4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID AMIDE

The 2-Pyridinecarboxamide,4-methoxy-, with CAS registry number 90151-10-3, belongs to the following product categories: (1)Amide; (2)Blocks; (3)Carboxes; (4)Pyridines. It has the systematic name of 4-methoxypyridine-2-carboxamide. And the chemical formula of this chemical is C₇H₈N₂O₂.

Physical properties of 2-Pyridinecarboxamide,4-methoxy-: (1)ACD/LogP: 0.46; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.46; (4)ACD/LogD (pH 7.4): 0.46; (5)ACD/BCF (pH 5.5): 1.31; (6)ACD/BCF (pH 7.4): 1.33; (7)ACD/KOC (pH 5.5): 42.1; (8)ACD/KOC (pH 7.4): 42.57; (9)#H bond acceptors: 4; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 42.43 Å²; (13)Index of Refraction: 1.55; (14)Molar Refractivity: 39.95 cm³; (15)Molar Volume: 125.3 cm³; (16)Polarizability: 15.83×10^-24cm³; (17)Surface Tension: 49.5 dyne/cm; (18)Enthalpy of Vaporization: 55.4 kJ/mol; (19)Vapour Pressure: 0.000513 mmHg at 25°C.

Preparation: this chemical can be prepared by 4-methoxy-pyridine-2-carboxylic acid methyl ester. This reaction will need reagent NH₃ and solvent methanol. The reaction time is 5 hour(s). The yield is about 85%.

Uses of p-Chloropropiophenone: it can be used to produce 4-methoxy-pyridin-2-ylamine. This reaction will need reagents aq. KOH, Br₂ and solvent dioxane. The reaction time is 90 min with reaction temperature of 20 - 55 ℃. The yield is about 45%.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(c1nccc(OC)c1)N
(2)InChI: InChI=1/C7H8N2O2/c1-11-5-2-3-9-6(4-5)7(8)10/h2-4H,1H3,(H2,8,10)
(3)InChIKey: DYHMIVKBJSIOCH-UHFFFAOYAR
(4)Std. InChI: InChI=1S/C7H8N2O2/c1-11-5-2-3-9-6(4-5)7(8)10/h2-4H,1H3,(H2,8,10)
(5)Std. InChIKey: DYHMIVKBJSIOCH-UHFFFAOYSA-N