1,4-dioxane
(2-chloroethoxy)-acetic acid
Conditions | Yield |
---|---|
With dipotassium peroxodisulfate; thionyl chloride at 25℃; for 4h; | 96.1% |
With hydrogenchloride; sodium hypochlorite |
(2-chloroethoxy)-acetic acid
Conditions | Yield |
---|---|
With hydrogenchloride; water for 2h; | 95% |
(2-chloro-ethoxy)-acetic acid ethyl ester
(2-chloroethoxy)-acetic acid
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran | 90% |
2-(2-Chloroethoxy)ethanol
(2-chloroethoxy)-acetic acid
Conditions | Yield |
---|---|
With chromium(VI) oxide; sulfuric acid In acetone at 0℃; for 6h; | 77% |
With sodium periodate; ruthenium trichloride In water; acetonitrile at 20℃; for 16h; | 74% |
Stage #1: 2-(2-Chloroethoxy)ethanol With calcium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate In dichloromethane; water at 20℃; for 0.5h; Stage #2: With sodium metabisulfite In dichloromethane; water | 72% |
2-chloroethyl cyanomethyl ether
(2-chloroethoxy)-acetic acid
Conditions | Yield |
---|---|
With hydrogenchloride |
carbon dioxide
(2-chloroethoxy)magnesium chloride
(2-chloroethoxy)-acetic acid
Conditions | Yield |
---|---|
In tetrahydrofuran at -60℃; |
1-chloro-2-(2-nitro-ethoxy)-ethane
(2-chloroethoxy)-acetic acid
Conditions | Yield |
---|---|
With hydrogenchloride |
diethylene glycol
(2-chloroethoxy)-acetic acid
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hypochlorite |
(2-chloroethoxy)-acetic acid
4-fluoro-2-methoxy-5-nitro-phenylamine
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide | 99% |
brecanavir
(2-chloroethoxy)-acetic acid
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 24h; | 92% |
(2-chloroethoxy)-acetic acid
butan-1-ol
2-Chlor-aethoxyesssigsaeure-butylester
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane Ambient temperature; | 91% |
(2-chloroethoxy)-acetic acid
Conditions | Yield |
---|---|
Stage #1: (2-chloroethoxy)-acetic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 30℃; for 0.333333h; Stage #2: 2-(1-aminopiperidin-4-yl)isoindoline-1,3-dione In N,N-dimethyl-formamide at 30℃; for 16h; | 89.3% |
(2-chloroethoxy)-acetic acid
2-(2-chloroethoxy)acetyl chloride
Conditions | Yield |
---|---|
With thionyl chloride In N,N-dimethyl-formamide | 88% |
With thionyl chloride; N,N-dimethyl-formamide at 25 - 70℃; for 20h; | 83% |
With thionyl chloride; N,N-dimethyl-formamide at 60℃; for 1 - 16h; Product distribution / selectivity; | 82% |
(2-chloroethoxy)-acetic acid
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
levocetirizine
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; sodium hydride In N,N-dimethyl-formamide at 95℃; for 5h; Inert atmosphere; | 86.5% |
(2-chloroethoxy)-acetic acid
4-nitro-aniline
4-(2-(2-chloroethoxy)acetamido)1-nitrobenzene
Conditions | Yield |
---|---|
With phenylboronic acid In toluene at 110 - 111℃; Dean-Stark; Reflux; | 83% |
(2-chloroethoxy)-acetic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 25℃; for 16.5h; | 79% |
(2-chloroethoxy)-acetic acid
Conditions | Yield |
---|---|
With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline In tetrahydrofuran at 60℃; for 4h; | 76% |
Stage #1: (2-chloroethoxy)-acetic acid; (S)-5-[2-[3-(3-chloro-2-fluorophenyl)-1H-pyrazole-3-carboxamido]-3-(4-aminophenyl)-propionamido] -1H-indole-2-carboxylic acid ethyl ester With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline In tetrahydrofuran at 60℃; for 4h; Inert atmosphere; Stage #2: With sodium hydride In tetrahydrofuran at 20 - 30℃; for 5h; Inert atmosphere; | 76% |
(2-chloroethoxy)-acetic acid
Conditions | Yield |
---|---|
Stage #1: (2-chloroethoxy)-acetic acid; (S)-2-{4-[(methoxycarbonyl)amino]benzamido}-3-(4-aminophenyl)propionic acid methyl ester With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline In tetrahydrofuran at 60℃; for 4h; Stage #2: With sodium hydride In tetrahydrofuran at 20℃; for 5h; | 76% |
