N,N-Dimethylacetamide supplier

Name
N,N-Dimethylacetamide
EINECS 204-826-4
CAS No. 127-19-5
Article Data169
CAS DataBase
Density 0.88 g/cm³
Solubility miscible with water
Melting Point -20 °C
Formula C₄H₉NO
Boiling Point 166.1 °C at 760 mmHg
Molecular Weight 87.1216
Flash Point 63.8 °C
Transport Information UN 1279 3/PG 2
Appearance colourless liquid with a faint ammonia odour
Safety 16-24-53-45-36-28-26
Risk Codes 11-20/22-61-20/21-36
Molecular Structure
Hazard Symbols F,Xn,T
Synonyms acetamide, N,N-dimethyl-;Acetyldimethylamine;Dimethylacetone amide;N,N-Dimethylacetamide solution;Dimethylamid kyseliny octove [Czech];Acetic acid, dimethylamide;N,N-dimethy Lacetamide (DMAC);Di-Methyl Acetamide;Dimethyl - Acetamide;N,N'-Dimethyl Acetamide;N,N-dimethyl Acetamide;N,N-dimethyl acetamide(DMAC);SK 7176;Acetdimethylamide;Dimethylamide acetate;Dimethylacetamide;N.N-Dimethylacetamide;
PSA 20.31000
LogP 0.09450

Synthetic route

: 201230-82-2
carbon monoxide

: 75-58-1
tertamethylammonium iodide

: 127-19-5
N,N-dimethyl acetamide

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride In 1-methyl-pyrrolidin-2-one at 190℃; for 6h; Catalytic behavior; Solvent; Time; Reagent/catalyst; Concentration;	99.1%
With cobalt(II) chloride; sodium sulfite; zinc In 1-methyl-pyrrolidin-2-one at 200℃; under 22502.3 Torr; for 7h; Solvent; Reagent/catalyst; Temperature; Pressure; Autoclave;	98.5%
With palladium dichloride In 1-methyl-pyrrolidin-2-one at 190℃; for 8h; Catalytic behavior; Temperature; Pressure;

: 124-40-3
dimethyl amine

: 75-36-5
acetyl chloride

: 127-19-5
N,N-dimethyl acetamide

Conditions

Conditions	Yield
With self-zirconium modification of the nanoscale solid alkali catalyst In diethyl ether at 20℃; for 5h; Inert atmosphere;	98.5%
In diethyl ether	20%
With diethyl ether
In tetrahydrofuran; dichloromethane at 20℃; Cooling with ice;
With triethylamine In dichloromethane at 20℃; for 12h;

: 201230-82-2
carbon monoxide

: 75-50-3
trimethylamine

: 127-19-5
N,N-dimethyl acetamide

Conditions

Conditions	Yield
With tertamethylammonium iodide; palladium dichloride In 1-methyl-pyrrolidin-2-one at 20 - 240℃; under 7500.75 - 48754.9 Torr; for 1.96667h; Product distribution / selectivity; Autoclave;	97%

: 79962-35-9
2-Dimethylamino-3-methyl-2,4,6-triphenyl-2H-pyran

A: 127-19-5
N,N-dimethyl acetamide

B: 92919-44-3
3-Methyl-2,4,6-triphenylpyryliumchlorid

Conditions

Conditions	Yield
With acetyl chloride In diethyl ether for 1h; Heating;	A 32% B 94%

: 79962-35-9
2-Dimethylamino-3-methyl-2,4,6-triphenyl-2H-pyran

: 75-36-5
acetyl chloride

A: 127-19-5
N,N-dimethyl acetamide

B: 92919-44-3
3-Methyl-2,4,6-triphenylpyryliumchlorid

Conditions

Conditions	Yield
In diethyl ether for 1h; Heating;	A 32% B 94%

...Expand

: 141-78-6
ethyl acetate

: 124-40-3
dimethyl amine

: 127-19-5
N,N-dimethyl acetamide

Conditions

Conditions	Yield
With [Zn(BH4)2(py)] In tetrahydrofuran for 0.34h; Heating;	93%

: N-methyl ephedrine

: 127-19-5
N,N-dimethyl acetamide

Conditions

Conditions	Yield
With potassium hydroxide; air In diethyl ether at 20℃; for 90h;	92%

