N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine supplier

Name
N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine
EINECS
CAS No. 1550-50-1
Article Data3
CAS DataBase
Density 1.17 g/cm³
Solubility
Melting Point
Formula C₄H₇F₄N
Boiling Point 47.451 °C at 760 mmHg
Molecular Weight 145.1
Flash Point -17.5 °C
Transport Information UN 2734 8/PG 1
Appearance
Safety 26-36/37/39-45
Risk Codes 11-35
Molecular Structure
Hazard Symbols F, C
Synonyms Ethylamine,1,1,2,2-tetrafluoro-N,N-dimethyl- (6CI,8CI);1,1,2,2-Tetrafluoro-N,N-dimethylethanamine;N-(1,1,2,2-Tetrafluoroethyl)dimethylamine;
PSA 3.24000
LogP 1.40590

Synthetic route

: 116-14-3
polytetrafluoroethylene

: 124-40-3
dimethyl amine

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

Conditions

Conditions	Yield
at 20℃; for 12h;	98%
at -70℃;

: 667-50-5
Difluoroacetic acid N,N-dimethylamide

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

Conditions

Conditions	Yield
With Carbonyl fluoride at 20 - 25℃; for 16h; Neat (no solvent);	85%

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: 924-99-2, 1117-37-9, 114894-59-6
ethyl 3-(dimethylamino)acrylate

: 1009318-76-6
N-[(2E)-1-(difluoromethyl)-3-(dimethylamino)-2-(ethoxycarbonyl)prop-2-en-1-ylidene]-N-methylmethanaminium tetrafluoroborate

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 0.5h; Inert atmosphere; Stage #2: ethyl 3-(dimethylamino)acrylate In dichloromethane at 20℃; for 2h; Product distribution / selectivity; Inert atmosphere;	100%

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: 34846-90-7
methyl 3-methoxyprop-2-enoate

: 1009318-81-3
N-[(2E)-1-(difluoromethyl)-3-methoxy-2-(methoxycarbonyl)prop-2-en-1-ylidene]-N-methyl-methanaminium tetrafluoroborate

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 0.5h; Inert atmosphere; Stage #2: methyl 3-methoxyprop-2-enoate In dichloromethane at 20℃; for 2h; Inert atmosphere;	100%

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: difluoromethyl lactate

A: 667-50-5
Difluoroacetic acid N,N-dimethylamide

B: difluoromethyl 2-fluoropropionate

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; difluoromethyl lactate at 10 - 80℃; for 2h; Stage #2: With N-pyrazolyl-N-cyclohexyl-N-ethylamine at 0℃;	A n/a B 98.95%

...Expand

: 547-64-8
methyl lactate

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

A: 2366-56-5
methyl 2-fluoropropanoate

B: 667-50-5
Difluoroacetic acid N,N-dimethylamide

Conditions

Conditions	Yield
Stage #1: methyl lactate; 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine at 10 - 40℃; for 5h; Stage #2: With triethylamine at 0℃;	A 98.92% B n/a

...Expand

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: trifluoroethyl lactate

A: 667-50-5
Difluoroacetic acid N,N-dimethylamide

B: 2-trifluoroethyl fluoropropionate

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; trifluoroethyl lactate at 10 - 100℃; for 1h; Stage #2: With N-piperidin-1-yl-N-pyrid-1-yl-N-ethylamine at 0℃;	A n/a B 98.85%

...Expand

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: trifluoropropyl lactate

A: 667-50-5
Difluoroacetic acid N,N-dimethylamide

B: trifluoropropyl 2-fluoropropionate

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; trifluoropropyl lactate at 10 - 60℃; for 3h; Stage #2: With N-cyclohexyl-N-cyclopentyl-N-ethylamine at 0℃;	A n/a B 97.52%

...Expand

: 97-64-3, 2676-33-7
ethyl 2-hydroxypropionate

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

A: 349-43-9
ethyl 2-fluoropropionate

B: 667-50-5
Difluoroacetic acid N,N-dimethylamide

Conditions

Conditions	Yield
Stage #1: ethyl 2-hydroxypropionate; 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine at 10 - 50℃; for 4h; Stage #2: With dmap at 0℃;	A 96.62% B n/a

...Expand

: 118800-67-2
2-Methyl-2-<β-dimethylamino-vinyl>-1,3-dioxolan

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: 60-34-4
methylhydrazine

: 3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxolan-2-yl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 2-Methyl-2-<β-dimethylamino-vinyl>-1,3-dioxolan; 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride In tetrahydrofuran at 0 - 20℃; for 2.5h; Stage #2: methylhydrazine In tetrahydrofuran at 5 - 20℃; for 2.5h;	93.6%

...Expand

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: C7H13NO2

: 60-34-4
methylhydrazine

: 3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxetan-2-yl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; C7H13NO2 With boron trifluoride In acetonitrile at 20℃; for 2.5h; Stage #2: methylhydrazine In acetonitrile at 5 - 20℃; for 2.5h; Temperature;	93.3%

