Ethyl 2,6-diaminohexanoate dihydrochloride supplier

Name
Ethyl 2,6-diaminohexanoate dihydrochloride
EINECS 223-340-3
CAS No. 3844-53-9
Article Data5
CAS DataBase
Density g/cm³
Solubility
Melting Point ~150 °C (dec.)
Formula C8H18 N2 O2 . 2 Cl H
Boiling Point 261.9 °C at 760 mmHg
Molecular Weight 247.165
Flash Point 97.3 °C
Transport Information
Appearance White Powder
Safety 22-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols 36/37/38:;
Synonyms L-Lysine,ethyl ester, dihydrochloride (9CI); Lysine, ethyl ester, dihydrochloride, L-(7CI,8CI); Lysine ethyl ester dihydrochloride; NSC 162742
PSA 78.34000
LogP 3.01040

Synthetic route

: 64-17-5
ethanol

: 657-27-2, 10098-89-2
L-Lysine hydrochloride

: 3844-53-9
L-lysine ethyl ester dihydrochloride

Conditions

Conditions	Yield
With thionyl chloride Reflux;	87%
With thionyl chloride at -10℃; for 6h; Reflux;	87%
With hydrogenchloride at 70℃; for 5h;

: 64-17-5
ethanol

L-lysine-dihydrochloride: L-lysine-dihydrochloride

: 3844-53-9
L-lysine ethyl ester dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride

: C11H15N2O5PolS

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: C22H38N4O6Pol2S2

Conditions

Conditions	Yield
Stage #1: C11H15N2O5PolS With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h; Stage #2: L-lysine ethyl ester dihydrochloride With dmap In dichloromethane at 20℃; for 42h;	94%

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: 76-83-5
trityl chloride

: ethyl 2-amino-6-(tritylamino)hexanoate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 6h;	88.8%

: 1521-38-6
2,3-dimethoxybenzoic acid

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: ethyl N2,N6-bis(2,3-dimethoxybenzoyl)-L-lysinate

Conditions

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;	85%

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: 552-30-7
trimellitic Anhydride

: 1281900-48-8
C26H22N2O10

Conditions

Conditions	Yield
With pyridine; acetic acid at 20℃; for 6h; Reflux;	79%
With pyridine; acetic acid for 8h; Reflux;

: 16024-56-9
2-(2-methoxyethoxy)acetic acid

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: di-(2-methoxyethoxyacetyl)-L-lysine ethyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; Cooling with ice;	77.8%

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: 30562-34-6
geldanmycin

: (S)-ethyl 2-amino-6-(((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-9-(carbamoyloxy)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-19-yl)amino)hexanoate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran; methanol at 60℃;	74.1%

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: 1010-93-1
2-methyl-5-nitroimidazole-1-acetic acid

: ethyl 2,6-bis(2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetamido)hexanoate

Conditions

Conditions	Yield
Stage #1: 2-methyl-5-nitroimidazole-1-acetic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide for 0.25h; Inert atmosphere; Stage #2: L-lysine ethyl ester dihydrochloride With triethylamine In N,N-dimethyl-formamide Inert atmosphere;	69%

: C29H51NO15

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: 870821-07-1
C52H102N2O26

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃;	66%

: 50-00-0
formaldehyd

: 368-54-7
2-sulfanylidene-6-(trifluoromethyl)-2,3-dihydropyrimidin-4(1H)-one

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: ethyl (2S)-2,6-bis(6-oxo-8-(trifluoromethyl)-3,4-dihydro-2,6-pyrimido[2,1-b][1,3,5]thiadiazin-3(2H,3H,4H,6H)-yl)hexanoate

Conditions

Conditions	Yield
In water; acetonitrile at 20℃;	51%
In water; acetonitrile at 20℃; Mannich Aminomethylation; regiospecific reaction;	51%

...Expand

: 82913-19-7
[(2R,3R,4R)-3,4-diacetoxy-5-[2-oxo-4-(1,2,4-triazol-1-yl)pyrimidin-1-yl]tetrahydrofuran-2-yl]methyl acetate

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: 4-[((1S)-1-amino-1-ethoxycarbonyl)pentyl]amino-1-(β-D-2,3,5-tri-O-acetylribofuranosyl)pyrimidine-2(1H)-one