: 201230-82-2
carbon monoxide

: 75-58-1
tertamethylammonium iodide

: 75-50-3
trimethylamine

: 127-19-5
N,N-dimethyl acetamide

Conditions

Conditions	Yield
With [2,2]bipyridinyl; palladium dichloride In 1-methyl-pyrrolidin-2-one at 20 - 200℃; under 22502.3 Torr; for 8h; Reagent/catalyst; Time; Autoclave;	90.8%

...Expand

: 15351-09-4
metamfepramone

: 127-19-5
N,N-dimethyl acetamide

Conditions

Conditions	Yield
With potassium hydroxide; air In diethyl ether at 20℃; for 30h;	90%

: 32115-55-2
N,N-Dimethylcarbamidsaeure-trimethylsilylester

: 75-36-5
acetyl chloride

: 127-19-5
N,N-dimethyl acetamide

Conditions

Conditions	Yield
In dichloromethane for 0.25h; Ambient temperature;	87%

: 3840-71-9
2-acetoxy-3,3-dimethyl-but-1-ene

: 30364-05-7
(t-C4H9)2SbN(CH3)2

A: 127-19-5
N,N-dimethyl acetamide

B: 53742-78-2
(t-C4H9)2SbCH2COC(CH3)3

Conditions

Conditions	Yield
under Ar, at 80-90°C, 4 h;	A n/a B 85%

...Expand

: 30364-05-7
(t-C4H9)2SbN(CH3)2

: 1424-22-2
1-cyclohexenyl acetate

A: 127-19-5
N,N-dimethyl acetamide

B: 53742-83-9
(t-C4H9)2SbOC6H9

Conditions

Conditions	Yield
under Ar, at 80-90°C, 4 h;	A n/a B 79%

...Expand

: 13893-75-9
3-acetoxy-2-pentene

: 30364-05-7
(t-C4H9)2SbN(CH3)2

A: 127-19-5
N,N-dimethyl acetamide

B: 53742-80-6, 53742-81-7
(t-C4H9)2SbOC(C2H5)CHCH3

C: 53742-82-8
(t-C4H9)2SbCH(CH3)COC2H5

Conditions

Conditions	Yield
under Ar, at 80-90°C, 4 h;	A n/a B n/a C 78%
under argon, at 80-90°C for 4 h, vac. distn.;

...Expand

: 2044-64-6
N,N-Dimethylacetoacetamid

: 10075-38-4
1,3-Dichloro-2-butene

A: 127-19-5
N,N-dimethyl acetamide

B: N,N-dimethyl-5-chloro-4-hexenamide

C: 83305-52-6
N,N-dimethyl-α-(3-chloro-2-butenyl)acetoacetamide

Conditions

Conditions	Yield
With potassium hydroxide; Katamin AB at 100℃; for 40h;	A 2.8% B 1.1% C 75%

...Expand

: 15521-18-3
2-(dimethylamino)propan-1-ol

: 127-19-5
N,N-dimethyl acetamide

Conditions

Conditions	Yield
With potassium hydroxide; air In diethyl ether at 20℃; for 90h;	73%