(2-chloroethoxy)-acetic acid
2-bromo-4-fluoro-5-nitrophenylamine
Conditions | Yield |
---|---|
Stage #1: (2-chloroethoxy)-acetic acid With pyridine; thionyl chloride In dichloromethane at 20℃; for 0.5h; Inert atmosphere; Stage #2: 2-bromo-4-fluoro-5-nitrophenylamine With dmap; triethylamine In dichloromethane at 20℃; for 18h; Inert atmosphere; | 51% |
(2-chloroethoxy)-acetic acid
Conditions | Yield |
---|---|
Stage #1: (2-chloroethoxy)-acetic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 25℃; for 0.5h; Stage #2: ethyl 6-(3-amino-3-azabicyclo[3.1.0]hexan-6-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate In dichloromethane at 25℃; for 16h; | 50% |
Conditions | Yield |
---|---|
With ammonium acetate; hydrogenchloride In ethanol; water; isopropyl alcohol | 12% |
(2-chloroethoxy)-acetic acid
p-dioxanone
Conditions | Yield |
---|---|
With sodium hydroxide unter vermindertem Druck; |
methanol
(2-chloroethoxy)-acetic acid
(2-Chloro-ethoxy)-acetic acid methyl ester
Conditions | Yield |
---|---|
With thionyl chloride |
(2-chloroethoxy)-acetic acid
(2R)-2-[(2R)-4-(4-aminophenyl)-3-oxomorpholin-2-yl]-N-(4-cyanophenyl)-2-hydroxyacetamde
(2R)-N-(4-cyanophenyl)-2-hydroxy-2-[(2R)-3-oxo-4-[4-(3-oxomorpholin-4-yl)phenyl]morpholin-2-yl]acetamide
Conditions | Yield |
---|---|
With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In N,N-dimethyl-formamide at 20℃; |
(2-chloroethoxy)-acetic acid
4-chloro-2-oxabutanyl-1-phosphonic acid
Conditions | Yield |
---|---|
With phosphorus(III) oxide; methanesulfonic acid at 20 - 30℃; for 2h; | |
Stage #1: (2-chloroethoxy)-acetic acid With phosphorus trichloride In chlorobenzene at 50℃; for 4h; Inert atmosphere; Stage #2: With water In chlorobenzene Inert atmosphere; |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; acetonitrile at 0 - 25℃; for 18h; | 484 mg |
(2-chloroethoxy)-acetic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 12℃; for 16h; | 2.8 g |
(2-chloroethoxy)-acetic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 25℃; for 16h; | 900 mg |
(2-chloroethoxy)-acetic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 12h; |
The Acetic acid,2-(2-chloroethoxy)-, with the CAS registry number 14869-41-1, is also known as 2-(2-Chloroethoxy)acetic acid. This chemical's molecular formula is C4H7ClO3 and molecular weight is 138.5496. Its systematic name is called (2-chloroethoxy)acetic acid.
Physical properties of Acetic acid,2-(2-chloroethoxy)-: (1)ACD/LogP: -0.18; (2)ACD/LogD (pH 5.5): -2; (3)ACD/LogD (pH 7.4): -4; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 3; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 4; (11)Index of Refraction: 1.45; (12)Molar Refractivity: 28.739 cm3; (13)Molar Volume: 106.935 cm3; (14)Surface Tension: 41.367 dyne/cm; (15)Density: 1.296 g/cm3; (16)Flash Point: 129.038 °C; (17)Enthalpy of Vaporization: 58.21 kJ/mol; (18)Boiling Point: 289.753 °C at 760 mmHg; (19)Vapour Pressure: 0.001 mmHg at 25°C.
Preparation: this chemical can be prepared by 2-(2-chloro-ethoxy)-ethanol. This reaction will need reagents CrO3, H2SO4 and solvent acetone. The reaction time is 6 hours with reaction temperature of 0 °C. The yield is about 77%.
Uses of Acetic acid,2-(2-chloroethoxy)-: it can be used to produce 2-Chlor-aethoxyesssigsaeure-butylester at ambient temperature. This reaction will need reagent DCC, 4-N,N-dimethylaminopyridine and solvent CH2Cl2. The yield is about 91%.
You can still convert the following datas into molecular structure:
(1)SMILES: OC(=O)COCCCl
(2)InChI: InChI=1/C4H7ClO3/c5-1-2-8-3-4(6)7/h1-3H2,(H,6,7)
(3)InChIKey: MHXJETVNZPUVEN-UHFFFAOYAR
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