Product Name

  • Name

    Methyl 4-piperidinecarboxylate

  • EINECS 203-126-8
  • CAS No. 7462-86-4
  • Article Data10
  • CAS DataBase
  • Density 1.06
  • Solubility
  • Melting Point 160°C
  • Formula C7H13 N O2 . Cl H
  • Boiling Point 193.8 °C at 760 mmHg
  • Molecular Weight 179.647
  • Flash Point 89 ºC
  • Transport Information
  • Appearance
  • Safety 26-36
  • Risk Codes R36/37/38   
  • Molecular Structure Molecular Structure of 7462-86-4 (Methyl 4-piperidinecarboxylate)
  • Hazard Symbols
  • Synonyms 4-Piperidinecarboxylicacid, methyl ester, hydrochloride (9CI); Methyl isonipecotate hydrochloride;Methyl piperidine-4-carboxylate hydrochloride
  • PSA 38.33000
  • LogP 1.28980

Synthetic route

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate
124443-68-1

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In dichloromethane; ethyl acetate at 20℃; for 1.5h; Inert atmosphere;99%
With hydrogenchloride In dichloromethane; ethyl acetate at 20℃; for 1.5h;99%
With hydrogenchloride In 1,4-dioxane at 20℃; for 4h;99.57%
methanol
67-56-1

methanol

isonipecotic acid
498-94-2

isonipecotic acid

methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 80℃; for 3h;98.8%
With thionyl chloride for 2h; Reflux;98.4%
With thionyl chloride at 20℃; for 20h; Esterification;84%
isonipecotic acid
498-94-2

isonipecotic acid

methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

Conditions
ConditionsYield
In tetrahydrofuran; hydrogenchloride; methanol; water
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

benzyl bromide
100-39-0

benzyl bromide

1-benzyl-4-piperidinecarboxylic acid methyl ester
10315-06-7

1-benzyl-4-piperidinecarboxylic acid methyl ester

Conditions
ConditionsYield
With triethylamine In methanol for 6h; Reflux;94.2%
With triethylamine In dichloromethane at 20℃; Alkylation;79.7%
With triethylamine In dichloromethane at 10 - 20℃;
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

2,2-dimethylpropanoic anhydride
1538-75-6

2,2-dimethylpropanoic anhydride

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate
124443-68-1

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

Conditions
ConditionsYield
With sodium hydroxide In tert-butyl alcohol for 48h;92%
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

benzyl chloroformate
501-53-1

benzyl chloroformate

piperidine-1,4-dicarboxylic acid 1-benzyl ester 4-methyl ester
138163-07-2

piperidine-1,4-dicarboxylic acid 1-benzyl ester 4-methyl ester

Conditions
ConditionsYield
Stage #1: methyl piperidine-4-carboxylate hydrochloride With sodium hydrogencarbonate In 1,4-dioxane; water at 0 - 5℃;
Stage #2: benzyl chloroformate In 1,4-dioxane; water at 0 - 20℃; for 24h;		85%
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetic acid
189060-51-3

(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetic acid

methyl 1-[[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-carboxylate
189059-66-3

methyl 1-[[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-carboxylate

Conditions
ConditionsYield
With diethylphosphoryl cyanide; triethylamine In N,N-dimethyl-formamide at 20℃; for 0.5h;79%
(S)-5-(1-((tert-butoxycarbonyl)amino)ethyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-1,3-oxazole-4-carboxylic acid

(S)-5-(1-((tert-butoxycarbonyl)amino)ethyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-1,3-oxazole-4-carboxylic acid

methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

(S)-methyl 1-(5-(1-((tert-butoxycarbonyl)amino)ethyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-1,3-oxazole-4-carbonyl)piperidine-4-carboxylate

(S)-methyl 1-(5-(1-((tert-butoxycarbonyl)amino)ethyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-1,3-oxazole-4-carbonyl)piperidine-4-carboxylate

Conditions
ConditionsYield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere;78%
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 12h;78%
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

pivaloyl chloride
3282-30-2

pivaloyl chloride

methyl 1-pivaloylpiperidine-4-carboxylate
505088-49-3

methyl 1-pivaloylpiperidine-4-carboxylate

Conditions
ConditionsYield
Stage #1: methyl piperidine-4-carboxylate hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane for 0.166667h;
Stage #2: pivaloyl chloride In dichloromethane at 20℃;		77%
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