: 1068-57-1
acetic acid hydrazide

: N,N-Dimethyl-N'-(dimethylamino-methoxymethyl)-formamidin

A: 288-88-0
1,2,4-Triazole

B: 127-19-5
N,N-dimethyl acetamide

Conditions

Conditions	Yield
In methanol for 8h; Heating;	A 71% B 52%

...Expand

: 21857-33-0
2-oxo-2-dimethylamino-4-methyl-1,3,2-dioxaphosphorinane

A: 31951-90-3
2-chloro-2-oxo-2-mercapto-4-methyl-1,3,2-dioxaphosphorinane

B: 127-19-5
N,N-dimethyl acetamide

Conditions

Conditions	Yield
With acetyl chloride In benzene for 1h; Heating;	A n/a B 70%

: 680-31-9
N,N,N,N,N,N-hexamethylphosphoric triamide

A: 127-19-5
N,N-dimethyl acetamide

B: 1605-65-8
N,N,N',N'-Tetramethylphosphorodiamidic chloride

Conditions

Conditions	Yield
With acetyl chloride In benzene for 1h; Heating;	A n/a B 67%

: 159924-61-5
4-chloropropiophenone enol acetate

: 30364-05-7
(t-C4H9)2SbN(CH3)2

A: 54266-19-2
(t-C4H9)2SbCH(CH3)COC6H4-4-Cl

B: 127-19-5
N,N-dimethyl acetamide

C: 54266-17-0, 54266-18-1
(t-C4H9)2SbOC(C6H4-4-Cl)CHCH3

Conditions

Conditions	Yield
under Ar, at 80-90°C, 8 h;	A 66% B n/a C n/a

...Expand

: 201230-82-2
carbon monoxide

: 64-20-0
tetramethylammonium bromide

: 127-19-5
N,N-dimethyl acetamide

Conditions

Conditions	Yield
With sodium tetracarbonyl cobaltate In 1-methyl-pyrrolidin-2-one at 200℃; under 22502.3 Torr; for 14h; Autoclave;	64.5%
With palladium dichloride In 1-methyl-pyrrolidin-2-one at 190℃; for 12h; Catalytic behavior;

: 30364-05-7
(t-C4H9)2SbN(CH3)2

: 933-06-2
1-acetoxycyclopentene

A: 43106-62-3
C13H25OSb

B: 127-19-5
N,N-dimethyl acetamide

C: 43106-63-4
(t-C4H9)2SbOC5H7

Conditions

Conditions	Yield
under Ar, at 80-90°C, 4 h;	A 64% B n/a C n/a

...Expand

: 631-67-4
N,N-dimethylthioacetamide

: 127-19-5
N,N-dimethyl acetamide

Conditions

Conditions	Yield
With triphenyltin(IV) hydroxide In benzene-d6 at 90℃; for 36h;	64%
With 6H(1+)*Mo9O40PV3(6-); oxygen In acetonitrile at 60℃; under 760.051 Torr; for 2h; Inert atmosphere; Glovebox;	53 %Chromat.

: 541-59-3
maleiimide

: 313263-46-6
2-dimethylamino-5-ethyl-4-methyloxazole

A: 127-19-5
N,N-dimethyl acetamide

B: 7-ethyl-6-methyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,4-c]pyridine-1,3,4-trione

Conditions

Conditions	Yield
In acetic acid for 3h; Cyclization; ring cleavage; Heating;	A n/a B 63%

...Expand

: 3550-35-4
1,1,1-triethyl-N,N-dimethylsilylamine

: 2754-27-0
trimethylsilyl acetate

A: 107-46-0
Hexamethyldisiloxane

B: 127-19-5
N,N-dimethyl acetamide

C: 2652-41-7
1,1,1-triethyl-3,3,3-trimethyl-disiloxane

D: 994-49-0
hexaethyl disiloxane

Conditions

Conditions	Yield
With N-Methylformamide at 50 - 75℃; for 21h;	A n/a B 60% C n/a D n/a
With N-Methylformamide at 50 - 75℃; for 21h; Product distribution; Mechanism; other amides as catalysts;	A n/a B 60% C n/a D n/a

