Hyaluronic acid

The Hyaluronic acid is a polymer of disaccharides composed of D-glucuronic acid and D-N-acetylglucosamine with molecular formula (C₁₄H₂₁NO₁₁)_n. With cas registry number of 9004-61-9, this chemcial is also known as Hyaluronan; HA. Besides, it also has other registry numbers wich include 165324-65-2, 29382-75-0, 37243-73-5, and 9039-38-7. It is unique among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi, and can be very large, with its molecular weight often reaching the millions.

Physical properties about Hyaluronic acid are: (1)ACD/LogP: -1.131; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): -3.85; (4)ACD/LogD (pH 7.4): -4.83; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00 ; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 12; (10)#H bond donors: 7; (11)#Freely Rotating Bonds: 10; (12)Flash Point: 432.5 °C ; (13)Enthalpy of Vaporization: 131.19 kJ/mol; (14)Boiling Point: 791.6 °C at 760 mmHg; (15)Vapour Pressure: 5.77E-29 mmHg at 25°C

Preparation of Hyaluronic acid: Hyaluronic acid is derived from hyalos (Greek for vitreous) and uronic acid because it was first isolated from the vitreous humour and possesses a high uronic acid content. It is synthesized by a class of integral membrane proteins called hyaluronan synthases, of which vertebrates have three types: HAS1, HAS2, and HAS3.

Uses of Hyaluronic acid: this compound is naturally found in many tissues of the body, such as skin, cartilage, and the vitreous humour. It is therefore well suited to biomedical applications targeting these tissues. Thus, it can be used as a common ingredient in skin care products which is considered as the natural molsturlzlng factor. It can be added to almost any cosmetics, widely used in cream, lotion, lotion, essence, facial cleanser, shower gel, shampoo, hair extension agent, mousse, lipstick and other cosmetics with adding amount 0.05 -0.5% in general. Besides, it is also used in treatment of articular disorders in horses, particularly those in competition or heavy work.

You can still convert the following datas into molecular structure:
(1)InChI: InChI=1/C28H44N2O23/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45)/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18?,19?,20+,21+,22+,25-,26+,27-,28-/m1/s1;
(2)Smiles: O([C@@H]1[C@H]([C@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3[C@H]([C@@H](O[C@@H]([C@H]3O)CO)O)NC(C)=O)[C@@H]([C@H]2O)O)C(O)=O)O[C@@H]([C@H]1O)CO)NC(C)=O)[C@@H]1O[C@@H]([C@@H](O)[C@@H]([C@H]1O)O)C(O)=O