-
Name
cyclohexyl methylphosphonofluoridate
- EINECS
- CAS No. 329-99-7
- Density 1.09g/cm3
- Solubility
- Melting Point -30oC
- Formula C7H14 F O2 P
- Boiling Point 237.2°Cat760mmHg
- Molecular Weight 180.159
- Flash Point 97.3°C
- Transport Information
- Appearance
- Safety A deadly poison by subcutaneous route. When heated to decomposition it emits toxic fumes of POx and F−.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms Phosphonofluoridicacid, methyl-, cyclohexyl ester (6CI,7CI,8CI,9CI); CMPF; Cyclohexylmethylphosphonofluoridate; Cyclosarin; Cyclosin; Cyclosin (chemical warfareagent); GF; GF (chemical warfare agent); Methyl cyclohexylfluorophosphonate;O-Cyclohexyl methylphosphonofluoridate
- PSA 36.11000
- LogP 3.12810
Cyclosarin Chemical Properties
The IUPAC name of Cyclosarin (CAS NO.329-99-7):
[Fluoro(methyl)phosphoryl]oxycyclohexane
Synonyms: Cyclohexyl methylphosphonofluoridate ; O-cyclohexyl-methylphosphonofluoridate ; Agentgf ; Methyl cyclohexylfluorophosphonate
CAS: 329-99-7
Molecular Weight: 180.157024 g/mol
Molecular Formula: C7H14FO2P
Molecular Structure:
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Index of Refraction: 1.414
Density: 1.09 g/cm3
Flash Point: 97.3 °C
Boiling Point: 237.2 °C at 760 mmHg
Air & Water Reactions:Likely hydrolyzed by water, rapidly hydrolyzed by dilute aqueous sodium hydroxide
Cyclosarin Production
Reactivity Profile: Acidic conditions produce hydrogen fluoride; alkaline conditions produce isopropyl alcohol and polymers. When heated to decomposition or reacted with steam, cyclohexyl methylphosphonofluoridate emits very toxic fumes of fluorides and oxides of phosphorus. Slightly corrosive to steel. Hydrolyzed by water.
Cyclosarin Toxicity Data With Reference
The toxicity of Cyclosarin (CAS NO.329-99-7):
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | subcutaneous | 100ug/kg (0.1mg/kg) | Canadian Journal of Physiology and Pharmacology. Vol. 44, Pg. 745, 1966. | |
| hamster | LD50 | subcutaneous | 130ug/kg (0.13mg/kg) | Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968. | |
| mouse | LD50 | subcutaneous | 400ug/kg (0.4mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA GASTROINTESTINAL: NAUSEA OR VOMITING | Science Journal. Vol. 3(4), Pg. 33, 1967. |
| rabbit | LD50 | subcutaneous | 100ug/kg (0.1mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: COMA | Science Journal. Vol. 3(4), Pg. 33, 1967. |
| rat | LD50 | intramuscular | 80ug/kg (0.08mg/kg) | Pharmacology and Toxicology Vol. 84, Pg. 41, 1999. | |
| rat | LD50 | subcutaneous | 225ug/kg (0.225mg/kg) | Canadian Journal of Physiology and Pharmacology. Vol. 44, Pg. 745, 1966. |
Cyclosarin Safety Profile
The safety information of Cyclosarin (CAS NO.329-99-7):
A deadly poison by subcutaneous route. When heated to decomposition it emits toxic fumes of POx and F−.
Health Hazard: Median lethal dose (mg-min/m3): 2500 by skin (vapor) or 350 (liquid); 35 inhaled. Median incapacitating dose: 25 inhaled. Eye/skin toxicity: Very high. Rate of action: Very rapid. Physiological action: Cessation of breath-death may follow. Detoxification rate: Low. (ANSER)
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