The systematic name of Hydroxyethyl starch is Starch, 2-hydroxyethyl ether. With the CAS registry number 9005-27-0, it is also named as 2-Hydroxyethyl starch ether. The product's categories are Carbohydrates; Carbohydrates A to; Carbohydrates H-LBiochemicals and Reagents; Polysaccharide, and the other registry numbers are 115252-32-9; 204144-00-3; 39363-84-3; 39363-85-4; 62253-20-7; 73666-73-6; 87140-13-4; 9057-07-2; 936087-55-7; 936087-60-4. Besides, it is a nonionic starch derivative.
Uses of Hydroxyethyl starch: because it can increase the blood volume, allowing red blood cells to continue to deliver oxygen to the body. This chemical can be used to prevent shock following severe blood loss caused by trauma, surgery, or some other problem.
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | > 300gm/kg (300000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 16, Pg. 431, 1974. | |
mouse | LD50 | intravenous | 20300mg/kg (20300mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972. |
mouse | LD50 | oral | > 12gm/kg (12000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972. | |
mouse | LD50 | subcutaneous | > 18gm/kg (18000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972. | |
rabbit | LD50 | intravenous | 8460mg/kg (8460mg/kg) | Drugs in Japan Vol. -, Pg. 1007, 1995. | |
rat | LD50 | intraperitoneal | > 300gm/kg (300000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 16, Pg. 431, 1974. | |
rat | LD50 | intravenous | 8280mg/kg (8280mg/kg) | Drugs in Japan Vol. -, Pg. 1007, 1995. | |
rat | LD50 | oral | > 50gm/kg (50000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 16, Pg. 431, 1974. | |
rat | LD50 | subcutaneous | > 18gm/kg (18000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972. |
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