Conditions

Conditions	Yield
With triethylamine In acetonitrile	42.3%

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: 136112-90-8
1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4-(1,2,4-triazol-1-yl)pyrimidin-2(1H)-one

: 4-[((1S)-1-amino-1-ethoxycarbonyl)pentyl]amino-1-(β-D-2,3,5-tri-O-benzoylribofuranosyl)pyrimidine-2(1H)-one

Conditions

Conditions	Yield
With triethylamine In acetonitrile	40.8%

: 50-00-0
formaldehyd

: 188540-42-3
m-xylylene diisocyanide

: 13574-13-5
Boc-Glu(OBzl)-OH

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: 1034473-44-3
C54H72N6O14

Conditions

Conditions	Yield
Stage #1: formaldehyd; L-lysine ethyl ester dihydrochloride In methanol at 20℃; for 2h; Ugi type macrocyclization; Stage #2: Boc-Glu(OBzl)-OH In methanol for 0.5h; Ugi type macrocyclization; Stage #3: m-xylylene diisocyanide In methanol Ugi type macrocyclization;	40%

...Expand

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: 13292-22-3
3-formylrifamycin SV

: C46H65N3O14

Conditions

Conditions	Yield
Stage #1: 3-formylrifamycin SV With hydrogenchloride In ethanol; dichloromethane Stage #2: L-lysine ethyl ester dihydrochloride With potassium hydroxide In methanol; ethanol; dichloromethane at 40℃; for 0.5h; Stage #3: With sodium cyanoborohydride In methanol; ethanol; dichloromethane at 20℃; for 1h;	33%

: 455-93-6
2-fluoro-1-methoxy-4-nitrobenzene

: 3844-53-9
L-lysine ethyl ester dihydrochloride

A: 636-93-1
5-nitroguaiacol

B: 124431-94-3
2-(2-methoxy-5-nitrophenyl)amino-ε-caprolactame

Conditions

Conditions	Yield
In acetonitrile for 4h; Ambient temperature; Irradiation; pH=10;	A 22% B 6%

...Expand

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: 3890-90-2
copper(II) o-hydroxybenzoate

: Nα,Nε-disalicylidene-L-lysine ethyl ester; copper (II)-salt

Conditions

Conditions	Yield
With ethanol; sodium acetate

: 112-38-9
10-undecenoic acid

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: 61796-85-8
N,N'-Bis-(10-undecenoyl)-L-lysinethylester

Conditions

Conditions	Yield
(i) ClCO2Et, Et3N, (ii) /BRN= 3697099/; Multistep reaction;
(i) Et3N, DMF, (ii) ClCO2Et, (iii) /BRN= 3697099/; Multistep reaction;

: 13303-10-1
tert-Butyl 4-nitrophenyl carbonate

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: 99872-16-9
Nα,Nε-Di-tert.-butyloxycarbonyl-L-lysin-ethylester

Conditions

Conditions	Yield
With pyridine

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: 112-13-0
n-decanoyl chloride

: 61796-82-5
N,N'-Bis-(decanoyl)-L-lysinethylester

Conditions

Conditions	Yield
With triethylamine
With triethylamine In N,N-dimethyl-formamide

: 3844-53-9
L-lysine ethyl ester dihydrochloride

A: 997-20-6
lysine tetrapeptide

B: 19431-21-1
poly(L-lysine), 5-mer

C: 56-87-1
L-lysine

D: 13184-13-9
dilysine

E: 13184-14-0
Lys-Lys-Lys

F: 554-38-1
hexalysine

Conditions

Conditions	Yield
multistep reaction; 1.) trypsin, Na2CO3 buffer pH 10.0, 25 deg C, 2.) NaOH, 60 deg C, 15 min; trypsin-catalyzed oligomerization of L-lysine esters, pH-dependence, reaction rate, kinetics, effect of NaCl; other L-lysin alkyl esters, enzyme or amino acids;

...Expand

: 3844-53-9
L-lysine ethyl ester dihydrochloride

A: 997-20-6
lysine tetrapeptide

B: 19431-21-1
poly(L-lysine), 5-mer

C: 13184-14-0
Lys-Lys-Lys

D: 21743-34-0
lysine peptide K8

Conditions

Conditions	Yield
With sodium hydroxide 1.) trypsin, sodium carbonate buffer pH 10.0, 25 deg C, 1 h, 2.) 60 deg C, 15 min; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given;