4-bromo-3-fluoroiodobenzene
136434-77-0

4-bromo-3-fluoroiodobenzene

methyl 1-(4-bromo-3-fluorophenyl)piperidine-4-carboxylate

methyl 1-(4-bromo-3-fluorophenyl)piperidine-4-carboxylate

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 12h; Inert atmosphere;74%
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 12h;74%
2-((2S,4R)-1-(5-((S)-1-((tert-butoxycarbonyl)amino)ethyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)oxazole-4-carbonyl)-4-((methoxycarbonyl)amino)pyrrolidin-2-yl)acetic acid

2-((2S,4R)-1-(5-((S)-1-((tert-butoxycarbonyl)amino)ethyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)oxazole-4-carbonyl)-4-((methoxycarbonyl)amino)pyrrolidin-2-yl)acetic acid

methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

methyl 1-(2-((2S,4R)-1-(5-((S)-1-((tert-butoxycarbonyl)amino)ethyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)oxazole-4-carbonyl)-4-((methoxycarbonyl)amino)pyrrolidin-2-yl)acetyl)piperidine-4-carboxylate

methyl 1-(2-((2S,4R)-1-(5-((S)-1-((tert-butoxycarbonyl)amino)ethyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)oxazole-4-carbonyl)-4-((methoxycarbonyl)amino)pyrrolidin-2-yl)acetyl)piperidine-4-carboxylate

Conditions
ConditionsYield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 10h; Cooling with ice;73%
6-fluoropyridine-3-sulfonyl chloride
1025509-80-1

6-fluoropyridine-3-sulfonyl chloride

methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

1-(6-fluoro-pyridine-3-sulfonyl)-piperidine-4-carboxylic acid methyl ester

1-(6-fluoro-pyridine-3-sulfonyl)-piperidine-4-carboxylic acid methyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 22℃; for 0.75h; Inert atmosphere;73%
With triethylamine In dichloromethane at 22℃; for 0.75h;73%
3-bromopropanol methyl ether
36865-41-5

3-bromopropanol methyl ether

methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

methyl-1-(3-methoxypropyl)piperidine-4-carboxylate

methyl-1-(3-methoxypropyl)piperidine-4-carboxylate

Conditions
ConditionsYield
With potassium carbonate In methanol at 75℃;72.2%
1-(2,5-bis(trifluoromethyl)phenyl)ethyl methanesulfonate

1-(2,5-bis(trifluoromethyl)phenyl)ethyl methanesulfonate

methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

methyl 1-(1-(2,5-bis(trifluoromethyl)phenyl)ethyl)piperidine-4-carboxylate

methyl 1-(1-(2,5-bis(trifluoromethyl)phenyl)ethyl)piperidine-4-carboxylate

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In acetonitrile at 85℃; for 12h;71%
(R)-tert-butyl 2-(3-bromo-5-fluorophenyl)-3-oxohexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylate

(R)-tert-butyl 2-(3-bromo-5-fluorophenyl)-3-oxohexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylate

methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

(R)-tert-butyl 2-(3-fluoro-5-(4-(methoxycarbonyl)piperidin-1-yl)phenyl)-3-oxohexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylate

(R)-tert-butyl 2-(3-fluoro-5-(4-(methoxycarbonyl)piperidin-1-yl)phenyl)-3-oxohexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxylate

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; tert-butyl XPhos In 1,4-dioxane at 90℃; for 12h; Inert atmosphere;70%
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

C21H19NO9

C21H19NO9

2-ethyl 3,4-dimethyl 5-[2-({1-[4-(methoxycarbonyl)piperidin-1-yl]-1-oxopropan-2-yl}carbamoyl)phenyl]furan-2,3,4-tricarboxylate

2-ethyl 3,4-dimethyl 5-[2-({1-[4-(methoxycarbonyl)piperidin-1-yl]-1-oxopropan-2-yl}carbamoyl)phenyl]furan-2,3,4-tricarboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 0.0833333h;66%
4-methoxyphenethyl bromide
14425-64-0

4-methoxyphenethyl bromide

methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

1-[2-(4-methoxyphenyl)-ethyl]-4-piperidinecarboxylic acid,methyl ester
124461-08-1

1-[2-(4-methoxyphenyl)-ethyl]-4-piperidinecarboxylic acid,methyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 90℃; for 17h; Heating;63%
With potassium carbonate In ethyl acetate; N,N-dimethyl-formamide; toluene
2-bromo-6-methyl-pyrazine
914452-71-4

