Product Name

  • Name

    Diazinon

  • EINECS 206-373-8
  • CAS No. 333-41-5
  • Article Data69
  • CAS DataBase
  • Density 1.168 g/cm3
  • Solubility slightly soluble in water
  • Melting Point >120 °C (dec.)
  • Formula C12H21N2O3PS
  • Boiling Point 353.9 °C at 760 mmHg
  • Molecular Weight 304.35
  • Flash Point 167.9 °C
  • Transport Information UN 2783/2810
  • Appearance light to dark brown liquid
  • Safety 24/25-60-61-36-26-16
  • Risk Codes 22-50/53-36-20/21/22-11
  • Molecular Structure Molecular Structure of 333-41-5 (Diazinon)
  • Hazard Symbols HarmfulXn, DangerousN, FlammableF
  • Synonyms Dassitox;Topclip 40;Diazinon AG 500;diethoxy-(6-methyl-2-propan-2-yl-pyrimidin-4-yl)oxy-sulfanylidene-phosphorane;Sarolex;Diazol;Drawizon;O,O-Diethyl O-(2-isopropyl-4-methyl-6-pyrimidinyl) phosphorothioate;Isopropylmethylpyrimidyl diethyl thiophosphate;o, o-Dietil-o- (2-isopropil-4-metil-pirimidin-il)-monotiofosato(ITALIA N);Ektoband;Kleen-Dok;O-2-Isopropyl-4-methylpyrimidyl-O,O-diethyl phosphorothioate;Diazajet;Dimpylat;Phosphorothioic acid, O, O-diethyl O- (2-isopropyl-6-methyl-4-pyrimidinyl) ester;Topclip Blue Shield;O, O-Diethyl-O- (2-isopropyl-4-methyl-pyrimidin-6-yl)-monothiofosfaat( DUTCH);O,O-Diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) thiophosphate;Basudin 10 G;Antigal;O,O-Diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) phosphorothioate;Diazitol;Phosphorothioic acid, O,O-diethyl {O-[6-methyl-2-(1-methylethyl)-4-pyrimidinyl]} ester;O,O-Diethyl O-6-methyl-2-isopropyl-4-pyrimidinyl phosphorothioate;Phosphorothioic acid, O,O-diethyl O-[6-methyl-2- (1-methylethyl)-4-pyrimidinyl] ester;Galesan;Exodin;Cooper's Flystrike Powder;Dizictol;4-Pyrimidinol, 2-isopropyl-6-methyl-, O-ester with O,O-diethyl phosphorothioate;Bazudin;Delzinon;G-24480;Dimpylate;Knox-out;O, O-Diethyl O-(2-isopropyl-4-methyl-6-pyrimidyl) thionophosphate;Diazinone;Nedcidol;Disonex;Garden Tox;KFM Blowfly Dressing;Spectracide;Phosphorothioate, O,O-diethyl O-6- (2-isopropyl-4-methylpyrimidyl);Flytrol;Bazanon;Nucidol;Topclip Blue;
  • PSA 95.37000
  • LogP 4.23530

Diazinon Chemical Properties

Product Name: Diazinon (CAS NO.333-41-5)

Molecular formula :C12H21N2O3PS
Molar mass :304.35 g/mol
Appearance :Colorless to dark brown liquid
Index of Refraction: 1.523 
Molar Refractivity: 79.64 cm3 
Molar Volume: 260.4 cm 
Surface Tension: 45.6 dyne/cm 
Density: 1.168 g/cm3 
Flash Point: 167.9 °C 
Enthalpy of Vaporization: 57.53 kJ/mol 
Boiling Point: 353.9 °C at 760 mmHg 
Vapour Pressure: 7.07E-05 mmHg at 25°C 
XLogP3-AA: 3.8
H-Bond Donor: 0
H-Bond Acceptor: 5
Structure Descriptors of Diazinon (CAS NO.333-41-5):
  IUPAC Name: diethoxy-(6-methyl-2-propan-2-ylpyrimidin-4-yl)oxy-sulfanylidene-λ5-phosphane
  Canonical SMILES: CCOP(=S)(OCC)OC1=NC(=NC(=C1)C)C(C)C
  InChI: InChI=1S/C12H21N2O3PS/c1-6-15-18(19,16-7-2)17-11-8-10(5)13-12(14-11)9(3)4/h8-9H,6-7H2,1-5H3 
  InChIKey: FHIVAFMUCKRCQO-UHFFFAOYSA-N
Classification Code: Acaricide; Agricultural Chemical; Cholinergic Agents; Cholinesterase inhibitors  Enzyme Inhibitors; Human Data; Insecticide; Insecticides; Mutation data; Nematocide; Neurotransmitter Agents; Pesticides; Reproductive Effect; Skin / Eye Irritant; Tumor data

Diazinon History

In 1952 , Diazinon is a thiophosphoric acid ester developed by Ciba-Geigy, a Swiss chemical company . It is a nonsystemic organophosphate insecticide formerly used to control cockroaches, silverfish, ants, and fleas in residential, non-food buildings. Diazinon was heavily used during the 1970s and early 1980s for general-purpose gardening use and indoor pest control. A bait form was used to control scavenger wasps in the western U.S.