...Expand

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: 60-34-4
methylhydrazine

: 927-63-9
3-dimethylaminoacrolein

: 1094484-55-5
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; 3-dimethylaminoacrolein With boron trifluoride In acetonitrile for 2.5h; Stage #2: methylhydrazine In acetonitrile at 5 - 20℃; for 2.5h;	92.8%

...Expand

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: C9H17NO2

: 60-34-4
methylhydrazine

: 3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxan-2-yl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; C9H17NO2 With boron trifluoride In acetonitrile at 0 - 30℃; for 2.5h; Stage #2: methylhydrazine In acetonitrile at 5 - 30℃; for 2.5h;	91.9%

...Expand

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: C7H13NO2

: 60-34-4
methylhydrazine

: 3-(difluoromethyl)-1-methyl-4-(1,3-dioxolan-2-yl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; C7H13NO2 With boron trifluoride In tetrahydrofuran at 0 - 20℃; for 2.5h; Stage #2: methylhydrazine In tetrahydrofuran at 5 - 20℃; for 2.5h; Temperature; Solvent;	91.6%

...Expand

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: 1190-91-6
4-dimethylamino-3-buten-2-one

: 60-34-4
methylhydrazine

: 1-(3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)ethan-1-one

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; 4-dimethylamino-3-buten-2-one With boron trifluoride In acetonitrile for 2.5h; Stage #2: methylhydrazine In acetonitrile at 5 - 20℃; for 2.5h;	90.3%

...Expand

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: 34846-90-7
methyl 3-methoxyprop-2-enoate

: 13466-29-0
1-benzylidene-2-methylhydrazine

: methyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; methyl 3-methoxyprop-2-enoate With boron trifluoride diethyl etherate In acetonitrile at 25 - 70℃; Inert atmosphere; Stage #2: 1-benzylidene-2-methylhydrazine In toluene; acetonitrile at 25℃; for 0.75h; Stage #3: With hydrogenchloride In water; toluene; acetonitrile for 3h; Reflux;	89%

...Expand

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: ethyleneglycoldi(3-N,N-dimethylaminopropyl)acrylate

: 60-34-4
methylhydrazine

: ethylene glycol bis((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carboxylate)

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; ethyleneglycoldi(3-N,N-dimethylaminopropyl)acrylate With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 2h; Stage #2: methylhydrazine In acetonitrile at 20℃; for 2h; Reagent/catalyst; Solvent; Temperature;	89%
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 0.5h; Stage #2: ethyleneglycoldi(3-N,N-dimethylaminopropyl)acrylate In dichloromethane at 20℃; for 2h; Stage #3: methylhydrazine In acetonitrile at 20℃; for 2h;	89%

...Expand

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: ethyl 4,4-difluoro-3-(phenylamino)but-2-enoate

: ethyl 2,4-bis(difluoromethyl)quinoline-3-carboxylate

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In acetonitrile for 0.25h; Inert atmosphere; Stage #2: ethyl 4,4-difluoro-3-(phenylamino)but-2-enoate In acetonitrile at 20 - 50℃; for 19.25h; Inert atmosphere;	89%
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In acetonitrile for 0.25h; Inert atmosphere; Stage #2: ethyl 4,4-difluoro-3-(phenylamino)but-2-enoate In acetonitrile at 20 - 50℃; for 19.25h;	89%

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: N-(1,1-difluoropropan-2-ylidene)propan-2-amine

: 77614-79-0
3,5-bis(difluoromethyl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride In acetonitrile at 10 - 20℃; for 1h; Stage #2: N-(1,1-difluoropropan-2-ylidene)propan-2-amine In acetonitrile at 40℃; for 13h; Stage #3: With hydrogenchloride; hydrazine hydrate In water; acetonitrile at 40 - 60℃; for 5h; Reagent/catalyst;	87%

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: hexane-1,6-diol bis(3-(N,N-dimethylamino)acrylate)

: 60-34-4
methylhydrazine

: hexylene glycol bis((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carboxylate)

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine; hexylene glycol bis(3-(N,N-dimethylamino)acrylate) With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 2h; Stage #2: methylhydrazine In acetonitrile at 20℃; for 2h;	86%
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 0.5h; Stage #2: hexylene glycol bis(3-(N,N-dimethylamino)acrylate) In dichloromethane at 20℃; for 2h; Stage #3: methylhydrazine In acetonitrile at 20℃; for 2h;	86%

...Expand

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: 1-(1,1-difluoropropan-2-ylidene)-2-(diphenylmethylene)hydrazine

: 77614-79-0
3,5-bis(difluoromethyl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With aluminum (III) chloride In acetonitrile at 10 - 20℃; for 1h; Stage #2: 1-(1,1-difluoropropan-2-ylidene)-2-(diphenylmethylene)hydrazine In acetonitrile at 20℃; Stage #3: With water In acetonitrile at 20 - 40℃; for 1h; Reagent/catalyst; Solvent; Temperature;	85%

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: 723294-90-4
N-(2,2,2-trifluoro-1-methylethylidene)propan-2-amine