...Expand

: 3844-53-9
L-lysine ethyl ester dihydrochloride

A: 997-20-6
lysine tetrapeptide

B: 19431-21-1
poly(L-lysine), 5-mer

C: 13184-14-0
Lys-Lys-Lys

D: 554-38-1
hexalysine

Conditions

Conditions	Yield
With sodium hydroxide 1.) trypsin, sodium carbonate buffer pH 10.0, 25 deg C, 1 h, 2.) 60 deg C, 15 min; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given;

...Expand

: 3844-53-9
L-lysine ethyl ester dihydrochloride

A: 997-20-6
lysine tetrapeptide

B: 19431-21-1
poly(L-lysine), 5-mer

C: 13184-14-0
Lys-Lys-Lys

D: 7532-36-7
(Lys)7

Conditions

Conditions	Yield
With sodium hydroxide 1.) trypsin, sodium carbonate buffer pH 10.0, 25 deg C, 1 h, 2.) 60 deg C, 15 min; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given;

...Expand

: 3844-53-9
L-lysine ethyl ester dihydrochloride

A: 997-20-6
lysine tetrapeptide

B: 56-87-1
L-lysine

C: 13184-13-9
dilysine

D: 13184-14-0
Lys-Lys-Lys

Conditions

Conditions	Yield
With sodium hydroxide 1.) trypsin, sodium carbonate buffer pH 10.0, 25 deg C, 3 h, 2.) 60 deg C, 15 min; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 3844-53-9
L-lysine ethyl ester dihydrochloride

A: 56-87-1
L-lysine

B: 13184-13-9
dilysine

C: 13184-14-0
Lys-Lys-Lys

Conditions

Conditions	Yield
With sodium hydroxide 1.) trypsin, sodium carbonate buffer pH 10.0, 25 deg C, 24 h, 2.) 60 deg C, 15 min; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: 501-53-1
benzyl chloroformate

: 83173-67-5
Nα,Nξ-di-Cbz-L-lysine ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In water for 20h;	14.00 g

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: 138207-66-6
Nα,Nε-bis(benzyloxycarbonyl)-D-lysinal

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 14.00 g / K2CO3 / H2O / 20 h 2: 89 percent / CaCl2, NaBH4 / tetrahydrofuran; ethanol / 20 h / 0 - 20 °C 3: 1.) DMSO, COCl2, 2.) Et3N / 1.) CH2Cl2, -63 deg C, 20 min, 2.) CH2Cl2, -63 deg C, 20 min View Scheme

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: 137649-64-0
N,N-bis-Cbz-L-lysinol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 14.00 g / K2CO3 / H2O / 20 h 2: 89 percent / CaCl2, NaBH4 / tetrahydrofuran; ethanol / 20 h / 0 - 20 °C View Scheme

: 3844-53-9
L-lysine ethyl ester dihydrochloride

: (1R,2R,3S)-1-cyclohexyl-3,7-bisheptane-1,2-diol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 14.00 g / K2CO3 / H2O / 20 h 2: 89 percent / CaCl2, NaBH4 / tetrahydrofuran; ethanol / 20 h / 0 - 20 °C 3: 1.) DMSO, COCl2, 2.) Et3N / 1.) CH2Cl2, -63 deg C, 20 min, 2.) CH2Cl2, -63 deg C, 20 min View Scheme

Ethyl 2,6-diaminohexanoate dihydrochloride Chemical Properties

Molecular Formula :C₈H₂₀Cl₂N₂O₂
Molecular Weight 247.1
Purity >98.0%
Appearance White powder
Melting point: ~150 °C (dec.)
Storage temp:-20°C
Sensitive Hygroscopic

Ethyl 2,6-diaminohexanoate dihydrochloride Toxicity Data With Reference

H-Lys-OEt-2HCl is irritate to skin and mucous membrane.And H-Lys-OEt-2HCl can induce breathing disorders.

Ethyl 2,6-diaminohexanoate dihydrochloride Safety Profile

Risk Statements 36/37/38
Safety Statements 22-24/25

Product Name

Ethyl 2,6-diaminohexanoate dihydrochloride

Synthetic route

Ethyl 2,6-diaminohexanoate dihydrochloride Chemical Properties

Ethyl 2,6-diaminohexanoate dihydrochloride Toxicity Data With Reference

Ethyl 2,6-diaminohexanoate dihydrochloride Safety Profile

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