Product Name

  • Name

    4-CHLOROPHENYLMAGNESIUM BROMIDE

  • EINECS 212-853-8
  • CAS No. 873-77-8
  • Article Data19
  • CAS DataBase
  • Density 0.887 g/mL at 25 °C
  • Solubility It reacts violently with water.
  • Melting Point
  • Formula C6H4BrClMg
  • Boiling Point 115 °C(Press: 0.04 Torr)
  • Molecular Weight 215.76
  • Flash Point -40 °F
  • Transport Information UN 3399
  • Appearance light grey to brown-black solution when properly
  • Safety 9-16-26-29-33-36/37/39-45
  • Risk Codes 12-19-22-34-67
  • Molecular Structure Molecular Structure of 873-77-8 (4-CHLOROPHENYLMAGNESIUM BROMIDE)
  • Hazard Symbols F+,C,F
  • Synonyms Magnesium,bromo(p-chlorophenyl)- (8CI);p-Chlorophenylmagnesium bromide (6CI);(4-Chlorophenyl)magnesium bromide;Bromo(4-chlorophenyl)magnesium;
  • PSA 0.00000
  • LogP 2.98580

Synthetic route

bromochlorobenzene
106-39-8

bromochlorobenzene

(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

Conditions
ConditionsYield
With magnesium In tetrahydrofuran at 20 - 25℃; for 5h;95%
With magnesium In diethyl ether
With magnesium In tetrahydrofuran
bromochlorobenzene
106-39-8

bromochlorobenzene

magnesium
7439-95-4

magnesium

(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

Conditions
ConditionsYield
iodine In tetrahydrofuran at 70℃; for 1.5h; Heating / reflux;
In tetrahydrofuran at 20℃; for 2h;
In tetrahydrofuran Inert atmosphere;
With iodine In tetrahydrofuran at 20℃;
With lithium chloride In tetrahydrofuran at 0 - 25℃; for 0.5h; Inert atmosphere; Schlenk technique;
bromochlorobenzene
106-39-8

bromochlorobenzene

1-azaspiro[4.5]decan-4-one

1-azaspiro[4.5]decan-4-one

ammonium chloride

ammonium chloride

(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

Conditions
ConditionsYield
In toluene
...Expand
bromochlorobenzene
106-39-8

bromochlorobenzene

1-azaspiro[5.5]undecan-5-one
158721-23-4

1-azaspiro[5.5]undecan-5-one

A

5-(4-chlorophenyl)-5-hydroxy-1-azaspiro[5.5]-undecane
158720-94-6

5-(4-chlorophenyl)-5-hydroxy-1-azaspiro[5.5]-undecane

B

(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

Conditions
ConditionsYield
In toluene
...Expand
bromochlorobenzene
106-39-8

bromochlorobenzene

6-azaspiro[4.5]decan-10-one
158721-26-7

6-azaspiro[4.5]decan-10-one

(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

Conditions
ConditionsYield
With sodium hydroxide In water
bromochlorobenzene
106-39-8

bromochlorobenzene

methyl 3-(1-benzyl-1H-imidazol-5-yl)propanoate
123261-02-9

methyl 3-(1-benzyl-1H-imidazol-5-yl)propanoate

(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

Conditions
ConditionsYield
With magnesium In tetrahydrofuran
2-chloro-N-methoxy-N-methyl-pyridine-3-carboxamide
488149-34-4

2-chloro-N-methoxy-N-methyl-pyridine-3-carboxamide

(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

2-chloro-3-(4-chlorobenzoyl)-pyridine
80099-85-0

2-chloro-3-(4-chlorobenzoyl)-pyridine

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 20℃; for 2h;100%
In tetrahydrofuran; diethyl ether at 5 - 8℃; Inert atmosphere;100%
In tetrahydrofuran; diethyl ether at 5 - 20℃; for 19.25h; Grignard reaction; Inert atmosphere;100%
In tetrahydrofuran at 0 - 20℃; for 2h;
(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

(Z)-3-(4-chloro-phenyl)-2-cyano-acrylic acid ethyl ester
29708-07-4

(Z)-3-(4-chloro-phenyl)-2-cyano-acrylic acid ethyl ester

ethyl 3,3-bis(4-chlorophenyl)-2-cyanoacrylate
14442-40-1

ethyl 3,3-bis(4-chlorophenyl)-2-cyanoacrylate

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether; toluene for 1h; Heating / reflux;100%
Stage #1: (4-chlorphenyl)magnesium bromide; (Z)-3-(4-chloro-phenyl)-2-cyano-acrylic acid ethyl ester In diethyl ether; toluene for 1h; Heating / reflux;
Stage #2: With hydrogenchloride; water In diethyl ether; toluene
Stage #3: With sodium hydrogencarbonate In diethyl ether; ethyl acetate; toluene		100%
pivalaldehyde
630-19-3

pivalaldehyde

(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

(+/-)-2,2-dimethyl-1-(p-chlorophenyl)propan-1-ol
6200-21-1

(+/-)-2,2-dimethyl-1-(p-chlorophenyl)propan-1-ol

Conditions
ConditionsYield
In diethyl ether100%
Dimethylamino-(1,4-dioxa-spiro[4.5]dec-8-yl)-acetonitrile
943002-79-7

Dimethylamino-(1,4-dioxa-spiro[4.5]dec-8-yl)-acetonitrile

(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

[(4-Chlorophenyl)-(1,4-dioxa-spiro[4.5]dec-8-yl)-methyl]-dimethyl-amine
943030-31-7

