6-bicyclo<3.1.0>hexan-6-ol
ethyl 3-cyclopentyl-3-oxopropionate
Conditions | Yield |
---|---|
In neat (no solvent) at 110℃; | 99% |
3-cyclopentyl-2-diazo-3-hydroxy-propionic acid ethyl ester
ethyl 3-cyclopentyl-3-oxopropionate
Conditions | Yield |
---|---|
With copper(II) sulfate at 20℃; for 3h; | 91% |
Cyclopentanecarboxylic acid chloride
ethyl 3-cyclopentyl-3-oxopropionate
Conditions | Yield |
---|---|
Stage #1: hydrogen ethyl malonate With [2,2]bipyridinyl; n-butyllithium In hexanes at -65 - -55℃; Stage #2: Cyclopentanecarboxylic acid chloride In hexanes at 20℃; | 89% |
Multi-step reaction with 2 steps 1: pyridine / CH2Cl2 / 2 h / 0 - 20 °C 2: toluene / 24 h / 80 °C View Scheme |
Cyclopentanecarboxylic acid chloride
ethyl potassium malonate
ethyl 3-cyclopentyl-3-oxopropionate
Conditions | Yield |
---|---|
With triethylamine; magnesium chloride In acetonitrile at 0℃; for 4h; | 77% |
6-bicyclo<3.1.0>hexan-6-ol
ethyl 3-cyclopentyl-3-oxopropionate
Conditions | Yield |
---|---|
at 300℃; for 1h; | 52% |
2-cyclopentanecarbonyl-3-oxo-butyric acid ethyl ester
ethyl 3-cyclopentyl-3-oxopropionate
Conditions | Yield |
---|---|
With diethyl ether; ammonia |
1-cyclopentylethanone
Diethyl carbonate
ethyl 3-cyclopentyl-3-oxopropionate
Conditions | Yield |
---|---|
With sodium amide |
ethanol
5-(cyclopentanecarbonyl)2,2-dimethyl-1,3-dioxane-4,6-dione
ethyl 3-cyclopentyl-3-oxopropionate
Conditions | Yield |
---|---|
In toluene at 80℃; for 24h; Yield given; |
diethyl malonate
ethyl 3-cyclopentyl-3-oxopropionate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1) Na / 1. benzene, reflux, 8 h; 2. 2h at 0 deg C, then 6 h room temp. 2: 52 percent / 1 h / 300 °C View Scheme |
Cyclopentanecarboxylic acid chloride
ethyl acetate
ethyl 3-cyclopentyl-3-oxopropionate
Conditions | Yield |
---|---|
Stage #1: ethyl acetate With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Inert atmosphere; Stage #2: Cyclopentanecarboxylic acid chloride In tetrahydrofuran; hexane at -78℃; for 0.0833333h; |
Cyclopentanecarboxylic acid chloride
ethyl acetate
A
ethyl 3-cyclopentyl-3-oxopropionate
Conditions | Yield |
---|---|
Stage #1: ethyl acetate With potassium hexamethylsilazane In tetrahydrofuran at -78℃; for 0.25h; Stage #2: Cyclopentanecarboxylic acid chloride In tetrahydrofuran at -78℃; for 2h; Overall yield = 643 mg; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C 2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C 2.2: 2 h / -78 °C View Scheme |
ethyl 3-cyclopentyl-3-oxopropionate
guanidine hydrochloride
Conditions | Yield |
---|---|
With potassium tert-butylate In methanol at 23 - 60℃; | 88% |
ethyl 3-cyclopentyl-3-oxopropionate
guanidine hydrochloride
2-amino-6-cyclopentyl-3H-pyrimidin-4-one
Conditions | Yield |
---|---|
Stage #1: ethyl 3-cyclopentyl-3-oxopropionate; guanidine hydrochloride With potassium tert-butylate In methanol at 20 - 60℃; Stage #2: With hydrogenchloride In methanol; water pH=5; | 87% |
With potassium tert-butylate In methanol at 23 - 60℃; |
2,6-di-tert-butyl-4-(4-methoxybenzylidene)-cyclohexa-2,5-dienone
ethyl 3-cyclopentyl-3-oxopropionate
Conditions | Yield |
---|---|
With C51H62N2O2; copper(II) bis(trifluoromethanesulfonate) In tetrahydrofuran at -15℃; for 18h; enantioselective reaction; | 86% |
