Conditions | Yield |
---|---|
With dimethylsulfide; hydrogen fluoride at 0℃; for 2h; Product distribution; Var.: HF in anisole; | 100% |
Boc-(S)-Lys(2-Cl-Z)-OH
L-lysine
Conditions | Yield |
---|---|
With Nafion H; dimethylsulfide; 3-methyl-phenol; trifluoroacetic acid for 3h; | 100% |
H-Lys(Mtr)-OH
L-lysine
Conditions | Yield |
---|---|
With methanesulfonic acid; methanesulfonic acid in trifluoroacetic acid-thioanisole; trifluoroacetic acid at 20℃; for 2h; Product distribution; effect of the concentration of methanesulfonic acid; deprotection of the Mtr group with various deprotecting agents (TFA-thioanisole, HF-thioanisole, TFA, methanesulfonic acid-thioanisole); | 99.3% |
With methanesulfonic acid; dimethylsulfide; TFA-thioanisole at 20℃; for 1h; Product distribution; in the presence or absence of methyl sulfide; variation of MSA concentration and time; | 98.9% |
With methanesulfonic acid; dimethylsulfide; methyl-phenyl-thioether; trifluoroacetic acid at 20℃; for 1h; Yield given; | |
With methanesulfonic acid In trifluoroacetic acid at 20℃; for 2h; |
Z(OMe)-Lys(Z)-OH
L-lysine
Conditions | Yield |
---|---|
With trimethylsilyl trifluoromethanesulfonate; methyl-phenyl-thioether In trifluoroacetic acid at 0℃; for 0.5h; | 98.7% |
With trimethylsilyl trifluoromethanesulfonate; methyl-phenyl-thioether In trifluoroacetic acid at 0℃; for 0.5h; Product distribution; further protected amino acids; var. of reagents, temperature and time; | 98.7% |
With trimethylsilyl trifluoromethanesulfonate; methyl-phenyl-thioether In trifluoroacetic acid at 22℃; for 1h; Product distribution; New peptide deprotection procedure: hard-soft acid-base concept; the role of soft bases (thioanisole, dimethylsulfide, diphenylsulfide) employed; effect of var. hard bases; var. reaction cond.; | 98.7% |
With trimethylsilyl trifluoromethanesulfonate; methyl-phenyl-thioether In trifluoroacetic acid for 0.5h; Product distribution; var. other protected amino acids; var. protecting groups; | 98.7% |
Conditions | Yield |
---|---|
With hydrogen; hydroxyapatite-bound Pd In methanol at 40℃; for 3h; | 93% |
With sodium tetrahydroborate In methanol; aq. phosphate buffer at 20℃; for 2h; Cooling with ice; Sealed tube; | 90% |
With formic acid; palladium In methanol | |
With cell extract of Sphingomonas paucimobilis SC 16113 In water at 42℃; for 20h; Enzymatic reaction; | 98 % Chromat. |
With ethylenediaminetetraacetic acid; phenylmethylsulphonyl fluoride; water In aq. phosphate buffer at 30℃; Kinetics; Reagent/catalyst; Microbiological reaction; Enzymatic reaction; |
Conditions | Yield |
---|---|
With tetradecyl(trihexyl)phosphonium bistriflamide; trifluoroacetic acid at 130℃; for 0.183333h; Ionic liquid; | 93% |
Multi-step reaction with 3 steps 1: dicyclohexyl-carbodiimide / dichloromethane / 20 °C 2: hydrogen bromide; acetic acid / 2 h / 20 °C 3: Pseudomonas aeruginosa ORF PA0919; mono-p-nitrophenyl phosphate / dimethyl sulfoxide; aq. phosphate buffer / 22 °C / pH 6.8 View Scheme |
L-lysine
Conditions | Yield |
---|---|
With dimethyl ether-poly(hydrogen fluoride) at 0℃; for 1h; | 91% |
L-lysine
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 20℃; for 0.5h; Inert atmosphere; | 91% |
Fmoc-Lys-OH
