• Name

  4,6-Dihydroxypyrimidine

• EINECS 214-772-3
• CAS No. 1193-24-4
• Article Data27
• CAS DataBase
• Density 1.4421 (rough estimate)
• Solubility 2.5 g/L (20 °C)
• Melting Point >300 °C(lit.)
• Formula C₄H₄N₂O₂
• Boiling Point 358.5 °C at 760 mmHg
• Molecular Weight 112.088
• Flash Point 170.6 °C
• Transport Information
• Appearance pale yellow crystals
• Safety 26-36-37/39
• Risk Codes 36/37/38
• Molecular Structure
• Hazard Symbols Xi
• Synonyms 6-hydroxy-1H-pyrimidin-4-one;4,6-Dihydroxypyrimidine(DHP);4 (1H)-Pyrimidinone, 6-hydroxy-;4(3H)-Pyrimidinone, 6-hydroxy-;6-hydroxy-3H-pyrimidin-4-one;4,6-Pyrimidinediol;4,6-Dihydroxy pyrimidine 98%;
• PSA 66.24000
• LogP -0.11220

Synthetic route

108-59-8

malonic acid dimethyl ester

1193-24-4

4,6-pyrimidinediol

Conditions

Conditions	Yield
With sulfuric acid; sodium methylate; formamide In methanol; water	96%
With hydrogenchloride	76%
With hydrogenchloride; sodium methylate; formamide In methanol; water	75.1%
In water	74.8%

77287-34-4, 77287-35-5, 60100-09-6

formamide

108-59-8

malonic acid dimethyl ester

1193-24-4

4,6-pyrimidinediol

Conditions

Conditions	Yield
With sodium methylate In methanol at 60 - 70℃; for 8h; Large scale;	90%
Stage #1: formamide; malonic acid dimethyl ester With sodium methylate In methanol at 95℃; for 1h; Stage #2: With hydrogenchloride In water at 35℃; pH=2.8; Temperature; pH-value; Reagent/catalyst; Solvent;	82.5%
With sodium methylate In methanol at 50℃; for 2h; Concentration; Temperature;

77287-34-4, 77287-35-5, 60100-09-6

formamide

105-53-3

diethyl malonate

1193-24-4

4,6-pyrimidinediol

Conditions

Conditions	Yield
With methanol; sodium methylate for 3h; Reflux;	85%
With sodium ethanolate In ethanol at 65 - 110℃; for 49h;	82%
Stage #1: formamide With sodium In ethanol at 45℃; for 10h; Stage #2: diethyl malonate In ethanol at 65 - 110℃; for 4h;	67.9%

3473-63-0

formamidine acetic acid

108-59-8

malonic acid dimethyl ester

1193-24-4

4,6-pyrimidinediol

Conditions

Conditions	Yield
Stage #1: formamidine acetic acid With sodium methylate In methanol at 0℃; for 0.0833333h; Inert atmosphere; Stage #2: malonic acid dimethyl ester In methanol at 0℃; for 5h; Reflux;	62%

141-52-6

sodium ethanolate

105-53-3

diethyl malonate

463-52-5

formamidine

1193-24-4

4,6-pyrimidinediol

Conditions

Conditions	Yield
reagiert analog mit Propionamidin;

...Expand

215934-32-0, 131860-33-8

azoxystrobin

A

C21H15N3O5

B

2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)acetic acid methyl ester

C

methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxyprop-2-enoate

D

1193-24-4

4,6-pyrimidinediol

Conditions

Conditions	Yield
In methanol; water at 19℃; Quantum yield; Further Variations:; pH-values; UV-irradiation;
In methanol; water at 19℃; Quantum yield; Irradiation;

...Expand

108-13-4

malonodiamide

109-94-4

formic acid ethyl ester

1193-24-4

4,6-pyrimidinediol

Conditions

Conditions	Yield
With sodium ethanolate In ethanol Reflux;

143-37-3

acetamidine

105-53-3

diethyl malonate

1193-24-4

4,6-pyrimidinediol

Conditions

Conditions	Yield
With sodium methylate In methanol at 0 - 25℃; for 18h;

4,6-Dihydroxypyrimidine Chemical Properties

4,6-Dihydroxypyrimidine Toxicity Data With Reference

4,6-Dihydroxypyrimidine Consensus Reports

4,6-Dihydroxypyrimidine Safety Profile

4,6-Dihydroxypyrimidine Specification