N,N-Dimethyl-1,3-phenylenediamine dihydrochloride supplier

Name
N,N-DIMETHYL-M-PHENYLENEDIAMINE DIHYDROCHLORIDE
EINECS 222-693-0
CAS No. 3575-32-4
Density 1.049g/cm3
Solubility Soluble in water, hot methanol
Melting Point 217-220 °C (dec.)
Formula C₈H₁₂N₂^.2(HCl)
Boiling Point 244.1 °C at 760 mmHg
Molecular Weight 209.119
Flash Point 88.8 °C
Transport Information UN 2811 6.1/PG 2
Appearance Off-White Crystalline Solid
Safety 36/37/39-45-26
Risk Codes 25-36/37/38-43-23/24/25
Molecular Structure
Hazard Symbols T
Synonyms 1,3-Benzenediamine,N,N-dimethyl-, dihydrochloride (9CI);m-Phenylenediamine, N,N-dimethyl-, dihydrochloride(8CI);3-Dimethylaminoaniline dihydrochloride;N,N-Dimethyl-1,3-benzenediaminedihydrochloride;N,N-Dimethyl-1,3-phenylenediamine dihydrochloride;N,N-Dimethyl-m-phenylenediamine dihydrochloride;
PSA 29.26000
LogP 3.52000

Synthetic route

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 2836-04-6
m-dimethylaminoaniline

Conditions

Conditions	Yield
With sodium carbonate In water at 20℃; for 0.166667h;	100%
With sodium hydrogencarbonate In water; ethyl acetate
With potassium carbonate In water	3.63 g

: di-tert-butyl (2E)-6,6′-bis(4-formylphenyl)-3,3′-dioxo-2,2′-biindole-1,1’(3H,3’H)-dicarboxylate

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: di-tert-butyl (2E)-6,6′-bis[4-((E)-{[3-(dimethylamino)phenyl]imino}methyl)phenyl]-3,3′-dioxo-2,2′-biindole-1,1’(3H,3’H)-dicarboxylate

Conditions

Conditions	Yield
With pyridine In chloroform at -20 - 20℃;	90%

: 143591-61-1
3-bromo-8-chloro-imidazo[1,2-a]pyrazine

: 936361-36-3
3,8-dibromo-imidazo[1,2-a]pyrazine

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 887474-76-2
C14H14BrN5

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 160℃; for 18h;	77%

...Expand

: 69214-33-1
8-chloroimidazo[1,2-α]pyrazine

: 69214-34-2
8-bromoimidazo[1,2-a]pyrazine

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 887474-76-2
C14H14BrN5

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 160℃; for 18h;	77%

...Expand

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 105-53-3
diethyl malonate

: 31136-93-3
2,4-dihydroxy-7-(dimethylamino)quinoline

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl-1,3-phenylenediamine dihydrochloride With sodium hydroxide In water Stage #2: diethyl malonate at 200℃; Dean-Stark;	75%

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 105-53-3
diethyl malonate

: 31136-93-3
7-(dimethylamino)-4-hydroxyquinolin-2(1H)-one

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl-1,3-phenylenediamine dihydrochloride With potassium carbonate In water pH=9 - 10; Stage #2: diethyl malonate In diphenylether Sealed tube; Heating;	74%

: 5815-08-7
tert-Butoxybis(dimethylamino)methane

: ethyl 2-(2-ethoxy-2-oxoethyl)-4,5-dimethoxybenzoate

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 2-[3-(dimethylamino)phenyl]-6,7-dimethoxy-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid

Conditions

Conditions	Yield
Stage #1: tert-Butoxybis(dimethylamino)methane; ethyl 2-(2-ethoxy-2-oxoethyl)-4,5-dimethoxybenzoate at 100℃; for 3h; Stage #2: N,N-dimethyl-1,3-phenylenediamine dihydrochloride With acetic acid at 20℃; for 2h; Stage #3: With sodium hydroxide In ethanol at 80℃; for 1h;	70%

...Expand

4N-hydrogen chloride: 4N-hydrogen chloride

: (3RS)-1-[(3-Azabicyclo[3.2.2]non-3-yl)carbonylmethyl]-5,9-dimethyl-2,3-dihydro-3-(imidazol-1-yl)carbonylamino-1H-1,4-benzodiazepin-2-one