ethyl 3-cyclopentyl-3-oxopropionate
3-cyclopentyl-2-methoxy-3-oxo-propionic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: ethyl 3-cyclopentyl-3-oxopropionate With [bis(acetoxy)iodo]benzene; boron trifluoride diethyl etherate In methanol at 20℃; Stage #2: With water; sodium hydrogencarbonate In dichloromethane | 43% |
ethyl 3-cyclopentyl-3-oxopropionate
acetic acid
2-amino-1-cyclopentyl-ethanone
Conditions | Yield |
---|---|
With sodium nitrite Behandeln des Reaktionsprodukts mit Zink und Acetanhydrid unter Zusatz von Eis und Erhitzen des danach isolierten Reaktionsprodukts mit wss. Salzsaeure; |
ethyl 3-cyclopentyl-3-oxopropionate
thiourea
Conditions | Yield |
---|---|
With ethanol; sodium ethanolate |
ethyl 3-cyclopentyl-3-oxopropionate
A
5-cyclopentylisoxazol-3-ol
B
3-cyclopentyl-2H-isoxazol-5-one
Conditions | Yield |
---|---|
(i) NH2OH*HCl, aq. NaOH, (ii) aq. HCl; Multistep reaction; |
ethyl 3-cyclopentyl-3-oxopropionate
3-cyclopentyl-2H-isoxazol-5-one
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride |
ethyl 3-cyclopentyl-3-oxopropionate
ethyl bromoacetate
diethyl 2-(cyclopentanecarbonyl)succinate
Conditions | Yield |
---|---|
With sodium In ethanol |
ethyl 3-cyclopentyl-3-oxopropionate
4-methoxybenzoic acid hydrazide
Conditions | Yield |
---|---|
In isopropyl alcohol for 0.5h; Heating; |
2,6-dichlorobenzohydroximoyl chloride
ethyl 3-cyclopentyl-3-oxopropionate
ethyl 5-cyclopentyl-3-(2,6-dichlorophenyl)-4-isoxazolecarboxylate
Conditions | Yield |
---|---|
With sodium ethanolate In tetrahydrofuran; ethanol at 0 - 20℃; |
ethyl 3-cyclopentyl-3-oxopropionate
4-cyclopentyl-4-oxobutanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Na / ethanol 2: aq. HCl View Scheme |
ethyl 3-cyclopentyl-3-oxopropionate
3-cyclopentyl-5-methoxy-isoxazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NH2OH*HCl View Scheme |
The CAS register number of Ethyl 3-cyclopentyl-3-oxopropanoate is 24922-00-7. It also can be called as Cyclopentanepropanoicacid, b-oxo-, ethyl ester and the IUPAC name about this chemical is ethyl 3-cyclopentyl-3-oxopropanoate. The molecular formula about this chemical is C10H16O3 and molecular weight is 184.23 .
Physical properties about Ethyl 3-cyclopentyl-3-oxopropanoate are: (1)ACD/LogP: 2.21; (2)ACD/LogD (pH 5.5): 2.21; (3)ACD/LogD (pH 7.4): 2.21; (4)ACD/BCF (pH 5.5): 28.23; (5)ACD/BCF (pH 7.4): 28.21; (6)ACD/KOC (pH 5.5): 380.19; (7)ACD/KOC (pH 7.4): 379.9; (8)#H bond acceptors: 3; (9)#Freely Rotating Bonds: 5; (10)Polar Surface Area: 43.37Å2; (11)Index of Refraction: 1.466; (12)Molar Refractivity: 47.93 cm3; (13)Molar Volume: 172.9 cm3; (14)Polarizability: 19x10-24cm3; (15)Surface Tension: 38 dyne/cm; (16)Enthalpy of Vaporization: 49.27 kJ/mol; (17)Boiling Point: 255.3 °C at 760 mmHg; (18)Vapour Pressure: 0.0165 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(CC(=O)OCC)C1CCCC1
(2)InChI: InChI=1/C10H16O3/c1-2-13-10(12)7-9(11)8-5-3-4-6-8/h8H,2-7H2,1H3
(3)InChIKey: MUDKQMLLCRJCEY-UHFFFAOYAU
(4)Std. InChI: InChI=1S/C10H16O3/c1-2-13-10(12)7-9(11)8-5-3-4-6-8/h8H,2-7H2,1H3
(5)Std. InChIKey: MUDKQMLLCRJCEY-UHFFFAOYSA-N
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