acetone at 80℃;	63%

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 1-(4-chloro-2-mercapto-5-methylbenzenesulfonyl)imidazolidin-2-one

: 1-[4-Chloro-2-(2-dimethylamino-1-methyl-ethylsulfanyl)-5-methyl-benzenesulfonyl]-imidazolidin-2-one

Conditions

Conditions	Yield
With sodium isopropylate In isopropyl alcohol for 16h; Heating;	57%

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 160985-01-3
1-(4-chloro-5-cyano-2-mercaptobenzenesulphonyl)-2-imidazolidinone

: 2-Chloro-4-(2-dimethylamino-1-methyl-ethylsulfanyl)-5-(2-oxo-imidazolidine-1-sulfonyl)-benzonitrile

Conditions

Conditions	Yield
With sodium isopropylate In isopropyl alcohol for 16h; Heating;	50%

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 50290-51-2
2-methyl-10H-pyrimido<1,2-a>benzimidazol-4-one

: 10-(2-Dimethylamino-1-methyl-ethyl)-2-methyl-10H-benzo[4,5]imidazo[1,2-a]pyrimidin-4-one

Conditions

Conditions	Yield
With potassium carbonate In acetone for 30h; Heating;	43%

: 97620-82-1
3-hydroxybenzo[b]naphtho[2,3-d]furane-6,11-dione

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 3-[2-(dimethylamino)isopropoxy]benzo[b]naphtho[2,3-d]furan-6,11-dione

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In chloroform; water Heating;	32.7%

: 924276-18-6
7-chloro-8-hydroxybenzo[4,5]furo[3,2-g]quinoline-5,11-dione

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 8-[1-(dimethylamino)propan-2-yloxy]-7-chlorobenzo[4,5]furo[3,2-g]quinoline-5,11-dione

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In chloroform; water Heating;	31%

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 151775-45-0
2-chloro-3-hydroxybenzo[b]naphtho[2,3-d]furan-6,11-dione

: 2-chloro-3-[2-(dimethylamino)isopropoxy]benzo[b]naphtho[2,3-d]furan-6,11-dione

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In chloroform; water Heating;	25.9%

: 1260244-03-8
2-(4-propoxyphenyl)-4-hydroxyquinoline

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 1443120-55-5
N,N-dimethyl-2-{[2-(4-propoxyphenyl)quinolin-4-yl]oxy}propan-1-amine hydrochloride

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 70℃; Inert atmosphere;	18%

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 151775-44-9
1,3-dihydroxybenzo[b]naphtho[2,3-d]furan-6,11-dione

: 1334592-04-9
3-[2-(dimethylamino)isopropoxy]-1-hydroxybenzo[b]naphtho[2,3-d]furan-6,11-dione

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In chloroform; water at 20℃; Reflux;	16%

: 924276-17-5
8-hydroxybenzo[4,5]furo[3,2-g]quinoline-5,11-dione

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 8-[1-(dimethylamino)propan-2-yloxy]benzo[4,5]furo[3,2-g]quinoline-5,11-dione

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In chloroform; water Heating;	15.7%

: 92-84-2
10H-phenothiazine

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 303-14-0
isopromethazine

Conditions

Conditions	Yield
With potassium hydroxide; Aliquat 336 at 80℃; for 1h;	12%

: 93317-24-9
N-benzhydrylpyrimidin-2-amine

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 1,N2,N2-trimethyl-N1-pyrimidin-2-yl-ethanediyldiamine

Conditions

Conditions	Yield
With lithium amide; benzene

: 124-41-4
sodium methylate

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

A: 44643-00-7
(β-methoxy-isopropyl)-dimethyl-amine

B: 44647-42-9
(2-methoxy-propyl)-dimethyl-amine

Conditions

Conditions	Yield
With methanol

...Expand

: 1021-91-6
N-[tricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,9,12,14-heptaen-2-ylidene]hydroxylamine

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: O-<2-Dimethylamino-propyl>-5H-dibenzo-cyclohepten-5-on-oxim

Conditions

Conditions	Yield
With sodium methylate In methanol Heating;

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 89416-69-3
3-<2-Dimethylamino-1-methyl-aethyl>-thiophosphorsaeure

Conditions

Conditions	Yield
With lithium thiophosphate powder

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 14346-24-8
5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

: 47046-21-9
3-(2-dimethylamino-1-methyl-ethyl)-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

Conditions

Conditions	Yield
(i) NaH, dioxane, (ii) /BRN= 3670215/; Multistep reaction;

: 574-66-3
Benzophenone oxime

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 74-88-4
methyl iodide

: O-(β-Trimethylammonium-isopropyl)-benzophenonoxim

Conditions

Conditions	Yield
(i) NaOMe, MeOH, (ii) /BRN= 969135/, acetone; Multistep reaction;

