Benzidamine hydrochloride supplier

Name
Benzidamine hydrochloride
EINECS 205-076-0
CAS No. 132-69-4
Density
Solubility soluble in water, alcohol, chloroform
Melting Point 147-153 °C
Formula C₁₉H₂₃N₃O^.HCl
Boiling Point 474.4 °C at 760 mmHg
Molecular Weight 345.872
Flash Point 240.7 °C
Transport Information
Appearance the white crystalline powder
Safety 26-36
Risk Codes 20/21/22-36
Molecular Structure
Hazard Symbols Xn
Synonyms 1-Propanamine,N,N-dimethyl-3-[[1-(phenylmethyl)-1H-indazol-3-yl]oxy]-, monohydrochloride(9CI);1-Benzyl-3-(3-dimethylaminopropoxy)-1H-indazole chloride;1-Benzyl-3-[3-(dimethylamino)propoxy]-1H-indazole hydrochloride;Algiflog;Andolex;Benalgin;Benciflam;Bendaminol;Benflogin;Benzyrin;Difflam;Difflam Cream;Dorinamin;Tamas;Tantum;
PSA 30.29000
LogP 4.21710

Synthetic route

chlorobase: chlorobase

: 7440-44-0
pyrographite

: 13185-09-6
1-benzyl-3-indazolol sodium salt

: 109-54-6
3-(Dimethylamino)propyl chloride

: 132-69-4
benzydamine hydrochloride

Conditions

Conditions	Yield
In 5,5-dimethyl-1,3-cyclohexadiene; hexane; water	73.6%

...Expand

: 132-69-4
benzydamine hydrochloride

: 2531-05-7
4-n-Butyl-1,2-diphenylpyrazolidinon-(3,5) Natriumsalz

: 37598-92-8
Phenylbutazon-Benzydamin-Salz

Conditions

Conditions	Yield
In acetone for 0.166667h; Heating;

: 132-69-4
benzydamine hydrochloride

A: 32852-16-7
N-Demethyl-Benzydamine

B: 36504-71-9
Benzydamine N-Oxide

Conditions

Conditions	Yield
With cattle liver microsomes; NADPH; magnesium chloride In phosphate buffer at 37℃; for 0.166667h; pH=7.4; Enzyme kinetics; Further Variations:; Solvents; pH-values;

: 2-(2-dimethylamino-ethoxy)-N,N-dimethylamino-methylene benzamide

: 132-69-4
benzydamine hydrochloride

: 2-{2-[2-(N,N-Dimethylamino)ethyl]oxy-phenyl}-4-phenyl-1,3,5-triazine

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran; ethyl acetate

Benzidamine hydrochloride Specification

The Benzidamine hydrochloride, with the CAS registry number 132-69-4, is also known as 3-[(1-Benzyl-1H-indazol-3-yl)oxy]-N,N-dimethylpropan-1-amine hydrochloride (1:1). It belongs to the product categories of Amines; Aromatics; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals. Its EINECS registry number is 205-076-0. This chemical's molecular formula is C₁₉H₂₃N₃O.ClH and molecular weight is 345.87. What's more, its IUPAC name is called 3-(1-Benzylindazol-3-yl)oxy-N,N-dimethylpropan-1-amine hydrochloride. It is used as a nonsteroidal anti-inflammatory drug with local anaesthetic, analgesic and antipyretic properties.

Physical properties about Benzidamine hydrochloride are: (1)ACD/LogP: 3.48; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.45; (4)ACD/LogD (pH 7.4): 1.56; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 3.15; (7)ACD/KOC (pH 5.5): 1.74; (8)ACD/KOC (pH 7.4): 22.64; (9)#H bond acceptors: 4 ; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 30.29 Å²; (13)Flash Point: 240.7 °C; (14)Enthalpy of Vaporization: 73.77 kJ/mol; (15)Boiling Point: 474.4 °C at 760 mmHg; (16)Vapour Pressure: 3.64E-09 mmHg at 25 °C.

When you are dealing with this chemical, you should be very careful. This chemical may cause damage to health and it is irritating to eyes. It is harmful by inhalation, in contact with skin and if swallowed. Therefore, you should wear suitable protective clothing. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: Cl.n2c(OCCCN(C)C)c1ccccc1n2Cc3ccccc3
(2) InChI: InChI=1S/C19H23N3O.ClH/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16;/h3-7,9-12H,8,13-15H2,1-2H3;1H
(3) InChIKey: HNNIWKQLJSNAEQ-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD	intraperitoneal	> 50mg/kg (50mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: NAUSEA OR VOMITING	Toxicology and Applied Pharmacology. Vol. 10, Pg. 148, 1967.
child	TDLo	oral	50mg/kg (50mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Archiv fuer Toxikologie. Vol. 23, Pg. 215, 1968.
dog	LD	oral	> 50mg/kg (50mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: NAUSEA OR VOMITING	Toxicology and Applied Pharmacology. Vol. 10, Pg. 148, 1967.
mouse	LD50	intraperitoneal	110mg/kg (110mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE WEAKNESS	Toxicology and Applied Pharmacology. Vol. 10, Pg. 148, 1967.
mouse	LD50	intravenous	33mg/kg (33mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Toxicology and Applied Pharmacology. Vol. 10, Pg. 148, 1967.
mouse	LD50	oral	440mg/kg (440mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA	Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978.
mouse	LD50	subcutaneous	218mg/kg (218mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Toxicology and Applied Pharmacology. Vol. 10, Pg. 148, 1967.
rabbit	LD	intravenous	> 5mg/kg (5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP BEHAVIORAL: EXCITEMENT	Toxicology and Applied Pharmacology. Vol. 10, Pg. 148, 1967.
rat	LD50	intraperitoneal	72mg/kg (72mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 620, 1969.
rat	LD50	intravenous	43500ug/kg (43.5mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 70, 1968.
rat	LD50	oral	740mg/kg (740mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Yakugaku Zasshi. Journal of Pharmacy. Vol. 99, Pg. 240, 1979.
rat	LD50	subcutaneous	720mg/kg (720mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 70, 1968.

Product Name

Benzidamine hydrochloride

Synthetic route

Benzidamine hydrochloride Specification

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