Benzeneacetic acid,2,4-dihydroxy- supplier

Name
2,4-dihydroxyphenylacetic acid
EINECS 210-397-4
CAS No. 614-82-4
Article Data3
CAS DataBase
Density 1.478 g/cm³
Solubility
Melting Point
Formula C₈H₈O₄
Boiling Point 419 °C at 760 mmHg
Molecular Weight 168.149
Flash Point 221.4 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Aceticacid, (2,4-dihydroxyphenyl)- (8CI);2,4-Dihydroxyphenylacetic acid;(2,4-dihydroxyphenyl)acetic acid;benzeneacetic acid, 2,4-dihydroxy-;
PSA 77.76000
LogP 0.72490

Synthetic route

: 66056-40-4
2-(2,4-bis(benzyloxy)phenyl)acetic acid

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

Conditions

Conditions	Yield
With ammonium formate; palladium on activated charcoal In N,N-dimethyl-formamide for 0.5h; Ambient temperature;	99%

: 88491-44-5
2-(2-bromo-4-hydroxyphenyl)acetic acid

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

Conditions

Conditions	Yield
With copper 8-hydroxyquinolinate; sodium hydroxide	83%
With bis(8-hydroxyquinolato)copper(II); sodium hydroxide at 110℃; for 6h; Concentration; Temperature; Reagent/catalyst;	81%

: 591-20-8
3-Bromophenol

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium hydroxide / water / 8 h / 40 °C 2: tin(II) chloride dihdyrate; hydrogenchloride / 3 h / 80 °C 3: bis(8-hydroxyquinolato)copper(II); sodium hydroxide / 6 h / 110 °C View Scheme
Multi-step reaction with 3 steps 1: sodium hydroxide 2: tin(II) chloride dihdyrate; hydrogenchloride / water 3: sodium hydroxide; copper 8-hydroxyquinolinate View Scheme

: 2-(2-bromo-4-hydroxyphenyl)-2-hydroxyacetic acid

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: tin(II) chloride dihdyrate; hydrogenchloride / water 2: sodium hydroxide; copper 8-hydroxyquinolinate View Scheme

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: 89-86-1
4-hydroxysalicylic acid

Conditions

Conditions	Yield
With iodine; dimethyl sulfoxide at 120℃; for 28h; Sealed tube; Green chemistry;	83%

: 123-11-5
4-methoxy-benzaldehyde

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: 6-hydroxy-3-[(4-methoxyphenyl)methylene]benzo[b]furan-2-one

Conditions

Conditions	Yield
With acetic anhydride; triethylamine at 110℃; for 6h; Green chemistry;	75%

: 123-08-0
4-hydroxy-benzaldehyde

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: 6-hydroxy-3-[(4-hydroxyphenyl)methylene]benzo[b]furan-2-one

Conditions

Conditions	Yield
With acetic anhydride; triethylamine at 110℃; for 6h; Green chemistry;	75%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: 6-hydroxy-3-[(3,4-dimethoxyphenyl)methylene]benzo[b]furan-2-one

Conditions

Conditions	Yield
With acetic anhydride; triethylamine at 110℃; for 6h; Green chemistry;	70%

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: 6-hydroxy-3-[(3,4,5-trimethoxyphenyl)methylene]benzo[b]furan-2-one

Conditions

Conditions	Yield
With acetic anhydride; triethylamine at 110℃; for 6h; Green chemistry;	68%

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: 6-hydroxy-3-[(3,5-dimethoxyphenyl)methylene]benzo[b]furan-2-one

Conditions

Conditions	Yield
With acetic anhydride; triethylamine at 110℃; for 6h; Green chemistry;	66%

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: 95-01-2
2,4-Dihydroxybenzaldehyde

: 7-hydroxy-3-(2’,4’-dihydroxyphenyl)coumarin

Conditions

Conditions	Yield
With acetic anhydride; triethylamine at 110℃; for 6h; Green chemistry;	65%
With sodium acetate; acetic anhydride; acetic acid for 24h; Reflux;	49%

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

A: (2,4-Dihydroxy-3-iodo-phenyl)-acetic acid

B: (2,4-Dihydroxy-5-iodo-phenyl)-acetic acid

C: (2,4-Dihydroxy-3,5-diiodo-phenyl)-acetic acid

Conditions

Conditions	Yield
With sodium acetate buffer; dihydrogen peroxide; potassium iodide; lactoperoxidase for 0.25h; Ambient temperature; incubation, pH=5.6;

...Expand

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: 538-75-0
dicyclohexyl-carbodiimide

