Di-tert-butyl N,N-diisopropylphosphoramidite supplier

Name
Di-tert-butyl N,N-diisopropylphosphoramidite
EINECS
CAS No. 137348-86-8
Article Data4
CAS DataBase
Density 0.879 g/cm³
Solubility
Melting Point 85-90 °C 0.2 mm Hg(lit.)
Formula C₁₄H₃₂NO₂P
Boiling Point 252.2 °C at 760 mmHg
Molecular Weight 277.387
Flash Point 106.4 °C
Transport Information
Appearance Clear Colourless Liquid
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Phosphoramidousacid, bis(1-methylethyl)-, bis(1,1-dimethylethyl) ester (9CI);Di-tert-butylN,N-diisopropylphosphoramidite;di-tert-butyl dipropan-2-ylphosphoramidoite;phosphoramidous acid, N,N-bis(1-methylethyl)-, bis(1,1-dimethylethyl) ester;
PSA 35.29000
LogP 4.96230

Di-tert-butyl N,N-diisopropylphosphoramidite Specification

The Di-tert-butyl N,N-diisopropylphosphoramidite, with the CAS registry number 137348-86-8, has the systematic name of di-tert-butyl dipropan-2-ylphosphoramidoite. It is a kind of clear colourless liquid, and belongs to the following product categories: Phospholipids - 13C & 2H; Phosphorylating and Phosphitylating Agents; Catalysis and Inorganic Chemistry; Phosphine Ligands; Phosphorus Compounds. And the molecular formula of the chemical is C₁₄H₃₂NO₂P.

The characteristics of Di-tert-butyl N,N-diisopropylphosphoramidite are as followings: (1)ACD/LogP: 5.72; (2)# of Rule of 5 Violations: 1; (3)#H bond acceptors: 3; (4)#H bond donors: 0; (5)#Freely Rotating Bonds: 7; (6)Polar Surface Area: 35.29 Å² ; (7)Flash Point: 106.4 °C; (8)Enthalpy of Vaporization: 48.96 kJ/mol; (9)Boiling Point: 252.2 °C at 760 mmHg; (10)Vapour Pressure: 0.0195 mmHg at 25°C.

Preparation of Di-tert-butyl N,N-diisopropylphosphoramidite: This chemical can be prepared by 2-methyl-propan-2-ol and (tert-Butoxy)bis(diisopropylamino)phosphine. The reaction will need reagent diisopropylammonium tetrazolide. The reaction time is 3 hours, and the yield is about 58%.

You should be cautious while dealing with this chemical. It irritates to eyes, respiratory system and skin. Therefore, you had better take the following instructions: Wear suitable protective clothing, and if in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: O(P(OC(C)(C)C)N(C(C)C)C(C)C)C(C)(C)C
(2)InChI: InChI=1/C14H32NO2P/c1-11(2)15(12(3)4)18(16-13(5,6)7)17-14(8,9)10/h11-12H,1-10H3
(3)InChIKey: YGFLCNPXEPDANQ-UHFFFAOYAB

Product Name

Di-tert-butyl N,N-diisopropylphosphoramidite

Di-tert-butyl N,N-diisopropylphosphoramidite Specification

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