...Expand

: 3550-35-4
1,1,1-triethyl-N,N-dimethylsilylamine

A: 107-46-0
Hexamethyldisiloxane

B: 127-19-5
N,N-dimethyl acetamide

C: 2652-41-7
1,1,1-triethyl-3,3,3-trimethyl-disiloxane

D: 994-49-0
hexaethyl disiloxane

Conditions

Conditions	Yield
With N-Methylformamide; trimethylsilyl acetate at 50 - 75℃; for 21h;	A n/a B 60% C n/a D n/a

...Expand

: 2754-27-0
trimethylsilyl acetate

A: 107-46-0
Hexamethyldisiloxane

B: 127-19-5
N,N-dimethyl acetamide

C: 2652-41-7
1,1,1-triethyl-3,3,3-trimethyl-disiloxane

D: 994-49-0
hexaethyl disiloxane

Conditions

Conditions	Yield
With N-Methylformamide; 1,1,1-triethyl-N,N-dimethylsilylamine at 50 - 75℃; for 21h;	A n/a B 60% C n/a D n/a

...Expand

: 5170-76-3
2-methyl-1-phenyl-1-acetoxy-1-propene

: 30364-05-7
(t-C4H9)2SbN(CH3)2

A: 127-19-5
N,N-dimethyl acetamide

B: 54266-23-8
(t-C4H9)2SbOC(C6H5)C(CH3)2

Conditions

Conditions	Yield
under Ar, at 80-90°C, 8 h;	A n/a B 58%

...Expand

: 64-19-7
acetic acid

: tris(dimethylamino)selenonium chloride

: 127-19-5
N,N-dimethyl acetamide

Conditions

Conditions	Yield
In dichloromethane for 5h;	57%

: 39623-95-5
1-phenylprop-1-enyl acetate

: 30364-05-7
(t-C4H9)2SbN(CH3)2

A: 54266-13-6
(t-C4H9)2SbCH(CH3)COC6H5

B: 127-19-5
N,N-dimethyl acetamide

C: 54266-11-4, 54266-12-5
(t-C4H9)2SbOC(C6H5)CHCH3

Conditions

Conditions	Yield
under Ar, at 80-90°C, 8 h;	A 57% B n/a C n/a
under argon, at 80-90°C, 8 h;

...Expand

: 6138-90-5
trans-geranyl bromide

: 127-19-5
N,N-dimethyl acetamide

: 89171-32-4
Geranylessigsaeure-N,N-dimethylamid

Conditions

Conditions	Yield
With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide In tetrahydrofuran at -78℃;	100%

: 127-19-5
N,N-dimethyl acetamide

: 623-00-7
4-bromobenzenecarbonitrile

: 79149-55-6
2-(4-cyanophenyl)-N,N-dimethylacetamide

Conditions

Conditions	Yield
With potassium In ammonia	100%
Stage #1: N,N-dimethyl acetamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h; Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; Stage #3: 4-bromobenzenecarbonitrile With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 4h;	89%

Yield

With potassium In ammonia

100%

Stage #1: N,N-dimethyl acetamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h;
Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h;
Stage #3: 4-bromobenzenecarbonitrile With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 4h;

89%

: 127-19-5
N,N-dimethyl acetamide

: 4-Methoxy-8-hydroxynaphthyl 4-methoxyphenyl ketone

: 8-Dimethylamino-3-methoxy-10-(4-methoxy-phenyl)-7-oxonia-cyclohepta[de]naphthalene; perchlorate

Conditions

Conditions	Yield
With perchloric acid; trichlorophosphate at 60 - 70℃;	100%

: 127-19-5
N,N-dimethyl acetamide

: 27607-77-8
trimethylsilyl trifluoromethanesulfonate

: dimethyl-N-(1-trimethylsilyloxy-1-methylmethylidene)ammonium trifluoromethanesulfonate