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 206000-79-5
N-[(3RS)-1-(3-azabicyclo[3.2.2]non-3-yl)carbonylmethyl-5,9-dimethyl-2,3-dihydro-2-oxo-1H-1,4-benzodiazepin-3-yl]-N'-[3-(N,N-dimethyl amino)phenyl]urea hydrochloride

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide	67.1%

...Expand

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 1-(3,3-dimethylureido)-3-(dimethylamino)benzene

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl-1,3-phenylenediamine dihydrochloride With potassium carbonate In water for 2h; Stage #2: N,N-Dimethylcarbamoyl chloride With triethylamine In dichloromethane at 0 - 20℃; Schotten-Baumann Reaction; Inert atmosphere;	67%

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 16588-74-2
3,5-ditrifluoromethylisocyanate

: 1325760-92-6
1-(3,5-bis(trifluoromethyl)phenyl)-3-((3-dimethylamino)phenyl)urea

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl-1,3-phenylenediamine dihydrochloride With sodium hydroxide In dichloromethane; water Stage #2: 3,5-ditrifluoromethylisocyanate In dichloromethane at 20℃; for 12h;	66%

: 194423-18-2
but-2-ynoic acid [3-cyano-4-(dimethylamino-methyleneamino)-phenyl]-amide

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: but-2-ynoic acid [4-(3-dimethylamino-phenylamino)-quinazolin-6-yl]-amide

Conditions

Conditions	Yield
With potassium carbonate In acetic acid; acetonitrile for 1h; Heating / reflux;	58%

: N,N-dibenzyl-2,4-dichloro-5,6,7,8-tetrahydroquinazolin-6-amine

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: N6,N6-dibenzyl-2-chloro-N4-[3-(dimethylamino)phenyl]-5,6,7,8-tetrahydroquinazoline-4,6-diamine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 100℃; for 6h; Microwave irradiation; Inert atmosphere;	56%

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 151620-15-4
2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

: N-(3-dimethylaminophenyl)-N'-[2,3,4,5,-tetrahydro-2,4-dioxo-1-(3-methylbutyl)-5-(2-fluorophenyl)-1H-1,5-benzodiazepin-3-yl]urea

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 160℃; for 2h; Condensation;	50%

: 25784-91-2
2-chloro-5-nitrobenzoylchloride

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 144-55-8
sodium hydrogencarbonate

: 372095-42-6
N-(3-Dimethylamino)phenyl-(2-chloro-5-nitrophenyl)carboxamide

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran; ethyl acetate	49%

...Expand

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 56-81-5
glycerol

: 89770-32-1
N,N-dimethylquinolin-7-amine

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl-1,3-phenylenediamine dihydrochloride With sodium hydroxide In water Stage #2: glycerol With sulfuric acid; sodium iodide at 140 - 150℃; for 3h; Skraup Quinoline Synthesis; Cooling with ice;	47%

etanol: etanol

: 209219-86-3, 209220-79-1, 209220-80-4
1-(2-toluoylmethyl)-2-oxo-3-amino-5-pivaloyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 530-62-1
1,1'-carbonyldiimidazole

: 209218-53-1
1-[1-(2-toluoylmethyl)-2-oxo-5-pivaloyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]-3-[3-(N,N-dimethylamino)phenyl]urea

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran	40.3%

...Expand

: 438249-83-3
4-chloro-6-(methoxymethyl)-2-(3-methylphenyl)pyrimidine

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 438247-50-8
4-(4-Dimethylaminoanilino)-6-(methoxymethyl)-2-(3-methylphenyl)pyrimidine

Conditions

Conditions	Yield
With hydrogenchloride In water	23%

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 214470-55-0
4-chloro-6,7-dimethoxyquinoline-3-carbonitrile

: 4-(3-dimethylaminophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile hydrochloride

Conditions

Conditions	Yield
In 2-ethoxy-ethanol for 3h; Substitution; Heating;	18%

: 109799-62-4
2-(2,4-dinitrophenyl)acetyl chloride

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: (2,4-dinitro-phenyl)-acetic acid-(3-dimethylamino-anilide)

Conditions

Conditions	Yield
With sodium hydrogencarbonate; benzene

: 107324-93-6
3-(p-nitrophenyl)propanoyl chloride

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 3-(4-nitro-phenyl)-propionic acid-(3-dimethylamino-anilide)

