Product Name

  • Name

    FLURBIPROFEN AXETIL

  • EINECS 1308068-626-2
  • CAS No. 91503-79-6
  • Article Data2
  • CAS DataBase
  • Density 1.169g/cm3
  • Solubility Insoluble in water
  • Melting Point
  • Formula C19H19 F O4
  • Boiling Point 424.3°Cat760mmHg
  • Molecular Weight 330.356
  • Flash Point 203°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion, subcutaneous, and intravenous routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of F−.
  • Risk Codes
  • Molecular Structure Molecular Structure of 91503-79-6 (FLURBIPROFEN AXETIL)
  • Hazard Symbols
  • Synonyms 1-Acetoxyethyl2-(2-fluoro-4-biphenylyl)propionate;Flurbiprofen axetil;LFP 83;Ropiopn;1-Acetoxyethyl 2-(2-fluorobiphenyl-4-yl)propanoate;
  • PSA 52.60000
  • LogP 4.04850

Flurbiprofen axetil Chemical Properties

Molecular Structure of Flurbiprofen axetil (CAS NO.91503-79-6):

IUPAC Name: 1-Acetyloxyethyl 2-(3-fluoro-4-phenylphenyl)propanoate 
Molecular Formula: C19H19FO4
Molecular Weight: 330.350163 g/mol
XLogP3: 4.9
H-Bond Donor: 0
H-Bond Acceptor: 5
Canonical SMILES: CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)OC(C)OC(=O)C
InChI: InChI=1S/C19H19FO4/c1-12(19(22)24-14(3)23-13(2)21)16-9-10-17(18(20)11-16)15-7-5-4-6-8-15/h4-12,14H,1-3H3
InChIKey: ALIVXCSEERJYHU-UHFFFAOYSA-N
Index of Refraction: 1.528
Molar Refractivity: 87.06 cm3
Molar Volume: 282.3 cm3
Surface Tension: 39.7 dyne/cm
Density: 1.169 g/cm3
Flash Point: 203 °C
Enthalpy of Vaporization: 67.87 kJ/mol
Boiling Point: 424.3 °C at 760 mmHg
Vapour Pressure: 2.09E-07 mmHg at 25 °C
Water Solubility of Flurbiprofen axetil (CAS NO.91503-79-6): 1.363 mg/L at 25 °C

Flurbiprofen axetil Toxicity Data With Reference

1.    

orl-rat LD50:66 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 22 (1988),3949.
2.    

scu-rat LD50:66 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 22 (1988),3949.
3.    

ivn-rat LD50:88 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 22 (1988),3949.
4.    

orl-mus LD50:69 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 22 (1988),3949.
5.    

scu-mus LD50:183 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 22 (1988),3949.
6.    

ivn-mus LD50:194 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 22 (1988),3949.

Flurbiprofen axetil Safety Profile

Poison by ingestion, subcutaneous, and intravenous routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of F−.

Flurbiprofen axetil Specification

  Flurbiprofen axetil is colorless to pale yellow transparent oily with slightly smelly, bitter taste, immiscibility in methanol, ethanol, acetonitrile or acetone . It is a prodrug of Flurbiprofen and often used to relieve pain of post-operative and various kinds of cancer. Flurbiprofen axetil with CAS registry number of 91503-79-6 is also known as FP 83 ; 1-Acetoxyethyl 2-(2-fluoro-4-biphenylyl)propionate ; 1-Acetoxyethyl-2-(2-fluoro-4-biphenylyl)propionate ; 2-Fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic acid 1-(acetyloxy)ethyl ester ; 4-Biphenylacetic acid, 2-fluoro-alpha-methyl-, 1-acetoxyethyl ester ; Flurbiprofen axetil ; LFP 83 ; Lipfen ; Lipo-flurbiprofen axetil ; Liposomal flurbiprofen axetil ; Ropion ; (1,1'-Biphenyl)-4-acetic acid, 2-fluoro-alpha-methyl-, 1-(acetyloxy)ethyl ester .

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