Conditions

Conditions	Yield
at 20℃; for 0.0833333h;	100%

: 127-19-5
N,N-dimethyl acetamide

: 685539-87-1
D-3,6-di-O-trifluoromethanesulfonyl-1,2:4,5-di-O-isopropylidene-myo-inositol

: 685539-88-2
(D)-2,5-di-O-acetyl-1,6:3,4-di-O-isopropylidene-allo-inositol

Conditions

Conditions	Yield
With potassium acetate at 70℃;	100%

: 624-28-2
2,5-dibromopyridine

: 127-19-5
N,N-dimethyl acetamide

: 214701-49-2
1-(5-bromopyridin-2-yl)ethanone

Conditions

Conditions	Yield
With n-butyllithium In hexane; toluene at -40 - 20℃; for 2h; Inert atmosphere;	100%
Stage #1: 2,5-dibromopyridine With n-butyllithium In hexane; toluene at -40℃; for 0.666667h; Stage #2: N,N-dimethyl acetamide In hexane; toluene at 20℃; for 1h; Further stages.;	83%
Stage #1: 2,5-dibromopyridine With n-butyllithium In toluene Inert atmosphere; Stage #2: N,N-dimethyl acetamide In toluene Inert atmosphere;	83%

: 127-19-5
N,N-dimethyl acetamide

: 331811-71-3
C13H10N2O4S

: 1296241-25-2
N,N-dimethyl-3-phenyl-3-(2-nitrobenezenesulfonylamino)propanamide

Conditions

Conditions	Yield
With triisopropylsilyl trifluoromethanesulfonate; triethylamine In toluene at 20℃; for 12h; Mannich type reaction;	100%

: 127-19-5
N,N-dimethyl acetamide

: 51608-60-7
N-(benzylidene)-p-methylbenzenesulfonamide

: 1061233-61-1
N,N-dimethyl-3-((4-methylphenyl)sulfonamido)-3-phenylpropanamide

Conditions

Conditions	Yield
With triisopropylsilyl trifluoromethanesulfonate; triethylamine In toluene at 20℃; for 12h; Mannich type reaction;	100%

: 127-19-5
N,N-dimethyl acetamide

: 73845-02-0
4-methyl-N-(3-nitrobenzylidene)benzenesulfonamide

: 1262117-69-0
N,N-dimethyl-3-(3-nitrophenyl)-3-(tosylamino)propanamide

Conditions

Conditions	Yield
With triisopropylsilyl trifluoromethanesulfonate; triethylamine In toluene at 20℃; for 12h; Mannich type reaction;	100%

: 127-19-5
N,N-dimethyl acetamide

: 3157-65-1
N-(p-chlorobenzylidene)-p-toluenesulfonamide

: 1262117-67-8
3-(4-chlorophenyl)-N,N-dimethyl-3-(tosylamino)propanamide

Conditions

Conditions	Yield
With triisopropylsilyl trifluoromethanesulfonate; triethylamine In toluene at 20℃; for 12h; Mannich type reaction;	100%

: 127-19-5
N,N-dimethyl acetamide

: 17692-84-1
N-(2-naphthylidene)-4-methylbenzenesulfonamide

: 1262117-71-4
N,N-dimethyl-3-(naphthalen-2-yl)-3-(tosylamino)propanamide

Conditions

Conditions	Yield
With triisopropylsilyl trifluoromethanesulfonate; triethylamine In toluene at 20℃; for 12h; Mannich type reaction;	100%

: 127-19-5
N,N-dimethyl acetamide

: 135822-92-3
N-(2,2-dimethylpropylidene)-p-toluenesulfonamide

: 1262117-74-7
N,N,4,4-tetramethyl-3-(tosylamino)pentanamide

Conditions

Conditions	Yield
With triisopropylsilyl trifluoromethanesulfonate; triethylamine In toluene at 20℃; for 12h; Mannich type reaction;	100%

