Nafamostat mesylate supplier | CasNO.82956-11-4

Name
Nafamostat mesylate
EINECS 692-168-2
CAS No. 82956-11-4
Article Data5
CAS DataBase
Density
Solubility
Melting Point 259-261 °C
Formula C₂₁H₂₅N₅O₈S₂
Boiling Point 637.2 °C at 760 mmHg
Molecular Weight 539.59
Flash Point 339.1 °C
Transport Information
Appearance Tan to pale orange solid
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Benzoic acid, 4-((aminoiminomethyl)amino)-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate;Ronastat;Nafamostat mesylate (USAN);Nafamostat dimethanesulfonate;Nafamostat mesilate;Benzoic acid,4-[(aminoiminomethyl)amino]-,6- (aminoiminomethyl)-2-naphthalenyl ester,dimethanesulfonate;FUT 175;Futhan;[N-[4-[6-(azaniumylcarbonimidoyl)naphthalen-2-yl]oxycarbonylphenyl]carbamimidoyl]azanium; methanesulfonate;Nafamostat mesilate (JAN);Nafamostat mesylate [USAN];Ronastat (TN);Nafamostat Mesilate(CAS No: 82956-11-4);6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate;
PSA 200.82000
LogP 4.90630

Nafamostat mesylate Chemical Properties

Molecular Structure:

Molecular Formula: C₂₁H₂₅N₅O₈S₂
Molecular Weight: 539.5819
IUPAC Name: (6-Carbamimidoylnaphthalen-2-yl) 4-(diaminomethylideneamino)benzoate; methanesulfonic acid
Synonyms of 6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate (CAS NO.82956-11-4): Nafamostat dimethanesulfonate ; Nafamostat mesylate [USAN] ; 6-Amidino-2-naphthyl p-guanidinobenzoate, dimethanesulfonate ; Benzoic acid, 4-((aminoiminomethyl)amino)-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate ; FUT 175 ; Nafamostat mesilate ; Nafamostat mesylate
CAS NO: 82956-11-4
Classification Code: Anticoagulant ; Antifibrinolytic ; Antifibrinolytic agents ; Drug / Therapeutic Agent ; Reproductive Effect
Melting Point: 259-261°C
H bond acceptors: 7
H bond donors: 7
Freely Rotating Bonds: 5
Polar Surface Area: 54.26 Å²
Flash Point: 339.1 °C
Enthalpy of Vaporization: 94.13 kJ/mol
Boiling Point: 637.2 °C at 760 mmHg
Vapour Pressure: 3.9E-16 mmHg at 25°C

Nafamostat mesylate Uses

6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate (CAS NO.82956-11-4) is used as a non-peptide proteaseinhibitor.

Nafamostat mesylate Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mammal (species unspecified)	LD50	intraperitoneal	200mg/kg (200mg/kg)	United States Patent Document. Vol. #4454338,
mammal (species unspecified)	LD50	oral	2500mg/kg (2500mg/kg)	United States Patent Document. Vol. #4454338,
mouse	LD50	intraperitoneal	269mg/kg (269mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse	LD50	intravenous	24400ug/kg (24.4mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse	LD50	oral	4600mg/kg (4600mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse	LD50	subcutaneous	6180mg/kg (6180mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat	LD50	intraperitoneal	162mg/kg (162mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat	LD50	intravenous	16400ug/kg (16.4mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat	LD50	oral	3050mg/kg (3050mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat	LD50	subcutaneous	9200mg/kg (9200mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.

Nafamostat mesylate Safety Profile

RTECS of 6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate (CAS NO.82956-11-4): DG2736000
A poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NO_x and SO_x.

Product Name

Nafamostat mesylate

Nafamostat mesylate Chemical Properties

Nafamostat mesylate Uses

Nafamostat mesylate Toxicity Data With Reference

Nafamostat mesylate Safety Profile

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