Product Name

  • Name

    Mepivacaine hydrochloride

  • EINECS 217-023-9
  • CAS No. 1722-62-9
  • Density
  • Solubility
  • Melting Point 255-257oC (dec.)
  • Formula C15H22N2O.HCl
  • Boiling Point 383.1 °C at 760 mmHg
  • Molecular Weight 282.813
  • Flash Point 185.5 °C
  • Transport Information
  • Appearance White or off white crystalline powder
  • Safety 22-24/25
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 1722-62-9 (Mepivacaine hydrochloride)
  • Hazard Symbols HarmfulXn
  • Synonyms Carbocaine monohydrochloride;Chlorocain;Meaverin;Mepicaton;Mepident;Mepivacaine monohydrochloride;Mepivastesin;Optocain;Scandicain;Scandonest;Mepivacaine HCL;2',6'-Pipecoloxylidide, 1-methyl-, monohydrochloride (6CI,8CI);Carbocaina;
  • PSA 32.34000
  • LogP 3.53910

Synthetic route

potassium acesulfame
55589-62-3

potassium acesulfame

mepivacaine hydrochloride
1722-62-9

mepivacaine hydrochloride

mepivacaine acesulfamate

mepivacaine acesulfamate

Conditions
ConditionsYield
In acetonitrile at 50℃; for 4h; Sonication;97%
saccharin sodium salt
128-44-9

saccharin sodium salt

mepivacaine hydrochloride
1722-62-9

mepivacaine hydrochloride

mepivacaine saccharinate

mepivacaine saccharinate

Conditions
ConditionsYield
In acetonitrile at 50℃; for 4h; Sonication;95%
mepivacaine hydrochloride
1722-62-9

mepivacaine hydrochloride

sodium hydrogencarbonate
144-55-8

sodium hydrogencarbonate

methyl iodide
74-88-4

methyl iodide

2-{[(2,6-Dimethylphenyl)amino]carbonyl}-1,1-dimethylpiperidinium iodide
345261-08-7

2-{[(2,6-Dimethylphenyl)amino]carbonyl}-1,1-dimethylpiperidinium iodide

Conditions
ConditionsYield
In dichloromethane; water80%
...Expand

Mepivacaine hydrochloride Chemical Properties

Product Name: Carbocaine hydrochloride (CAS NO.1722-62-9)


IUPAC Name: N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide hydrochloride
Molecular Formula: C15H23ClN2O
Molecular Weight: 282.8089 g/mol
Mol File: 1722-62-9.mol
Appearance: White or off white crystalline powder
Boiling point: 383.1 °C at 760 mmHg
Flash Point: 185.5 °C
Enthalpy of Vaporization: 63.16 kJ/mol
Vapour Pressure: 4.52E-06 mmHg at 25°C
H-Bond Donor: 2
H-Bond Acceptor:2

Mepivacaine hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 20mg/kg (20mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 295, 1960.
guinea pig LD50 subcutaneous 94mg/kg (94mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 295, 1960.
mouse LD50 implant 260mg/kg (260mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 69, 1969.
mouse LD50 intraperitoneal 117mg/kg (117mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 40, Pg. 592, 1988.
mouse LD50 intravenous 32mg/kg (32mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 295, 1960.
mouse LD50 subcutaneous 260mg/kg (260mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 295, 1960.
rabbit LD50 implant 110mg/kg (110mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 69, 1969.
rabbit LD50 intravenous 22mg/kg (22mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 69, 1969.
rabbit LD50 subcutaneous 110mg/kg (110mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 295, 1960.

Mepivacaine hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

Mepivacaine hydrochloride Safety Profile

Poison by subcutaneous, intravenous, subcutaneous, and implant routes. Experimental reproductive effects. An anesthetic. When heated to decomposition it emits very toxic fumes of HCl and NOx.
Safety Information of Carbocaine hydrochloride (CAS NO.1722-62-9):
Hazard Codes: Xn
Risk Statements: 22 
22:  Harmful if swallowed
Safety Statements: 22-24/25
22:  Do not breathe dust 
24:  Avoid contact with skin 
25:  Avoid contact with eyes 

Mepivacaine hydrochloride Specification

 Carbocaine hydrochloride ,its CAS NO. is 1722-62-9,the synonyms is (+-)-1-Methyl-2',6'-pipecoloxylidide monohydrochloride ; (1-Methyl-DL-piperidine-2-carboxylic acid)-2,6-dimethylanilide hydrochloride ; 1-Methyl-2',6'-pipecoloxylidide hydrochloride ; 1-Methyl-2',6'-pipecoloxylidide monohydrochloride ; 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride, (+-)- ; Arestocaine hydrochloride ; Carbocain ; Carbocaina ; Carbocaine ; Isocaine hydrochloride ; Meaverin ; Mepivacaine HCl ; Mepivacaine hydrochloride ; Mepivastesin ; Polocaine ; Polocaine-MPF ; Sabol ; Scandicain ; Scandicaine ; Scandinibsa ; Scandonest ; Scandonest Plain ; 2',6'-Pipecoloxylidide, 1-methyl -, monohydrochloride ; 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, hydrochloride (1:1) ; 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride .

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