: 127-19-5
N,N-dimethyl acetamide

: N-cyclopropylmethylene-4-methyl-benzenesulfonamide

: 1262117-75-8
3-cyclopropyl-N,N-dimethyl-3-(tosylamino)propanamide

Conditions

Conditions	Yield
With triisopropylsilyl trifluoromethanesulfonate; triethylamine In toluene at 20℃; for 12h; Mannich type reaction;	100%

: 127-19-5
N,N-dimethyl acetamide

: 1214742-49-0
C26H44N2O3

: 1191073-29-6
C27H44N2O4

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl acetamide With trichlorophosphate at 0 - 5℃; for 1h; Stage #2: C26H44N2O3 In ISOPROPYLAMIDE; water at 10℃; for 2h; Stage #3: With sodium hydroxide In ISOPROPYLAMIDE; water at 20℃; for 2h; pH=9 - 10;	100%

: 884495-14-1
3-bromo-4-methyl-5-nitro-6-methoxypyridine

: 127-19-5
N,N-dimethyl acetamide

: (E)-2-(5-bromo-2-methoxy-3-nitropyridin-4-yl)-N,N-dimethylethylene-1-amine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 80 - 95℃; for 5h;	100%

: 127-19-5
N,N-dimethyl acetamide

: [Co(H2O)6][bis(trifluoromethylsulfonyl)imide]2

: [Co(N,N-dimethylacetamide)6][bis(trifluoromethylsulfonyl)imide]2

Conditions

Conditions	Yield
In ethanol for 0.0833333h;	100%

: 939-23-1
p-phenylpyridine

: 127-19-5
N,N-dimethyl acetamide

: {[Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2](4,4’-bipyridine)}n

: {[Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2](DMA)(4-phenylpyridine)}

Conditions

Conditions	Yield
In diethyl ether	100%

...Expand

: 939-23-1
p-phenylpyridine

: 127-19-5
N,N-dimethyl acetamide

: {[Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2](pyridine)2}

: {[Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2](DMA)(4-phenylpyridine)}

Conditions

Conditions	Yield
In diethyl ether	100%

...Expand

: 127-19-5
N,N-dimethyl acetamide

: [Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2]

: {[Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2](DMA)2}

Conditions

Conditions	Yield
at 50℃; for 1h;	100%

: 127-19-5
N,N-dimethyl acetamide

: (3S)-7-amino-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxine-6-carbonitrile

: N'-[(2S)-7-cyano-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]N,N-dimethylmethanimidamide

Conditions

Conditions	Yield
With acetic acid In N,N-dimethyl-formamide; toluene at 105℃; for 3h;	100%

: 127-19-5
N,N-dimethyl acetamide

: 141-97-9
ethyl acetoacetate

: 134653-70-6, 51145-57-4
ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate

Conditions

Conditions	Yield
In ethanol; N,N-dimethyl-formamide at 60℃; for 2h;	100%

: 127-19-5
N,N-dimethyl acetamide

: 2-(bromomethyl)-4-fluorothiophene

: 1-(4-fluorothiophen-2-yl)-N,N-dimethylmethanamine

Conditions

Conditions	Yield
With butoxytributylazanium sulfate In chloroform at 60℃; for 2h;	99.5%

: 765-43-5
Cyclopropyl methyl ketone

: 127-19-5
N,N-dimethyl acetamide

: 89898-26-0
2-cyclopropyl-2-oxoethyl acetate

Conditions

Conditions	Yield
Stage #1: Cyclopropyl methyl ketone; N,N-dimethyl acetamide With trifluorormethanesulfonic acid; thallium(III) acetate at 60℃; for 0.333333h; Stage #2: With water for 0.166667h; Further stages.;	99%

: 127-19-5
N,N-dimethyl acetamide

: 4495-66-3
4-benzyloxypropiophenone

: 200353-85-1
Acetic acid 2-(4-benzyloxy-phenyl)-1-methyl-2-oxo-ethyl ester

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl acetamide; 4-benzyloxypropiophenone With trifluorormethanesulfonic acid; thallium(III) acetate at 60℃; for 0.333333h; Stage #2: With water for 0.166667h; Further stages.;	99%