L-lysine
Conditions | Yield |
---|---|
With sodium azide In N,N-dimethyl-formamide at 50℃; for 4h; | 90% |
Conditions | Yield |
---|---|
With hydrogen; hydroxyapatite-bound Pd In methanol at 40℃; for 12h; | 88% |
With cell extract of Sphingomonas paucimobilis SC 16113 In water at 42℃; for 20h; Enzymatic reaction; | 72 % Chromat. |
L-lysine
Conditions | Yield |
---|---|
With ruthenium nanoparticles dispersed in a polyvinylpyrrolidone matrix; amberlyst A-21 In methanol; dichloromethane | 82% |
propan-1-ol
L-Lysine ethyl ester
A
L-lysine
B
L-lysine n-propyl ester
Conditions | Yield |
---|---|
immobilized trypsin at 25℃; 5percent 0.1 M acetate buffer, pH:6.2; | A n/a B 80% |
ethanol
L-lysine n-propyl ester
A
L-Lysine ethyl ester
B
L-lysine
Conditions | Yield |
---|---|
immobilized trypsin at 25℃; 5percent 0.1 M acetate buffer, pH:6.2; | A 80% B n/a |
L-lysine
Conditions | Yield |
---|---|
With trypsin In water for 24h; Product distribution; several reaction times; | 60% |
Conditions | Yield |
---|---|
With hydrogenchloride at 115℃; for 18h; Product distribution; also influence of D-glucose; | A 35% B n/a |
(S)-6-acetamido-2-((tertbutoxycarbonyl)amino)hexanoic acid
1,1-bis(4-aminophenyl)-2,2-diphenylethene
A
L-lysine
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 5h; Inert atmosphere; | A n/a B 12% |
2,6-diaminocaproic acid
D-(+)-camphoric acid
L-lysine
2,6-diaminocaproic acid
L-lysine
Conditions | Yield |
---|---|
With (-)-(R,R)-dibenzoyltartaric acid | |
With N-acetyl-3,5-dibromo-L-tyrosine | |
With L-glutamic acid |
Conditions | Yield |
---|---|
Herstellung mit Hilfe von Backhefe oder von Torulopsis utilis; |
Conditions | Yield |
---|---|
With ammonium chloride Herstellung mit Hilfe von Micrococcus glutamicus; | |
With PO4 Herstellung mit Hilfe von Ustilago maydis; |
Conditions | Yield |
---|---|
Herstellung mit Hilfe eines Enzym-Praeparats aus Pseudomonas; |
Conditions | Yield |
---|---|
Herstellung mit Hilfe eines Enzym-Praeparats aus Aspergillus oryzae; |
methanol
A
L-threonine
B
L-lysine
C
L-Aspartic acid
D
L-glutamic acid
Conditions | Yield |
---|---|
at 30℃; for 72h; Product distribution; time-course, Methylobacillus glycogenes ATCC 21371 (ATR80) mutant, other mutants, other strains; |
Conditions | Yield |
---|---|
In water-d2 at 25℃; Equilibrium constant; effect of the pH; |
2,6-diaminocaproic acid
A
D-lysine
B
L-lysine
Conditions | Yield |
---|---|
at 30℃; pH 6.0; Saccaromyces cerevisiae strain AJI4599; other strains; |
Conditions | Yield |
---|---|
With methyl-phenyl-thioether In trifluoroacetic acid at 25℃; for 3h; Yield given; | |
With trifluoroacetic acid In dichloromethane at 20℃; Rate constant; | |
With methyl-phenyl-thioether; trifluoroacetic acid at 25℃; Product distribution; conversion as a function of time, also in the case of other reagents: TFA/DMSO, TFA/anisole; | |
With methyl-phenyl-thioether; trifluoroacetic acid at 28℃; for 24h; Product distribution; var. reag.: dimethylsulfide, ethanedithiol, 2-mercaptoethanol; var. time; | |
With cell extract of Sphingomonas paucimobilis SC 16113 In water at 42℃; for 20h; Enzymatic reaction; | 98 % Chromat. |
Conditions | Yield |
---|---|