...Expand

: 574-66-3
Benzophenone oxime

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 74-88-4
methyl iodide

: O-(2-Trimethylammonium-propyl)-benzophenonoxim

Conditions

Conditions	Yield
(i) NaOMe, MeOH, (ii) /BRN= 969135/, acetone; Multistep reaction;

...Expand

: 1136-58-9
N-[cyclohexyl(phenyl)methylidene]hydroxylamine

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 74-88-4
methyl iodide

: O-<2-Trimethylammonium-propyl>-

Conditions

Conditions	Yield
(i) NaOMe, MeOH, (ii) /BRN= 969135/, acetone; Multistep reaction;

...Expand

: 71225-69-9
(2-chlorophenyl)phenylmethanone oxime

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 74-88-4
methyl iodide

: 2-Chlor-O-<2-trimethylammonium-propyl>-benzophenon-oxim

Conditions

Conditions	Yield
(i) NaOMe, MeOH, (ii) /BRN= 969135/, acetone; Multistep reaction;

...Expand

: 71225-69-9
(2-chlorophenyl)phenylmethanone oxime

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 74-88-4
methyl iodide

: 2-Chlor-O-<β-trimethylammonium-isopropyl>-benzophenon-oxim

Conditions

Conditions	Yield
(i) NaOMe, MeOH, (ii) /BRN= 969135/, acetone; Multistep reaction;

...Expand

: 21352-19-2
N-(2-chloro-3-pyridinyl)acetamide

: 4584-49-0
(2-chloropropyl)dimethylamine hydrochloride

: 138768-69-1
1-(2,4-Dimethyl-3,4-dihydro-2H-pyrido[2,3-b]pyrazin-1-yl)-ethanone

Conditions

Conditions	Yield
With sodium hydride 1.) DMF, 0 deg C, 10 min, 2.) 80 deg C, 1 h; Yield given. Multistep reaction;

2-Dimethylaminoisopropyl chloride hydrochloride Chemical Properties

IUPAC Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride
Synonyms of 1-Propanamine,2-chloro-N,N-dimethyl-, hydrochloride (1:1) (CAS NO.4584-49-0): 2-Chloropropyl)dimethylamine monohydrochloride ; 1-(Dimethylamino)-2-chloropropane hydrochloride ; 1-Methyl-2-dimethylaminoethyl chloride hydrochloride ; 2-(Dimethylamino)-1-methylethyl chloride hydrochloride ; 2-(Dimethylamino)isopropyl chloride hydrochloride ; 2-Chloro-N',N'-dimethylaminopropane hydrochloride ; 2-Chloro-N,N-dimethyl-1-propanamine hydrochloride ; 2-Chloropropyl-dimethylamine hydrochloride ; AI3-26684 ; EINECS 224-971-7 ; N,N-Dimethyl-2-chloropropylamine hydrochloride ; NSC 53532 ; NSC 5367 ; Propane, 1-(N,N-dimethylamino)-2-chloro-, hydrochloride
CAS NO: 4584-49-0
Classification Code: Drug / Therapeutic Agent
Molecular Formula of 1-Propanamine,2-chloro-N,N-dimethyl-, hydrochloride (1:1) (CAS NO.4584-49-0): C₅H₁₃Cl₂N
Molecular Weight: 158.0694
Molecular Structure:

Melting Point: 187-190 °C
Polar Surface Area: 3.24 Å²
Flash Point of 1-Propanamine,2-chloro-N,N-dimethyl-, hydrochloride (1:1) (CAS NO.4584-49-0): 2.9 °C
Enthalpy of Vaporization: 32.18 kJ/mol
Boiling Point: 81.1 °C at 760 mmHg
Vapour Pressure: 83 mmHg at 25°C

2-Dimethylaminoisopropyl chloride hydrochloride Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	subcutaneous	200mg/kg (200mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Journal of Pharmacology and Experimental Therapeutics. Vol. 98, Pg. 121, 1950.

2-Dimethylaminoisopropyl chloride hydrochloride Safety Profile

Hazard Codes: Harmful Xn, Irritant Xi
Risk Statements: 22-36/37/38
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
RIDADR: 2811
WGK Germany: 3
RTECS: TY1225000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29211980

Product Name

2-Dimethylaminoisopropyl chloride hydrochloride

Synthetic route

2-Dimethylaminoisopropyl chloride hydrochloride Chemical Properties

2-Dimethylaminoisopropyl chloride hydrochloride Toxicity Data With Reference

2-Dimethylaminoisopropyl chloride hydrochloride Safety Profile

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