: 127-19-5
N,N-dimethyl acetamide

: 108-94-1
cyclohexanone

: 17472-04-7
2-acetoxycyclohexanone

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl acetamide; cyclohexanone With trifluorormethanesulfonic acid; thallium(III) acetate at 60℃; for 0.333333h; Stage #2: With water for 0.166667h; Further stages.;	99%

: 127-19-5
N,N-dimethyl acetamide

: 83-33-0
inden-1-one

: 1579-15-3
2-acetoxyindan-1-one

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl acetamide; inden-1-one With trifluorormethanesulfonic acid; thallium(III) acetate at 60℃; for 0.333333h; Stage #2: With water for 0.166667h; Further stages.;	99%

: 127-19-5
N,N-dimethyl acetamide

: 120-92-3
cyclopentanone

: 52789-75-0
2-acetoxycyclopentanone

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl acetamide; cyclopentanone With trifluorormethanesulfonic acid; thallium(III) acetate at 60℃; for 0.333333h; Stage #2: With water for 0.166667h; Further stages.;	99%

: 127-19-5
N,N-dimethyl acetamide

: 172467-97-9
[chloro-(p-tolylsulfinyl)methylidene]cyclopentadecane

: 823213-54-3
2-{1-[chloro(p-tolylsulfinyl)methyl]cyclopentadecyl}-N,N-dimethylacetamide

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl acetamide With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.166667h; Stage #2: [chloro-(p-tolylsulfinyl)methylidene]cyclopentadecane In tetrahydrofuran at -78 - -50℃; for 0.666667h; Further stages.;	99%
Stage #1: N,N-dimethyl acetamide With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.166667h; Stage #2: [chloro-(p-tolylsulfinyl)methylidene]cyclopentadecane In tetrahydrofuran at -78℃; for 3h;

: 127-19-5
N,N-dimethyl acetamide

: 685539-84-8
D-3-O-trifluoromethanesulfonyl-1,2:4,5-di-O-isopropylidene-myo-inositol

: 685539-85-9
1L-1-O-acetyl-2,3:5,6-di-O-isopropylidene-chiro-inositol

Conditions

Conditions	Yield
With potassium acetate at 70℃;	99%

N,N-Dimethylacetamide Consensus Reports

Reported in EPA TSCA Inventory.

N,N-Dimethylacetamide Standards and Recommendations

OSHA PEL: TWA 10 ppm (skin)
ACGIH TLV: TWA 10 ppm (skin); Not Classifiable as a Human Carcinogen; BEI: 30 mg/g creatinine of N-methylacetamide in urine at end of shift
DFG MAK: 10 ppm (36 mg/m³)

N,N-Dimethylacetamide Analytical Methods

For occupational chemical analysis use NIOSH: Dimethylacetamide, 2004.

N,N-Dimethylacetamide Specification

The IUPAC name of this chemical is N,N-dimethylacetamide. With the CAS registry number 127-19-5, it is also named as Acetic acid, dimethylamide. The product's categories are Peptide Synthesis; Solvents and Mixtures for Peptide Synthesis; Specialty Synthesis; Aliphatics Analytical Standards; AmidesVolatiles / Semivolatiles; Alpha Sort; Amines; Chemical Class. It is colourless liquid with a faint ammonia odour, which is miscible with water, alcohol, ether, ester, benzene, chloroform, and aromatic compounds and other organic solvents. Additionally, this chemical should be sealed in the container and stored in the cool and dry place.