Diazinon Uses

Among cultivators of carnivorous plants, diazinon is known as the most effective systemic insecticide, capable of eradicating severe infestations of aphids, mealybugs and other sucking parasites while leaving the plant unharmed. For cultivators unable to obtain diazinon, Malathion and Acephate have been reported as less effective substitutes.

Diazinon Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 2mg/kg (2mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
chicken LD50 oral 8400ug/kg (8.4mg/kg)   "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
duck LD50 oral 3500ug/kg (3.5mg/kg)   Down to Earth. Vol. 35, Pg. 25, 1979.
guinea pig LC50 inhalation 5500mg/m3/4H (5500mg/m3)   Proceedings of the European Society for the Study of Drug Toxicity. Vol. 15, Pg. 239, 1974.
guinea pig LD50 oral 250mg/kg (250mg/kg)   "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
human TDLo oral 214mg/kg (214mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: MUSCLE WEAKNESS

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER
Clinical Toxicology. Vol. 12, Pg. 435, 1978.
mammal (species unspecified) LD50 unreported 76mg/kg (76mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 338, 1971.
mouse LC50 inhalation 1600mg/m3/4H (1600mg/m3)   Proceedings of the European Society for the Study of Drug Toxicity. Vol. 15, Pg. 239, 1974.
mouse LD50 intraperitoneal 33mg/kg (33mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 495, 1960.
mouse LD50 intravenous 180mg/kg (180mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00023,
mouse LD50 oral 17mg/kg (17mg/kg)   Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. Vol. 24, Pg. 268, 1983.
mouse LD50 skin 2750mg/kg (2750mg/kg)   Journal of Toxicology and Environmental Health. Vol. 9, Pg. 491, 1982.
mouse LD50 subcutaneous 58mg/kg (58mg/kg)   Osaka Igaku Zasshi. Vol. 71, Pg. 6099, 1959.
pig LD50 oral 320mg/kg (320mg/kg)   Yakkyoku. Pharmacy. Vol. 31, Pg. 459, 1980.
pig LD50 skin 633mg/kg (633mg/kg)   Yakkyoku. Pharmacy. Vol. 31, Pg. 459, 1980.
pigeon LD50 oral 3160ug/kg (3.16mg/kg)   ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979.
quail LD50 oral 4210ug/kg (4.21mg/kg)   ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979.
rabbit LD50 oral 143mg/kg (143mg/kg)   Yakkyoku. Pharmacy. Vol. 31, Pg. 459, 1980.
rabbit LD50 skin 3600mg/kg (3600mg/kg)   "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A131, Pg. 1983,
rat LC50 inhalation 3500mg/m3/4H (3500mg/m3)   Farm Chemicals Handbook. Vol. -, Pg. C101, 1991.
rat LD50 intraperitoneal 65mg/kg (65mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 436, 1955.
rat LD50 intratracheal 210mg/kg (210mg/kg)   JAT, Journal of Applied Toxicology. Vol. 19, Pg. 133, 1999.
rat LD50 oral 66mg/kg (66mg/kg)   Down to Earth. Vol. 35, Pg. 25, 1979.
rat LD50 skin 180mg/kg (180mg/kg)   Proceedings of the Annual Meeting of the New Jersey Mosquito Extermination Association. Vol. -, Pg. 155, 1957.
rat LD50 unreported 250mg/kg (250mg/kg)   Rinsho Shinkeigaku. Clinical Neurology. Vol. 23, Pg. 101, 1983.

Diazinon Safety Profile

Safety Information of Diazinon (CAS NO.333-41-5):
Hazard Codes: XnHarmful;NDangerous
Risk Statements: R22;R50/53   
R22:Harmful if swallowed. 
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: S24/25;S60;S61 
S24:Avoid contact with skin. 
S25:Avoid contact with eyes. 
S60:This material and its container must be disposed of as hazardous waste. 
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.

Diazinon Specification

 Diazinon , its CAS NO. is 333-41-5, the synonyms are O,O-Diethyl O-2-isopropyl-4-methyl-6-pyrimidyl thiophosphate ;  O,O-Diethyl O-(6-methyl-2-(1-methylethyl)-4-pyrimidinyl) phosophorothioate .

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