With wheat carboxypeptidase from wheat bran at 30℃; Rate constant; pH 4.0; structure-reactivity relationship; |
L-lysine ethyl ester dihydrochloride
A
lysine tetrapeptide
B
poly(L-lysine), 5-mer
C
L-lysine
D
dilysine
E
Lys-Lys-Lys
F
hexalysine
Conditions | Yield |
---|---|
multistep reaction; 1.) trypsin, Na2CO3 buffer pH 10.0, 25 deg C, 2.) NaOH, 60 deg C, 15 min; trypsin-catalyzed oligomerization of L-lysine esters, pH-dependence, reaction rate, kinetics, effect of NaCl; other L-lysin alkyl esters, enzyme or amino acids; |
methanol
L-lysine
lysine methyl ester dihydrochloride
Conditions | Yield |
---|---|
Stage #1: methanol With thionyl chloride at 0℃; for 0.166667h; Stage #2: L-lysine at 0℃; for 3.16667h; Reflux; | 100% |
Stage #1: methanol With thionyl chloride at 0℃; Stage #2: L-lysine at 0 - 80℃; for 1.66667h; | 96% |
With hydrogenchloride | 87% |
Stage #1: methanol; L-lysine With thionyl chloride at 0℃; Reflux; Stage #2: With hydrogenchloride | 85.8% |
Stage #1: methanol With thionyl chloride at 0℃; for 0.5h; Stage #2: L-lysine Heating; |
L-lysine
S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid
Conditions | Yield |
---|---|
In methanol; water at 65 - 70℃; for 0.25h; Product distribution / selectivity; | 100% |
In water; acetone at 70℃; for 1h; Product distribution / selectivity; |
L-lysine
Conditions | Yield |
---|---|
In methanol at 20℃; for 2h; | 100% |
L-lysine
Conditions | Yield |
---|---|
In ethanol; water Heating; | 100% |
Conditions | Yield |
---|---|
With thionyl chloride at 0℃; for 0.333333h; | 100% |
L-lysine
1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate
Conditions | Yield |
---|---|
In water pH=9.63; Cooling with ice; | 100% |
Conditions | Yield |
---|---|
In water at 10℃; pH=Ca. 6 - 6.2; | 100% |
L-lysine
3,3,4,4,5,5,6,6,7,7,8,8,8,9,10,10,10,10-heptadecafluoro-1-decathioacetic acid
Conditions | Yield |
---|---|
In methanol; water for 2h; Reflux; | 100% |
L-lysine
Conditions | Yield |
---|---|
In methanol; water for 2h; Reflux; | 100% |
Conditions | Yield |
---|---|
In methanol at 20℃; for 4.5h; | 99.98% |
Conditions | Yield |
---|---|
With sodium hydroxide In 1,4-dioxane; water at 20℃; for 1h; pH=10 - 11; | 99% |
With sodium carbonate In diethyl ether; water at 0℃; for 5h; | 95% |
With sodium carbonate In diethyl ether; water at 0℃; for 5h; | 93% |
Conditions | Yield |
---|---|
In methanol; water at 10 - 15℃; | 99% |
L-lysine
Conditions | Yield |
---|---|
In water at 10℃; pH=Ca. 6.4 - 6.7; | 99% |
L-lysine
Conditions | Yield |
---|---|
In methanol for 2h; Reflux; | 99% |
Conditions | Yield |
---|---|
In methanol; water Heating; | 99% |
Conditions | Yield |
---|---|
In methanol; water Heating; | 99% |
Conditions | Yield |
---|---|
In methanol; water Heating; | 99% |
Conditions | Yield |
---|---|
In methanol; water Heating; | 99% |
Conditions | Yield |
---|---|
In methanol; water Heating; | 99% |
L-lysine
3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctanoic acid
Conditions | Yield |
---|---|
In methanol; water Heating; | 99% |
L-lysine
2-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)-malonic acid
Conditions | Yield |
---|---|
In methanol; water Heating; | 99% |
L-lysine
2-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)-malonic acid
Conditions | Yield |