The other characteristics of this product can be summarized as: (1)ACD/LogP: -0.75; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.75; (4)ACD/LogD (pH 7.4): -0.75; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 9.35; (8)ACD/KOC (pH 7.4): 9.35; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Index of Refraction: 1.406; (13)Molar Refractivity: 24.33 cm³; (14)Molar Volume: 98.9 cm³; (15)Polarizability: 9.64×10^-24 cm³; (16)Surface Tension: 25.3 dyne/cm; (17)Enthalpy of Vaporization: 40.26 kJ/mol; (18)Vapour Pressure: 1.81 mmHg at 25°C; (19)Exact Mass: 87.068414; (20)MonoIsotopic Mass: 87.068414; (21)Topological Polar Surface Area: 20.3; (22)Heavy Atom Count: 6; (23)Complexity: 58.6.

Preparation of N,N-Dimethylacetamide: It can be obtained by dimethylamine and acetic anhydride.
(CH₃CO)₂O+HN(CH₃)₂→this product+CH₃COOH

Uses of N,N-Dimethylacetamide: It is commonly used as a polar solvent in organic chemistry. It is also used as a solvent for fibers or in the adhesive industry. In addition, this chemical is used in organic synthesis. For example: it reacts with sulfuric acid dimethyl ester to get N,N-dimethylacetamide-dimethyl sulfate complex. This reaction reacts at temperature of 70-80 °C. The reaction time is 3 hours. The yield is 98%.

When you are using this chemical, please be cautious about it as the following:
It is highly flammable, so people should keep it away from sources of ignition. It is harmful by inhalation, in contact with skin and if swallowed. It is also irritating to eyes and may cause harm to the unborn child. So people should aAvoid contact with skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. After contact with skin, wash immediately with plenty of soap-suds. If you want to contact this product, you must wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
1. SMILES:O=C(N(C)C)C
2. InChI:InChI=1/C4H9NO/c1-4(6)5(2)3/h1-3H3
3. InChIKey:FXHOOIRPVKKKFG-UHFFFAOYAE

The following are the toxicity data which has been tested.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
chicken	LDLo	intravenous	12gm/kg (12000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1242, 1970.
mammal (species unspecified)	LCLo	inhalation	406ppm (406ppm)	LIVER: FATTY LIVER DEGERATION	Toxicology and Applied Pharmacology. Vol. 3, Pg. 12, 1961.
mouse	LC50	inhalation	7200mg/m³ (7200mg/m³)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LIVER: OTHER CHANGES	Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. Vol. 13, Pg. 29, 1979.
mouse	LD50	intraperitoneal	2800mg/kg (2800mg/kg)		Yokohama Igaku. Yokohama Medicine. Vol. 31, Pg. 327, 1980.
mouse	LD50	intravenous	3020mg/kg (3020mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
mouse	LD50	oral	4620mg/kg (4620mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
mouse	LD50	skin	9600mg/kg (9600mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LIVER: OTHER CHANGES	Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. Vol. 13, Pg. 29, 1979.
rabbit	LD50	skin	2240mg/kg (2240mg/kg)	SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE	American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.
rabbit	LDLo	intravenous	8340mg/kg (8340mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1242, 1970.
rat	LC50	inhalation	2475ppm/1H (2475ppm)		Drug and Chemical Toxicology. Vol. 9, Pg. 147, 1986.
rat	LD50	intraperitoneal	2750mg/kg (2750mg/kg)		Journal of Reproduction and Fertility. Vol. 4, Pg. 219, 1962.
rat	LD50	intravenous	2640mg/kg (2640mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
rat	LD50	oral	4300mg/kg (4300mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(6), Pg. 76, 1980.
rat	LD50	skin	> 2gm/kg (2000mg/kg)		United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-1190-0981,
rat	LD50	unreported	3gm/kg (3000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1073, 1969.

Product Name

N,N-Dimethylacetamide

Synthetic route

N,N-Dimethylacetamide Consensus Reports

N,N-Dimethylacetamide Standards and Recommendations

N,N-Dimethylacetamide Analytical Methods

N,N-Dimethylacetamide Specification

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