Conditions

Conditions	Yield
With sodium hydrogencarbonate; benzene

: 858218-33-4
3-(2,4-dinitro-phenyl)-propionyl chloride

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 52887-16-8
3-(2,4-dinitro-phenyl)-propionic acid-(3-dimethylamino-anilide)

Conditions

Conditions	Yield
With sodium hydrogencarbonate; benzene

: 590-28-3
potassium cyanate

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 26455-21-0
3-ureido-1-dimethylaminobenzene

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 122-04-3
4-nitro-benzoyl chloride

: 4-nitro-benzoic acid-(3-dimethylamino-anilide)

Conditions

Conditions	Yield
With sodium hydrogencarbonate; benzene
With pyridine; acetone

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 121-90-4
m-nitrobenzoic acid chloride

: 3-nitro-benzoic acid-(3-dimethylamino-anilide)

Conditions

Conditions	Yield
With sodium hydrogencarbonate; benzene

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 50434-36-1
4-nitrophenylacetyl chloride

: (4-nitro-phenyl)-acetic acid-(3-dimethylamino-anilide)

Conditions

Conditions	Yield
With sodium hydrogencarbonate; benzene

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 99-33-2
3,5-dinitrobenoyl chloride

: 108299-43-0
3,5-dinitro-benzoic acid-(3-dimethylamino-anilide)

Conditions

Conditions	Yield
With sodium hydrogencarbonate; benzene

: 19262-73-8
4-Acetyl-phenyl-diazonium

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 1-[4-(2-Amino-4-dimethylamino-phenylazo)-phenyl]-ethanone

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 78246-53-4
4-Hydroxymethyl-benzenediazonium

: [4-(2-Amino-4-dimethylamino-phenylazo)-phenyl]-methanol

: 463-71-8
thiophosgene

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 2392-67-8
3-N,N-dimethylaminophenylisothiocyanate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In toluene at 75℃;

: 3575-32-4
N,N-dimethyl-1,3-phenylenediamine dihydrochloride

: 153930-53-1
1-(2-cyclopentylethyl)-2,4-dioxo-5-(2-fluorophenyl)-3-isocyanato-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

: 1-[1-(2-cyclopentyl-ethyl)-5-(2-fluoro-phenyl)-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-3-(3-dimethylamino-phenyl)-urea

Conditions

Conditions	Yield
In acetonitrile for 7h; Addition;

N,N-Dimethyl-1,3-phenylenediamine dihydrochloride Specification

The cas register number of N,N-Dimethyl-1,3-phenylenediamine dihydrochloride is 3575-32-4. It also can be called as N,N-Dimethyl-m-phenylenediamine dihydrochloride and the IUPAC Name about this chemical is 3-N,3-N-dimethylbenzene-1,3-diamine dihydrochloride. It belongs to the following product categories, such as Aromatics Compounds, Aromatics and so on.

Physical properties about N,N-Dimethyl-1,3-phenylenediamine dihydrochloride are: (1)ACD/LogP: 1.05; (2)ACD/LogD (pH 5.5): 0.9; (3)ACD/LogD (pH 7.4): 1.04; (4)ACD/BCF (pH 5.5): 2.64; (5)ACD/BCF (pH 7.4): 3.65; (6)ACD/KOC (pH 5.5): 63.51; (7)ACD/KOC (pH 7.4): 87.81; (8)#H bond acceptors: 2; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 6.48Å²; (12)Flash Point: 88.8 °C; (13)Enthalpy of Vaporization: 48.11 kJ/mol; (14)Boiling Point: 244.1 °C at 760 mmHg; (15)Vapour Pressure: 0.0309 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical is toxic by inhalation, in contact with skin and if swallowed and it is irritating to eyes, respiratory system and skin, it also may cause sensitization by skin contact. When you are using it, wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice and in case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CN(C)C1=CC=CC(=C1)N.Cl.Cl
(2)InChI: InChI=1S/C8H12N2.2ClH/c1-10(2)8-5-3-4-7(9)6-8;;/h3-6H,9H2,1-2H3;2*1H
(3)InChIKey: BZJPIQKDEGXVFG-UHFFFAOYSA-N

Product Name

N,N-DIMETHYL-M-PHENYLENEDIAMINE DIHYDROCHLORIDE

Synthetic route

N,N-Dimethyl-1,3-phenylenediamine dihydrochloride Specification

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