• Name

  2-(HYDROXYMETHYL)-1,3-PROPANEDIOL

• EINECS 225-187-8
• CAS No. 4704-94-3
• Article Data11
• CAS DataBase
• Density 1.213 g/cm³
• Solubility
• Melting Point 63-68 °C (dec.)(lit.)
• Formula C₄H₁₀O₃
• Boiling Point 294.9 °C at 760 mmHg
• Molecular Weight 106.122
• Flash Point 153.9 °C
• Transport Information
• Appearance
• Safety 22-24/25
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Trimethylolmethane;Tris(hydroxymethyl)methane;
• PSA 60.69000
• LogP -1.42050

Synthetic route

113967-50-3

2-Benzoyloxymethyl-1,3-propanediol dibenzoate

4704-94-3

2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
With sodium methylate In methanol for 20h; Heating;	98%
With sodium methylate In methanol for 20h; Time; Reflux;	90%

465540-17-4

[2-(4-methoxyphenyl)-[1,3]dioxan-5-yl]methanol

4704-94-3

2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
With water; Selectfluor In acetonitrile at 20℃; for 5h;	90%

6279-86-3

methanetricarboxylic acid triethyl ester

4704-94-3

2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
With dimethylsulfide borane complex 1.) reflux, 8 h, 2.) methanol, 15 h;	83%
With lithium aluminium tetrahydride; diethyl ether

40364-80-5

bis-(hydroxymethyl)-acetaldehyde

4704-94-3

2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
With hydrogen; ruthenium In water at 25℃; under 2585.7 Torr; for 24h; Yield given;
PtO2 In water

50-00-0

formaldehyd

75-07-0

acetaldehyde

A

68516-39-2

2,2-di(hydroxymethyl)-acetic acid

B

115-77-5

Pentaerythritol

C

4704-94-3

2-hydroxymethyl-1,3-propanediol

D

2831-90-5

α,α,α-tris(hydroxymethyl)acetic acid

E

68658-38-8

2-Hydroxymethyl-2-(methoxymethoxymethyl)-1,3-propandiol

F

504-63-2

trimethyleneglycol

Conditions

Conditions	Yield
With calcium hydroxide Mechanism;

...Expand

50-00-0

formaldehyd

75-07-0

acetaldehyde

A

115-77-5

Pentaerythritol

B

2163-42-0

2-methyl-1.3-propanediol

C

4704-94-3

2-hydroxymethyl-1,3-propanediol

D

504-63-2

trimethyleneglycol

Conditions

Conditions	Yield
With sodium hydroxide; sulfuric acid; hydrogen; 5% activated charcoal-supported ruthenium catalyst 1.) 25 deg C, 30 min, 2.) 50 psi, 25 deg C, 4 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
With sodium hydroxide; sulfuric acid; hydrogen; Ru-carbon 1.) 25 deg C, 30 min, 2.) 50 psi, 25 deg C 4 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

50-00-0

formaldehyd

107-02-8

acrolein

A

4704-94-3

2-hydroxymethyl-1,3-propanediol

B

504-63-2

trimethyleneglycol

Conditions

Conditions	Yield
With sulfuric acid; hydrogen; iron(II) sulfate; palladium on activated charcoal; Ru-carbon 1.) 25 deg C, 5 h, 2.) 50 psi, 25 deg C, 42 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

555-43-1

glycerol tristearate

A

4704-94-3

2-hydroxymethyl-1,3-propanediol

B

57-11-4

stearic acid

Conditions

Conditions	Yield
With lipase from Pseudomonas stutzeri PS59 In aq. phosphate buffer; isopropyl alcohol at 30℃; for 0.25h; pH=8; Enzymatic reaction;

555-44-2

glyceroltripalmitate

A

4704-94-3

2-hydroxymethyl-1,3-propanediol

B

57-10-3

1-hexadecylcarboxylic acid

Conditions

Conditions	Yield
With lipase from Pseudomonas stutzeri PS59 In aq. phosphate buffer; isopropyl alcohol at 30℃; for 0.25h; pH=8; Enzymatic reaction;

122-32-7

trioleoylglycerol

A

112-80-1

cis-Octadecenoic acid

B

4704-94-3

2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
With lipase from Pseudomonas stutzeri PS59 In aq. phosphate buffer; isopropyl alcohol at 30℃; for 0.25h; pH=8; Enzymatic reaction;

2-Hydroxymethyl-1,3-propanediol Chemical Properties

2-Hydroxymethyl-1,3-propanediol Safety Profile

2-Hydroxymethyl-1,3-propanediol Specification