: 1015780-64-9
3-(difluoromethyl)-5-(trifluoromethyl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In acetonitrile at 10 - 20℃; for 1h; Stage #2: N-(2,2,2-trifluoro-1-methylethylidene)propan-2-amine In acetonitrile at 40℃; for 13h; Stage #3: With hydrogenchloride; hydrazine hydrate In water; acetonitrile at 40 - 60℃; for 5h;	85%

: 27871-49-4
(S)-Methyl lactate

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

A: 667-50-5
Difluoroacetic acid N,N-dimethylamide

B: 146805-74-5
(R)-2-fluoropropionic acid methyl ester

Conditions

Conditions	Yield
at 20 - 30℃; for 12h;	A n/a B 83%

...Expand

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: 1-(diphenylmethylene)-2-(1,1,1-trifluoropropan-2-ylidene)hydrazine

: 1015780-64-9
3-(difluoromethyl)-5-(trifluoromethyl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 0.25h; Inert atmosphere; Stage #2: 1-(diphenylmethylene)-2-(1,1,1-trifluoropropan-2-ylidene)hydrazine In acetonitrile at 20 - 50℃; for 24h; Inert atmosphere; Stage #3: With hydrogenchloride In water; acetonitrile at 20℃; for 1h; Inert atmosphere;	83%

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: bis(1,1-difluoropropan-2-ylidene)hydrazine

: 77614-79-0
3,5-bis(difluoromethyl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In acetonitrile at 10 - 20℃; for 0.25h; Inert atmosphere; Stage #2: bis(1,1-difluoropropan-2-ylidene)hydrazine In acetonitrile at 20℃; for 18h; Stage #3: With hydrazine hydrochloride In water; acetonitrile at 40℃; for 4h;	81%

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: 100-63-0
phenylhydrazine

: sodium 3-ethoxy-1-(methylsulfonyl)-3-oxoprop-1-en-2-olate

: ethyl 5-(difluoromethyl)-4-methylsulfonyl-2-phenylpyrazole-3-carboxylate

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With acetonitrile boron trifluoride complex In acetonitrile at 20℃; for 0.25h; Inert atmosphere; Stage #2: sodium 3-ethoxy-1-(methylsulfonyl)-3-oxoprop-1-en-2-olate With pyridine In acetonitrile at 10 - 20℃; for 10h; Stage #3: phenylhydrazine In acetonitrile at -10 - 20℃; for 4h;	81%

...Expand

: 4438-85-1
3H-chromene-2,4-dione

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: 3-difluoroacetylchromene-2,4-dione

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 16h; Inert atmosphere;	80%

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: 1700-88-5
ethyl 4,4,4-trifluoro-3-(phenylamino)but-2-enoate

: ethyl 4-(difluoromethyl)-2-(trifluoromethyl)quinoline-3-carboxylate

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In acetonitrile for 0.25h; Inert atmosphere; Stage #2: ethyl 4,4,4-trifluoro-3-(phenylamino)but-2-enoate With sulfuric acid In acetonitrile at 20 - 50℃; for 19.25h; Inert atmosphere;	80%

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: ethyl 4,4,4-trifluoro-3-(phenylamino)but-2-enoate

: ethyl 4-(difluoromethyl)-2-(trifluoromethyl)quinoline-3-carboxylate

Conditions

Conditions	Yield
Stage #1: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine With boron trifluoride diethyl etherate In acetonitrile for 0.25h; Inert atmosphere; Stage #2: ethyl 4,4,4-trifluoro-3-(phenylamino)but-2-enoate In acetonitrile at 20 - 50℃; for 19.25h;	80%

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

: 141-78-6
ethyl acetate

: 352-24-9
ethyl 4,4-difluoro-3-oxobutyrate

Conditions

Conditions	Yield
Stage #1: ethyl acetate With sodium hydride In ethanol at 20℃; for 1h; Stage #2: 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine In ethanol at 30℃; for 2h; Product distribution / selectivity;	79%

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine Specification

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine , with CAS no: 1550-50-1, is also known as Ethylamine,1,1,2,2-tetrafluoro-N,N-dimethyl- (6CI,8CI) or 1,1,2,2-Tetrafluoro-N,N-dimethylethanamine .

Its physical properties include the following items. The index of refraction is 1.324, molar refractivity is 24.881 cm³ and molar volume is 124.032 cm³. Besides, it has the polarizability 9.864×10-24cm³, surface tension 15.852 dyne/cm, enthalpy of vaporization 29.119 kJ/mol and the vapour pressure 322.306 mmHg at 25°C.

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine is a kind of transparent liquid with no color, with a low ignition point; It is being used in many different ways, such as medicine, pesticide intermediates, and halogenation agent fluoride. You could convert the chemical data into molecular structure through the folllowing chainings:
SMILES:
FC(F)C(F)(F)N(C)C
InChI:
InChI=1/C4H7F4N/c1-9(2)4(7,8)3(5)6/h3H,1-2H3.

Product Name

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine

Synthetic route

N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine Specification

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