A: C16H14O7

B: 2387-23-7
1,3-Dicyclohexylurea

Conditions

Conditions	Yield
In water; ethyl acetate at 20℃; for 3h;

...Expand

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: 95-01-2
2,4-Dihydroxybenzaldehyde

: 479-13-0
coumestrol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic anhydride; sodium acetate; acetic acid / 24 h / Reflux 2: copper diacetate / diphenylether / 18 h / 258 °C View Scheme

: 123-11-5
4-methoxy-benzaldehyde

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: E-2,4-dihydroxy-4’-methoxystilbene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine; acetic anhydride / 6 h / 110 °C / Green chemistry 2: potassium hydroxide / propylene glycol / 0.5 h / 180 °C / Green chemistry View Scheme

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: E-2,4-dihydroxy-3’,4’-dimethoxystilbene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine; acetic anhydride / 6 h / 110 °C / Green chemistry 2: potassium hydroxide / propylene glycol / 0.5 h / 180 °C / Green chemistry View Scheme

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: E-2,4-dihydroxy-3’,5’-dimethoxystilbene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine; acetic anhydride / 6 h / 110 °C / Green chemistry 2: potassium hydroxide / propylene glycol / 0.5 h / 180 °C / Green chemistry View Scheme

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: E-2,4-dihydroxy-3’,4’,5’-trimethoxystilbene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine; acetic anhydride / 6 h / 110 °C / Green chemistry 2: potassium hydroxide / propylene glycol / 0.5 h / 180 °C / Green chemistry View Scheme

: 123-08-0
4-hydroxy-benzaldehyde

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: 2',4',4-trihydroxystilbene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine; acetic anhydride / 6 h / 110 °C / Green chemistry 2: potassium hydroxide / propylene glycol / 0.5 h / 180 °C / Green chemistry View Scheme

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: 95-01-2
2,4-Dihydroxybenzaldehyde

: E-2,2’,4,4’-tetrahydroxystilbene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine; acetic anhydride / 6 h / 110 °C / Green chemistry 2: potassium hydroxide / propylene glycol / 0.5 h / 140 °C / Green chemistry View Scheme

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: 479-13-0
coumestrol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: triethylamine / 6 h / 110 °C 2: sodium hydroxide / water 3: copper diacetate; 1,10-Phenanthroline / dimethyl sulfoxide; water / 18 h / 135 °C / Sealed tube; Green chemistry View Scheme

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: 7-hydroxy-3-(2’,4’-dihydroxyphenyl)coumarin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / 6 h / 110 °C 2: sodium hydroxide / water View Scheme

: 108-24-7
acetic anhydride

: 614-82-4
(2,4-dihydroxyphenyl)acetic acid

: 95-01-2
2,4-Dihydroxybenzaldehyde

: C21H16O8

Conditions

Conditions	Yield
With triethylamine at 110℃; for 6h;

...Expand

Benzeneacetic acid,2,4-dihydroxy- Specification

The Benzeneacetic acid,2,4-dihydroxy-, with the CAS registry number 614-82-4 and EINECS registry number 210-397-4, has the systematic name of (2,4-dihydroxyphenyl)acetic acid. And the molecular formula of this chemical is C₈H₈O₄. It is a kind of organics, and should be stored in the dry and cool environment.

The physical properties of Benzeneacetic acid,2,4-dihydroxy- are as following: (1)ACD/LogP: 0.05; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.27; (4)ACD/LogD (pH 7.4): -3.05; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1.2; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 4; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 44.76 Å²; (13)Index of Refraction: 1.642; (14)Molar Refractivity: 41.12 cm³; (15)Molar Volume: 113.7 cm³; (16)Polarizability: 16.3×10^-24cm³; (17)Surface Tension: 75.8 dyne/cm; (18)Density: 1.478 g/cm³; (19)Flash Point: 221.4 °C; (20)Enthalpy of Vaporization: 70.92 kJ/mol; (21)Boiling Point: 419 °C at 760 mmHg; (22)Vapour Pressure: 9.04E-08 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)Cc1ccc(O)cc1O
(2)InChI: InChI=1/C8H8O4/c9-6-2-1-5(3-8(11)12)7(10)4-6/h1-2,4,9-10H,3H2,(H,11,12)
(3)InChIKey: FSQDURCMBCGCIK-UHFFFAOYAX

Product Name

2,4-dihydroxyphenylacetic acid

Synthetic route

Benzeneacetic acid,2,4-dihydroxy- Specification

Related Products

Hot Products