[(4-Chlorophenyl)-(1,4-dioxa-spiro[4.5]dec-8-yl)-methyl]-dimethyl-amine

Conditions
ConditionsYield
In diethyl ether at 0 - 20℃; for 20h;100%
In tetrahydrofuran at 0 - 20℃; for 20h;100%
In diethyl ether at 0 - 20℃; for 20h;100%
Stage #1: Dimethylamino-(1,4-dioxa-spiro[4.5]dec-8-yl)-acetonitrile; (4-chlorphenyl)magnesium bromide In diethyl ether at 20℃; for 20h;
Stage #2: With ammonium chloride In diethyl ether; water at 0℃;		100%
Stage #1: Dimethylamino-(1,4-dioxa-spiro[4.5]dec-8-yl)-acetonitrile; (4-chlorphenyl)magnesium bromide In diethyl ether at 20℃; Inert atmosphere; Cooling with ice;
Stage #2: With water; ammonium chloride In tetrahydrofuran Cooling with ice;		100%
(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

N2-(tert-butoxycarbonyl)-N-methoxy-N-methyl-D,L-valinamide
293329-55-2

N2-(tert-butoxycarbonyl)-N-methoxy-N-methyl-D,L-valinamide

tert-butyl 1-(4-chlorophenyl)-3-methyl-1-oxobutan-2-ylcarbamate
1394017-59-4

tert-butyl 1-(4-chlorophenyl)-3-methyl-1-oxobutan-2-ylcarbamate

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 16h; Inert atmosphere;100%
In tetrahydrofuran at -50 - 20℃; for 5.16667h;3.6 g
In tetrahydrofuran at -50 - 20℃; for 5.16667h;
6-((triisopropylsilyl)oxy)hex-2-yn-1-yl methanesulfonate

6-((triisopropylsilyl)oxy)hex-2-yn-1-yl methanesulfonate

(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

((4-(4-chlorophenyl)hexa-4,5-dien-1-yl)oxy)triisopropylsilane

((4-(4-chlorophenyl)hexa-4,5-dien-1-yl)oxy)triisopropylsilane

Conditions
ConditionsYield
Stage #1: (4-chlorphenyl)magnesium bromide With copper(l) iodide; lithium bromide In tetrahydrofuran at -78℃; for 2h; Inert atmosphere;
Stage #2: 6-((triisopropylsilyl)oxy)hex-2-yn-1-yl methanesulfonate In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;		100%
(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

pentan-3-one
96-22-0

pentan-3-one

3-(4'-chlorophenyl)pentan-3-ol
76481-35-1

3-(4'-chlorophenyl)pentan-3-ol

Conditions
ConditionsYield
In dichloromethane at 0 - 20℃;99%
In tetrahydrofuran for 0.5h;
(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

(E)-1-(2-(methylthio)phenyl)-2-pyrrolidinyl-1-nitroethene
389838-02-2

(E)-1-(2-(methylthio)phenyl)-2-pyrrolidinyl-1-nitroethene

(E)-2-(4-chlorophenyl)-1-[2-(methylthio)phenyl]-1-nitroethylene
728895-74-7

(E)-2-(4-chlorophenyl)-1-[2-(methylthio)phenyl]-1-nitroethylene

Conditions
ConditionsYield
In tetrahydrofuran at -78℃;99%

Magnesium,bromo(4-chlorophenyl)- Specification

This chemical is called Magnesium,bromo(4-chlorophenyl)-, and its systematic name is bromo(4-chlorophenyl)magnesium. With the molecular formula of C6H4BrClMg, its molecular weight is 215.76. The CAS registry number of this chemical is 873-77-8. Additionally, its product categories are Aryl; Grignard Reagents; Organometallic Reagents.

Other characteristics of the Magnesium,bromo(4-chlorophenyl)- can be summarised as followings: (1)H-Bond Donor: 0; (2)H-Bond Acceptor: 2; (3)Rotatable Bond Count: 0; (4)Exact Mass: 213.903532; (5)MonoIsotopic Mass: 213.903532; (6)Topological Polar Surface Area: 0; (7)Heavy Atom Count: 9; (8)Formal Charge: 0; (9)Complexity: 133; (10)Isotope Atom Count: 0; (11)Defined Atom StereoCenter Count: 0; (12)Undefined Atom StereoCenter Count: 0; (13)Defined Bond StereoCenter Count: 0; (14)Undefined Bond StereoCenter Count: 0; (15)Covalently-Bonded Unit Count: 3.

Uses of this chemical: The 1-(4-chloro-phenyl)-2,2,2-trifluoro-ethanone could be obtained by the reactants of Magnesium,bromo(4-chlorophenyl)- and trifluoroacetic acid. This reaction needs the reagent of diethyl ether. The other condition is heating.

When you are using this chemical, please be cautious about it as the following: This chemical is extremely flammable. Keep it away from sources of ignition. It may form explosive peroxides, and its vapours may cause drowsiness and dizziness. Keep its container in a well-ventilated place. Do not empty it into drains. Wear suitable protective clothing, gloves and eye/face protection. Take precautionary measures against static discharges. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice. 

You can still convert the following datas into molecular structure: 
1.SMILES: Br[Mg]c1ccc(Cl)cc1
2.InChI: InChI=1/C6H4Cl.BrH.Mg/c7-6-4-2-1-3-5-6;;/h2-5H;1H;/q;;+1/p-1/rC6H4BrClMg/c7-9-6-3-1-5(8)2-4-6/h1-4H
3.InChIKey: CDEMHJCJMMOFMB-OOYVXOOFAU

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