2-bromo-6-methyl-pyrazine

methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

methyl 1-(6-methylpyrazin-2-yl)piperidine-4-carboxylate

methyl 1-(6-methylpyrazin-2-yl)piperidine-4-carboxylate

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In toluene at 90℃; for 16h;62.99%
2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetic acid
351185-23-4

2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetic acid

methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

1-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetylamino]piperidine-4-carboxylic acid

1-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetylamino]piperidine-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetic acid With benzotriazol-1-ol In N,N-dimethyl-formamide at 20℃; for 2h;
Stage #2: methyl piperidine-4-carboxylate hydrochloride With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 5h;
Stage #3: With sodium hydroxide at 20℃; for 1.5h;		55%
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

methyl 1-(1H-imidazole-1-carbonyl)piperidine-4-carboxylate

methyl 1-(1H-imidazole-1-carbonyl)piperidine-4-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;54%
indole
120-72-9

indole

formaldehyd
50-00-0

formaldehyd

methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

1-indol-3-ylmethyl-piperidine-4-carboxylic acid methyl ester

1-indol-3-ylmethyl-piperidine-4-carboxylic acid methyl ester

...Expand
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

piperidine-4-carboxylic acid hydrazide
42596-58-7

piperidine-4-carboxylic acid hydrazide

Conditions
ConditionsYield
With hydrazine hydrate
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

1-[8-(triphenylmethylsulfanyl)octyl]piperazine
337468-25-4

1-[8-(triphenylmethylsulfanyl)octyl]piperazine

cyclopentadienyl(1,4-dichlorobenzene)ruthenium hexafluorophosphate

cyclopentadienyl(1,4-dichlorobenzene)ruthenium hexafluorophosphate

bis[8-[4-[4-(4-methoxycarbonylpiperidino)phenyl]piperazino]octyl]disulfide

bis[8-[4-[4-(4-methoxycarbonylpiperidino)phenyl]piperazino]octyl]disulfide

Conditions
ConditionsYield
Stage #1: 1-[8-(triphenylmethylsulfanyl)octyl]piperazine; cyclopentadienyl(1,4-dichlorobenzene)ruthenium hexafluorophosphate With potassium carbonate In tetrahydrofuran at 20℃;
Stage #2: methyl piperidine-4-carboxylate hydrochloride With sodium hydroxide; potassium carbonate In tetrahydrofuran at 65 - 70℃; for 60h;
Stage #3: With ammonium hydroxide In acetonitrile for 48h; UV-irradiation;		20 mg
...Expand
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

1-benzyl-4-formylpiperidine
22065-85-6

1-benzyl-4-formylpiperidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 79.7 percent / Et3N / CH2Cl2 / 20 °C
2: 69.5 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 50 °C
3: 94.3 percent / oxalyl chloride; dimethyl sulfoxide; Et3N / CH2Cl2 / 0.25 h / -55 °C
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine / methanol / 6 h / Reflux
2.1: water; methanol; sodium hydroxide / 2 h / Reflux
3.1: thionyl chloride / 2 h / Reflux
3.2: 0.5 h / Cooling with ice
4.1: thionyl chloride / 5 h / Reflux
5.1: diisobutylaluminium hydride / toluene / 1 h / 0 °C
5.2: 0.5 h / pH 8
View Scheme
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

1-benzyl-4-piperidinemethanol
67686-01-5

1-benzyl-4-piperidinemethanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 79.7 percent / Et3N / CH2Cl2 / 20 °C
2: 69.5 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 50 °C
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / methanol / 6 h / Reflux
2: diisobutylaluminium hydride / toluene / 1 h / 0 °C
View Scheme
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

N-benzyl-4-[hydroxy(3-methoxyphenyl)methyl]piperidine
255723-94-5

N-benzyl-4-[hydroxy(3-methoxyphenyl)methyl]piperidine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 79.7 percent / Et3N / CH2Cl2 / 20 °C
2.1: 69.5 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 50 °C
3.1: 94.3 percent / oxalyl chloride; dimethyl sulfoxide; Et3N / CH2Cl2 / 0.25 h / -55 °C
4.1: Mg / tetrahydrofuran / 0.5 h / Heating
4.2: 94.3 percent / tetrahydrofuran / 2 h / 20 °C
View Scheme
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