---|---|
In methanol; water Heating; | 99% |
L-lysine
3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-1-octa-6-thiohexanoic acid
Conditions | Yield |
---|---|
In methanol; water for 2h; Reflux; | 99% |
L-lysine
Conditions | Yield |
---|---|
In water at 20℃; for 2h; | 98.16% |
Conditions | Yield |
---|---|
In methanol; ethanol at 20℃; for 2h; | 98.1% |
Conditions | Yield |
---|---|
In methanol Ambient temperature; | 98% |
Stage #1: L-lysine; acrylic acid methyl ester With sodium hydroxide In methanol Reflux; Stage #2: With hydrogenchloride In methanol | 48.8% |
With sodium hydroxide In methanol for 48h; Michael Addition; Heating; | 48.8% |
The L-Lysine, with the cas registry number 56-87-1, has the IUPAC name of (2S)-2,6-diaminohexanoic acid. This is a kind of white or almost white crystalline powder with no odour, and it is stable chemically but incompatible with strong oxidizing agents. Besides, its product categories are various, including Amino Acid Derivatives; Lysine [Lys, K]; Amino Acids; alpha-Amino Acids; Biochemistry; Nutritional Supplements; Amino Acids.
The characteristics of this kind of chemical are as follows: (1)ACD/LogP: -1.04; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -4.54; (4)ACD/LogD (pH 7.4): -4.5; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 4; (10)#H bond donors: 5; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 32.78; (13)Index of Refraction: 1.503; (14)Molar Refractivity: 38.43 cm3; (15)Molar Volume: 129.9 cm3; (16)Polarizability: 15.23×10-24 cm3; (17)Surface Tension: 51.5 dyne/cm; (18)Density: 1.125 g/cm3; (19)Flash Point: 142.2 °C; (20)Enthalpy of Vaporization: 60.75 kJ/mol; (21)Boiling Point: 311.5 °C at 760 mmHg; (22)Vapour Pressure: 0.000123 mmHg at 25°C; (23)Exact Mass: 146.105528; (24)MonoIsotopic Mass: 146.105528; (25)Topological Polar Surface Area: 89.3; (26)Heavy Atom Count: 10; (27)Formal Charge: 0; (28)Complexity: 106.
The production methods of this chemical are as follows: (1) Free L-Lysine could be obtained from L-lysine hydrochloride. (2) Firstly prepare raw material of Red blood cells, and then suspend it in sulfuric acid solution; Secondly, use the calcium hydroxide to precipitate, and then go through the washing, crystallization to get L-Lysine (CAS NO.56-87-1). (3) Synthesis method: caprolactam and furfural as the raw material.
As to its usage, it is widely applied in many ways. It could be used as the nutrition enhancer which could enhance the lysine in intensified [enriched] food; It could also used in biochemistry to cure the symptom of malnutrition, inappetence and hypoplasia; And it could be as the Aminoacetic Acid, and the feed additives.
Below are the safety information of this chemical: Being a kind of irritant chemical, it may cause inflammation to the skin or other mucous membranes, so you should avoid contacting with skin and eyes while using.
Additionally, the following datas could be converted into the molecular structure:
(1)Canonical SMILES: C(CCN)CC(C(=O)O)N
(2)Isomeric SMILES: C(CCN)C[C@@H](C(=O)O)N
(3)InChI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/m0/s1
(4)InChIKey: KDXKERNSBIXSRK-YFKPBYRVSA-N
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