3-[(1-benzyl-piperidin-4-yl)-(4-tert-butyl-phenyl)-methyl]-phenol

3-[(1-benzyl-piperidin-4-yl)-(4-tert-butyl-phenyl)-methyl]-phenol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 79.7 percent / Et3N / CH2Cl2 / 20 °C
2.1: 69.5 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 50 °C
3.1: 94.3 percent / oxalyl chloride; dimethyl sulfoxide; Et3N / CH2Cl2 / 0.25 h / -55 °C
4.1: Mg / tetrahydrofuran / 0.5 h / Heating
4.2: 94.3 percent / tetrahydrofuran / 2 h / 20 °C
5.1: 94.3 percent / AlCl3 / 0.05 h / Heating
6.1: 31 percent / BBr3 / CH2Cl2 / 1 h / 20 °C
View Scheme
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

N-benzyl-4-(4-tert-butyl-3'-methoxybenzhydryl)piperidine
255723-95-6

N-benzyl-4-(4-tert-butyl-3'-methoxybenzhydryl)piperidine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 79.7 percent / Et3N / CH2Cl2 / 20 °C
2.1: 69.5 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 50 °C
3.1: 94.3 percent / oxalyl chloride; dimethyl sulfoxide; Et3N / CH2Cl2 / 0.25 h / -55 °C
4.1: Mg / tetrahydrofuran / 0.5 h / Heating
4.2: 94.3 percent / tetrahydrofuran / 2 h / 20 °C
5.1: 94.3 percent / AlCl3 / 0.05 h / Heating
View Scheme
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]carbonyl]-1-piperidinecarboxylic acid,1,1-dimethylethyl ester
124443-69-2

4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]carbonyl]-1-piperidinecarboxylic acid,1,1-dimethylethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 92 percent / 1M aq. NaOH / 2-methyl-propan-2-ol / 48 h
2: 1.) n-BuLi / 1.) -78 deg C, THF, hexane, 15 min 2.) THF, 15 min, -78 deg C
View Scheme
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone
124461-07-0

[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl][1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]methanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 63 percent / dimethylformamide / 17 h / 90 °C / Heating
2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 15 min 2.) THF, a) 5-10 min, -78 deg C b) without cooling
View Scheme
Multi-step reaction with 4 steps
1: 92 percent / 1M aq. NaOH / 2-methyl-propan-2-ol / 48 h
2: 1.) n-BuLi / 1.) -78 deg C, THF, hexane, 15 min 2.) THF, 15 min, -78 deg C
3: 84 percent / 0.5 h / Ambient temperature
4: 57 percent / K2CO3 / dimethylformamide / 22 h / 90 °C
View Scheme
methyl piperidine-4-carboxylate hydrochloride
7462-86-4

methyl piperidine-4-carboxylate hydrochloride

<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>-4-piperidinylmethanone mono(trifluoroacetate)
124443-71-6

<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>-4-piperidinylmethanone mono(trifluoroacetate)

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / 1M aq. NaOH / 2-methyl-propan-2-ol / 48 h
2: 1.) n-BuLi / 1.) -78 deg C, THF, hexane, 15 min 2.) THF, 15 min, -78 deg C
3: 84 percent / 0.5 h / Ambient temperature
View Scheme

Methyl 4-piperidinecarboxylate Chemical Properties

Molecular Structure of Methyl 4-piperidinecarboxylate (CAS NO.7462-86-4):

IUPAC Name: methyl piperidine-4-carboxylate 
Empirical Formula: C7H13NO2
Molecular Weight: 143.1836
H bond acceptors: 3
H bond donors: 1
Freely Rotating Bonds: 2
Polar Surface Area: 29.54Å2
Index of Refraction: 1.445
Molar Refractivity: 37.35 cm3
Molar Volume: 140 cm3
Surface Tension: 31.7 dyne/cm
Density: 1.021 g/cm3
Flash Point: 71 °C
Enthalpy of Vaporization: 42.99 kJ/mol
Boiling Point: 193.8 °C at 760 mmHg
Vapour Pressure: 0.457 mmHg at 25°C
Melting point: 160°C
Product Categories: Esters; Pyrans, Piperidines &Piperazines; Pyrans, Piperidines & Piperazines

Methyl 4-piperidinecarboxylate Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.

Methyl 4-piperidinecarboxylate Specification

  Methyl 4-piperidinecarboxylate , with CAS number of 7462-86-4, can be called 4-piperidinecarboxylic acid, methyl ester ; Methyl piperidin-4-carboxylate ; Methyl piperidine-4-carboxylate ; Methylpiperidin-4-carboxylat .

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